Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-147 |
Sentence |
denotes |
Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases. |
T2 |
148-168 |
Sentence |
denotes |
BACKGROUND AND AIMS: |
T3 |
169-274 |
Sentence |
denotes |
Appendicectomy and smoking are environmental factors that are known to influence ulcerative colitis (UC). |
T4 |
275-373 |
Sentence |
denotes |
The phenotype of UC is different in patients with coexistent primary sclerosing cholangitis (PSC). |
T5 |
374-494 |
Sentence |
denotes |
This study investigates the interaction of appendicectomy and PSC on the epidemiology and clinical behaviour of colitis. |
T6 |
495-503 |
Sentence |
denotes |
METHODS: |
T7 |
504-564 |
Sentence |
denotes |
Patients were from the Brisbane IBD Research Group database. |
T8 |
565-613 |
Sentence |
denotes |
Controls were from the Australian twin registry. |
T9 |
614-827 |
Sentence |
denotes |
Seventy eight PSC-inflammatory bowel disease (PSC-IBD) patients, 12 pure PSC, and 294 UC patients were matched with 1466 controls by sex and birth cohort that comprised randomly selected twins from each twin pair. |
T10 |
828-1177 |
Sentence |
denotes |
The effects of appendicectomy, smoking, or PSC on the onset of disease, disease extent, disease severity (as identified by immunosuppression-colectomy or liver transplant), and disease related complications (high grade dysplasia, colorectal cancer, or cholangiocarcinoma) were investigated using univariate and multiple logistic regression analyses. |
T11 |
1178-1350 |
Sentence |
denotes |
RESULTS: PSC-IBD patients had a more extensive colitis than UC patients (p<0.0001) but required less immunosuppression (p = 0.007), which was independent of disease extent. |
T12 |
1351-1452 |
Sentence |
denotes |
They were more likely to have high grade dysplasia or colorectal cancer (p = 0.029) than UC patients. |
T13 |
1453-1637 |
Sentence |
denotes |
Appendicectomy rates in the PSC groups were not different from the control groups (p = 0.72, 0.76), which was in sharp contrast with UC where the rate was four times less (p = 0.0001). |
T14 |
1638-1823 |
Sentence |
denotes |
Prior appendicectomy appeared to be associated with an approximate five year delay in the onset of intestinal (PSC-IBD or UC) or hepatic (PSC) disease, which was independent of smoking. |
T15 |
1824-1908 |
Sentence |
denotes |
Appendicectomy did not independently alter the extent or severity of disease in PSC. |
T16 |
1909-2098 |
Sentence |
denotes |
In contrast, prior appendicectomy in UC was associated with more extensive disease but with a lesser requirement for immunosuppression or colectomy for the treatment of colitis (p = 0.004). |
T17 |
2099-2206 |
Sentence |
denotes |
There were trends for high grade dysplasia or colorectal cancer with appendicectomy in both PSC-IBD and UC. |
T18 |
2207-2409 |
Sentence |
denotes |
Although these trends were not statistically significant, colorectal cancer appeared more frequent with appendicectomy in a meta-analysis of the available UC data from this and another Australian study. |
T19 |
2410-2422 |
Sentence |
denotes |
CONCLUSIONS: |
T20 |
2423-2617 |
Sentence |
denotes |
In contradistinction to UC, appendicectomy did not significantly influence the prevalence of the PSC groups, or the extent of colitis in PSC-IBD, but as with UC, did appear to delay their onset. |
T21 |
2618-2727 |
Sentence |
denotes |
The extensive milder colitis, which is characteristic of PSC-IBD, relates to other poorly understood factors. |
T22 |
2728-2895 |
Sentence |
denotes |
Further prospective studies are required to determine any influence of appendicectomy on the extent of colitis in IBD and an associated dysplasia or colorectal cancer. |
T1 |
0-147 |
Sentence |
denotes |
Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases. |
T2 |
148-168 |
Sentence |
denotes |
BACKGROUND AND AIMS: |
T3 |
169-274 |
Sentence |
denotes |
Appendicectomy and smoking are environmental factors that are known to influence ulcerative colitis (UC). |
T4 |
275-373 |
Sentence |
denotes |
The phenotype of UC is different in patients with coexistent primary sclerosing cholangitis (PSC). |
T5 |
374-494 |
Sentence |
denotes |
This study investigates the interaction of appendicectomy and PSC on the epidemiology and clinical behaviour of colitis. |
T6 |
495-503 |
Sentence |
denotes |
METHODS: |
T7 |
504-564 |
Sentence |
denotes |
Patients were from the Brisbane IBD Research Group database. |
T8 |
565-613 |
Sentence |
denotes |
Controls were from the Australian twin registry. |
T9 |
614-827 |
Sentence |
denotes |
Seventy eight PSC-inflammatory bowel disease (PSC-IBD) patients, 12 pure PSC, and 294 UC patients were matched with 1466 controls by sex and birth cohort that comprised randomly selected twins from each twin pair. |
T10 |
828-1177 |
Sentence |
denotes |
The effects of appendicectomy, smoking, or PSC on the onset of disease, disease extent, disease severity (as identified by immunosuppression-colectomy or liver transplant), and disease related complications (high grade dysplasia, colorectal cancer, or cholangiocarcinoma) were investigated using univariate and multiple logistic regression analyses. |
T11 |
1178-1350 |
Sentence |
denotes |
RESULTS: PSC-IBD patients had a more extensive colitis than UC patients (p<0.0001) but required less immunosuppression (p = 0.007), which was independent of disease extent. |
T12 |
1351-1452 |
Sentence |
denotes |
They were more likely to have high grade dysplasia or colorectal cancer (p = 0.029) than UC patients. |
T13 |
1453-1637 |
Sentence |
denotes |
Appendicectomy rates in the PSC groups were not different from the control groups (p = 0.72, 0.76), which was in sharp contrast with UC where the rate was four times less (p = 0.0001). |
T14 |
1638-1823 |
Sentence |
denotes |
Prior appendicectomy appeared to be associated with an approximate five year delay in the onset of intestinal (PSC-IBD or UC) or hepatic (PSC) disease, which was independent of smoking. |
T15 |
1824-1908 |
Sentence |
denotes |
Appendicectomy did not independently alter the extent or severity of disease in PSC. |
T16 |
1909-2098 |
Sentence |
denotes |
In contrast, prior appendicectomy in UC was associated with more extensive disease but with a lesser requirement for immunosuppression or colectomy for the treatment of colitis (p = 0.004). |
T17 |
2099-2206 |
Sentence |
denotes |
There were trends for high grade dysplasia or colorectal cancer with appendicectomy in both PSC-IBD and UC. |
T18 |
2207-2409 |
Sentence |
denotes |
Although these trends were not statistically significant, colorectal cancer appeared more frequent with appendicectomy in a meta-analysis of the available UC data from this and another Australian study. |
T19 |
2410-2422 |
Sentence |
denotes |
CONCLUSIONS: |
T20 |
2423-2617 |
Sentence |
denotes |
In contradistinction to UC, appendicectomy did not significantly influence the prevalence of the PSC groups, or the extent of colitis in PSC-IBD, but as with UC, did appear to delay their onset. |
T21 |
2618-2727 |
Sentence |
denotes |
The extensive milder colitis, which is characteristic of PSC-IBD, relates to other poorly understood factors. |
T22 |
2728-2895 |
Sentence |
denotes |
Further prospective studies are required to determine any influence of appendicectomy on the extent of colitis in IBD and an associated dysplasia or colorectal cancer. |