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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases.
T2 148-168 Sentence denotes BACKGROUND AND AIMS:
T3 169-274 Sentence denotes Appendicectomy and smoking are environmental factors that are known to influence ulcerative colitis (UC).
T4 275-373 Sentence denotes The phenotype of UC is different in patients with coexistent primary sclerosing cholangitis (PSC).
T5 374-494 Sentence denotes This study investigates the interaction of appendicectomy and PSC on the epidemiology and clinical behaviour of colitis.
T6 495-503 Sentence denotes METHODS:
T7 504-564 Sentence denotes Patients were from the Brisbane IBD Research Group database.
T8 565-613 Sentence denotes Controls were from the Australian twin registry.
T9 614-827 Sentence denotes Seventy eight PSC-inflammatory bowel disease (PSC-IBD) patients, 12 pure PSC, and 294 UC patients were matched with 1466 controls by sex and birth cohort that comprised randomly selected twins from each twin pair.
T10 828-1177 Sentence denotes The effects of appendicectomy, smoking, or PSC on the onset of disease, disease extent, disease severity (as identified by immunosuppression-colectomy or liver transplant), and disease related complications (high grade dysplasia, colorectal cancer, or cholangiocarcinoma) were investigated using univariate and multiple logistic regression analyses.
T11 1178-1350 Sentence denotes RESULTS: PSC-IBD patients had a more extensive colitis than UC patients (p<0.0001) but required less immunosuppression (p = 0.007), which was independent of disease extent.
T12 1351-1452 Sentence denotes They were more likely to have high grade dysplasia or colorectal cancer (p = 0.029) than UC patients.
T13 1453-1637 Sentence denotes Appendicectomy rates in the PSC groups were not different from the control groups (p = 0.72, 0.76), which was in sharp contrast with UC where the rate was four times less (p = 0.0001).
T14 1638-1823 Sentence denotes Prior appendicectomy appeared to be associated with an approximate five year delay in the onset of intestinal (PSC-IBD or UC) or hepatic (PSC) disease, which was independent of smoking.
T15 1824-1908 Sentence denotes Appendicectomy did not independently alter the extent or severity of disease in PSC.
T16 1909-2098 Sentence denotes In contrast, prior appendicectomy in UC was associated with more extensive disease but with a lesser requirement for immunosuppression or colectomy for the treatment of colitis (p = 0.004).
T17 2099-2206 Sentence denotes There were trends for high grade dysplasia or colorectal cancer with appendicectomy in both PSC-IBD and UC.
T18 2207-2409 Sentence denotes Although these trends were not statistically significant, colorectal cancer appeared more frequent with appendicectomy in a meta-analysis of the available UC data from this and another Australian study.
T19 2410-2422 Sentence denotes CONCLUSIONS:
T20 2423-2617 Sentence denotes In contradistinction to UC, appendicectomy did not significantly influence the prevalence of the PSC groups, or the extent of colitis in PSC-IBD, but as with UC, did appear to delay their onset.
T21 2618-2727 Sentence denotes The extensive milder colitis, which is characteristic of PSC-IBD, relates to other poorly understood factors.
T22 2728-2895 Sentence denotes Further prospective studies are required to determine any influence of appendicectomy on the extent of colitis in IBD and an associated dysplasia or colorectal cancer.
T1 0-147 Sentence denotes Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases.
T2 148-168 Sentence denotes BACKGROUND AND AIMS:
T3 169-274 Sentence denotes Appendicectomy and smoking are environmental factors that are known to influence ulcerative colitis (UC).
T4 275-373 Sentence denotes The phenotype of UC is different in patients with coexistent primary sclerosing cholangitis (PSC).
T5 374-494 Sentence denotes This study investigates the interaction of appendicectomy and PSC on the epidemiology and clinical behaviour of colitis.
T6 495-503 Sentence denotes METHODS:
T7 504-564 Sentence denotes Patients were from the Brisbane IBD Research Group database.
T8 565-613 Sentence denotes Controls were from the Australian twin registry.
T9 614-827 Sentence denotes Seventy eight PSC-inflammatory bowel disease (PSC-IBD) patients, 12 pure PSC, and 294 UC patients were matched with 1466 controls by sex and birth cohort that comprised randomly selected twins from each twin pair.
T10 828-1177 Sentence denotes The effects of appendicectomy, smoking, or PSC on the onset of disease, disease extent, disease severity (as identified by immunosuppression-colectomy or liver transplant), and disease related complications (high grade dysplasia, colorectal cancer, or cholangiocarcinoma) were investigated using univariate and multiple logistic regression analyses.
T11 1178-1350 Sentence denotes RESULTS: PSC-IBD patients had a more extensive colitis than UC patients (p<0.0001) but required less immunosuppression (p = 0.007), which was independent of disease extent.
T12 1351-1452 Sentence denotes They were more likely to have high grade dysplasia or colorectal cancer (p = 0.029) than UC patients.
T13 1453-1637 Sentence denotes Appendicectomy rates in the PSC groups were not different from the control groups (p = 0.72, 0.76), which was in sharp contrast with UC where the rate was four times less (p = 0.0001).
T14 1638-1823 Sentence denotes Prior appendicectomy appeared to be associated with an approximate five year delay in the onset of intestinal (PSC-IBD or UC) or hepatic (PSC) disease, which was independent of smoking.
T15 1824-1908 Sentence denotes Appendicectomy did not independently alter the extent or severity of disease in PSC.
T16 1909-2098 Sentence denotes In contrast, prior appendicectomy in UC was associated with more extensive disease but with a lesser requirement for immunosuppression or colectomy for the treatment of colitis (p = 0.004).
T17 2099-2206 Sentence denotes There were trends for high grade dysplasia or colorectal cancer with appendicectomy in both PSC-IBD and UC.
T18 2207-2409 Sentence denotes Although these trends were not statistically significant, colorectal cancer appeared more frequent with appendicectomy in a meta-analysis of the available UC data from this and another Australian study.
T19 2410-2422 Sentence denotes CONCLUSIONS:
T20 2423-2617 Sentence denotes In contradistinction to UC, appendicectomy did not significantly influence the prevalence of the PSC groups, or the extent of colitis in PSC-IBD, but as with UC, did appear to delay their onset.
T21 2618-2727 Sentence denotes The extensive milder colitis, which is characteristic of PSC-IBD, relates to other poorly understood factors.
T22 2728-2895 Sentence denotes Further prospective studies are required to determine any influence of appendicectomy on the extent of colitis in IBD and an associated dysplasia or colorectal cancer.