| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
94-191 |
DRI_Background |
denotes |
Shaping a developing organ or embryo relies on the spatial regulation of cell division and shape. |
| T2 |
192-305 |
DRI_Background |
denotes |
However, morphogenesis also occurs through changes in cell-neighbourhood relationships produced by intercalation. |
| T3 |
306-435 |
DRI_Background |
denotes |
Intercalation poses a special problem in epithelia because of the adherens junctions, which maintain the integrity of the tissue. |
| T4 |
436-642 |
DRI_Approach |
denotes |
Here we address the mechanism by which an ordered process of cell intercalation directs polarized epithelial morphogenesis during germ-band elongation, the developmental elongation of the Drosophila embryo. |
| T5 |
643-802 |
DRI_Approach |
denotes |
Intercalation progresses because junctions are spatially reorganized in the plane of the epithelium following an ordered pattern of disassembly and reassembly. |
| T6 |
803-944 |
DRI_Background |
denotes |
The planar remodelling of junctions is not driven by external forces at the tissue boundaries but depends on local forces at cell boundaries. |
| T7 |
945-1127 |
DRI_Background |
denotes |
Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are required for planar junction remodelling and cell intercalation. |
| T8 |
1128-1233 |
DRI_Background |
denotes |
This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs. |
