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PubMed:15156398 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 59-68 gene:836 denotes caspase-3
T1 126-140 disease:C1140680 denotes ovarian cancer
T2 59-68 gene:836 denotes caspase-3
T3 126-140 disease:C0029925 denotes ovarian cancer
T4 428-431 gene:1678 denotes DDP
T5 433-447 disease:C1140680 denotes ovarian cancer
T6 428-431 gene:1678 denotes DDP
T7 433-447 disease:C0029925 denotes ovarian cancer
T8 1250-1255 gene:598 denotes Bcl-X
T9 1354-1368 disease:C0029925 denotes ovarian cancer
T10 1240-1245 gene:596 denotes Bcl-2
T11 1354-1368 disease:C1140680 denotes ovarian cancer
T12 1240-1245 gene:596 denotes Bcl-2
T13 1354-1368 disease:C0029925 denotes ovarian cancer
T14 1250-1255 gene:598 denotes Bcl-X
T15 1354-1368 disease:C1140680 denotes ovarian cancer
T16 1250-1255 gene:8915 denotes Bcl-X
T17 1354-1368 disease:C0029925 denotes ovarian cancer
T18 1250-1255 gene:8915 denotes Bcl-X
T19 1354-1368 disease:C1140680 denotes ovarian cancer
T20 1282-1291 gene:836 denotes caspase-3
T21 1354-1368 disease:C0029925 denotes ovarian cancer
T22 1282-1291 gene:836 denotes caspase-3
T23 1354-1368 disease:C1140680 denotes ovarian cancer
R1 T0 T1 associated_with caspase-3,ovarian cancer
R2 T2 T3 associated_with caspase-3,ovarian cancer
R3 T4 T5 associated_with DDP,ovarian cancer
R4 T6 T7 associated_with DDP,ovarian cancer
R5 T8 T9 associated_with Bcl-X,ovarian cancer
R6 T10 T11 associated_with Bcl-2,ovarian cancer
R7 T12 T13 associated_with Bcl-2,ovarian cancer
R8 T14 T15 associated_with Bcl-X,ovarian cancer
R9 T16 T17 associated_with Bcl-X,ovarian cancer
R10 T18 T19 associated_with Bcl-X,ovarian cancer
R11 T20 T21 associated_with caspase-3,ovarian cancer
R12 T22 T23 associated_with caspase-3,ovarian cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15156398-0#59#68#gene836 59-68 gene836 denotes caspase-3
15156398-0#126#140#diseaseC0029925 126-140 diseaseC0029925 denotes ovarian cancer
15156398-0#126#140#diseaseC1140680 126-140 diseaseC1140680 denotes ovarian cancer
15156398-3#113#116#gene1678 428-431 gene1678 denotes DDP
15156398-3#118#132#diseaseC0029925 433-447 diseaseC0029925 denotes ovarian cancer
15156398-3#118#132#diseaseC1140680 433-447 diseaseC1140680 denotes ovarian cancer
15156398-8#58#63#gene596 1240-1245 gene596 denotes Bcl-2
15156398-8#68#73#gene598 1250-1255 gene598 denotes Bcl-X
15156398-8#68#73#gene8915 1250-1255 gene8915 denotes Bcl-X
15156398-8#172#186#diseaseC0029925 1354-1368 diseaseC0029925 denotes ovarian cancer
15156398-8#172#186#diseaseC1140680 1354-1368 diseaseC1140680 denotes ovarian cancer
15156398-8#172#186#diseaseC0029925 1354-1368 diseaseC0029925 denotes ovarian cancer
15156398-8#172#186#diseaseC1140680 1354-1368 diseaseC1140680 denotes ovarian cancer
15156398-8#172#186#diseaseC0029925 1354-1368 diseaseC0029925 denotes ovarian cancer
15156398-8#172#186#diseaseC1140680 1354-1368 diseaseC1140680 denotes ovarian cancer
59#68#gene836126#140#diseaseC0029925 15156398-0#59#68#gene836 15156398-0#126#140#diseaseC0029925 associated_with caspase-3,ovarian cancer
59#68#gene836126#140#diseaseC1140680 15156398-0#59#68#gene836 15156398-0#126#140#diseaseC1140680 associated_with caspase-3,ovarian cancer
113#116#gene1678118#132#diseaseC0029925 15156398-3#113#116#gene1678 15156398-3#118#132#diseaseC0029925 associated_with DDP,ovarian cancer
113#116#gene1678118#132#diseaseC1140680 15156398-3#113#116#gene1678 15156398-3#118#132#diseaseC1140680 associated_with DDP,ovarian cancer
58#63#gene596172#186#diseaseC0029925 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC0029925 associated_with Bcl-2,ovarian cancer
58#63#gene596172#186#diseaseC1140680 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC1140680 associated_with Bcl-2,ovarian cancer
58#63#gene596172#186#diseaseC0029925 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC0029925 associated_with Bcl-2,ovarian cancer
58#63#gene596172#186#diseaseC1140680 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC1140680 associated_with Bcl-2,ovarian cancer
58#63#gene596172#186#diseaseC0029925 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC0029925 associated_with Bcl-2,ovarian cancer
58#63#gene596172#186#diseaseC1140680 15156398-8#58#63#gene596 15156398-8#172#186#diseaseC1140680 associated_with Bcl-2,ovarian cancer
68#73#gene598172#186#diseaseC0029925 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene598172#186#diseaseC1140680 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer
68#73#gene598172#186#diseaseC0029925 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene598172#186#diseaseC1140680 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer
68#73#gene598172#186#diseaseC0029925 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene598172#186#diseaseC1140680 15156398-8#68#73#gene598 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC0029925 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC1140680 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC0029925 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC1140680 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC0029925 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC0029925 associated_with Bcl-X,ovarian cancer
68#73#gene8915172#186#diseaseC1140680 15156398-8#68#73#gene8915 15156398-8#172#186#diseaseC1140680 associated_with Bcl-X,ovarian cancer

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 149-613 OBJECTIVE denotes Resistance to cisplatin is the main reason for treatment failure in ovarian cancer. Apoptosis is the main mechanism of action of most cancer chemotherapeutic agents. The apoptosis-associated proteins expressed in cisplatin-sensitive (A2780, COC1) and -resistant (A2780/DDP, COC1/DDP) ovarian cancer cell lines, as well as their effects on caspase-3 activity in these cells, were studied by reverse transcriptase polymerase chain reaction and Western blot analysis.
T2 623-753 METHODS denotes The apoptotic ratios of A2780, COC1, A2780/DDP, and COC1/DDP cells after treatment with cisplatin were measured by flow cytometry.
T3 763-1169 RESULTS denotes Expression of Bcl-2 and Bcl-X(L) in A2780/DDP and COC1/DDP cells was significantly higher than that in A2780 and COC1 cells, respectively. Expression of Bax and Bcl-Xs did not differ in cisplatin-resistant and -sensitive cells. Caspase-3 activity was reduced markedly and apoptotic ratios were significantly lower in A2780/DDP and COC1/DDP cells than in A2780 and COC1 cells after treatment with cisplatin.
T4 1182-1369 CONCLUSIONS denotes We conclude that overexpression of antiapoptotic proteins Bcl-2 and Bcl-X(L) and down-regulation of caspase-3 activity may be associated with cisplatin resistance in human ovarian cancer.