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PubMed:15190008 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 48-62 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T2 330-336 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T3 529-543 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T4 545-551 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T5 642-648 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T6 907-913 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T7 1296-1302 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T8 1391-1397 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T9 1461-1467 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 48-62 Glycan_Motif denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T2 330-336 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T3 529-543 Glycan_Motif denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T4 545-551 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T5 642-648 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T6 907-913 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T7 1296-1302 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T8 1391-1397 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T9 1461-1467 Glycan_Motif denotes sLe(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 48-62 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T2 55-62 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T3 330-336 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T4 529-543 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T5 536-543 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T6 545-551 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T7 642-648 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T8 907-913 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T9 1296-1302 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T10 1391-1397 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)
T11 1461-1467 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLe(x)

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
TextSentencer_T2 110-608 Sentence denotes Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to treat ischemia-reperfusion injury and other complement-mediated diseases and injuries. sCR1-sLe(x) produced in the FT-VI-expressing mutant CHO cell line LEC11 exists as a heterogeneous mixture of glycoforms, a fraction of which include structures with one or more antennae terminated by the sialyl Lewis X (sLe(x)) [Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc]) epitope.
TextSentencer_T3 609-750 Sentence denotes Such multivalent presentation of sLe(x) was shown previously to effectively target sCR1 to activated endothelial cells expressing E-selectin.
TextSentencer_T4 751-997 Sentence denotes Here, we describe the use of the soluble, recombinant alpha2-3 sialyltransferase ST3Gal-III and the alpha1-3 fucosyltransferase FT-VI in vitro to introduce sLe(x) moieties onto the N-glycan chains of sCR1 overexpressed in standard CHO cell lines.
TextSentencer_T5 998-1696 Sentence denotes The product (sCR1-S/F) of these in vitro enzymatic glycan remodeling reactions performed at the 10-g scale has approximately 14 N-glycan chains per sCR1 molecule, comprised of biantennary (90%), triantennary (8.5%), and tetraantennary (1.5%) structures, nearly all of whose antennae terminate with sLe(x) moieties. sCR1-S/F retained complement inhibitory activity and, in comparison with sCR1-sLe(x) produced in the LEC11 cell line, contained twice the number of sLe(x) moieties per mole glycoprotein, exhibited a twofold increase in area under the intravenous clearance curve in a rat pharmacokinetic model, and exhibited a 10-fold increase in affinity for E-selectin in an in vitro binding assay.
TextSentencer_T6 1697-1905 Sentence denotes These results demonstrate that in vitro glycosylation of the sCR1 drug product reduces heterogeneity of the glycan profile, improves pharmacokinetics, and enhances carbohydrate-mediated binding to E-selectin.
T1 0-109 Sentence denotes Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
T2 110-608 Sentence denotes Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to treat ischemia-reperfusion injury and other complement-mediated diseases and injuries. sCR1-sLe(x) produced in the FT-VI-expressing mutant CHO cell line LEC11 exists as a heterogeneous mixture of glycoforms, a fraction of which include structures with one or more antennae terminated by the sialyl Lewis X (sLe(x)) [Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc]) epitope.
T3 609-750 Sentence denotes Such multivalent presentation of sLe(x) was shown previously to effectively target sCR1 to activated endothelial cells expressing E-selectin.
T4 751-997 Sentence denotes Here, we describe the use of the soluble, recombinant alpha2-3 sialyltransferase ST3Gal-III and the alpha1-3 fucosyltransferase FT-VI in vitro to introduce sLe(x) moieties onto the N-glycan chains of sCR1 overexpressed in standard CHO cell lines.
T5 998-1696 Sentence denotes The product (sCR1-S/F) of these in vitro enzymatic glycan remodeling reactions performed at the 10-g scale has approximately 14 N-glycan chains per sCR1 molecule, comprised of biantennary (90%), triantennary (8.5%), and tetraantennary (1.5%) structures, nearly all of whose antennae terminate with sLe(x) moieties. sCR1-S/F retained complement inhibitory activity and, in comparison with sCR1-sLe(x) produced in the LEC11 cell line, contained twice the number of sLe(x) moieties per mole glycoprotein, exhibited a twofold increase in area under the intravenous clearance curve in a rat pharmacokinetic model, and exhibited a 10-fold increase in affinity for E-selectin in an in vitro binding assay.
T6 1697-1905 Sentence denotes These results demonstrate that in vitro glycosylation of the sCR1 drug product reduces heterogeneity of the glycan profile, improves pharmacokinetics, and enhances carbohydrate-mediated binding to E-selectin.
T1 0-109 Sentence denotes Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
T2 110-608 Sentence denotes Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to treat ischemia-reperfusion injury and other complement-mediated diseases and injuries. sCR1-sLe(x) produced in the FT-VI-expressing mutant CHO cell line LEC11 exists as a heterogeneous mixture of glycoforms, a fraction of which include structures with one or more antennae terminated by the sialyl Lewis X (sLe(x)) [Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc]) epitope.
T3 609-750 Sentence denotes Such multivalent presentation of sLe(x) was shown previously to effectively target sCR1 to activated endothelial cells expressing E-selectin.
T4 751-997 Sentence denotes Here, we describe the use of the soluble, recombinant alpha2-3 sialyltransferase ST3Gal-III and the alpha1-3 fucosyltransferase FT-VI in vitro to introduce sLe(x) moieties onto the N-glycan chains of sCR1 overexpressed in standard CHO cell lines.
T5 998-1696 Sentence denotes The product (sCR1-S/F) of these in vitro enzymatic glycan remodeling reactions performed at the 10-g scale has approximately 14 N-glycan chains per sCR1 molecule, comprised of biantennary (90%), triantennary (8.5%), and tetraantennary (1.5%) structures, nearly all of whose antennae terminate with sLe(x) moieties. sCR1-S/F retained complement inhibitory activity and, in comparison with sCR1-sLe(x) produced in the LEC11 cell line, contained twice the number of sLe(x) moieties per mole glycoprotein, exhibited a twofold increase in area under the intravenous clearance curve in a rat pharmacokinetic model, and exhibited a 10-fold increase in affinity for E-selectin in an in vitro binding assay.
T6 1697-1905 Sentence denotes These results demonstrate that in vitro glycosylation of the sCR1 drug product reduces heterogeneity of the glycan profile, improves pharmacokinetics, and enhances carbohydrate-mediated binding to E-selectin.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 48-62 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X
T2 529-543 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 502-510 http://purl.obolibrary.org/obo/MAT_0000086 denotes antennae
T2 1272-1280 http://purl.obolibrary.org/obo/MAT_0000086 denotes antennae

ICD10

Id Subject Object Predicate Lexical cue
T1 221-234 http://purl.bioontology.org/ontology/ICD10/Z72.2 denotes use as a drug
T2 265-271 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T3 315-323 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injuries

uniprot-human

Id Subject Object Predicate Lexical cue
T1 136-162 http://www.uniprot.org/uniprot/P17927 denotes complement receptor type 1
T2 136-160 http://www.uniprot.org/uniprot/P20023 denotes complement receptor type
T3 147-162 http://www.uniprot.org/uniprot/O43613 denotes receptor type 1
T4 147-162 http://www.uniprot.org/uniprot/P30872 denotes receptor type 1
T5 147-162 http://www.uniprot.org/uniprot/P47211 denotes receptor type 1
T6 147-162 http://www.uniprot.org/uniprot/P30989 denotes receptor type 1
T7 147-162 http://www.uniprot.org/uniprot/Q14643 denotes receptor type 1
T8 147-162 http://www.uniprot.org/uniprot/Q16602 denotes receptor type 1
T9 147-162 http://www.uniprot.org/uniprot/P21817 denotes receptor type 1
T10 147-162 http://www.uniprot.org/uniprot/Q04771 denotes receptor type 1
T11 739-749 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T12 1656-1666 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T13 1894-1904 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T14 832-842 http://www.uniprot.org/uniprot/Q8IX54 denotes ST3Gal-III
T15 858-878 http://www.uniprot.org/uniprot/P21217 denotes 3 fucosyltransferase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 739-749 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T2 1656-1666 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T3 1894-1904 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T4 832-842 http://www.uniprot.org/uniprot/P97325 denotes ST3Gal-III
T5 1207-1210 http://www.uniprot.org/uniprot/P47759 denotes 8.5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 409-422 http://purl.bioontology.org/ontology/NCBITAXON/1113441 denotes heterogeneous
T2 409-422 http://purl.bioontology.org/ontology/NCBITAXON/691256 denotes heterogeneous
T3 502-510 http://purl.bioontology.org/ontology/NCBITAXON/293542 denotes antennae
T4 722-727 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1272-1280 http://purl.bioontology.org/ontology/NCBITAXON/293542 denotes antennae
T6 1532-1536 http://purl.bioontology.org/ontology/NCBITAXON/293505 denotes area
T7 1784-1797 http://purl.bioontology.org/ontology/NCBITAXON/1113441 denotes heterogeneity
T8 1784-1797 http://purl.bioontology.org/ontology/NCBITAXON/691256 denotes heterogeneity

GO-BP

Id Subject Object Predicate Lexical cue
T1 48-54 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T2 529-535 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T3 84-97 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 182-194 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T5 377-380 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T6 982-985 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T7 700-727 http://purl.obolibrary.org/obo/GO_0042118 denotes activated endothelial cells
T8 700-727 http://purl.obolibrary.org/obo/GO_0045603 denotes activated endothelial cells
T9 700-727 http://purl.obolibrary.org/obo/GO_1901552 denotes activated endothelial cells
T10 700-727 http://purl.obolibrary.org/obo/GO_0001938 denotes activated endothelial cells
T11 812-831 http://purl.obolibrary.org/obo/GO_0004513 denotes 3 sialyltransferase

GO-MF

Id Subject Object Predicate Lexical cue
T1 741-749 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T2 1658-1666 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T3 1896-1904 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T4 1682-1689 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1883-1890 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 1682-1689 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 1883-1890 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 1682-1689 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1883-1890 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 1682-1689 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 1883-1890 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 381-385 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 986-990 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 722-727 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 502-510 http://purl.obolibrary.org/obo/UBERON_0000972 denotes antennae
T2 1272-1280 http://purl.obolibrary.org/obo/UBERON_0000972 denotes antennae
T3 1099-1104 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale
T4 1481-1485 http://purl.obolibrary.org/obo/UBERON_1000010 denotes mole

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 591-597 chem:24139 denotes GlcNAc

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 502-510 http://purl.obolibrary.org/obo/MAT_0000086 denotes antennae
T2 1272-1280 http://purl.obolibrary.org/obo/MAT_0000086 denotes antennae

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 48-60 http://rdf.glycoinfo.org/glycan/G00053MO denotes sialyl Lewis
T2 529-541 http://rdf.glycoinfo.org/glycan/G00053MO denotes sialyl Lewis
T3 48-62 http://rdf.glycoinfo.org/glycan/G00054MO denotes sialyl Lewis X
T4 529-543 http://rdf.glycoinfo.org/glycan/G00054MO denotes sialyl Lewis X
T5 55-60 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T6 536-541 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T7 55-62 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis X
T8 536-543 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis X
T9 330-335 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T10 545-550 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T11 642-647 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T12 907-912 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T13 1296-1301 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T14 1391-1396 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T15 1461-1466 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLe(x
T16 932-940 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycan
T17 1126-1134 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycan

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 739-749 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T2 1656-1666 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T3 1894-1904 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T4 741-749 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T5 1658-1666 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T6 1896-1904 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T7 741-749 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T8 1658-1666 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T9 1896-1904 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 48-60 http://www.glycoepitope.jp/epitopes/EP0008 denotes sialyl Lewis
PD-GlycoEpitope-B_T2 529-541 http://www.glycoepitope.jp/epitopes/EP0008 denotes sialyl Lewis
PD-GlycoEpitope-B_T3 48-62 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X
PD-GlycoEpitope-B_T4 529-543 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X
PD-GlycoEpitope-B_T5 55-62 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X
PD-GlycoEpitope-B_T6 536-543 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 591-597 "http://rdf.glycoinfo.org/glycan/G26693XF" denotes GlcNAc
GlycanIUPAC_T2 591-597 "http://rdf.glycoinfo.org/glycan/G01864SU" denotes GlcNAc
GlycanIUPAC_T3 591-597 "http://rdf.glycoinfo.org/glycan/G17605FD" denotes GlcNAc
GlycanIUPAC_T4 591-597 "http://rdf.glycoinfo.org/glycan/G41950LU" denotes GlcNAc
GlycanIUPAC_T5 591-597 "http://rdf.glycoinfo.org/glycan/G57195RJ" denotes GlcNAc
GlycanIUPAC_T6 591-597 "http://rdf.glycoinfo.org/glycan/G85391SA" denotes GlcNAc
GlycanIUPAC_T7 591-597 "http://rdf.glycoinfo.org/glycan/G89565QL" denotes GlcNAc
GlycanIUPAC_T8 591-597 "http://rdf.glycoinfo.org/glycan/G80869MR" denotes GlcNAc
GlycanIUPAC_T9 591-597 "http://rdf.glycoinfo.org/glycan/G55978NL" denotes GlcNAc
GlycanIUPAC_T10 591-597 "http://rdf.glycoinfo.org/glycan/G54644LT" denotes GlcNAc
GlycanIUPAC_T11 591-597 "http://rdf.glycoinfo.org/glycan/G25694UG" denotes GlcNAc
GlycanIUPAC_T12 591-597 "http://rdf.glycoinfo.org/glycan/G25126RB" denotes GlcNAc
GlycanIUPAC_T13 591-597 "http://rdf.glycoinfo.org/glycan/G51848AD" denotes GlcNAc
GlycanIUPAC_T14 591-597 "http://rdf.glycoinfo.org/glycan/G94667GM" denotes GlcNAc
GlycanIUPAC_T15 591-597 "http://rdf.glycoinfo.org/glycan/G30124BO" denotes GlcNAc
GlycanIUPAC_T16 591-597 "http://rdf.glycoinfo.org/glycan/G82777EZ" denotes GlcNAc
GlycanIUPAC_T17 591-597 "http://rdf.glycoinfo.org/glycan/G10151YZ" denotes GlcNAc
GlycanIUPAC_T18 591-597 "http://rdf.glycoinfo.org/glycan/G17585ZM" denotes GlcNAc
GlycanIUPAC_T19 591-597 "http://rdf.glycoinfo.org/glycan/G04411CJ" denotes GlcNAc
GlycanIUPAC_T20 591-597 "http://rdf.glycoinfo.org/glycan/G38254HJ" denotes GlcNAc
GlycanIUPAC_T21 591-597 "http://rdf.glycoinfo.org/glycan/G75188FS" denotes GlcNAc
GlycanIUPAC_T22 591-597 "http://rdf.glycoinfo.org/glycan/G70374VG" denotes GlcNAc
GlycanIUPAC_T23 591-597 "http://rdf.glycoinfo.org/glycan/G45176LJ" denotes GlcNAc
GlycanIUPAC_T24 591-597 "http://rdf.glycoinfo.org/glycan/G30874VW" denotes GlcNAc
GlycanIUPAC_T25 591-597 "http://rdf.glycoinfo.org/glycan/G69333MI" denotes GlcNAc
GlycanIUPAC_T26 591-597 "http://rdf.glycoinfo.org/glycan/G10676XO" denotes GlcNAc
GlycanIUPAC_T27 591-597 "http://rdf.glycoinfo.org/glycan/G14843DJ" denotes GlcNAc
GlycanIUPAC_T28 591-597 "http://rdf.glycoinfo.org/glycan/G47546FR" denotes GlcNAc
GlycanIUPAC_T29 591-597 "http://rdf.glycoinfo.org/glycan/G73695ZM" denotes GlcNAc
GlycanIUPAC_T30 591-597 "http://rdf.glycoinfo.org/glycan/G31923TJ" denotes GlcNAc
GlycanIUPAC_T31 591-597 "http://rdf.glycoinfo.org/glycan/G60519EP" denotes GlcNAc
GlycanIUPAC_T32 591-597 "http://rdf.glycoinfo.org/glycan/G07933IA" denotes GlcNAc
GlycanIUPAC_T33 591-597 "http://rdf.glycoinfo.org/glycan/G40745NH" denotes GlcNAc
GlycanIUPAC_T34 591-597 "http://rdf.glycoinfo.org/glycan/G54496YV" denotes GlcNAc
GlycanIUPAC_T35 591-597 "http://rdf.glycoinfo.org/glycan/G62953SQ" denotes GlcNAc
GlycanIUPAC_T36 591-597 "http://rdf.glycoinfo.org/glycan/G70070AY" denotes GlcNAc
GlycanIUPAC_T37 591-597 "http://rdf.glycoinfo.org/glycan/G78792WC" denotes GlcNAc
GlycanIUPAC_T38 591-597 "http://rdf.glycoinfo.org/glycan/G25238AV" denotes GlcNAc
GlycanIUPAC_T39 591-597 "http://rdf.glycoinfo.org/glycan/G40510DP" denotes GlcNAc
GlycanIUPAC_T40 591-597 "http://rdf.glycoinfo.org/glycan/G61120TK" denotes GlcNAc
GlycanIUPAC_T41 591-597 "http://rdf.glycoinfo.org/glycan/G41342KV" denotes GlcNAc
GlycanIUPAC_T42 591-597 "http://rdf.glycoinfo.org/glycan/G90703NA" denotes GlcNAc
GlycanIUPAC_T43 591-597 "http://rdf.glycoinfo.org/glycan/G01591HR" denotes GlcNAc
GlycanIUPAC_T44 591-597 "http://rdf.glycoinfo.org/glycan/G56520XN" denotes GlcNAc
GlycanIUPAC_T45 591-597 "http://rdf.glycoinfo.org/glycan/G81830JX" denotes GlcNAc
GlycanIUPAC_T46 1259-1262 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T47 1259-1262 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T48 1259-1262 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T49 1259-1262 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T50 1259-1262 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T51 1259-1262 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T52 1259-1262 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T53 1259-1262 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T54 1259-1262 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T55 1259-1262 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T56 1259-1262 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T57 1259-1262 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T58 1259-1262 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T59 1259-1262 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T60 1259-1262 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T61 1259-1262 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T62 1259-1262 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T63 1259-1262 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T64 1259-1262 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T65 1259-1262 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T66 1259-1262 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T67 1259-1262 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T68 1259-1262 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T69 1259-1262 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T70 1259-1262 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T71 1259-1262 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T72 1259-1262 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T73 1259-1262 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T74 1259-1262 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T75 1259-1262 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T76 1259-1262 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T77 1259-1262 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T78 1259-1262 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T79 1259-1262 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T80 1259-1262 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T81 1259-1262 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T82 1259-1262 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T83 1259-1262 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T84 1259-1262 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T85 1259-1262 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T86 1259-1262 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T87 1259-1262 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T88 1259-1262 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T89 1259-1262 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T90 1259-1262 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T91 1259-1262 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T92 1259-1262 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T93 1259-1262 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T94 1259-1262 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T95 1259-1262 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T96 1259-1262 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T97 1259-1262 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T98 1259-1262 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T99 1259-1262 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T100 1259-1262 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T101 1259-1262 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T102 1259-1262 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T103 1259-1262 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T104 1259-1262 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T105 1259-1262 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T106 1259-1262 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T107 1259-1262 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T108 1259-1262 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T109 1259-1262 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T110 1259-1262 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T111 1259-1262 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T112 1259-1262 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T113 1259-1262 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T114 1259-1262 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T115 1259-1262 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T116 1259-1262 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T117 1259-1262 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T118 1259-1262 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T119 1259-1262 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T120 1259-1262 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T121 1259-1262 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T122 1259-1262 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T123 1259-1262 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T124 1259-1262 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T125 1259-1262 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T126 1259-1262 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T127 1259-1262 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T128 1259-1262 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T129 1259-1262 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T130 1259-1262 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T131 1259-1262 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T132 1259-1262 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T133 1259-1262 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T134 1259-1262 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T135 1259-1262 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T136 1259-1262 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T137 1259-1262 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T138 1259-1262 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T139 1259-1262 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T140 1259-1262 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T141 1259-1262 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T142 1259-1262 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T143 1259-1262 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 502-510 http://purl.obolibrary.org/obo/UBERON_0000972 denotes antennae
PD-UBERON-AE-B_T2 1272-1280 http://purl.obolibrary.org/obo/UBERON_0000972 denotes antennae
PD-UBERON-AE-B_T3 1099-1104 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale
PD-UBERON-AE-B_T4 1481-1485 http://purl.obolibrary.org/obo/UBERON_1000010 denotes mole

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 48-62 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 330-336 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T3 529-543 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T4 545-551 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T5 642-648 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T6 907-913 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T7 1296-1302 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T8 1391-1397 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T9 1461-1467 Glycan denotes sLe(x) https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 244-271 Disease denotes ischemia-reperfusion injury http://purl.obolibrary.org/obo/MONDO_0005203
T2 1481-1485 Disease denotes mole http://purl.obolibrary.org/obo/MONDO_0005073

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 330-333 Phenotype denotes sLe HP:0002725
T2 545-548 Phenotype denotes sLe HP:0002725
T3 642-645 Phenotype denotes sLe HP:0002725
T4 907-910 Phenotype denotes sLe HP:0002725
T5 1296-1299 Phenotype denotes sLe HP:0002725
T6 1391-1394 Phenotype denotes sLe HP:0002725
T7 1461-1464 Phenotype denotes sLe HP:0002725
T8 1481-1485 Phenotype denotes mole HP:0003764

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 48-62 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012
T2 529-543 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1481-1485 Phenotype denotes mole HP:0003764

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 48-62 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 529-543 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 710-727 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 244-252 Disease denotes ischemia MONDO:0005053
T2 1481-1485 Disease denotes mole MONDO:0005073

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 130-135 Organism denotes human 9606
T2 1580-1583 Organism denotes rat 10114|10116

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
T2 110-608 Sentence denotes Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to treat ischemia-reperfusion injury and other complement-mediated diseases and injuries. sCR1-sLe(x) produced in the FT-VI-expressing mutant CHO cell line LEC11 exists as a heterogeneous mixture of glycoforms, a fraction of which include structures with one or more antennae terminated by the sialyl Lewis X (sLe(x)) [Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc]) epitope.
T3 609-750 Sentence denotes Such multivalent presentation of sLe(x) was shown previously to effectively target sCR1 to activated endothelial cells expressing E-selectin.
T4 751-997 Sentence denotes Here, we describe the use of the soluble, recombinant alpha2-3 sialyltransferase ST3Gal-III and the alpha1-3 fucosyltransferase FT-VI in vitro to introduce sLe(x) moieties onto the N-glycan chains of sCR1 overexpressed in standard CHO cell lines.
T5 998-1696 Sentence denotes The product (sCR1-S/F) of these in vitro enzymatic glycan remodeling reactions performed at the 10-g scale has approximately 14 N-glycan chains per sCR1 molecule, comprised of biantennary (90%), triantennary (8.5%), and tetraantennary (1.5%) structures, nearly all of whose antennae terminate with sLe(x) moieties. sCR1-S/F retained complement inhibitory activity and, in comparison with sCR1-sLe(x) produced in the LEC11 cell line, contained twice the number of sLe(x) moieties per mole glycoprotein, exhibited a twofold increase in area under the intravenous clearance curve in a rat pharmacokinetic model, and exhibited a 10-fold increase in affinity for E-selectin in an in vitro binding assay.
T6 1697-1905 Sentence denotes These results demonstrate that in vitro glycosylation of the sCR1 drug product reduces heterogeneity of the glycan profile, improves pharmacokinetics, and enhances carbohydrate-mediated binding to E-selectin.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 48-62 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012
T2 330-336 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T3 529-543 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012
T4 545-551 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T5 642-648 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T6 907-913 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T7 1296-1302 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T8 1391-1397 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012
T9 1461-1467 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sLe(x) http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 710-727 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 1099-1104 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 710-727 Body_part denotes endothelial cells FMA:66772

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 502-510 Body_part denotes antennae http://purl.obolibrary.org/obo/MAT_0000086
T2 1272-1280 Body_part denotes antennae http://purl.obolibrary.org/obo/MAT_0000086

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 130-135 OrganismTaxon denotes human 9606
T2 1580-1583 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 710-727 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 1099-1104 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T3 1481-1485 Body_part denotes mole http://purl.obolibrary.org/obo/UBERON_1000010

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 502-510 Body_part denotes antennae http://purl.obolibrary.org/obo/MAT_0000086
T2 1272-1280 Body_part denotes antennae http://purl.obolibrary.org/obo/MAT_0000086

GlyCosmos15-Lectin

Id Subject Object Predicate Lexical cue
T1 739-749 GL_002002 denotes E-selectin
T2 1656-1666 GL_002002 denotes E-selectin
T3 1894-1904 GL_002002 denotes E-selectin

Lectin_test

Id Subject Object Predicate Lexical cue
T1 739-749 GL_002002 denotes E-selectin
T2 1656-1666 GL_002002 denotes E-selectin
T3 1894-1904 GL_002002 denotes E-selectin

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 710-727 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115