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PubMed:15198993 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 138-230 DRI_Approach denotes The expansion of CAG.CTG repeat sequences is the cause of several inherited human disorders.
T2 231-416 DRI_Background denotes Longer alleles are associated with an earlier age of onset and more severe symptoms, and are highly unstable in the germline and soma with a marked tendency towards repeat length gains.
T3 417-627 DRI_Challenge denotes Germinal expansions underlie anticipation; whereas age-dependent, tissue-specific, expansion-biased somatic instability probably contributes toward the progressive nature and tissue-specificity of the symptoms.
T4 628-777 DRI_Outcome denotes The mechanism(s) of repeat instability is not known, but recent data have implicated mismatch-repair (MMR) gene mutS homologues in driving expansion.
T5 778-963 DRI_Outcome denotes To gain further insight into the expansion mechanism, we have determined the levels of somatic mosaicism of a transgenic expanded CAG.CTG repeat in mice deficient for the Pms2 MMR gene.
T6 964-1063 DRI_Challenge denotes Pms2 is a MutL homologue that plays a critical role in the downstream processing of DNA mismatches.
T7 1064-1145 DRI_Background denotes The rate of somatic expansion was reduced by approximately 50% in Pms2-null mice.
T8 1146-1235 DRI_Background denotes A higher frequency of rare, but very large, deletions was also detected in these animals.
T9 1236-1424 DRI_Background denotes No significant differences were observed between Pms2(+/+) and Pms2(+/-) mice, indicating that a single functional Pms2 allele is sufficient to generate normal levels of somatic mosaicism.
T10 1425-1636 DRI_Outcome denotes These findings reveal that as well as MMR enzymes that directly bind mismatched DNA, proteins that are subsequently recruited to the complex also play a central role in the accumulation of repeat length changes.
T11 1637-1834 DRI_Outcome denotes These data suggest that somatic expansion results not by replication slippage, single stranded annealing or simple MutS-mediated stabilization of secondary structures, but by inappropriate DNA MMR.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-3 CHEBI:53396 denotes Pms
T4 0-3 CHEBI:53430 denotes Pms
T6 0-3 CHEBI:8055 denotes Pms
T7 0-4 PR:P54279 denotes Pms2
T8 0-4 PR:F1NQJ3 denotes Pms2
T9 0-4 PR:P38920 denotes Pms2
T10 0-4 PR:000012914 denotes Pms2
T11 0-4 PR:P54278 denotes Pms2
T12 18-26 SO:0000165 denotes enhancer
T13 30-43 CHEBI:74953 denotes trinucleotide
T14 44-47 CVCL_D569 denotes CAG
T15 52-58 SO:0001068 denotes repeat
T16 120-126 SO:0001068 denotes repeat
T17 155-158 CVCL_D569 denotes CAG
T18 163-169 SO:0001068 denotes repeat
T19 214-219 D006801 denotes human
T20 360-364 204362 denotes soma
T21 360-364 D002328 denotes soma
T22 360-364 D002328 denotes soma
T23 396-402 SO:0001068 denotes repeat
T24 483-489 UBERON:0000479 denotes tissue
T25 592-598 UBERON:0000479 denotes tissue
T26 648-654 SO:0001068 denotes repeat
T27 713-728 GO:0006298 denotes mismatch-repair
T30 730-733 P22897 denotes MMR
T31 730-733 PR:000002972 denotes MMR
T32 730-733 Q61830 denotes MMR
T29 730-733 CVCL_E779 denotes MMR
T28 730-733 GO:0006298 denotes MMR
T33 735-739 SO:0000704 denotes gene
T34 740-744 PR:000023326 denotes mutS
T35 740-744 PR:P23909 denotes mutS
T36 740-744 PR:Q2FYZ9 denotes mutS
T37 781-785 SO:0001742 denotes gain
T38 888-898 SO:0000781 denotes transgenic
T39 908-911 CVCL_D569 denotes CAG
T40 916-922 SO:0001068 denotes repeat
T42 926-930 D051379 denotes mice
T44 926-930 10095 denotes mice
T41 926-930 PR:000005054 denotes mice
T43 926-930 O89094 denotes mice
T45 949-952 CHEBI:53396 denotes Pms
T48 949-952 CHEBI:53430 denotes Pms
T50 949-952 CHEBI:8055 denotes Pms
T51 949-953 PR:P54279 denotes Pms2
T52 949-953 PR:F1NQJ3 denotes Pms2
T53 949-953 PR:P38920 denotes Pms2
T54 949-953 PR:000012914 denotes Pms2
T55 949-953 PR:P54278 denotes Pms2
T56 954-957 GO:0006298 denotes MMR
T58 954-957 P22897 denotes MMR
T59 954-957 PR:000002972 denotes MMR
T60 954-957 Q61830 denotes MMR
T57 954-957 CVCL_E779 denotes MMR
T61 958-962 SO:0000704 denotes gene
T62 964-967 CHEBI:53396 denotes Pms
T65 964-967 CHEBI:53430 denotes Pms
T67 964-967 CHEBI:8055 denotes Pms
T68 964-968 PR:P54279 denotes Pms2
T69 964-968 PR:F1NQJ3 denotes Pms2
T70 964-968 PR:P38920 denotes Pms2
T71 964-968 PR:000012914 denotes Pms2
T72 964-968 PR:P54278 denotes Pms2
T73 974-978 PR:000023324 denotes MutL
T74 974-978 PR:Q93T05 denotes MutL
T75 974-978 PR:P23367 denotes MutL
T76 979-988 SO:0000853 denotes homologue
T77 1023-1033 SO:0001633 denotes downstream
T80 1048-1051 SO:0000352 denotes DNA
T78 1048-1051 GO:0005574 denotes DNA
T79 1048-1051 CHEBI:16991 denotes DNA
T81 1048-1051 D004247 denotes DNA
T82 1130-1133 CHEBI:53396 denotes Pms
T85 1130-1133 CHEBI:53430 denotes Pms
T87 1130-1133 CHEBI:8055 denotes Pms
T88 1130-1134 PR:P54279 denotes Pms2
T89 1130-1134 PR:F1NQJ3 denotes Pms2
T90 1130-1134 PR:P38920 denotes Pms2
T91 1130-1134 PR:000012914 denotes Pms2
T92 1130-1134 PR:P54278 denotes Pms2
T93 1140-1144 PR:000005054 denotes mice
T95 1140-1144 O89094 denotes mice
T94 1140-1144 D051379 denotes mice
T96 1140-1144 10095 denotes mice
T97 1285-1288 CHEBI:53396 denotes Pms
T100 1285-1288 CHEBI:53430 denotes Pms
T102 1285-1288 CHEBI:8055 denotes Pms
T103 1285-1289 PR:P54279 denotes Pms2
T104 1285-1289 PR:F1NQJ3 denotes Pms2
T105 1285-1289 PR:P38920 denotes Pms2
T106 1285-1289 PR:000012914 denotes Pms2
T107 1285-1289 PR:P54278 denotes Pms2
T108 1299-1302 CHEBI:53396 denotes Pms
T111 1299-1302 CHEBI:53430 denotes Pms
T113 1299-1302 CHEBI:8055 denotes Pms
T114 1299-1303 PR:P54279 denotes Pms2
T115 1299-1303 PR:F1NQJ3 denotes Pms2
T116 1299-1303 PR:P38920 denotes Pms2
T117 1299-1303 PR:000012914 denotes Pms2
T118 1299-1303 PR:P54278 denotes Pms2
T119 1309-1313 PR:000005054 denotes mice
T121 1309-1313 O89094 denotes mice
T120 1309-1313 D051379 denotes mice
T122 1309-1313 10095 denotes mice
T123 1351-1354 CHEBI:53396 denotes Pms
T126 1351-1354 CHEBI:53430 denotes Pms
T128 1351-1354 CHEBI:8055 denotes Pms
T129 1351-1355 PR:P54279 denotes Pms2
T130 1351-1355 PR:F1NQJ3 denotes Pms2
T131 1351-1355 PR:P38920 denotes Pms2
T132 1351-1355 PR:000012914 denotes Pms2
T133 1351-1355 PR:P54278 denotes Pms2
T134 1356-1362 SO:0001023 denotes allele
T135 1463-1466 GO:0006298 denotes MMR
T137 1463-1466 P22897 denotes MMR
T138 1463-1466 PR:000002972 denotes MMR
T139 1463-1466 Q61830 denotes MMR
T136 1463-1466 CVCL_E779 denotes MMR
T142 1505-1508 SO:0000352 denotes DNA
T141 1505-1508 CHEBI:16991 denotes DNA
T143 1505-1508 D004247 denotes DNA
T140 1505-1508 GO:0005574 denotes DNA
T144 1510-1518 CHEBI:36080 denotes proteins
T145 1614-1620 SO:0001068 denotes repeat
T146 1752-1756 PR:000023326 denotes MutS
T147 1752-1756 PR:P23909 denotes MutS
T148 1752-1756 PR:Q2FYZ9 denotes MutS
T151 1826-1829 SO:0000352 denotes DNA
T149 1826-1829 GO:0005574 denotes DNA
T150 1826-1829 CHEBI:16991 denotes DNA
T152 1826-1829 D004247 denotes DNA
T153 1830-1833 GO:0006298 denotes MMR
T154 1830-1833 CVCL_E779 denotes MMR
T155 1830-1833 P22897 denotes MMR
T156 1830-1833 PR:000002972 denotes MMR
T157 1830-1833 Q61830 denotes MMR