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PubMed:15115909 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-40 Sentence denotes Galectin-4 in normal tissues and cancer.
TextSentencer_T2 41-167 Sentence denotes Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain.
TextSentencer_T3 168-304 Sentence denotes The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical.
TextSentencer_T4 305-482 Sentence denotes Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larger saccharides, are distinctly different.
TextSentencer_T5 483-621 Sentence denotes Thus galectin-4 has a property of a natural cross-linker, but in a modified sense since each domain prefers a different subset of ligands.
TextSentencer_T6 622-726 Sentence denotes Similarly to other galectins, galectin-4 is synthesized as a cytosolic protein, but can be externalized.
TextSentencer_T7 727-868 Sentence denotes During development and in adult normal tissues, galectin-4 is expressed only in the alimentary tract, from the tongue to the large intestine.
TextSentencer_T8 869-1065 Sentence denotes It is often found in relatively insoluble complexes, as a component of either adherens junctions or lipid rafts in the microvillus membrane, and it has been proposed to stabilize these structures.
TextSentencer_T9 1066-1180 Sentence denotes Strong expression of galectin-4 can be induced, however, in cancers from other tissues including breast and liver.
TextSentencer_T10 1181-1380 Sentence denotes Within a collection of human epithelial cancer cell lines, galectin-4 is overexpressed and soluble in those forming highly differentiated polarized monolayers, but absent in less differentiated ones.
TextSentencer_T11 1381-1539 Sentence denotes In cultured cells, intracellular galectin-4 may promote resistance to nutrient starvation, whereas--as an extracellular protein--it can mediate cell adhesion.
TextSentencer_T12 1540-1712 Sentence denotes Because of its distinct induction in breast and other cancers, it may be a valuable diagnostic marker and target for the development of inhibitory carbohydrate-based drugs.
T1 0-40 Sentence denotes Galectin-4 in normal tissues and cancer.
T2 41-167 Sentence denotes Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain.
T3 168-304 Sentence denotes The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical.
T4 305-482 Sentence denotes Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larger saccharides, are distinctly different.
T5 483-621 Sentence denotes Thus galectin-4 has a property of a natural cross-linker, but in a modified sense since each domain prefers a different subset of ligands.
T6 622-726 Sentence denotes Similarly to other galectins, galectin-4 is synthesized as a cytosolic protein, but can be externalized.
T7 727-868 Sentence denotes During development and in adult normal tissues, galectin-4 is expressed only in the alimentary tract, from the tongue to the large intestine.
T8 869-1065 Sentence denotes It is often found in relatively insoluble complexes, as a component of either adherens junctions or lipid rafts in the microvillus membrane, and it has been proposed to stabilize these structures.
T9 1066-1180 Sentence denotes Strong expression of galectin-4 can be induced, however, in cancers from other tissues including breast and liver.
T10 1181-1380 Sentence denotes Within a collection of human epithelial cancer cell lines, galectin-4 is overexpressed and soluble in those forming highly differentiated polarized monolayers, but absent in less differentiated ones.
T11 1381-1539 Sentence denotes In cultured cells, intracellular galectin-4 may promote resistance to nutrient starvation, whereas--as an extracellular protein--it can mediate cell adhesion.
T12 1540-1712 Sentence denotes Because of its distinct induction in breast and other cancers, it may be a valuable diagnostic marker and target for the development of inhibitory carbohydrate-based drugs.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 838-844 http://purl.obolibrary.org/obo/MAT_0000040 denotes tongue
T2 852-867 http://purl.obolibrary.org/obo/MAT_0000046 denotes large intestine
T3 858-867 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T4 1174-1179 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1087-1097 gene:3960 denotes galectin-4
T1 1126-1133 disease:C0006826 denotes cancers
R1 T0 T1 associated_with galectin-4,cancers

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 323-330 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 33-39 Phenotype denotes cancer HP:0002664
T2 1221-1227 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 33-39 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 1221-1227 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 323-330 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 33-39 Phenotype denotes cancer HP:0002664
T2 1221-1227 Phenotype denotes cancer HP:0002664

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1221-1232 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 1384-1398 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 811-827 Body_part denotes alimentary tract http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0005409
T4 838-844 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T5 852-867 Body_part denotes large intestine http://purl.obolibrary.org/obo/UBERON_0000059
T6 956-965 Body_part denotes junctions http://purl.obolibrary.org/obo/UBERON_0007651
T7 988-999 Body_part denotes microvillus http://purl.obolibrary.org/obo/GO_0005902|http://purl.obolibrary.org/obo/UBERON_0012423
T9 1000-1008 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T10 1163-1169 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T11 1174-1179 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T12 1400-1413 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T13 1487-1500 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T14 1577-1583 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 33-39 Disease denotes cancer MONDO:0004992
T2 1221-1227 Disease denotes cancer MONDO:0004992

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 1204-1209 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-40 Sentence denotes Galectin-4 in normal tissues and cancer.
T2 41-167 Sentence denotes Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain.
T3 168-304 Sentence denotes The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical.
T4 305-482 Sentence denotes Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larger saccharides, are distinctly different.
T5 483-621 Sentence denotes Thus galectin-4 has a property of a natural cross-linker, but in a modified sense since each domain prefers a different subset of ligands.
T6 622-726 Sentence denotes Similarly to other galectins, galectin-4 is synthesized as a cytosolic protein, but can be externalized.
T7 727-868 Sentence denotes During development and in adult normal tissues, galectin-4 is expressed only in the alimentary tract, from the tongue to the large intestine.
T8 869-1065 Sentence denotes It is often found in relatively insoluble complexes, as a component of either adherens junctions or lipid rafts in the microvillus membrane, and it has been proposed to stabilize these structures.
T9 1066-1180 Sentence denotes Strong expression of galectin-4 can be induced, however, in cancers from other tissues including breast and liver.
T10 1181-1380 Sentence denotes Within a collection of human epithelial cancer cell lines, galectin-4 is overexpressed and soluble in those forming highly differentiated polarized monolayers, but absent in less differentiated ones.
T11 1381-1539 Sentence denotes In cultured cells, intracellular galectin-4 may promote resistance to nutrient starvation, whereas--as an extracellular protein--it can mediate cell adhesion.
T12 1540-1712 Sentence denotes Because of its distinct induction in breast and other cancers, it may be a valuable diagnostic marker and target for the development of inhibitory carbohydrate-based drugs.

GlyCosmos15-Lectin-Jamboree

Id Subject Object Predicate Lexical cue glycosmos_id
T1 0-10 Lectin denotes Galectin-4 GL_003994
T2 41-51 Lectin denotes Galectin-4 GL_003994

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 21-28 Body_part denotes tissues FMA:9637
T2 683-692 Body_part denotes cytosolic FMA:66836
T3 766-773 Body_part denotes tissues FMA:9637
T4 811-827 Body_part denotes alimentary tract FMA:317863
T5 838-844 Body_part denotes tongue FMA:54640
T6 852-867 Body_part denotes large intestine FMA:7201
T7 947-965 Body_part denotes adherens junctions FMA:67400
T8 988-999 Body_part denotes microvillus FMA:67296
T9 1145-1152 Body_part denotes tissues FMA:9637
T10 1163-1169 Body_part denotes breast FMA:9601
T11 1174-1179 Body_part denotes liver FMA:7197
T12 1577-1583 Body_part denotes breast FMA:9601

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 838-844 Body_part denotes tongue http://purl.obolibrary.org/obo/MAT_0000040
T2 852-867 Body_part denotes large intestine http://purl.obolibrary.org/obo/MAT_0000046
T3 1174-1179 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1204-1209 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 838-844 Body_part denotes tongue http://purl.obolibrary.org/obo/MAT_0000040
T2 852-867 Body_part denotes large intestine http://purl.obolibrary.org/obo/MAT_0000046
T3 1174-1179 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 811-827 Body_part denotes alimentary tract http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0005409
T4 838-844 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T5 852-867 Body_part denotes large intestine http://purl.obolibrary.org/obo/UBERON_0000059
T6 956-965 Body_part denotes junctions http://purl.obolibrary.org/obo/UBERON_0007651
T7 988-999 Body_part denotes microvillus http://purl.obolibrary.org/obo/GO_0005902|http://purl.obolibrary.org/obo/UBERON_0012423
T9 1000-1008 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T12 1163-1169 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T13 1174-1179 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T14 1400-1413 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T15 1487-1500 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T16 1577-1583 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1221-1232 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 1384-1398 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010