> top > docs > PubMed:15003892 > annotations

PubMed:15003892 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 159-538 OBJECTIVE denotes Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells. It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis. We wanted to investigate the potential role of OPN in multiple myeloma.
T2 559-940 METHODS denotes Myeloma cells and stromal cells from myeloma patients were investigated as potential OPN-producers. Furthermore, OPN was tested in proliferation, migration and adhesion assays with myeloma cells. Serum and plasma OPN in myeloma patients were measured by enzyme-linked immunosorbent assay (ELISA). OPN levels were correlated to disease variables at diagnosis and to disease outcome.
T3 950-1763 RESULTS denotes Myeloma cells produce OPN, and stromal cells from myeloma patients express higher levels of OPN than stromal cells from healthy controls. The myeloma cell lines ANBL-6 and INA-6 adhered to OPN. NOD/SCID mice inoculated with OPN-producing ANBL-6 cells had elevated levels of murine OPN in serum, whereas human OPN was not detectable. Plasma and serum levels of OPN were significantly higher in myeloma patients than in healthy individuals. Interpretation and Conclusions. Myeloma cell lines adhere to OPN, indicating that elevated stromal expression of OPN may be one of the factors responsible for the retention of myeloma cells in the bone marrow. The elevated plasma OPN levels in myeloma patients could be due to both production of OPN by the tumor cells and tumor-induced production of OPN by non-tumor cells.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.
T2 132-158 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 159-307 Sentence denotes Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells.
T4 308-466 Sentence denotes It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis.
T5 467-538 Sentence denotes We wanted to investigate the potential role of OPN in multiple myeloma.
T6 539-558 Sentence denotes DESIGN AND METHODS:
T7 559-658 Sentence denotes Myeloma cells and stromal cells from myeloma patients were investigated as potential OPN-producers.
T8 659-754 Sentence denotes Furthermore, OPN was tested in proliferation, migration and adhesion assays with myeloma cells.
T9 755-855 Sentence denotes Serum and plasma OPN in myeloma patients were measured by enzyme-linked immunosorbent assay (ELISA).
T10 856-940 Sentence denotes OPN levels were correlated to disease variables at diagnosis and to disease outcome.
T11 941-949 Sentence denotes RESULTS:
T12 950-1087 Sentence denotes Myeloma cells produce OPN, and stromal cells from myeloma patients express higher levels of OPN than stromal cells from healthy controls.
T13 1088-1143 Sentence denotes The myeloma cell lines ANBL-6 and INA-6 adhered to OPN.
T14 1144-1282 Sentence denotes NOD/SCID mice inoculated with OPN-producing ANBL-6 cells had elevated levels of murine OPN in serum, whereas human OPN was not detectable.
T15 1283-1388 Sentence denotes Plasma and serum levels of OPN were significantly higher in myeloma patients than in healthy individuals.
T16 1389-1420 Sentence denotes Interpretation and Conclusions.
T17 1421-1598 Sentence denotes Myeloma cell lines adhere to OPN, indicating that elevated stromal expression of OPN may be one of the factors responsible for the retention of myeloma cells in the bone marrow.
T18 1599-1763 Sentence denotes The elevated plasma OPN levels in myeloma patients could be due to both production of OPN by the tumor cells and tumor-induced production of OPN by non-tumor cells.
T1 0-131 Sentence denotes Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.
T2 132-158 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 159-307 Sentence denotes Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells.
T4 308-466 Sentence denotes It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis.
T5 467-538 Sentence denotes We wanted to investigate the potential role of OPN in multiple myeloma.
T6 539-558 Sentence denotes DESIGN AND METHODS:
T7 559-658 Sentence denotes Myeloma cells and stromal cells from myeloma patients were investigated as potential OPN-producers.
T8 659-754 Sentence denotes Furthermore, OPN was tested in proliferation, migration and adhesion assays with myeloma cells.
T9 755-855 Sentence denotes Serum and plasma OPN in myeloma patients were measured by enzyme-linked immunosorbent assay (ELISA).
T10 856-940 Sentence denotes OPN levels were correlated to disease variables at diagnosis and to disease outcome.
T11 941-949 Sentence denotes RESULTS:
T12 950-1087 Sentence denotes Myeloma cells produce OPN, and stromal cells from myeloma patients express higher levels of OPN than stromal cells from healthy controls.
T13 1088-1143 Sentence denotes The myeloma cell lines ANBL-6 and INA-6 adhered to OPN.
T14 1144-1282 Sentence denotes NOD/SCID mice inoculated with OPN-producing ANBL-6 cells had elevated levels of murine OPN in serum, whereas human OPN was not detectable.
T15 1283-1388 Sentence denotes Plasma and serum levels of OPN were significantly higher in myeloma patients than in healthy individuals.
T16 1389-1420 Sentence denotes Interpretation and Conclusions.
T17 1421-1598 Sentence denotes Myeloma cell lines adhere to OPN, indicating that elevated stromal expression of OPN may be one of the factors responsible for the retention of myeloma cells in the bone marrow.
T18 1599-1763 Sentence denotes The elevated plasma OPN levels in myeloma patients could be due to both production of OPN by the tumor cells and tumor-induced production of OPN by non-tumor cells.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15003892-0#0#11#gene6696 0-11 gene6696 denotes Osteopontin
15003892-0#38#45#diseaseC0026764 38-45 diseaseC0026764 denotes myeloma
15003892-0#114#130#diseaseC0026764 114-130 diseaseC0026764 denotes multiple myeloma
15003892-9#34#37#gene9118 1122-1125 gene9118 denotes INA
15003892-9#4#11#diseaseC0026764 1092-1099 diseaseC0026764 denotes myeloma
0#11#gene669638#45#diseaseC0026764 15003892-0#0#11#gene6696 15003892-0#38#45#diseaseC0026764 associated_with Osteopontin,myeloma
0#11#gene6696114#130#diseaseC0026764 15003892-0#0#11#gene6696 15003892-0#114#130#diseaseC0026764 associated_with Osteopontin,multiple myeloma
34#37#gene91184#11#diseaseC0026764 15003892-9#34#37#gene9118 15003892-9#4#11#diseaseC0026764 associated_with INA,myeloma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1310-1313 gene:6696 denotes OPN
T1 1343-1350 disease:C0026764 denotes myeloma
R1 T0 T1 associated_with OPN,myeloma