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PubMed:15142875 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation.
TextSentencer_T2 123-318 Sentence denotes Hepatic venoocclusive disease (HVOD) in bone marrow transplantation (BMT) is attributed to toxicity of cytoreductive agents, especially busulfan and cyclophosphamide, in the conditioning therapy.
TextSentencer_T3 319-483 Sentence denotes Busulfan, as well as the metabolites of cyclophosphamide, are conjugated with glutathione (GSH), catalyzed by enzymes of the glutathione S-transferase (GST) family.
TextSentencer_T4 484-659 Sentence denotes To assess the impact of polymorphisms of the GST genes, GSTM1 and GSTT1, on the risk of HVOD, we evaluated 114 consecutive patients with beta-thalassemia major undergoing BMT.
TextSentencer_T5 660-834 Sentence denotes There was a significantly increased incidence of HVOD in patients with the GSTM1-null genotype compared with those with the GSTM1-positive genotype (46.5% vs 18.3%; P =.001).
TextSentencer_T6 835-1150 Sentence denotes Pharmacokinetic analysis in these patients showed that the clearance of busulfan was higher and first-dose steady-state concentration was lower among those with HVOD (0.403 +/- 0.06 vs 0.33 +/- 0.071 L/h/kg, Student t test P value =.000 01; and 508 +/- 125 vs 656 +/- 255 ng/mL, t test P value =.001, respectively).
TextSentencer_T7 1151-1358 Sentence denotes We conclude that the GSTM1-null genotype predisposes to HVOD, and the sinusoidal endothelial cells and hepatocyte damage may be mediated by metabolites of busulfan through depletion of the cellular GSH pool.
T1 0-122 Sentence denotes Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation.
T2 123-318 Sentence denotes Hepatic venoocclusive disease (HVOD) in bone marrow transplantation (BMT) is attributed to toxicity of cytoreductive agents, especially busulfan and cyclophosphamide, in the conditioning therapy.
T3 319-483 Sentence denotes Busulfan, as well as the metabolites of cyclophosphamide, are conjugated with glutathione (GSH), catalyzed by enzymes of the glutathione S-transferase (GST) family.
T4 484-659 Sentence denotes To assess the impact of polymorphisms of the GST genes, GSTM1 and GSTT1, on the risk of HVOD, we evaluated 114 consecutive patients with beta-thalassemia major undergoing BMT.
T5 660-834 Sentence denotes There was a significantly increased incidence of HVOD in patients with the GSTM1-null genotype compared with those with the GSTM1-positive genotype (46.5% vs 18.3%; P =.001).
T6 835-1150 Sentence denotes Pharmacokinetic analysis in these patients showed that the clearance of busulfan was higher and first-dose steady-state concentration was lower among those with HVOD (0.403 +/- 0.06 vs 0.33 +/- 0.071 L/h/kg, Student t test P value =.000 01; and 508 +/- 125 vs 656 +/- 255 ng/mL, t test P value =.001, respectively).
T7 1151-1358 Sentence denotes We conclude that the GSTM1-null genotype predisposes to HVOD, and the sinusoidal endothelial cells and hepatocyte damage may be mediated by metabolites of busulfan through depletion of the cellular GSH pool.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15142875-0#0#28#gene2944 0-28 gene2944 denotes Glutathione S-transferase M1
15142875-0#0#28#gene2946 0-28 gene2946 denotes Glutathione S-transferase M1
15142875-0#69#90#diseaseC0948441 69-90 diseaseC0948441 denotes venoocclusive disease
15142875-3#66#71#gene2952 550-555 gene2952 denotes GSTT1
15142875-3#137#159#diseaseC0002875 621-643 diseaseC0002875 denotes beta-thalassemia major
0#28#gene294469#90#diseaseC0948441 15142875-0#0#28#gene2944 15142875-0#69#90#diseaseC0948441 associated_with Glutathione S-transferase M1,venoocclusive disease
0#28#gene294669#90#diseaseC0948441 15142875-0#0#28#gene2946 15142875-0#69#90#diseaseC0948441 associated_with Glutathione S-transferase M1,venoocclusive disease
66#71#gene2952137#159#diseaseC0002875 15142875-3#66#71#gene2952 15142875-3#137#159#diseaseC0002875 associated_with GSTT1,beta-thalassemia major

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 94-105 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 163-174 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T3 1221-1231 http://purl.obolibrary.org/obo/UBERON_0003909 denotes sinusoidal

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1288 0-28 gene:2944 denotes Glutathione S-transferase M1
T1289 69-90 disease:C0948441 denotes venoocclusive disease
R1 T1288 T1289 associated_with Glutathione S-transferase M1,venoocclusive disease
R2 T1288 T1289 associated_with Glutathione S-transferase M1,venoocclusive disease

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 94-105 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 163-174 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T3 1221-1231 http://purl.obolibrary.org/obo/UBERON_0003909 denotes sinusoidal

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-28 gene:2944 denotes Glutathione S-transferase M1
T1 69-90 disease:C0948441 denotes venoocclusive disease
T2 0-28 gene:2946 denotes Glutathione S-transferase M1
T3 69-90 disease:C0948441 denotes venoocclusive disease
T4 550-555 gene:2952 denotes GSTT1
T5 621-643 disease:C0002875 denotes beta-thalassemia major
R1 T0 T1 associated_with Glutathione S-transferase M1,venoocclusive disease
R2 T2 T3 associated_with Glutathione S-transferase M1,venoocclusive disease
R3 T4 T5 associated_with GSTT1,beta-thalassemia major