PubMed:15131127
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-79 | Sentence | denotes | Galectin-12 is required for adipogenic signaling and adipocyte differentiation. |
| T2 | 80-223 | Sentence | denotes | Galectin-12 is a member of the galectin family consisting of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. |
| T3 | 224-311 | Sentence | denotes | This protein is preferentially expressed in peripheral blood leukocytes and adipocytes. |
| T4 | 312-462 | Sentence | denotes | We previously showed that galectin-12 is induced by cell cycle block at the G(1) phase and causes G(1) arrest when overexpressed (Yang, R.-Y., Hsu, D. |
| T5 | 463-507 | Sentence | denotes | K., Yu, L., Ni, J., and Liu, F.-T. (2001) J. |
| T6 | 508-513 | Sentence | denotes | Biol. |
| T7 | 514-519 | Sentence | denotes | Chem. |
| T8 | 520-538 | Sentence | denotes | 276, 20252-20260). |
| T9 | 539-801 | Sentence | denotes | Here, we show that the galectin-12 gene is expressed in mouse preadipocytes and is up-regulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation. |
| T10 | 802-964 | Sentence | denotes | Following a brief down-regulation 1 day after adipogenic treatment, its expression was once again markedly elevated when cells underwent terminal differentiation. |
| T11 | 965-1305 | Sentence | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling. |
| T12 | 1306-1483 | Sentence | denotes | We conclude that galectin-12 is required for signal transduction that conveys hormone stimulation to the induction of adipogenic factors essential for adipocyte differentiation. |
| T13 | 1484-1573 | Sentence | denotes | The findings suggest that galectin-12 is a major regulator of adipose tissue development. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 279-284 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T2 | 279-284 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T3 | 1546-1560 | http://purl.obolibrary.org/obo/MAT_0000015 | denotes | adipose tissue |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Pparg) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000542 | 539-801 | cat(p(MGI:Lgals12)) increases bp(GOBP:"fat cell differentiation") | denotes | Here, we show that the galectin-12 gene is expressed in mouse preadipocytes and is up-regulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation. |
| BEL:20000544 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Cebpa) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000546 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Cebpb) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000548 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Pparg) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000550 | 965-1304 | cat(p(MGI:Lgals12)) increases bp(GOBP:"fat cell differentiation") | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000542 | 539-800 | cat(p(MGI:Lgals12)) increases bp(GOBP:"fat cell differentiation") | denotes | Here, we show that the galectin-12 gene is expressed in mouse preadipocytes and is up-regulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation |
| BEL:20000544 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Cebpa) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000546 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Cebpb) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000548 | 965-1304 | cat(p(MGI:Lgals12)) increases r(MGI:Pparg) | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20000550 | 965-1304 | cat(p(MGI:Lgals12)) increases bp(GOBP:"fat cell differentiation") | denotes | Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling |
| BEL:20031890 | 312-536 | cat(p(MGI:Lgals12)) decreases bp(GOBP:"cell cycle") | denotes | We previously showed that galectin-12 is induced by cell cycle block at the G(1) phase and causes G(1) arrest when overexpressed (Yang, R.-Y., Hsu, D. K., Yu, L., Ni, J., and Liu, F.-T. (2001) J. Biol. Chem. 276, 20252-20260 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 595-600 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 53-62 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T2 | 279-284 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 285-295 | Body_part | denotes | leukocytes | http://purl.obolibrary.org/obo/CL_0000738 |
| T4 | 300-310 | Body_part | denotes | adipocytes | http://purl.obolibrary.org/obo/CL_0000136 |
| T5 | 364-374 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T6 | 601-614 | Body_part | denotes | preadipocytes | http://purl.obolibrary.org/obo/CL_0002334 |
| T7 | 640-653 | Body_part | denotes | preadipocytes | http://purl.obolibrary.org/obo/CL_0002334 |
| T8 | 662-672 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T9 | 1233-1242 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T10 | 1457-1466 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T11 | 1546-1560 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 279-284 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 1546-1560 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/MAT_0000015 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 53-62 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |
| T2 | 285-295 | Cell | denotes | leukocytes | http://purl.obolibrary.org/obo/CL:0000738 |
| T3 | 300-310 | Cell | denotes | adipocytes | http://purl.obolibrary.org/obo/CL:0000136 |
| T4 | 601-614 | Cell | denotes | preadipocytes | http://purl.obolibrary.org/obo/CL:0002334 |
| T5 | 640-653 | Cell | denotes | preadipocytes | http://purl.obolibrary.org/obo/CL:0002334 |
| T6 | 1233-1242 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |
| T7 | 1457-1466 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |