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PubMed:15083191 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-65 Sentence denotes Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
TextSentencer_T2 66-229 Sentence denotes Our study aimed at elucidating which genetic alterations tend to form a network and could be applied as molecular markers of larynx squamous cell carcinoma (LSCC).
TextSentencer_T3 230-290 Sentence denotes A panel of genes involved in tumorigenesis was investigated.
TextSentencer_T4 291-549 Sentence denotes To search for the possible mechanisms of gene silencing, loss of heterozygosity (LOH) was analysed followed by testing DNA methylation and protein expression for those genes found with the highest frequency of LOH (CDKN2A (55.4%), MLH1 (46.0%), RB1 (35.7%)).
TextSentencer_T5 550-655 Sentence denotes A correlation of both LOH and hypermethylation with the loss of expression for CDKN2A and MLH1 was found.
TextSentencer_T6 656-922 Sentence denotes Disrupted Rb pathway (loss of expression of RB1 and/or of CDKN2A) in 55.9% of analysed cases confirmed the hypothesis that RB1 pathway is altered in head and neck squamous cell carcinomas, with CDKN2A (45%), rather than RB1 (11.8%) being more frequently inactivated.
TextSentencer_T7 923-986 Sentence denotes In LSCC, LOH tends to occur together in gene pairs or triplets.
TextSentencer_T8 987-1100 Sentence denotes The pair MLH1/CDKN2A and triplets MLH1/TSG on 8p22/CDKN2A and MLH1/CDKN2A/RB1 are related to staging and grading.
TextSentencer_T9 1101-1180 Sentence denotes LOH in MLH1 correlates with lower and LOH in CDKN2A with higher grades of LSCC.
TextSentencer_T10 1181-1281 Sentence denotes It can be concluded that MLH1 and CDKN2A play an important role in LSCC development and progression.
T1 0-65 Sentence denotes Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
T2 66-229 Sentence denotes Our study aimed at elucidating which genetic alterations tend to form a network and could be applied as molecular markers of larynx squamous cell carcinoma (LSCC).
T3 230-290 Sentence denotes A panel of genes involved in tumorigenesis was investigated.
T4 291-549 Sentence denotes To search for the possible mechanisms of gene silencing, loss of heterozygosity (LOH) was analysed followed by testing DNA methylation and protein expression for those genes found with the highest frequency of LOH (CDKN2A (55.4%), MLH1 (46.0%), RB1 (35.7%)).
T5 550-655 Sentence denotes A correlation of both LOH and hypermethylation with the loss of expression for CDKN2A and MLH1 was found.
T6 656-922 Sentence denotes Disrupted Rb pathway (loss of expression of RB1 and/or of CDKN2A) in 55.9% of analysed cases confirmed the hypothesis that RB1 pathway is altered in head and neck squamous cell carcinomas, with CDKN2A (45%), rather than RB1 (11.8%) being more frequently inactivated.
T7 923-986 Sentence denotes In LSCC, LOH tends to occur together in gene pairs or triplets.
T8 987-1100 Sentence denotes The pair MLH1/CDKN2A and triplets MLH1/TSG on 8p22/CDKN2A and MLH1/CDKN2A/RB1 are related to staging and grading.
T9 1101-1180 Sentence denotes LOH in MLH1 correlates with lower and LOH in CDKN2A with higher grades of LSCC.
T10 1181-1281 Sentence denotes It can be concluded that MLH1 and CDKN2A play an important role in LSCC development and progression.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15083191-0#23#29#gene1029 23-29 gene1029 denotes CDKN2A
15083191-0#14#18#gene4292 14-18 gene4292 denotes MLH1
15083191-0#23#29#gene1029 23-29 gene1029 denotes CDKN2A
15083191-0#48#64#diseaseC0007107 48-64 diseaseC0007107 denotes laryngeal cancer
15083191-0#48#64#diseaseC0595989 48-64 diseaseC0595989 denotes laryngeal cancer
15083191-0#33#44#diseaseC0596263 33-44 diseaseC0596263 denotes oncogenesis
15083191-5#58#64#gene1029 714-720 gene1029 denotes CDKN2A
15083191-5#163#187#diseaseC0007137 819-843 diseaseC0007137 denotes squamous cell carcinomas
15083191-9#25#29#gene4292 1206-1210 gene4292 denotes MLH1
15083191-9#34#40#gene1029 1215-1221 gene1029 denotes CDKN2A
15083191-9#67#71#diseaseC0280324 1248-1252 diseaseC0280324 denotes LSCC
23#29#gene102948#64#diseaseC0007107 15083191-0#23#29#gene1029 15083191-0#48#64#diseaseC0007107 associated_with CDKN2A,laryngeal cancer
23#29#gene102948#64#diseaseC0595989 15083191-0#23#29#gene1029 15083191-0#48#64#diseaseC0595989 associated_with CDKN2A,laryngeal cancer
23#29#gene102933#44#diseaseC0596263 15083191-0#23#29#gene1029 15083191-0#33#44#diseaseC0596263 associated_with CDKN2A,oncogenesis
14#18#gene429248#64#diseaseC0007107 15083191-0#14#18#gene4292 15083191-0#48#64#diseaseC0007107 associated_with MLH1,laryngeal cancer
14#18#gene429248#64#diseaseC0595989 15083191-0#14#18#gene4292 15083191-0#48#64#diseaseC0595989 associated_with MLH1,laryngeal cancer
14#18#gene429233#44#diseaseC0596263 15083191-0#14#18#gene4292 15083191-0#33#44#diseaseC0596263 associated_with MLH1,oncogenesis
23#29#gene102948#64#diseaseC0007107 15083191-0#23#29#gene1029 15083191-0#48#64#diseaseC0007107 associated_with CDKN2A,laryngeal cancer
23#29#gene102948#64#diseaseC0595989 15083191-0#23#29#gene1029 15083191-0#48#64#diseaseC0595989 associated_with CDKN2A,laryngeal cancer
23#29#gene102933#44#diseaseC0596263 15083191-0#23#29#gene1029 15083191-0#33#44#diseaseC0596263 associated_with CDKN2A,oncogenesis
58#64#gene1029163#187#diseaseC0007137 15083191-5#58#64#gene1029 15083191-5#163#187#diseaseC0007137 associated_with CDKN2A,squamous cell carcinomas
25#29#gene429267#71#diseaseC0280324 15083191-9#25#29#gene4292 15083191-9#67#71#diseaseC0280324 associated_with MLH1,LSCC
34#40#gene102967#71#diseaseC0280324 15083191-9#34#40#gene1029 15083191-9#67#71#diseaseC0280324 associated_with CDKN2A,LSCC

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T219 23-29 gene:1029 denotes CDKN2A
T220 48-64 disease:C0007107 denotes laryngeal cancer
R1 T219 T220 associated_with CDKN2A,laryngeal cancer
R2 T219 T220 associated_with CDKN2A,laryngeal cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 191-197 http://purl.obolibrary.org/obo/UBERON_0001737 denotes larynx
PD-UBERON-AE-B_T2 805-809 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T3 814-818 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 805-809 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T2 191-197 http://purl.obolibrary.org/obo/UBERON_0001737 denotes larynx
PD-UBERON-AE-B_T3 814-818 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1108-1112 gene:4292 denotes MLH1
T1 1175-1179 disease:C0280324 denotes LSCC
T2 1146-1152 gene:1029 denotes CDKN2A
T3 1175-1179 disease:C0280324 denotes LSCC
R1 T0 T1 associated_with MLH1,LSCC
R2 T2 T3 associated_with CDKN2A,LSCC