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PubMed:1505523 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 DNA denotes TAR
T2 35-38 protein denotes Tat
T3 118-129 protein denotes Tat protein
T4 264-267 protein denotes Tat
T5 383-397 DNA denotes viral promoter
T6 703-706 protein denotes Tat
T7 723-733 RNA denotes RNA target
T8 741-744 RNA denotes TAR
T9 746-772 RNA denotes transactivation responsive
T10 821-832 RNA denotes HIV-1 mRNAs
T11 975-992 cell_line denotes CNS-derived cells
T12 993-996 protein denotes Tat
T13 1038-1041 DNA denotes TAR
T14 1065-1087 DNA denotes Tat-responsive element
T15 1117-1131 DNA denotes viral promoter
T16 1140-1164 cell_line denotes glial-derived cell lines
T17 1206-1209 RNA denotes TAR
T18 1232-1258 DNA denotes hybrid promoter constructs
T19 1297-1319 DNA denotes Tat-responsive element
T20 1357-1383 DNA denotes viral long terminal repeat
T21 1385-1388 DNA denotes LTR
T22 1419-1433 DNA denotes HIV-1 enhancer
T23 1438-1455 DNA denotes NF-kappa B domain
T24 1489-1499 protein denotes NF-kappa B
T25 1566-1582 cell_type denotes T lymphoid cells
T26 1609-1628 DNA denotes TAR-deleted mutants
T27 1681-1692 cell_type denotes glial cells
T28 1746-1763 protein denotes viral p24 antigen

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-31 NP denotes TAR-independent transactivation
C2 35-38 NP denotes Tat
C3 42-68 NP denotes cells derived from the CNS
C4 91-96 NP denotes HIV-1
C6 133-176 NP denotes human immunodeficiency virus type 1 (HIV-1)
C5 114-176 NP denotes The Tat protein of human immunodeficiency virus type 1 (HIV-1)
C7 264-267 NP denotes Tat
C9 291-296 NP denotes HIV-1
C8 269-312 NP denotes a potent activator of HIV-1 gene expression
C10 379-397 NP denotes the viral promoter
C11 399-413 NP denotes This induction
C12 415-420 NP denotes which
C13 536-610 NP denotes increased transcriptional initiation, increased transcriptional elongation
C14 632-647 NP denotes these processes
C15 703-706 NP denotes Tat
C16 712-773 NP denotes a specific RNA target termed TAR (transactivation responsive)
C17 774-779 NP denotes which
C18 821-826 NP denotes HIV-1
C19 967-992 NP denotes certain CNS-derived cells
C20 993-996 NP denotes Tat
C21 1022-1027 NP denotes HIV-1
C22 1063-1087 NP denotes A Tat-responsive element
C23 1113-1131 NP denotes the viral promoter
C24 1132-1136 NP denotes that
C25 1206-1209 NP denotes TAR
C26 1276-1319 NP denotes the newly identified Tat-responsive element
C28 1419-1424 NP denotes HIV-1
C27 1415-1433 NP denotes the HIV-1 enhancer
C29 1438-1455 NP denotes NF-kappa B domain
C31 1489-1516 NP denotes NF-kappa B binding activity
C32 1520-1531 NP denotes glial cells
C30 1489-1531 NP denotes NF-kappa B binding activity in glial cells
C33 1532-1536 NP denotes that
C34 1550-1554 NP denotes that
C35 1632-1637 NP denotes HIV-1
C36 1681-1692 NP denotes glial cells
R1 C6 C4 coref-ident human immunodeficiency virus type 1 (HIV-1),HIV-1
R2 C5 C2 coref-ident The Tat protein of human immunodeficiency virus type 1 (HIV-1),Tat
R3 C7 C5 coref-ident Tat,The Tat protein of human immunodeficiency virus type 1 (HIV-1)
R4 C9 C6 coref-ident HIV-1,human immunodeficiency virus type 1 (HIV-1)
R5 C8 C7 coref-appos a potent activator of HIV-1 gene expression,Tat
R6 C12 C11 coref-relat which,This induction
R7 C14 C13 coref-ident these processes,"increased transcriptional initiation, increased transcriptional elongation"
R8 C15 C7 coref-ident Tat,Tat
R9 C17 C16 coref-relat which,a specific RNA target termed TAR (transactivation responsive)
R10 C18 C9 coref-ident HIV-1,HIV-1
R11 C19 C3 coref-ident certain CNS-derived cells,cells derived from the CNS
R12 C20 C15 coref-ident Tat,Tat
R13 C21 C18 coref-ident HIV-1,HIV-1
R14 C23 C10 coref-ident the viral promoter,the viral promoter
R15 C24 C23 coref-relat that,the viral promoter
R16 C25 C16 coref-ident TAR,a specific RNA target termed TAR (transactivation responsive)
R17 C26 C22 coref-ident the newly identified Tat-responsive element,A Tat-responsive element
R18 C28 C21 coref-ident HIV-1,HIV-1
R19 C29 C27 coref-other NF-kappa B domain,the HIV-1 enhancer
R20 C33 C30 coref-relat that,NF-kappa B binding activity in glial cells
R21 C34 C31 coref-pron that,NF-kappa B binding activity
R22 C35 C28 coref-ident HIV-1,HIV-1
R23 C36 C32 coref-ident glial cells,glial cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-113 Sentence denotes TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.
S2 114-263 Sentence denotes The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy.
S3 264-398 Sentence denotes Tat, a potent activator of HIV-1 gene expression, serves to greatly increase the rate of transcription directed by the viral promoter.
S4 399-648 Sentence denotes This induction, which seems to be an important component in the progression of acquired immune deficiency syndrome (AIDS), may be due to increased transcriptional initiation, increased transcriptional elongation, or a combination of these processes.
S5 649-833 Sentence denotes Much attention has been focused on the interaction of Tat with a specific RNA target termed TAR (transactivation responsive) which is present in the leader sequence of all HIV-1 mRNAs.
S6 834-928 Sentence denotes This interaction is believed to be an important component of the mechanism of transactivation.
S7 929-1062 Sentence denotes In this report we demonstrate that in certain CNS-derived cells Tat is capable of activating HIV-1 through a TAR-independent pathway.
S8 1063-1210 Sentence denotes A Tat-responsive element is found upstream within the viral promoter that in glial-derived cell lines allows transactivation in the absence of TAR.
S9 1211-1456 Sentence denotes Deletion mapping and hybrid promoter constructs demonstrate that the newly identified Tat-responsive element corresponds to a sequence within the viral long terminal repeat (LTR) previously identified as the HIV-1 enhancer, or NF-kappa B domain.
S10 1457-1583 Sentence denotes DNA band-shift analysis reveals NF-kappa B binding activity in glial cells that differs from that present in T lymphoid cells.
S11 1584-1764 Sentence denotes Further, we observe that TAR-deleted mutants of HIV-1 demonstrate normal late gene expression in glial cells as evidenced by syncytia formation and production of viral p24 antigen.
S12 1764-1797 Sentence denotes (ABSTRACT TRUNCATED AT 250 WORDS)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 DNA_domain_or_region denotes TAR
T2 35-38 protein_molecule denotes Tat
T3 91-96 virus denotes HIV-1
T4 118-129 protein_molecule denotes Tat protein
T5 133-168 virus denotes human immunodeficiency virus type 1
T6 170-175 virus denotes HIV-1
T7 245-262 other_name denotes antiviral therapy
T8 264-267 protein_molecule denotes Tat
T9 291-296 virus denotes HIV-1
T10 353-366 other_name denotes transcription
T11 383-397 DNA_domain_or_region denotes viral promoter
T12 478-513 other_name denotes acquired immune deficiency syndrome
T13 515-519 other_name denotes AIDS
T14 536-572 other_name denotes increased transcriptional initiation
T15 584-610 other_name denotes transcriptional elongation
T16 703-706 protein_molecule denotes Tat
T17 723-733 RNA_family_or_group denotes RNA target
T18 741-744 RNA_domain_or_region denotes TAR
T19 746-772 RNA_domain_or_region denotes transactivation responsive
T20 821-832 RNA_family_or_group denotes HIV-1 mRNAs
T21 899-927 other_name denotes mechanism of transactivation
T22 975-992 cell_line denotes CNS-derived cells
T23 993-996 protein_molecule denotes Tat
T24 1022-1027 virus denotes HIV-1
T25 1038-1041 DNA_domain_or_region denotes TAR
T26 1065-1068 protein_molecule denotes Tat
T27 1117-1131 DNA_domain_or_region denotes viral promoter
T28 1140-1164 cell_line denotes glial-derived cell lines
T29 1206-1209 RNA_domain_or_region denotes TAR
T30 1232-1258 DNA_family_or_group denotes hybrid promoter constructs
T31 1297-1300 protein_molecule denotes Tat
T32 1357-1383 DNA_domain_or_region denotes viral long terminal repeat
T33 1385-1388 DNA_domain_or_region denotes LTR
T34 1419-1424 virus denotes HIV-1
T35 1438-1455 DNA_domain_or_region denotes NF-kappa B domain
T36 1457-1480 other_name denotes DNA band-shift analysis
T37 1489-1499 protein_molecule denotes NF-kappa B
T38 1566-1582 cell_type denotes T lymphoid cells
T39 1609-1628 DNA_family_or_group denotes TAR-deleted mutants
T40 1632-1637 virus denotes HIV-1
T41 1650-1677 other_name denotes normal late gene expression
T42 1681-1692 cell_type denotes glial cells
T43 1709-1727 other_name denotes syncytia formation
T44 1746-1763 protein_molecule denotes viral p24 antigen