| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-129 |
Sentence |
denotes |
Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer. |
| TextSentencer_T2 |
130-221 |
Sentence |
denotes |
BRCA1/BRCA2 germline mutations are associated with an increased breast/ovarian cancer risk. |
| TextSentencer_T3 |
222-307 |
Sentence |
denotes |
Offspring gender ratios may be skewed against male births in BRCA1 mutation carriers. |
| TextSentencer_T4 |
308-459 |
Sentence |
denotes |
In addition, the lack of viable homozygous BRCA1/BRCA2-mutation carriers implies that recurrent miscarriages may be associated with homozygous fetuses. |
| TextSentencer_T5 |
460-676 |
Sentence |
denotes |
Jewish Israeli high-risk women who were tested for being carriers of the predominant BRCA1/BRCA2 mutations in Jewish high-risk families were analyzed for the sex of offspring and the rate of spontaneous miscarriages. |
| TextSentencer_T6 |
677-709 |
Sentence |
denotes |
Overall, 817 women participated: |
| TextSentencer_T7 |
710-840 |
Sentence |
denotes |
393 BRCA1/BRCA2-mutation carriers (229 with breast/ovarian cancer) and 424 high-risk noncarriers (208 with breast/ovarian cancer). |
| TextSentencer_T8 |
841-931 |
Sentence |
denotes |
No differences between the male-to-female offspring ratios of all study groups were noted. |
| TextSentencer_T9 |
932-1007 |
Sentence |
denotes |
Among mutation carriers, the offspring male-to-female ratio was 0.97 (444 : |
| TextSentencer_T10 |
1008-1072 |
Sentence |
denotes |
460), and among mutation carriers with cancer it was 0.92 (262 : |
| TextSentencer_T11 |
1073-1078 |
Sentence |
denotes |
284). |
| TextSentencer_T12 |
1079-1185 |
Sentence |
denotes |
Similarly, no offspring gender skewing was noted among high-risk noncarriers, regardless of health status. |
| TextSentencer_T13 |
1186-1390 |
Sentence |
denotes |
The rates of three or more spontaneous miscarriages among participants with at least one live birth were 4.37% (15/343) among mutation carriers and 3% (12/401) among high-risk women (P = not significant). |
| TextSentencer_T14 |
1391-1503 |
Sentence |
denotes |
In conclusion, the offspring gender ratio is similar in high-risk Jewish families and in the general population. |
| TextSentencer_T15 |
1504-1592 |
Sentence |
denotes |
The issue of the rate of recurrent miscarriages in high-risk Jewish women is unresolved. |
| T1 |
0-129 |
Sentence |
denotes |
Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer. |
| T2 |
130-221 |
Sentence |
denotes |
BRCA1/BRCA2 germline mutations are associated with an increased breast/ovarian cancer risk. |
| T3 |
222-307 |
Sentence |
denotes |
Offspring gender ratios may be skewed against male births in BRCA1 mutation carriers. |
| T4 |
308-459 |
Sentence |
denotes |
In addition, the lack of viable homozygous BRCA1/BRCA2-mutation carriers implies that recurrent miscarriages may be associated with homozygous fetuses. |
| T5 |
460-676 |
Sentence |
denotes |
Jewish Israeli high-risk women who were tested for being carriers of the predominant BRCA1/BRCA2 mutations in Jewish high-risk families were analyzed for the sex of offspring and the rate of spontaneous miscarriages. |
| T6 |
677-709 |
Sentence |
denotes |
Overall, 817 women participated: |
| T7 |
710-840 |
Sentence |
denotes |
393 BRCA1/BRCA2-mutation carriers (229 with breast/ovarian cancer) and 424 high-risk noncarriers (208 with breast/ovarian cancer). |
| T8 |
841-931 |
Sentence |
denotes |
No differences between the male-to-female offspring ratios of all study groups were noted. |
| T9 |
932-1007 |
Sentence |
denotes |
Among mutation carriers, the offspring male-to-female ratio was 0.97 (444 : |
| T10 |
1008-1072 |
Sentence |
denotes |
460), and among mutation carriers with cancer it was 0.92 (262 : |
| T11 |
1073-1078 |
Sentence |
denotes |
284). |
| T12 |
1079-1185 |
Sentence |
denotes |
Similarly, no offspring gender skewing was noted among high-risk noncarriers, regardless of health status. |
| T13 |
1186-1390 |
Sentence |
denotes |
The rates of three or more spontaneous miscarriages among participants with at least one live birth were 4.37% (15/343) among mutation carriers and 3% (12/401) among high-risk women (P = not significant). |
| T14 |
1391-1503 |
Sentence |
denotes |
In conclusion, the offspring gender ratio is similar in high-risk Jewish families and in the general population. |
| T15 |
1504-1592 |
Sentence |
denotes |
The issue of the rate of recurrent miscarriages in high-risk Jewish women is unresolved. |