
PubMed:15099024
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 14-20 | UBERON:0027368 | denotes | matrix |
T3 | 14-40 | P28863 | denotes | matrix metalloproteinase-3 |
T4 | 14-40 | P08254 | denotes | matrix metalloproteinase-3 |
T5 | 14-40 | Q28397 | denotes | matrix metalloproteinase-3 |
T6 | 14-40 | Q6Y4Q5 | denotes | matrix metalloproteinase-3 |
T7 | 14-40 | P28862 | denotes | matrix metalloproteinase-3 |
T8 | 14-40 | PR:000010488 | denotes | matrix metalloproteinase-3 |
T9 | 14-40 | P03957 | denotes | matrix metalloproteinase-3 |
T2 | 14-40 | D019278 | denotes | matrix metalloproteinase-3 |
T11 | 45-50 | A2ASQ1 | denotes | agrin |
T12 | 45-50 | Q90404 | denotes | agrin |
T13 | 45-50 | P25304 | denotes | agrin |
T14 | 45-50 | PR:O00468 | denotes | agrin |
T15 | 45-50 | O00468 | denotes | agrin |
T17 | 45-50 | PR:000003845 | denotes | agrin |
T18 | 45-50 | PR:A2ASQ1 | denotes | agrin |
T19 | 45-50 | P31696 | denotes | agrin |
T20 | 45-50 | PR:P25304 | denotes | agrin |
T16 | 45-50 | D018171 | denotes | agrin |
T21 | 63-80 | D002545 | denotes | cerebral ischemia |
T22 | 63-80 | D002545 | denotes | cerebral ischemia |
T25 | 101-120 | C5P507 | denotes | metalloproteinase-3 |
T26 | 119-125 | PR:Q5XF51 | denotes | 3 (MMP |
T27 | 122-125 | CHEBI:340824 | denotes | MMP |
T30 | 122-125 | CHEBI:59761 | denotes | MMP |
T31 | 122-127 | P28863 | denotes | MMP-3 |
T32 | 122-127 | P08254 | denotes | MMP-3 |
T33 | 122-127 | Q28397 | denotes | MMP-3 |
T34 | 122-127 | PR:P08254 | denotes | MMP-3 |
T35 | 122-127 | PR:P03957 | denotes | MMP-3 |
T36 | 122-127 | Q6Y4Q5 | denotes | MMP-3 |
T37 | 122-127 | P28862 | denotes | MMP-3 |
T39 | 122-127 | PR:000010488 | denotes | MMP-3 |
T40 | 122-127 | PR:P28862 | denotes | MMP-3 |
T41 | 122-127 | P03957 | denotes | MMP-3 |
T38 | 122-127 | GO:0004248 | denotes | MMP-3 |
T43 | 156-176 | GO:0031012 | denotes | extracellular matrix |
T44 | 170-176 | UBERON:0027368 | denotes | matrix |
T45 | 204-216 | GO:0009405 | denotes | pathogenesis |
T46 | 297-300 | CHEBI:340824 | denotes | MMP |
T49 | 297-300 | CHEBI:59761 | denotes | MMP |
T50 | 297-302 | P28863 | denotes | MMP-3 |
T51 | 297-302 | P08254 | denotes | MMP-3 |
T52 | 297-302 | Q28397 | denotes | MMP-3 |
T53 | 297-302 | PR:P08254 | denotes | MMP-3 |
T54 | 297-302 | PR:P03957 | denotes | MMP-3 |
T55 | 297-302 | Q6Y4Q5 | denotes | MMP-3 |
T56 | 297-302 | P28862 | denotes | MMP-3 |
T58 | 297-302 | PR:000010488 | denotes | MMP-3 |
T59 | 297-302 | PR:P28862 | denotes | MMP-3 |
T60 | 297-302 | P03957 | denotes | MMP-3 |
T57 | 297-302 | GO:0004248 | denotes | MMP-3 |
T61 | 323-328 | A2ASQ1 | denotes | agrin |
T62 | 323-328 | Q90404 | denotes | agrin |
T63 | 323-328 | P25304 | denotes | agrin |
T64 | 323-328 | PR:O00468 | denotes | agrin |
T65 | 323-328 | O00468 | denotes | agrin |
T67 | 323-328 | PR:000003845 | denotes | agrin |
T68 | 323-328 | PR:A2ASQ1 | denotes | agrin |
T69 | 323-328 | P31696 | denotes | agrin |
T70 | 323-328 | PR:P25304 | denotes | agrin |
T66 | 323-328 | D018171 | denotes | agrin |
T71 | 333-336 | CHEBI:340824 | denotes | MMP |
T74 | 333-336 | CHEBI:59761 | denotes | MMP |
T75 | 333-338 | P28863 | denotes | MMP-3 |
T76 | 333-338 | P08254 | denotes | MMP-3 |
T77 | 333-338 | Q28397 | denotes | MMP-3 |
T78 | 333-338 | PR:P08254 | denotes | MMP-3 |
T79 | 333-338 | PR:P03957 | denotes | MMP-3 |
T80 | 333-338 | Q6Y4Q5 | denotes | MMP-3 |
T81 | 333-338 | P28862 | denotes | MMP-3 |
T83 | 333-338 | PR:000010488 | denotes | MMP-3 |
T84 | 333-338 | PR:P28862 | denotes | MMP-3 |
T85 | 333-338 | P03957 | denotes | MMP-3 |
T82 | 333-338 | GO:0004248 | denotes | MMP-3 |
T86 | 370-392 | UBERON:0001627 | denotes | middle cerebral artery |
T87 | 370-402 | D020244 | denotes | middle cerebral artery occlusion |
T88 | 370-402 | D020244 | denotes | middle cerebral artery occlusion |
T94 | 410-413 | PR:P63003-1 | denotes | rat |
T95 | 410-413 | PR:Q2G0B1 | denotes | rat |
T96 | 410-413 | PR:Q8VHJ4 | denotes | rat |
T93 | 410-413 | 10116 | denotes | rat |
T97 | 410-413 | D051381 | denotes | rat |
T98 | 415-418 | CHEBI:340824 | denotes | MMP |
T101 | 415-418 | CHEBI:59761 | denotes | MMP |
T102 | 415-420 | P28863 | denotes | MMP-3 |
T103 | 415-420 | P08254 | denotes | MMP-3 |
T104 | 415-420 | Q28397 | denotes | MMP-3 |
T105 | 415-420 | PR:P08254 | denotes | MMP-3 |
T106 | 415-420 | PR:P03957 | denotes | MMP-3 |
T107 | 415-420 | Q6Y4Q5 | denotes | MMP-3 |
T108 | 415-420 | P28862 | denotes | MMP-3 |
T110 | 415-420 | PR:000010488 | denotes | MMP-3 |
T111 | 415-420 | PR:P28862 | denotes | MMP-3 |
T112 | 415-420 | P03957 | denotes | MMP-3 |
T109 | 415-420 | GO:0004248 | denotes | MMP-3 |
T113 | 438-446 | D007511 | denotes | ischemia |
T114 | 438-446 | D007511 | denotes | ischemia |
T115 | 529-540 | GO:0009056 | denotes | degradation |
T116 | 557-560 | CHEBI:340824 | denotes | MMP |
T119 | 557-560 | CHEBI:59761 | denotes | MMP |
T120 | 557-562 | P28863 | denotes | MMP-3 |
T121 | 557-562 | P08254 | denotes | MMP-3 |
T122 | 557-562 | Q28397 | denotes | MMP-3 |
T123 | 557-562 | PR:P08254 | denotes | MMP-3 |
T124 | 557-562 | PR:P03957 | denotes | MMP-3 |
T125 | 557-562 | Q6Y4Q5 | denotes | MMP-3 |
T126 | 557-562 | P28862 | denotes | MMP-3 |
T128 | 557-562 | PR:000010488 | denotes | MMP-3 |
T129 | 557-562 | PR:P28862 | denotes | MMP-3 |
T130 | 557-562 | P03957 | denotes | MMP-3 |
T127 | 557-562 | GO:0004248 | denotes | MMP-3 |
T131 | 637-655 | CL:0002629 | denotes | reactive microglia |
T133 | 687-690 | CHEBI:340824 | denotes | MMP |
T136 | 687-690 | CHEBI:59761 | denotes | MMP |
T137 | 687-692 | P28863 | denotes | MMP-3 |
T138 | 687-692 | P08254 | denotes | MMP-3 |
T139 | 687-692 | Q28397 | denotes | MMP-3 |
T140 | 687-692 | PR:P08254 | denotes | MMP-3 |
T141 | 687-692 | PR:P03957 | denotes | MMP-3 |
T142 | 687-692 | Q6Y4Q5 | denotes | MMP-3 |
T143 | 687-692 | P28862 | denotes | MMP-3 |
T145 | 687-692 | PR:000010488 | denotes | MMP-3 |
T146 | 687-692 | PR:P28862 | denotes | MMP-3 |
T147 | 687-692 | P03957 | denotes | MMP-3 |
T144 | 687-692 | GO:0004248 | denotes | MMP-3 |
T149 | 792-807 | CL:0000128 | denotes | oligodendrocyte |
T150 | 836-845 | CL:0000129 | denotes | microglia |
T152 | 847-853 | 862460 | denotes | Casein |
T151 | 847-853 | CHEBI:3448 | denotes | Casein |
T153 | 847-853 | D002364 | denotes | Casein |
T154 | 874-877 | CHEBI:340824 | denotes | MMP |
T157 | 874-877 | CHEBI:59761 | denotes | MMP |
T158 | 874-879 | P28863 | denotes | MMP-3 |
T159 | 874-879 | P08254 | denotes | MMP-3 |
T160 | 874-879 | Q28397 | denotes | MMP-3 |
T161 | 874-879 | PR:P08254 | denotes | MMP-3 |
T162 | 874-879 | PR:P03957 | denotes | MMP-3 |
T163 | 874-879 | Q6Y4Q5 | denotes | MMP-3 |
T164 | 874-879 | P28862 | denotes | MMP-3 |
T166 | 874-879 | PR:000010488 | denotes | MMP-3 |
T167 | 874-879 | PR:P28862 | denotes | MMP-3 |
T168 | 874-879 | P03957 | denotes | MMP-3 |
T165 | 874-879 | GO:0004248 | denotes | MMP-3 |
T169 | 901-906 | A2ASQ1 | denotes | Agrin |
T170 | 901-906 | Q90404 | denotes | Agrin |
T171 | 901-906 | P25304 | denotes | Agrin |
T172 | 901-906 | PR:O00468 | denotes | Agrin |
T173 | 901-906 | O00468 | denotes | Agrin |
T175 | 901-906 | PR:000003845 | denotes | Agrin |
T176 | 901-906 | PR:A2ASQ1 | denotes | Agrin |
T177 | 901-906 | P31696 | denotes | Agrin |
T178 | 901-906 | PR:P25304 | denotes | Agrin |
T174 | 901-906 | D018171 | denotes | Agrin |
T179 | 969-974 | UBERON:6110636 | denotes | brain |
T180 | 969-974 | UBERON:0000955 | denotes | brain |
T181 | 975-981 | UBERON:0000479 | denotes | tissue |
T182 | 983-988 | A2ASQ1 | denotes | agrin |
T183 | 983-988 | Q90404 | denotes | agrin |
T184 | 983-988 | P25304 | denotes | agrin |
T185 | 983-988 | PR:O00468 | denotes | agrin |
T186 | 983-988 | O00468 | denotes | agrin |
T188 | 983-988 | PR:000003845 | denotes | agrin |
T189 | 983-988 | PR:A2ASQ1 | denotes | agrin |
T190 | 983-988 | P31696 | denotes | agrin |
T191 | 983-988 | PR:P25304 | denotes | agrin |
T187 | 983-988 | D018171 | denotes | agrin |
T192 | 1028-1036 | D007511 | denotes | ischemia |
T193 | 1028-1036 | D007511 | denotes | ischemia |
T194 | 1094-1097 | CHEBI:340824 | denotes | MMP |
T197 | 1094-1097 | CHEBI:59761 | denotes | MMP |
T198 | 1094-1099 | P28863 | denotes | MMP-3 |
T199 | 1094-1099 | P08254 | denotes | MMP-3 |
T200 | 1094-1099 | Q28397 | denotes | MMP-3 |
T201 | 1094-1099 | PR:P08254 | denotes | MMP-3 |
T202 | 1094-1099 | PR:P03957 | denotes | MMP-3 |
T203 | 1094-1099 | Q6Y4Q5 | denotes | MMP-3 |
T204 | 1094-1099 | P28862 | denotes | MMP-3 |
T206 | 1094-1099 | PR:000010488 | denotes | MMP-3 |
T207 | 1094-1099 | PR:P28862 | denotes | MMP-3 |
T208 | 1094-1099 | P03957 | denotes | MMP-3 |
T205 | 1094-1099 | GO:0004248 | denotes | MMP-3 |
T213 | 1103-1110 | SO:0000104 | denotes | protein |
T212 | 1103-1110 | PR:000000001 | denotes | protein |
T210 | 1103-1110 | CHEBI:36080 | denotes | protein |
T211 | 1103-1110 | CHEBI:11122 | denotes | protein |
T209 | 1103-1110 | GO:0003675 | denotes | protein |
T214 | 1133-1138 | UBERON:6110636 | denotes | brain |
T215 | 1133-1138 | UBERON:0000955 | denotes | brain |
T216 | 1155-1160 | A2ASQ1 | denotes | agrin |
T217 | 1155-1160 | Q90404 | denotes | agrin |
T218 | 1155-1160 | P25304 | denotes | agrin |
T219 | 1155-1160 | PR:O00468 | denotes | agrin |
T220 | 1155-1160 | O00468 | denotes | agrin |
T222 | 1155-1160 | PR:000003845 | denotes | agrin |
T223 | 1155-1160 | PR:A2ASQ1 | denotes | agrin |
T224 | 1155-1160 | P31696 | denotes | agrin |
T225 | 1155-1160 | PR:P25304 | denotes | agrin |
T221 | 1155-1160 | D018171 | denotes | agrin |
T226 | 1161-1172 | GO:0009056 | denotes | degradation |
T227 | 1184-1192 | D007511 | denotes | ischemia |
T228 | 1184-1192 | D007511 | denotes | ischemia |
T229 | 1206-1211 | A2ASQ1 | denotes | agrin |
T230 | 1206-1211 | Q90404 | denotes | agrin |
T231 | 1206-1211 | P25304 | denotes | agrin |
T232 | 1206-1211 | PR:O00468 | denotes | agrin |
T233 | 1206-1211 | O00468 | denotes | agrin |
T235 | 1206-1211 | PR:000003845 | denotes | agrin |
T236 | 1206-1211 | PR:A2ASQ1 | denotes | agrin |
T237 | 1206-1211 | P31696 | denotes | agrin |
T238 | 1206-1211 | PR:P25304 | denotes | agrin |
T234 | 1206-1211 | D018171 | denotes | agrin |
T239 | 1233-1239 | UBERON:0000479 | denotes | tissue |
T240 | 1240-1248 | UBERON:0000094 | denotes | membrane |
T242 | 1240-1248 | UBERON:0000158 | denotes | membrane |
T243 | 1240-1257 | GO:0005624 | denotes | membrane fraction |
T244 | 1272-1277 | A2ASQ1 | denotes | agrin |
T245 | 1272-1277 | Q90404 | denotes | agrin |
T246 | 1272-1277 | P25304 | denotes | agrin |
T247 | 1272-1277 | PR:O00468 | denotes | agrin |
T248 | 1272-1277 | O00468 | denotes | agrin |
T250 | 1272-1277 | PR:000003845 | denotes | agrin |
T251 | 1272-1277 | PR:A2ASQ1 | denotes | agrin |
T252 | 1272-1277 | P31696 | denotes | agrin |
T253 | 1272-1277 | PR:P25304 | denotes | agrin |
T249 | 1272-1277 | D018171 | denotes | agrin |
T254 | 1278-1286 | SO:0000731 | denotes | fragment |
T255 | 1300-1306 | UBERON:0000479 | denotes | tissue |
T260 | 1307-1314 | SO:0000104 | denotes | protein |
T259 | 1307-1314 | PR:000000001 | denotes | protein |
T257 | 1307-1314 | CHEBI:36080 | denotes | protein |
T258 | 1307-1314 | CHEBI:11122 | denotes | protein |
T256 | 1307-1314 | GO:0003675 | denotes | protein |
T261 | 1350-1353 | CHEBI:340824 | denotes | MMP |
T264 | 1350-1353 | CHEBI:59761 | denotes | MMP |
T265 | 1350-1355 | P28863 | denotes | MMP-3 |
T266 | 1350-1355 | P08254 | denotes | MMP-3 |
T267 | 1350-1355 | Q28397 | denotes | MMP-3 |
T268 | 1350-1355 | PR:P08254 | denotes | MMP-3 |
T269 | 1350-1355 | PR:P03957 | denotes | MMP-3 |
T270 | 1350-1355 | Q6Y4Q5 | denotes | MMP-3 |
T271 | 1350-1355 | P28862 | denotes | MMP-3 |
T273 | 1350-1355 | PR:000010488 | denotes | MMP-3 |
T274 | 1350-1355 | PR:P28862 | denotes | MMP-3 |
T275 | 1350-1355 | P03957 | denotes | MMP-3 |
T272 | 1350-1355 | GO:0004248 | denotes | MMP-3 |
T276 | 1380-1393 | SO:0001077 | denotes | transmembrane |
T277 | 1380-1393 | GO:0044214 | denotes | transmembrane |
T278 | 1380-1393 | GO:0016021 | denotes | transmembrane |
T279 | 1394-1399 | A2ASQ1 | denotes | agrin |
T280 | 1394-1399 | Q90404 | denotes | agrin |
T281 | 1394-1399 | P25304 | denotes | agrin |
T282 | 1394-1399 | PR:O00468 | denotes | agrin |
T283 | 1394-1399 | O00468 | denotes | agrin |
T285 | 1394-1399 | PR:000003845 | denotes | agrin |
T286 | 1394-1399 | PR:A2ASQ1 | denotes | agrin |
T287 | 1394-1399 | P31696 | denotes | agrin |
T288 | 1394-1399 | PR:P25304 | denotes | agrin |
T284 | 1394-1399 | D018171 | denotes | agrin |
T289 | 1415-1423 | D007511 | denotes | ischemia |
T290 | 1415-1423 | D007511 | denotes | ischemia |
T291 | 1467-1470 | CHEBI:340824 | denotes | MMP |
T294 | 1467-1470 | CHEBI:59761 | denotes | MMP |
T295 | 1467-1472 | P28863 | denotes | MMP-3 |
T296 | 1467-1472 | P08254 | denotes | MMP-3 |
T297 | 1467-1472 | Q28397 | denotes | MMP-3 |
T298 | 1467-1472 | PR:P08254 | denotes | MMP-3 |
T299 | 1467-1472 | PR:P03957 | denotes | MMP-3 |
T300 | 1467-1472 | Q6Y4Q5 | denotes | MMP-3 |
T301 | 1467-1472 | P28862 | denotes | MMP-3 |
T303 | 1467-1472 | PR:000010488 | denotes | MMP-3 |
T304 | 1467-1472 | PR:P28862 | denotes | MMP-3 |
T305 | 1467-1472 | P03957 | denotes | MMP-3 |
T302 | 1467-1472 | GO:0004248 | denotes | MMP-3 |
T306 | 1481-1486 | UBERON:6110636 | denotes | brain |
T307 | 1481-1486 | UBERON:0000955 | denotes | brain |
T308 | 1487-1492 | A2ASQ1 | denotes | agrin |
T309 | 1487-1492 | Q90404 | denotes | agrin |
T310 | 1487-1492 | P25304 | denotes | agrin |
T311 | 1487-1492 | PR:O00468 | denotes | agrin |
T312 | 1487-1492 | O00468 | denotes | agrin |
T314 | 1487-1492 | PR:000003845 | denotes | agrin |
T315 | 1487-1492 | PR:A2ASQ1 | denotes | agrin |
T316 | 1487-1492 | P31696 | denotes | agrin |
T317 | 1487-1492 | PR:P25304 | denotes | agrin |
T313 | 1487-1492 | D018171 | denotes | agrin |
T318 | 1516-1524 | D007511 | denotes | ischemia |
T319 | 1516-1524 | D007511 | denotes | ischemia |
T320 | 1533-1536 | CHEBI:340824 | denotes | MMP |
T323 | 1533-1536 | CHEBI:59761 | denotes | MMP |
T324 | 1533-1538 | P28863 | denotes | MMP-3 |
T325 | 1533-1538 | P08254 | denotes | MMP-3 |
T326 | 1533-1538 | Q28397 | denotes | MMP-3 |
T327 | 1533-1538 | PR:P08254 | denotes | MMP-3 |
T328 | 1533-1538 | PR:P03957 | denotes | MMP-3 |
T329 | 1533-1538 | Q6Y4Q5 | denotes | MMP-3 |
T330 | 1533-1538 | P28862 | denotes | MMP-3 |
T332 | 1533-1538 | PR:000010488 | denotes | MMP-3 |
T333 | 1533-1538 | PR:P28862 | denotes | MMP-3 |
T334 | 1533-1538 | P03957 | denotes | MMP-3 |
T331 | 1533-1538 | GO:0004248 | denotes | MMP-3 |
T335 | 1557-1562 | A2ASQ1 | denotes | agrin |
T336 | 1557-1562 | Q90404 | denotes | agrin |
T337 | 1557-1562 | P25304 | denotes | agrin |
T338 | 1557-1562 | PR:O00468 | denotes | agrin |
T339 | 1557-1562 | O00468 | denotes | agrin |
T341 | 1557-1562 | PR:000003845 | denotes | agrin |
T342 | 1557-1562 | PR:A2ASQ1 | denotes | agrin |
T343 | 1557-1562 | P31696 | denotes | agrin |
T344 | 1557-1562 | PR:P25304 | denotes | agrin |
T340 | 1557-1562 | D018171 | denotes | agrin |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-93 | DRI_Approach | denotes | Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion. |
T2 | 94-227 | DRI_Approach | denotes | Matrix metalloproteinase-3 (MMP-3) degrades components of the extracellular matrix and may participate in the pathogenesis of stroke. |
T3 | 228-414 | DRI_Challenge | denotes | Here we examine the expression, activation, and cellular location of MMP-3 and the cleavage of agrin, an MMP-3 substrate, following transient middle cerebral artery occlusion in the rat. |
T4 | 415-556 | DRI_Background | denotes | MMP-3 was activated by ischemia/reperfusion, which was revealed by the appearance of a cleaved form and increased degradation of a substrate. |
T5 | 557-668 | DRI_Background | denotes | MMP-3 was observed in ischemic neurons, oligodendrocytes, microvasculature, and reactive microglia/macrophages. |
T6 | 669-846 | DRI_Background | denotes | In cell cultures, MMP-3 expression was observed in neurons and, to a lesser extent, in mature oligodendrocytes, but not in oligodendrocyte progenitors, astrocytes, or microglia. |
T7 | 847-900 | DRI_Background | denotes | Casein zymography revealed MMP-3 in cultured neurons. |
T8 | 901-965 | DRI_Background | denotes | Agrin was expressed in cultured neurons and cultured astrocytes. |
T9 | 966-1081 | DRI_Background | denotes | In brain tissue, agrin was detected in neurons, and following ischemia it was also detected in reactive astrocytes. |
T10 | 1082-1173 | DRI_Background | denotes | Addition of MMP-3 to protein extracts from control brain caused neuronal agrin degradation. |
T11 | 1174-1324 | DRI_Background | denotes | Following ischemia/reperfusion, agrin disappeared from the tissue membrane fraction and a cleaved agrin fragment was found in tissue protein extracts. |
T12 | 1325-1436 | DRI_Outcome | denotes | The present results show MMP-3 activation and neuronal transmembrane agrin cleavage after ischemia/reperfusion. |
T13 | 1437-1515 | DRI_Outcome | denotes | In addition, the finding that MMP-3 cleaves brain agrin strongly suggests that |
T14 | 1516-1538 | Token_Label.OUTSIDE | denotes | ischemia-induced MMP-3 |
T15 | 1539-1572 | DRI_Outcome | denotes | activation causes agrin cleavage. |