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PubMed:15044387 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 199-210 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 414-425 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 623-634 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 199-210 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 414-425 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 623-634 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 199-210 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 414-425 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 623-634 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 16-26 FMAID:62860 denotes neutrophil
_T2 16-26 FMAID:167159 denotes neutrophil
_T3 16-26 FMAID:167158 denotes neutrophil
_T4 63-72 FMAID:66326 denotes pulmonary
_T5 63-72 FMAID:171535 denotes pulmonary
_T6 63-81 FMAID:45621 denotes pulmonary vascular
_T7 63-81 FMAID:175909 denotes pulmonary vascular
_T8 63-81 FMAID:141935 denotes pulmonary vascular
_T9 82-93 FMAID:63916 denotes endothelial
_T10 82-93 FMAID:162384 denotes endothelial
_T11 94-101 FMAID:50594 denotes surface
_T12 94-101 FMAID:146300 denotes surface
_T13 124-134 FMAID:167159 denotes neutrophil
_T14 124-134 FMAID:167158 denotes neutrophil
_T15 124-134 FMAID:62860 denotes neutrophil
_T16 172-183 FMAID:162384 denotes endothelium
_T17 172-183 FMAID:63916 denotes endothelium
_T18 218-225 FMAID:50594 denotes surface
_T19 218-225 FMAID:146300 denotes surface
_T20 218-232 FMAID:25456 denotes surface of the
_T21 218-232 FMAID:117867 denotes surface of the
_T22 218-232 FMAID:25241 denotes surface of the
_T23 218-232 FMAID:117967 denotes surface of the
_T24 218-232 FMAID:25320 denotes surface of the
_T25 218-232 FMAID:167552 denotes surface of the
_T26 218-232 FMAID:118168 denotes surface of the
_T27 218-232 FMAID:63163 denotes surface of the
_T28 233-243 FMAID:62860 denotes neutrophil
_T29 233-243 FMAID:167158 denotes neutrophil
_T30 233-243 FMAID:167159 denotes neutrophil
_T31 296-301 FMAID:169002 denotes cells
_T32 296-301 FMAID:68646 denotes cells
_T33 380-386 FMAID:162307 denotes plasma
_T34 380-395 FMAID:166047 denotes plasma membrane
_T35 380-395 FMAID:63841 denotes plasma membrane
_T36 380-395 FMAID:66843 denotes plasma membrane
_T37 380-395 FMAID:162306 denotes plasma membrane
_T38 380-395 FMAID:210691 denotes plasma membrane
_T39 380-395 FMAID:164993 denotes plasma membrane
_T40 431-444 FMAID:212684 denotes cell surfaces
_T41 431-444 FMAID:200942 denotes cell surfaces
_T42 436-444 FMAID:146300 denotes surfaces
_T43 436-444 FMAID:50594 denotes surfaces
_T44 542-549 FMAID:146300 denotes surface
_T45 542-549 FMAID:50594 denotes surface
_T46 675-684 FMAID:66326 denotes pulmonary
_T47 675-684 FMAID:171535 denotes pulmonary
_T48 675-693 FMAID:45621 denotes pulmonary vascular
_T49 675-693 FMAID:141935 denotes pulmonary vascular
_T50 675-693 FMAID:175909 denotes pulmonary vascular
_T51 694-705 FMAID:63916 denotes endothelial
_T52 694-705 FMAID:162384 denotes endothelial
_T53 694-710 FMAID:169653 denotes endothelial cell
_T54 694-710 FMAID:69075 denotes endothelial cell
_T55 694-710 FMAID:66772 denotes endothelial cell
_T56 694-710 FMAID:164926 denotes endothelial cell
_T57 1021-1028 FMAID:50594 denotes surface
_T58 1021-1028 FMAID:146300 denotes surface
_T59 1171-1181 FMAID:167180 denotes antibodies
_T60 1475-1480 FMAID:177242 denotes added
_T61 1594-1604 FMAID:167267 denotes E-selectin
_T62 1594-1604 FMAID:167268 denotes E-selectin
_T63 1594-1604 FMAID:167265 denotes E-selectin
_T64 1594-1604 FMAID:62933 denotes E-selectin
_T65 1594-1604 FMAID:62932 denotes E-selectin
_T66 1594-1604 FMAID:62931 denotes E-selectin
_T67 1596-1604 FMAID:165243 denotes selectin
_T68 1596-1604 FMAID:61795 denotes selectin
_T69 1630-1640 FMAID:167180 denotes antibodies
_T70 1857-1864 FMAID:67257 denotes protein
_T71 1857-1864 FMAID:165447 denotes protein
_T72 2003-2010 FMAID:146300 denotes surface
_T73 2003-2010 FMAID:50594 denotes surface

uniprot-human

Id Subject Object Predicate Lexical cue
T1 1076-1080 http://www.uniprot.org/uniprot/Q9UCR9 denotes IL-8
T2 1085-1089 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3 1594-1604 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T4 1611-1615 http://www.uniprot.org/uniprot/P05362 denotes CD54
T5 1625-1629 http://www.uniprot.org/uniprot/P05107 denotes CD18
T6 1667-1688 http://www.uniprot.org/uniprot/P01375 denotes tumor necrosis factor
T7 1667-1688 http://www.uniprot.org/uniprot/Q06643 denotes tumor necrosis factor

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1085-1089 http://www.uniprot.org/uniprot/P08505 denotes IL-6
T2 1594-1604 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T3 1611-1615 http://www.uniprot.org/uniprot/P13597 denotes CD54
T4 1625-1629 http://www.uniprot.org/uniprot/P11835 denotes CD18
T5 1667-1688 http://www.uniprot.org/uniprot/P06804 denotes tumor necrosis factor

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 63-72 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T2 296-301 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 675-684 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T4 1232-1238 http://purl.bioontology.org/ontology/NCBITAXON/167960 denotes pseudo
T5 1777-1786 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-184 Sentence denotes Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium.
TextSentencer_T2 185-302 Sentence denotes The amount of sialic acid on the surface of the neutrophil (PMN) influences its ability to interact with other cells.
TextSentencer_T3 303-445 Sentence denotes PMN activation with various stimuli mobilizes intracellular sialidase to the plasma membrane, where it cleaves sialic acid from cell surfaces.
TextSentencer_T4 446-736 Sentence denotes Because enhanced PMN adherence, spreading, deformability, and motility each are associated with surface desialylation and are critical to PMN diapedesis, we studied the role of sialic acid on PMN adhesion to and migration across pulmonary vascular endothelial cell (EC) monolayers in vitro.
TextSentencer_T5 737-841 Sentence denotes Neuraminidase treatment of either PMN or EC increased adhesion and migration in a dose-dependent manner.
TextSentencer_T6 842-964 Sentence denotes Neuraminidase treatment of both PMNs and ECs increased PMN adhesion to EC more than treatment of either PMNs or ECs alone.
TextSentencer_T7 965-1090 Sentence denotes Moreover, neuraminidase treatment of ECs did not change surface expression of adhesion molecules or release of IL-8 and IL-6.
TextSentencer_T8 1091-1380 Sentence denotes Inhibition of endogenous sialidase by either cross-protective antineuraminidase antibodies (45.5% inhibition) or competitive inhibition with pseudo-substrate (41.2% inhibition) decreased PMN adhesion to ECs; the inhibitable sialidase activity appeared to be associated with activated PMNs.
TextSentencer_T9 1381-1579 Sentence denotes Finally, EC monolayers preincubated with activated PMNs became hyperadhesive for subsequently added resting PMNs, and this hyperadhesive state was mediated through endogenous PMN sialidase activity.
TextSentencer_T10 1580-1730 Sentence denotes Blocking anti-E-selectin, anti-CD54 and anti-CD18 antibodies decreased PMN adhesion to tumor necrosis factor-activated ECs but not to PMN-treated ECs.
TextSentencer_T11 1731-1915 Sentence denotes These data implicate desialylation as a novel mechanism through which PMN-EC adhesion can be regulated independent of de novo protein synthesis or altered adhesion molecule expression.
TextSentencer_T12 1916-2117 Sentence denotes The ability of activated PMNs, through endogenous sialidase activity, to render the EC surface hyperadherent for unstimulated PMNs may provide for rapid amplification of the PMN-mediated host response.
T1 0-184 Sentence denotes Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium.
T2 185-302 Sentence denotes The amount of sialic acid on the surface of the neutrophil (PMN) influences its ability to interact with other cells.
T3 303-445 Sentence denotes PMN activation with various stimuli mobilizes intracellular sialidase to the plasma membrane, where it cleaves sialic acid from cell surfaces.
T4 446-736 Sentence denotes Because enhanced PMN adherence, spreading, deformability, and motility each are associated with surface desialylation and are critical to PMN diapedesis, we studied the role of sialic acid on PMN adhesion to and migration across pulmonary vascular endothelial cell (EC) monolayers in vitro.
T5 737-841 Sentence denotes Neuraminidase treatment of either PMN or EC increased adhesion and migration in a dose-dependent manner.
T6 842-964 Sentence denotes Neuraminidase treatment of both PMNs and ECs increased PMN adhesion to EC more than treatment of either PMNs or ECs alone.
T7 965-1090 Sentence denotes Moreover, neuraminidase treatment of ECs did not change surface expression of adhesion molecules or release of IL-8 and IL-6.
T8 1091-1380 Sentence denotes Inhibition of endogenous sialidase by either cross-protective antineuraminidase antibodies (45.5% inhibition) or competitive inhibition with pseudo-substrate (41.2% inhibition) decreased PMN adhesion to ECs; the inhibitable sialidase activity appeared to be associated with activated PMNs.
T9 1381-1579 Sentence denotes Finally, EC monolayers preincubated with activated PMNs became hyperadhesive for subsequently added resting PMNs, and this hyperadhesive state was mediated through endogenous PMN sialidase activity.
T10 1580-1730 Sentence denotes Blocking anti-E-selectin, anti-CD54 and anti-CD18 antibodies decreased PMN adhesion to tumor necrosis factor-activated ECs but not to PMN-treated ECs.
T11 1731-1915 Sentence denotes These data implicate desialylation as a novel mechanism through which PMN-EC adhesion can be regulated independent of de novo protein synthesis or altered adhesion molecule expression.
T12 1916-2117 Sentence denotes The ability of activated PMNs, through endogenous sialidase activity, to render the EC surface hyperadherent for unstimulated PMNs may provide for rapid amplification of the PMN-mediated host response.
T1 0-184 Sentence denotes Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium.
T2 185-302 Sentence denotes The amount of sialic acid on the surface of the neutrophil (PMN) influences its ability to interact with other cells.
T3 303-445 Sentence denotes PMN activation with various stimuli mobilizes intracellular sialidase to the plasma membrane, where it cleaves sialic acid from cell surfaces.
T4 446-736 Sentence denotes Because enhanced PMN adherence, spreading, deformability, and motility each are associated with surface desialylation and are critical to PMN diapedesis, we studied the role of sialic acid on PMN adhesion to and migration across pulmonary vascular endothelial cell (EC) monolayers in vitro.
T5 737-841 Sentence denotes Neuraminidase treatment of either PMN or EC increased adhesion and migration in a dose-dependent manner.
T6 842-964 Sentence denotes Neuraminidase treatment of both PMNs and ECs increased PMN adhesion to EC more than treatment of either PMNs or ECs alone.
T7 965-1090 Sentence denotes Moreover, neuraminidase treatment of ECs did not change surface expression of adhesion molecules or release of IL-8 and IL-6.
T8 1091-1380 Sentence denotes Inhibition of endogenous sialidase by either cross-protective antineuraminidase antibodies (45.5% inhibition) or competitive inhibition with pseudo-substrate (41.2% inhibition) decreased PMN adhesion to ECs; the inhibitable sialidase activity appeared to be associated with activated PMNs.
T9 1381-1579 Sentence denotes Finally, EC monolayers preincubated with activated PMNs became hyperadhesive for subsequently added resting PMNs, and this hyperadhesive state was mediated through endogenous PMN sialidase activity.
T10 1580-1730 Sentence denotes Blocking anti-E-selectin, anti-CD54 and anti-CD18 antibodies decreased PMN adhesion to tumor necrosis factor-activated ECs but not to PMN-treated ECs.
T11 1731-1915 Sentence denotes These data implicate desialylation as a novel mechanism through which PMN-EC adhesion can be regulated independent of de novo protein synthesis or altered adhesion molecule expression.
T12 1916-2117 Sentence denotes The ability of activated PMNs, through endogenous sialidase activity, to render the EC surface hyperadherent for unstimulated PMNs may provide for rapid amplification of the PMN-mediated host response.

GO-BP

Id Subject Object Predicate Lexical cue
T1 27-45 http://purl.obolibrary.org/obo/GO_0004308 denotes sialidase activity
T2 1315-1333 http://purl.obolibrary.org/obo/GO_0004308 denotes sialidase activity
T3 1560-1578 http://purl.obolibrary.org/obo/GO_0004308 denotes sialidase activity
T4 1966-1984 http://purl.obolibrary.org/obo/GO_0004308 denotes sialidase activity
T5 116-123 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T6 1481-1488 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T7 245-248 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T8 303-306 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T9 463-466 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T10 584-587 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T11 638-641 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T12 771-774 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T13 897-900 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T14 1278-1281 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T15 1556-1559 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T16 1651-1654 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T17 1714-1717 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T18 1801-1804 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T19 2090-2093 http://purl.obolibrary.org/obo/GO_0034727 denotes PMN
T20 588-598 http://purl.obolibrary.org/obo/GO_0050904 denotes diapedesis
T21 1085-1101 http://purl.obolibrary.org/obo/GO_1900165 denotes IL-6. Inhibition
T22 1303-1333 http://purl.obolibrary.org/obo/GO_1903016 denotes inhibitable sialidase activity
T23 1673-1681 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T24 1673-1681 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T25 1673-1681 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T26 1673-1681 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T27 1824-1833 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T28 1857-1874 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T29 1865-1874 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T30 2103-2116 http://purl.obolibrary.org/obo/GO_0075136 denotes host response

GO-MF

Id Subject Object Predicate Lexical cue
T1 1079-1087 http://purl.obolibrary.org/obo/GO_0005153 denotes 8 and IL
T2 1085-1089 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3 1171-1181 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4 1630-1640 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T5 1596-1604 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin

GO-CC

Id Subject Object Predicate Lexical cue
T1 296-301 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 431-435 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 706-710 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 349-362 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T5 380-395 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T6 387-395 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T7 431-444 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surfaces
T8 2103-2107 http://purl.obolibrary.org/obo/GO_0018995 denotes host

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 172-183 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 276-284 http://edamontology.org/topic_0602 denotes interact
T2 603-610 http://edamontology.org/topic_3678 denotes studied
T3 1052-1061 http://edamontology.org/topic_2839 denotes molecules
T4 1857-1864 http://edamontology.org/topic_0078 denotes protein
T5 1895-1903 http://edamontology.org/topic_2839 denotes molecule

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 712-714 http://edamontology.org/data_1011 denotes EC
T2 778-780 http://edamontology.org/data_1011 denotes EC
T3 883-886 http://edamontology.org/data_1011 denotes ECs
T4 913-915 http://edamontology.org/data_1011 denotes EC
T5 954-957 http://edamontology.org/data_1011 denotes ECs
T6 1002-1005 http://edamontology.org/data_1011 denotes ECs
T7 1294-1297 http://edamontology.org/data_1011 denotes ECs
T8 1390-1392 http://edamontology.org/data_1011 denotes EC
T9 1699-1702 http://edamontology.org/data_1011 denotes ECs
T10 1726-1729 http://edamontology.org/data_1011 denotes ECs
T11 1737-1741 http://edamontology.org/data_0006 denotes data
T12 1805-1807 http://edamontology.org/data_1011 denotes EC
T13 1857-1864 http://edamontology.org/data_1467 denotes protein
T14 1857-1864 http://edamontology.org/format_1208 denotes protein
T15 1989-1995 http://edamontology.org/operation_0337 denotes render
T16 2000-2002 http://edamontology.org/data_1011 denotes EC

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 1594-1604 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T2 1596-1604 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T3 1596-1604 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 172-183 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1667-1672 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 16-26 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T2 124-134 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T3 172-183 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T4 233-243 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T5 349-362 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 380-395 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T7 685-710 Body_part denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL_0002139
T8 712-714 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T9 778-780 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T10 913-915 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T11 1390-1392 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T12 1805-1807 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T13 2000-2002 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1667-1672 Phenotype denotes tumor HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 16-26 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T2 124-134 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T3 233-243 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T4 685-710 Cell denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL:0002139
T5 694-710 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T6 712-714 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T7 778-780 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T8 913-915 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T9 1390-1392 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T10 1805-1807 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T11 2000-2002 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115