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PubMed:14996747 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-222 Sentence denotes Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress.
TextSentencer_T2 223-506 Sentence denotes Clusterin/Apolipoprotein J (CLU) is a heterodimeric ubiquitously expressed secreted glycoprotein that is implicated in several physiological processes and is differentially expressed in many severe physiological disturbances, including tumor formation and in vivo cancer progression.
TextSentencer_T3 507-647 Sentence denotes Despite extensive efforts, clarification of CLU's biological role has been exceptionally difficult and its precise function remains elusive.
TextSentencer_T4 648-791 Sentence denotes Short RNA duplexes, referred to as small interfering RNAs (siRNAs), provide a new approach for the elucidation of gene function in human cells.
TextSentencer_T5 792-963 Sentence denotes Here, we describe siRNA-mediated CLU gene silencing in osteosarcoma and prostate human cancer cells and illustrate that CLU mRNA is amenable to siRNA-mediated degradation.
TextSentencer_T6 964-1128 Sentence denotes Our data demonstrate that CLU knockdown in human cancer cells induces significant reduction of cellular growth and higher rates of spontaneous endogenous apoptosis.
TextSentencer_T7 1129-1296 Sentence denotes Moreover, CLU knockdown cancer cells were significantly sensitized to both genotoxic and oxidative stress induced by chemotherapeutic drugs and H(2)O(2), respectively.
TextSentencer_T8 1297-1484 Sentence denotes These effects were more pronounced in cell lines that express high endogenous steady-state levels of the CLU protein and occur through hyperactivation of the cellular apoptotic machinery.
TextSentencer_T9 1485-1692 Sentence denotes Overall, our results reveal that, in the distinct cellular contexts of the osteosarcoma and prostate cancer cells assayed, CLU is a central molecule in cell homeostasis that exerts a cytoprotective function.
TextSentencer_T10 1693-1911 Sentence denotes The described CLU-specific siRNA oligonucleotides that can potently silence CLU gene expression may thus prove valuable agents during antitumor therapy or at other pathological conditions where CLU has been implicated.
T1 0-222 Sentence denotes Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress.
T2 223-506 Sentence denotes Clusterin/Apolipoprotein J (CLU) is a heterodimeric ubiquitously expressed secreted glycoprotein that is implicated in several physiological processes and is differentially expressed in many severe physiological disturbances, including tumor formation and in vivo cancer progression.
T3 507-647 Sentence denotes Despite extensive efforts, clarification of CLU's biological role has been exceptionally difficult and its precise function remains elusive.
T4 648-791 Sentence denotes Short RNA duplexes, referred to as small interfering RNAs (siRNAs), provide a new approach for the elucidation of gene function in human cells.
T5 792-963 Sentence denotes Here, we describe siRNA-mediated CLU gene silencing in osteosarcoma and prostate human cancer cells and illustrate that CLU mRNA is amenable to siRNA-mediated degradation.
T6 964-1128 Sentence denotes Our data demonstrate that CLU knockdown in human cancer cells induces significant reduction of cellular growth and higher rates of spontaneous endogenous apoptosis.
T7 1129-1296 Sentence denotes Moreover, CLU knockdown cancer cells were significantly sensitized to both genotoxic and oxidative stress induced by chemotherapeutic drugs and H(2)O(2), respectively.
T8 1297-1484 Sentence denotes These effects were more pronounced in cell lines that express high endogenous steady-state levels of the CLU protein and occur through hyperactivation of the cellular apoptotic machinery.
T9 1485-1692 Sentence denotes Overall, our results reveal that, in the distinct cellular contexts of the osteosarcoma and prostate cancer cells assayed, CLU is a central molecule in cell homeostasis that exerts a cytoprotective function.
T10 1693-1911 Sentence denotes The described CLU-specific siRNA oligonucleotides that can potently silence CLU gene expression may thus prove valuable agents during antitumor therapy or at other pathological conditions where CLU has been implicated.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 459-464 HP_0002664 denotes tumor
T2 487-493 HP_0002664 denotes cancer
T3 847-859 HP_0002669 denotes osteosarcoma
T4 879-885 HP_0002664 denotes cancer
T5 1013-1019 HP_0002664 denotes cancer
T6 1153-1159 HP_0002664 denotes cancer
T7 1432-1447 HP_0000752 denotes hyperactivation
T8 1560-1572 HP_0002669 denotes osteosarcoma
T9 1577-1592 HP_0012125 denotes prostate cancer
T10 1586-1592 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14996747-1#0#9#gene1191 223-232 gene1191 denotes Clusterin
14996747-1#264#282#diseaseC0178874 487-505 diseaseC0178874 denotes cancer progression
14996747-4#33#36#gene1191 825-828 gene1191 denotes CLU
14996747-4#55#67#diseaseC0029463 847-859 diseaseC0029463 denotes osteosarcoma
14996747-4#55#67#diseaseC0585442 847-859 diseaseC0585442 denotes osteosarcoma
0#9#gene1191264#282#diseaseC0178874 14996747-1#0#9#gene1191 14996747-1#264#282#diseaseC0178874 associated_with Clusterin,cancer progression
33#36#gene119155#67#diseaseC0029463 14996747-4#33#36#gene1191 14996747-4#55#67#diseaseC0029463 associated_with CLU,osteosarcoma
33#36#gene119155#67#diseaseC0585442 14996747-4#33#36#gene1191 14996747-4#55#67#diseaseC0585442 associated_with CLU,osteosarcoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2107 825-828 gene:1191 denotes CLU
T2108 847-859 disease:C0029463 denotes osteosarcoma
R1 T2107 T2108 associated_with CLU,osteosarcoma
R2 T2107 T2108 associated_with CLU,osteosarcoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 515-524 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 1617-1624 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1617-1624 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 515-524 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive

DisGeNET

Id Subject Object Predicate Lexical cue
T0 223-232 gene:1191 denotes Clusterin
T1 487-505 disease:C0178874 denotes cancer progression
R1 T0 T1 associated_with Clusterin,cancer progression