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PubMed:15042566 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-89 Sentence denotes DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
TextSentencer_T2 90-101 Sentence denotes BACKGROUND:
TextSentencer_T3 102-250 Sentence denotes Aristolochic acid-associated nephropathy (AAN) is a specific type of renal disease that predisposes patients to a high risk of urothelial carcinoma.
TextSentencer_T4 251-424 Sentence denotes The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver.
TextSentencer_T5 425-631 Sentence denotes METHODS AND RESULTS: DNA was isolated from the primary breast tumor, the liver tumor, and the original urothelial malignancy and assayed for aristolochic acid (AA)-DNA adducts and mutations in the p53 gene.
TextSentencer_T6 632-747 Sentence denotes The adduct detected was the adenosine adduct of aristolochic acid I 7-(deoxyadenosin-N6-yl)aristolactam I (dA-AAI).
TextSentencer_T7 748-887 Sentence denotes In DNA from the breast and liver tumors the authors showed the same missense mutation in codon 245 (GGC-->GAC; Gly-->Asp) of exon 7 of p53.
TextSentencer_T8 888-1007 Sentence denotes In contrast, DNA extracted from the urothelial tumor showed an AAG to TAG mutation in codon 139 (Lys-->Stop) of exon 5.
TextSentencer_T9 1008-1019 Sentence denotes CONCLUSION:
TextSentencer_T10 1020-1227 Sentence denotes A to T transversions, as observed here, are the typical mutations observed in the H-ras gene of tumors induced when rodents are treated with AA and correspond with DNA adduct formation at adenosine residues.
TextSentencer_T11 1228-1321 Sentence denotes These data indicate the probable molecular mechanism whereby AA causes urothelial malignancy.
T1 0-89 Sentence denotes DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
T2 90-101 Sentence denotes BACKGROUND:
T3 102-250 Sentence denotes Aristolochic acid-associated nephropathy (AAN) is a specific type of renal disease that predisposes patients to a high risk of urothelial carcinoma.
T4 251-424 Sentence denotes The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver.
T5 425-631 Sentence denotes METHODS AND RESULTS: DNA was isolated from the primary breast tumor, the liver tumor, and the original urothelial malignancy and assayed for aristolochic acid (AA)-DNA adducts and mutations in the p53 gene.
T6 632-747 Sentence denotes The adduct detected was the adenosine adduct of aristolochic acid I 7-(deoxyadenosin-N6-yl)aristolactam I (dA-AAI).
T7 748-887 Sentence denotes In DNA from the breast and liver tumors the authors showed the same missense mutation in codon 245 (GGC-->GAC; Gly-->Asp) of exon 7 of p53.
T8 888-1007 Sentence denotes In contrast, DNA extracted from the urothelial tumor showed an AAG to TAG mutation in codon 139 (Lys-->Stop) of exon 5.
T9 1008-1019 Sentence denotes CONCLUSION:
T10 1020-1227 Sentence denotes A to T transversions, as observed here, are the typical mutations observed in the H-ras gene of tumors induced when rodents are treated with AA and correspond with DNA adduct formation at adenosine residues.
T11 1228-1321 Sentence denotes These data indicate the probable molecular mechanism whereby AA causes urothelial malignancy.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15042566-0#16#19#gene7157 16-19 gene7157 denotes p53
15042566-0#77#88#diseaseC0022658 77-88 diseaseC0022658 denotes nephropathy
15042566-5#100#103#gene79017 848-851 gene79017 denotes GGC
15042566-5#106#109#gene2744 854-857 gene2744 denotes GAC
15042566-5#135#138#gene7157 883-886 gene7157 denotes p53
15042566-5#27#39#diseaseC0023903 775-787 diseaseC0023903 denotes liver tumors
16#19#gene715777#88#diseaseC0022658 15042566-0#16#19#gene7157 15042566-0#77#88#diseaseC0022658 associated_with p53,nephropathy
100#103#gene7901727#39#diseaseC0023903 15042566-5#100#103#gene79017 15042566-5#27#39#diseaseC0023903 associated_with GGC,liver tumors
106#109#gene274427#39#diseaseC0023903 15042566-5#106#109#gene2744 15042566-5#27#39#diseaseC0023903 associated_with GAC,liver tumors
135#138#gene715727#39#diseaseC0023903 15042566-5#135#138#gene7157 15042566-5#27#39#diseaseC0023903 associated_with p53,liver tumors

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 131-142 HP:0000112 denotes nephropathy
TI1 77-88 HP:0000112 denotes nephropathy
AB2 240-249 HP:0030731 denotes carcinoma
AB3 376-392 HP:0003002 denotes breast carcinoma

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 865-868 ORDO:63442 denotes Asp

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 418-423 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 498-503 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 775-780 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 376-382 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 480-486 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 764-770 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 16-19 gene:7157 denotes p53
T1 77-88 disease:C0022658 denotes nephropathy
T2 854-857 gene:2744 denotes GAC
T3 775-787 disease:C0023903 denotes liver tumors
T4 848-851 gene:79017 denotes GGC
T5 775-787 disease:C0023903 denotes liver tumors
T6 883-886 gene:7157 denotes p53
T7 775-787 disease:C0023903 denotes liver tumors
R1 T0 T1 associated_with p53,nephropathy
R2 T2 T3 associated_with GAC,liver tumors
R3 T4 T5 associated_with GGC,liver tumors
R4 T6 T7 associated_with p53,liver tumors