PubMed:15200408 / 2136-2512 JSONTXT

{"project":"LitCoin-entities","denotations":[{"id":"926","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"927","span":{"begin":87,"end":95},"obj":"OrganismTaxon"},{"id":"928","span":{"begin":157,"end":163},"obj":"GeneOrGeneProduct"},{"id":"929","span":{"begin":173,"end":177},"obj":"OrganismTaxon"},{"id":"930","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"931","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"932","span":{"begin":251,"end":265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"933","span":{"begin":301,"end":310},"obj":"GeneOrGeneProduct"},{"id":"934","span":{"begin":369,"end":375},"obj":"OrganismTaxon"}],"attributes":[{"id":"A41","pred":"db_id","subj":"926","obj":"MESH:C564042"},{"id":"A42","pred":"db_id","subj":"927","obj":"NCBITaxon:9606"},{"id":"A43","pred":"db_id","subj":"928","obj":"NCBIGene:22270"},{"id":"A44","pred":"db_id","subj":"929","obj":"NCBITaxon:10090"},{"id":"A45","pred":"db_id","subj":"930","obj":"MESH:C564042"},{"id":"A46","pred":"db_id","subj":"931","obj":"MESH:D006869"},{"id":"A47","pred":"db_id","subj":"932","obj":"MESH:D066087"},{"id":"A48","pred":"db_id","subj":"933","obj":"NCBIGene:11045"},{"id":"A49","pred":"db_id","subj":"933","obj":"NCBIGene:7380"},{"id":"A50","pred":"db_id","subj":"934","obj":"NCBITaxon:9606"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":376},"obj":"Sentence"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T6","span":{"begin":173,"end":177},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":369,"end":375},"obj":"OrganismTaxon"}],"attributes":[{"id":"A6","pred":"db_id","subj":"T6","obj":"NCBItxid:10095"},{"id":"A7","pred":"db_id","subj":"T6","obj":"NCBItxid:10088"},{"id":"A8","pred":"db_id","subj":"T8","obj":"NCBItxid:9605"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T6","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005510"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T49","span":{"begin":4,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T50","span":{"begin":17,"end":27},"obj":"GeneOrGeneProduct"},{"id":"T51","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"T52","span":{"begin":43,"end":52},"obj":"GeneOrGeneProduct"},{"id":"T53","span":{"begin":83,"end":86},"obj":"GeneOrGeneProduct"},{"id":"T54","span":{"begin":121,"end":128},"obj":"GeneOrGeneProduct"},{"id":"T55","span":{"begin":148,"end":153},"obj":"GeneOrGeneProduct"},{"id":"T56","span":{"begin":157,"end":163},"obj":"GeneOrGeneProduct"},{"id":"T57","span":{"begin":164,"end":172},"obj":"GeneOrGeneProduct"},{"id":"T58","span":{"begin":173,"end":177},"obj":"GeneOrGeneProduct"},{"id":"T59","span":{"begin":178,"end":183},"obj":"GeneOrGeneProduct"},{"id":"T60","span":{"begin":211,"end":214},"obj":"GeneOrGeneProduct"},{"id":"T61","span":{"begin":267,"end":273},"obj":"GeneOrGeneProduct"},{"id":"T62","span":{"begin":295,"end":300},"obj":"GeneOrGeneProduct"},{"id":"T63","span":{"begin":311,"end":320},"obj":"GeneOrGeneProduct"},{"id":"T64","span":{"begin":359,"end":365},"obj":"GeneOrGeneProduct"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T29","span":{"begin":4,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":83,"end":86},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":157,"end":163},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":164,"end":172},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":211,"end":214},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":295,"end":300},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":359,"end":365},"obj":"GeneOrGeneProduct"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T20","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":251,"end":265},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A20","pred":"originalLabel","subj":"T20","obj":"D014718"},{"id":"A21","pred":"originalLabel","subj":"T21","obj":"D014718"},{"id":"A22","pred":"originalLabel","subj":"T22","obj":"D006869"},{"id":"A23","pred":"originalLabel","subj":"T23","obj":"D066087"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T7","span":{"begin":4,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":157,"end":163},"obj":"GeneOrGeneProduct"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T29","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T31","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T33","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A29","pred":"mondo_id","subj":"T29","obj":"0008653"},{"id":"A30","pred":"mondo_id","subj":"T29","obj":"0006007"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"0008653"},{"id":"A32","pred":"mondo_id","subj":"T31","obj":"0006007"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"0005510"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T21","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T24","span":{"begin":251,"end":265},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A21","pred":"ID:","subj":"T21","obj":"D014718"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D014718"},{"id":"A23","pred":"ID:","subj":"T23","obj":"D006869"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D066087"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T19","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":251,"end":265},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A19","pred":"#label","subj":"T19","obj":"D014718"},{"id":"A20","pred":"#label","subj":"T20","obj":"D014718"},{"id":"A21","pred":"#label","subj":"T21","obj":"D006869"},{"id":"A22","pred":"#label","subj":"T22","obj":"D066087"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T7","span":{"begin":87,"end":95},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":173,"end":177},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":369,"end":375},"obj":"OrganismTaxon"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T8","span":{"begin":157,"end":163},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":4,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":251,"end":265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":232,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":211,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":83,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T92547","span":{"begin":369,"end":375},"obj":"OrganismTaxon"},{"id":"T89180","span":{"begin":173,"end":177},"obj":"OrganismTaxon"},{"id":"T55980","span":{"begin":87,"end":95},"obj":"OrganismTaxon"}],"attributes":[{"id":"A22","pred":"#label","subj":"T22","obj":"D066087"},{"id":"A21","pred":"#label","subj":"T21","obj":"D006869"},{"id":"A20","pred":"#label","subj":"T20","obj":"D014718"},{"id":"A19","pred":"#label","subj":"T19","obj":"D014718"}],"text":"The fact that no truncation or frame shift mutations have been found in any of the VUR patients, coupled with our recent finding that some breeding pairs of UP III knockout mice yield litters that show not only VUR, but also severe hydronephrosis and neonatal death, raises the possibility that major uroplakin mutations could be embryonically or postnatally lethal in humans."}