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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-155 Sentence denotes Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells: regulation through c-Fos and c-Jun.
T2 156-286 Sentence denotes Tissue factor is critically important for initiating the activation of coagulation zymogens leading to the generation of thrombin.
T3 287-460 Sentence denotes Quiescent endothelial cells do not express tissue factor on their surface, but many stimuli including cytokines and coagulation proteases can elicit tissue factor synthesis.
T4 461-765 Sentence denotes We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin.
T5 766-860 Sentence denotes We observed a remarkable synergy in the expression of tissue factor by thrombin plus TNFalpha.
T6 861-941 Sentence denotes This was due to altered regulation of the transcription factors c-Jun and c-Fos.
T7 942-1055 Sentence denotes The activation of c-Jun was greater and more sustained than that obtained with either thrombin or TNFalpha alone.
T8 1056-1167 Sentence denotes Thrombin-stimulated expression of c-Fos was both enhanced and prolonged by the concurrent presence of TNFalpha.
T9 1168-1305 Sentence denotes These changes support the increased availability of c-Jun/c-Fos AP-1 complexes for mediating transcription at the tissue factor promoter.
T10 1306-1526 Sentence denotes Transcription factors downstream of the extracellular signal-regulated kinases as well as changes in NFkappaB regulation were not involved in the synergistic increase in tissue factor expression by thrombin and TNFalpha.
T11 1527-1784 Sentence denotes Thus, concurrent exposure of vascular endothelial cells to cytokines and procoagulant proteases such as thrombin can result in greatly enhanced tissue factor expression on the endothelium, thereby perpetuating the prothrombotic phenotype of the endothelium.
T1 0-155 Sentence denotes Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells: regulation through c-Fos and c-Jun.
T2 156-286 Sentence denotes Tissue factor is critically important for initiating the activation of coagulation zymogens leading to the generation of thrombin.
T3 287-460 Sentence denotes Quiescent endothelial cells do not express tissue factor on their surface, but many stimuli including cytokines and coagulation proteases can elicit tissue factor synthesis.
T4 461-765 Sentence denotes We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin.
T5 766-860 Sentence denotes We observed a remarkable synergy in the expression of tissue factor by thrombin plus TNFalpha.
T6 861-941 Sentence denotes This was due to altered regulation of the transcription factors c-Jun and c-Fos.
T7 942-1055 Sentence denotes The activation of c-Jun was greater and more sustained than that obtained with either thrombin or TNFalpha alone.
T8 1056-1167 Sentence denotes Thrombin-stimulated expression of c-Fos was both enhanced and prolonged by the concurrent presence of TNFalpha.
T9 1168-1305 Sentence denotes These changes support the increased availability of c-Jun/c-Fos AP-1 complexes for mediating transcription at the tissue factor promoter.
T10 1306-1526 Sentence denotes Transcription factors downstream of the extracellular signal-regulated kinases as well as changes in NFkappaB regulation were not involved in the synergistic increase in tissue factor expression by thrombin and TNFalpha.
T11 1527-1784 Sentence denotes Thus, concurrent exposure of vascular endothelial cells to cytokines and procoagulant proteases such as thrombin can result in greatly enhanced tissue factor expression on the endothelium, thereby perpetuating the prothrombotic phenotype of the endothelium.

sentences

Id Subject Object Predicate Lexical cue
T1 0-155 Sentence denotes Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells: regulation through c-Fos and c-Jun.
T2 156-286 Sentence denotes Tissue factor is critically important for initiating the activation of coagulation zymogens leading to the generation of thrombin.
T3 287-460 Sentence denotes Quiescent endothelial cells do not express tissue factor on their surface, but many stimuli including cytokines and coagulation proteases can elicit tissue factor synthesis.
T4 461-765 Sentence denotes We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin.
T5 766-860 Sentence denotes We observed a remarkable synergy in the expression of tissue factor by thrombin plus TNFalpha.
T6 861-941 Sentence denotes This was due to altered regulation of the transcription factors c-Jun and c-Fos.
T7 942-1055 Sentence denotes The activation of c-Jun was greater and more sustained than that obtained with either thrombin or TNFalpha alone.
T8 1056-1167 Sentence denotes Thrombin-stimulated expression of c-Fos was both enhanced and prolonged by the concurrent presence of TNFalpha.
T9 1168-1305 Sentence denotes These changes support the increased availability of c-Jun/c-Fos AP-1 complexes for mediating transcription at the tissue factor promoter.
T10 1306-1526 Sentence denotes Transcription factors downstream of the extracellular signal-regulated kinases as well as changes in NFkappaB regulation were not involved in the synergistic increase in tissue factor expression by thrombin and TNFalpha.
T11 1527-1784 Sentence denotes Thus, concurrent exposure of vascular endothelial cells to cytokines and procoagulant proteases such as thrombin can result in greatly enhanced tissue factor expression on the endothelium, thereby perpetuating the prothrombotic phenotype of the endothelium.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 654-660 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15201277-3#58#85#gene7124 519-546 gene7124 denotes tumor necrosis factor alpha
15201277-3#87#95#gene7124 548-556 gene7124 denotes TNFalpha
15201277-3#162#168#diseaseC0036690 623-629 diseaseC0036690 denotes sepsis
15201277-3#162#168#diseaseC0243026 623-629 diseaseC0243026 denotes sepsis
15201277-3#184#207#diseaseC0010054 645-668 diseaseC0010054 denotes coronary artery disease
15201277-3#184#207#diseaseC0010068 645-668 diseaseC0010068 denotes coronary artery disease
15201277-3#184#207#diseaseC1956346 645-668 diseaseC1956346 denotes coronary artery disease
15201277-3#162#168#diseaseC0036690 623-629 diseaseC0036690 denotes sepsis
15201277-3#162#168#diseaseC0243026 623-629 diseaseC0243026 denotes sepsis
15201277-3#184#207#diseaseC0010054 645-668 diseaseC0010054 denotes coronary artery disease
15201277-3#184#207#diseaseC0010068 645-668 diseaseC0010068 denotes coronary artery disease
15201277-3#184#207#diseaseC1956346 645-668 diseaseC1956346 denotes coronary artery disease
58#85#gene7124162#168#diseaseC0036690 15201277-3#58#85#gene7124 15201277-3#162#168#diseaseC0036690 associated_with tumor necrosis factor alpha,sepsis
58#85#gene7124162#168#diseaseC0243026 15201277-3#58#85#gene7124 15201277-3#162#168#diseaseC0243026 associated_with tumor necrosis factor alpha,sepsis
58#85#gene7124184#207#diseaseC0010054 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC0010054 associated_with tumor necrosis factor alpha,coronary artery disease
58#85#gene7124184#207#diseaseC0010068 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC0010068 associated_with tumor necrosis factor alpha,coronary artery disease
58#85#gene7124184#207#diseaseC1956346 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC1956346 associated_with tumor necrosis factor alpha,coronary artery disease
58#85#gene7124162#168#diseaseC0036690 15201277-3#58#85#gene7124 15201277-3#162#168#diseaseC0036690 associated_with tumor necrosis factor alpha,sepsis
58#85#gene7124162#168#diseaseC0243026 15201277-3#58#85#gene7124 15201277-3#162#168#diseaseC0243026 associated_with tumor necrosis factor alpha,sepsis
58#85#gene7124184#207#diseaseC0010054 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC0010054 associated_with tumor necrosis factor alpha,coronary artery disease
58#85#gene7124184#207#diseaseC0010068 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC0010068 associated_with tumor necrosis factor alpha,coronary artery disease
58#85#gene7124184#207#diseaseC1956346 15201277-3#58#85#gene7124 15201277-3#184#207#diseaseC1956346 associated_with tumor necrosis factor alpha,coronary artery disease
87#95#gene7124162#168#diseaseC0036690 15201277-3#87#95#gene7124 15201277-3#162#168#diseaseC0036690 associated_with TNFalpha,sepsis
87#95#gene7124162#168#diseaseC0243026 15201277-3#87#95#gene7124 15201277-3#162#168#diseaseC0243026 associated_with TNFalpha,sepsis
87#95#gene7124184#207#diseaseC0010054 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC0010054 associated_with TNFalpha,coronary artery disease
87#95#gene7124184#207#diseaseC0010068 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC0010068 associated_with TNFalpha,coronary artery disease
87#95#gene7124184#207#diseaseC1956346 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC1956346 associated_with TNFalpha,coronary artery disease
87#95#gene7124162#168#diseaseC0036690 15201277-3#87#95#gene7124 15201277-3#162#168#diseaseC0036690 associated_with TNFalpha,sepsis
87#95#gene7124162#168#diseaseC0243026 15201277-3#87#95#gene7124 15201277-3#162#168#diseaseC0243026 associated_with TNFalpha,sepsis
87#95#gene7124184#207#diseaseC0010054 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC0010054 associated_with TNFalpha,coronary artery disease
87#95#gene7124184#207#diseaseC0010068 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC0010068 associated_with TNFalpha,coronary artery disease
87#95#gene7124184#207#diseaseC1956346 15201277-3#87#95#gene7124 15201277-3#184#207#diseaseC1956346 associated_with TNFalpha,coronary artery disease

DisGeNET

Id Subject Object Predicate Lexical cue
T0 519-546 gene:7124 denotes tumor necrosis factor alpha
T1 623-629 disease:C0036690 denotes sepsis
T2 519-546 gene:7124 denotes tumor necrosis factor alpha
T3 623-629 disease:C0243026 denotes sepsis
T4 519-546 gene:7124 denotes tumor necrosis factor alpha
T5 645-668 disease:C0010054 denotes coronary artery disease
T6 519-546 gene:7124 denotes tumor necrosis factor alpha
T7 645-668 disease:C0010068 denotes coronary artery disease
T8 519-546 gene:7124 denotes tumor necrosis factor alpha
T9 645-668 disease:C1956346 denotes coronary artery disease
T10 548-556 gene:7124 denotes TNFalpha
T11 623-629 disease:C0036690 denotes sepsis
T12 548-556 gene:7124 denotes TNFalpha
T13 623-629 disease:C0243026 denotes sepsis
T14 548-556 gene:7124 denotes TNFalpha
T15 645-668 disease:C0010054 denotes coronary artery disease
T16 548-556 gene:7124 denotes TNFalpha
T17 645-668 disease:C0010068 denotes coronary artery disease
T18 548-556 gene:7124 denotes TNFalpha
T19 645-668 disease:C1956346 denotes coronary artery disease
R1 T0 T1 associated_with tumor necrosis factor alpha,sepsis
R2 T2 T3 associated_with tumor necrosis factor alpha,sepsis
R3 T4 T5 associated_with tumor necrosis factor alpha,coronary artery disease
R4 T6 T7 associated_with tumor necrosis factor alpha,coronary artery disease
R5 T8 T9 associated_with tumor necrosis factor alpha,coronary artery disease
R6 T10 T11 associated_with TNFalpha,sepsis
R7 T12 T13 associated_with TNFalpha,sepsis
R8 T14 T15 associated_with TNFalpha,coronary artery disease
R9 T16 T17 associated_with TNFalpha,coronary artery disease
R10 T18 T19 associated_with TNFalpha,coronary artery disease

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 13-18 Phenotype denotes tumor HP:0002664
T2 519-524 Phenotype denotes tumor HP:0002664
T3 623-629 Phenotype denotes sepsis HP:0100806

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 13-18 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 519-524 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 631-639 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T4 645-668 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 95-100 OrganismTaxon denotes human 9606
T2 475-480 OrganismTaxon denotes human 9606
T3 623-629 OrganismTaxon denotes sepsis 137507

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 67-73 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 101-118 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T3 156-162 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 297-314 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T5 330-336 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 436-442 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T7 481-498 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T8 645-660 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T9 820-826 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 1282-1288 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T11 1346-1359 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T12 1476-1482 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 1556-1582 Body_part denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T14 1671-1677 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 1703-1714 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T16 1772-1783 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 654-660 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 101-118 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T2 297-314 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T3 481-498 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T4 1556-1582 Cell denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139