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Id Subject Object Predicate Lexical cue
T1 0-15 1407750 denotes Herbal medicine
T2 7-15 CHEBI:23888 denotes medicine
T3 16-19 PR:000015571 denotes Sho
T4 16-19 PR:Q5BIV9 denotes Sho
T6 16-28 C461320 denotes Sho-saiko-to
T7 16-28 C461320 denotes Sho-saiko-to
T8 20-25 D029972 denotes saiko
T9 30-34 C461320 denotes TJ-9
T10 30-34 C461320 denotes TJ-9
T11 57-63 UBERON:0027368 denotes matrix
T12 57-82 D020782 denotes matrix metalloproteinases
T14 84-88 D020782 denotes MMPs
T15 117-123 UBERON:0000479 denotes tissue
T16 117-155 D019714 denotes tissue inhibitor of metalloproteinases
T20 167-170 PR:P63003-1 denotes rat
T21 167-170 PR:Q2G0B1 denotes rat
T22 167-170 PR:Q8VHJ4 denotes rat
T19 167-170 10116 denotes rat
T23 167-170 D051381 denotes rat
T24 208-211 PR:000015571 denotes Sho
T25 208-211 PR:Q5BIV9 denotes Sho
T27 208-220 C461320 denotes Sho-saiko-to
T28 208-220 C461320 denotes Sho-saiko-to
T29 212-217 D029972 denotes saiko
T30 222-226 C461320 denotes TJ-9
T31 222-226 C461320 denotes TJ-9
T32 237-242 UBERON:0002107 denotes liver
T33 237-251 D008103 denotes liver fibrosis
T34 237-251 D008103 denotes liver fibrosis
T37 264-268 SO:0001742 denotes gain
T38 305-309 C461320 denotes TJ-9
T39 305-309 C461320 denotes TJ-9
T40 315-321 UBERON:0027368 denotes matrix
T41 315-340 D020782 denotes matrix metalloproteinases
T43 342-346 D020782 denotes MMPs
T44 348-354 UBERON:0000479 denotes tissue
T45 355-365 CHEBI:35222 denotes inhibitors
T46 369-387 D045726 denotes metalloproteinases
T47 467-471 UBERON:0003101 denotes male
T48 467-471 CHEBI:30780 denotes male
T49 472-483 10116 denotes Wistar rats
T50 472-483 D017208 denotes Wistar rats
T54 502-506 C461320 denotes TJ-9
T55 502-506 C461320 denotes TJ-9
T56 597-601 D020782 denotes MMPs
T57 619-623 C461320 denotes TJ-9
T58 619-623 C461320 denotes TJ-9
T59 650-666 D024141 denotes type IV collagen
T61 658-666 2714 denotes collagen
T60 658-666 GO:0005202 denotes collagen
T64 687-694 4716 denotes gelatin
T65 687-694 D005780 denotes gelatin
T66 687-694 CHEBI:5291 denotes gelatin
T67 710-717 SO:0001031 denotes reverse
T68 815-818 CHEBI:340824 denotes MMP
T71 815-818 CHEBI:59761 denotes MMP
T72 815-820 PR:P08253 denotes MMP-2
T73 815-820 Q9GLE5 denotes MMP-2
T74 815-820 P08253 denotes MMP-2
T75 815-820 Q90611 denotes MMP-2
T77 815-820 PR:Q8MPP3 denotes MMP-2
T78 815-820 P33436 denotes MMP-2
T79 815-820 PR:Q90611 denotes MMP-2
T80 815-820 PR:P33436 denotes MMP-2
T81 815-820 PR:000010479 denotes MMP-2
T82 815-820 PR:P33434 denotes MMP-2
T83 815-820 P33434 denotes MMP-2
T84 815-820 P50757 denotes MMP-2
T76 815-820 GO:0004228 denotes MMP-2
T89 829-835 P81546 denotes TIMP-1
T90 829-835 O02722 denotes TIMP-1
T91 829-835 P49061 denotes TIMP-1
T92 829-835 P50122 denotes TIMP-1
T93 829-835 P20614 denotes TIMP-1
T94 829-835 P12032 denotes TIMP-1
T95 829-835 P35624 denotes TIMP-1
T96 829-835 P20414 denotes TIMP-1
T97 829-835 Q95KL9 denotes TIMP-1
T98 829-835 Q5RC60 denotes TIMP-1
T99 829-835 PR:P30120 denotes TIMP-1
T100 829-835 P30120 denotes TIMP-1
T101 829-835 PR:000016352 denotes TIMP-1
T103 829-835 PR:P12032 denotes TIMP-1
T104 829-835 PR:P01033 denotes TIMP-1
T105 829-835 P01033 denotes TIMP-1
T102 829-835 D019715 denotes TIMP-1
T106 843-847 C461320 denotes TJ-9
T107 843-847 C461320 denotes TJ-9
T108 901-904 CHEBI:340824 denotes MMP
T111 901-904 CHEBI:59761 denotes MMP
T112 901-906 PR:P08253 denotes MMP-2
T113 901-906 Q9GLE5 denotes MMP-2
T114 901-906 P08253 denotes MMP-2
T115 901-906 Q90611 denotes MMP-2
T117 901-906 PR:Q8MPP3 denotes MMP-2
T118 901-906 P33436 denotes MMP-2
T119 901-906 PR:Q90611 denotes MMP-2
T120 901-906 PR:P33436 denotes MMP-2
T121 901-906 PR:000010479 denotes MMP-2
T122 901-906 PR:P33434 denotes MMP-2
T123 901-906 P33434 denotes MMP-2
T124 901-906 P50757 denotes MMP-2
T116 901-906 GO:0004228 denotes MMP-2
T127 911-915 SO:0000234 denotes mRNA
T125 911-915 D012333 denotes mRNA
T126 911-915 CHEBI:33699 denotes mRNA
T132 938-944 P81546 denotes TIMP-1
T133 938-944 O02722 denotes TIMP-1
T134 938-944 P49061 denotes TIMP-1
T135 938-944 P50122 denotes TIMP-1
T136 938-944 P20614 denotes TIMP-1
T137 938-944 P12032 denotes TIMP-1
T138 938-944 P35624 denotes TIMP-1
T139 938-944 P20414 denotes TIMP-1
T140 938-944 Q95KL9 denotes TIMP-1
T141 938-944 Q5RC60 denotes TIMP-1
T142 938-944 PR:P30120 denotes TIMP-1
T143 938-944 P30120 denotes TIMP-1
T144 938-944 PR:000016352 denotes TIMP-1
T146 938-944 PR:P12032 denotes TIMP-1
T147 938-944 PR:P01033 denotes TIMP-1
T148 938-944 P01033 denotes TIMP-1
T145 938-944 D019715 denotes TIMP-1
T151 945-949 SO:0000234 denotes mRNA
T149 945-949 D012333 denotes mRNA
T150 945-949 CHEBI:33699 denotes mRNA
T152 971-978 4716 denotes Gelatin
T153 971-978 D005780 denotes Gelatin
T154 971-978 CHEBI:5291 denotes Gelatin
T155 991-998 SO:0001031 denotes reverse
T156 1039-1055 D024141 denotes type IV collagen
T158 1047-1055 2714 denotes collagen
T157 1047-1055 GO:0005202 denotes collagen
T161 1090-1094 C461320 denotes TJ-9
T162 1090-1094 C461320 denotes TJ-9
T163 1105-1108 CHEBI:340824 denotes MMP
T166 1105-1108 CHEBI:59761 denotes MMP
T167 1105-1110 PR:P08253 denotes MMP-2
T168 1105-1110 Q9GLE5 denotes MMP-2
T169 1105-1110 P08253 denotes MMP-2
T170 1105-1110 Q90611 denotes MMP-2
T172 1105-1110 PR:Q8MPP3 denotes MMP-2
T173 1105-1110 P33436 denotes MMP-2
T174 1105-1110 PR:Q90611 denotes MMP-2
T175 1105-1110 PR:P33436 denotes MMP-2
T176 1105-1110 PR:000010479 denotes MMP-2
T177 1105-1110 PR:P33434 denotes MMP-2
T178 1105-1110 P33434 denotes MMP-2
T179 1105-1110 P50757 denotes MMP-2
T171 1105-1110 GO:0004228 denotes MMP-2
T184 1134-1140 P81546 denotes TIMP-1
T185 1134-1140 O02722 denotes TIMP-1
T186 1134-1140 P49061 denotes TIMP-1
T187 1134-1140 P50122 denotes TIMP-1
T188 1134-1140 P20614 denotes TIMP-1
T189 1134-1140 P12032 denotes TIMP-1
T190 1134-1140 P35624 denotes TIMP-1
T191 1134-1140 P20414 denotes TIMP-1
T192 1134-1140 Q95KL9 denotes TIMP-1
T193 1134-1140 Q5RC60 denotes TIMP-1
T194 1134-1140 PR:P30120 denotes TIMP-1
T195 1134-1140 P30120 denotes TIMP-1
T196 1134-1140 PR:000016352 denotes TIMP-1
T198 1134-1140 PR:P12032 denotes TIMP-1
T199 1134-1140 PR:P01033 denotes TIMP-1
T200 1134-1140 P01033 denotes TIMP-1
T197 1134-1140 D019715 denotes TIMP-1
T201 1183-1191 CHEBI:90705 denotes SB203580
T202 1183-1191 C093642 denotes SB203580
T203 1183-1191 C093642 denotes SB203580
T204 1207-1216 MOP:0000569 denotes reduction
T207 1220-1224 SO:0000234 denotes mRNA
T205 1220-1224 D012333 denotes mRNA
T206 1220-1224 CHEBI:33699 denotes mRNA
T212 1252-1258 P81546 denotes TIMP-1
T213 1252-1258 O02722 denotes TIMP-1
T214 1252-1258 P49061 denotes TIMP-1
T215 1252-1258 P50122 denotes TIMP-1
T216 1252-1258 P20614 denotes TIMP-1
T217 1252-1258 P12032 denotes TIMP-1
T218 1252-1258 P35624 denotes TIMP-1
T219 1252-1258 P20414 denotes TIMP-1
T220 1252-1258 Q95KL9 denotes TIMP-1
T221 1252-1258 Q5RC60 denotes TIMP-1
T222 1252-1258 PR:P30120 denotes TIMP-1
T223 1252-1258 P30120 denotes TIMP-1
T224 1252-1258 PR:000016352 denotes TIMP-1
T226 1252-1258 PR:P12032 denotes TIMP-1
T227 1252-1258 PR:P01033 denotes TIMP-1
T228 1252-1258 P01033 denotes TIMP-1
T225 1252-1258 D019715 denotes TIMP-1
T229 1262-1266 C461320 denotes TJ-9
T230 1262-1266 C461320 denotes TJ-9
T233 1284-1288 SO:0000234 denotes mRNA
T231 1284-1288 D012333 denotes mRNA
T232 1284-1288 CHEBI:33699 denotes mRNA
T234 1316-1319 CHEBI:340824 denotes MMP
T237 1316-1319 CHEBI:59761 denotes MMP
T238 1316-1321 PR:P08253 denotes MMP-2
T239 1316-1321 Q9GLE5 denotes MMP-2
T240 1316-1321 P08253 denotes MMP-2
T241 1316-1321 Q90611 denotes MMP-2
T243 1316-1321 PR:Q8MPP3 denotes MMP-2
T244 1316-1321 P33436 denotes MMP-2
T245 1316-1321 PR:Q90611 denotes MMP-2
T246 1316-1321 PR:P33436 denotes MMP-2
T247 1316-1321 PR:000010479 denotes MMP-2
T248 1316-1321 PR:P33434 denotes MMP-2
T249 1316-1321 P33434 denotes MMP-2
T250 1316-1321 P50757 denotes MMP-2
T242 1316-1321 GO:0004228 denotes MMP-2
T251 1347-1351 C461320 denotes TJ-9
T252 1347-1351 C461320 denotes TJ-9
T253 1362-1365 CHEBI:340824 denotes MMP
T256 1362-1365 CHEBI:59761 denotes MMP
T257 1362-1367 PR:P08253 denotes MMP-2
T258 1362-1367 Q9GLE5 denotes MMP-2
T259 1362-1367 P08253 denotes MMP-2
T260 1362-1367 Q90611 denotes MMP-2
T262 1362-1367 PR:Q8MPP3 denotes MMP-2
T263 1362-1367 P33436 denotes MMP-2
T264 1362-1367 PR:Q90611 denotes MMP-2
T265 1362-1367 PR:P33436 denotes MMP-2
T266 1362-1367 PR:000010479 denotes MMP-2
T267 1362-1367 PR:P33434 denotes MMP-2
T268 1362-1367 P33434 denotes MMP-2
T269 1362-1367 P50757 denotes MMP-2
T261 1362-1367 GO:0004228 denotes MMP-2
T274 1394-1400 P81546 denotes TIMP-1
T275 1394-1400 O02722 denotes TIMP-1
T276 1394-1400 P49061 denotes TIMP-1
T277 1394-1400 P50122 denotes TIMP-1
T278 1394-1400 P20614 denotes TIMP-1
T279 1394-1400 P12032 denotes TIMP-1
T280 1394-1400 P35624 denotes TIMP-1
T281 1394-1400 P20414 denotes TIMP-1
T282 1394-1400 Q95KL9 denotes TIMP-1
T283 1394-1400 Q5RC60 denotes TIMP-1
T284 1394-1400 PR:P30120 denotes TIMP-1
T285 1394-1400 P30120 denotes TIMP-1
T286 1394-1400 PR:000016352 denotes TIMP-1
T288 1394-1400 PR:P12032 denotes TIMP-1
T289 1394-1400 PR:P01033 denotes TIMP-1
T290 1394-1400 P01033 denotes TIMP-1
T287 1394-1400 D019715 denotes TIMP-1
T291 1436-1439 PR:000005882 denotes P38
T292 1436-1439 O24473 denotes P38
T293 1436-1439 P46108 denotes P38
T294 1436-1439 Q64010 denotes P38
T295 1436-1439 A0A0H3M950 denotes P38
T296 1436-1439 P0C797 denotes P38
T297 1436-1439 P04383 denotes P38
T298 1436-1439 O95433 denotes P38
T299 1436-1439 Q63768 denotes P38
T300 1436-1439 PR:Q9LDA4 denotes P38
T301 1436-1439 P06663 denotes P38
T302 1436-1439 P0C796 denotes P38
T303 1436-1439 PR:000003860 denotes P38
T304 1436-1439 Q9NV58 denotes P38
T305 1436-1439 O75791 denotes P38
T306 1436-1439 PR:000008220 denotes P38
T307 1436-1439 A0A0H3MBK5 denotes P38
T308 1436-1439 P80350 denotes P38
T309 1436-1439 PR:000012967 denotes P38
T310 1436-1439 O97628 denotes P38
T311 1436-1439 A0A0H3MBL5 denotes P38
T312 1436-1439 Q9Y2S7 denotes P38
T313 1436-1439 PR:000014113 denotes P38
T314 1436-1439 P82869 denotes P38
T315 1436-1439 Q9Q6X7 denotes P38
T316 1436-1439 P9WGU1 denotes P38
T317 1436-1439 Q04929 denotes P38
T318 1440-1447 CHEBI:34922 denotes pathway

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-185 DRI_Background denotes Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell.
T2 186-260 DRI_Approach denotes We have reported that Sho-saiko-to (TJ-9) prevents liver fibrosis in vivo.
T3 261-417 DRI_Approach denotes To gain further insights into the effect of TJ-9, the matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) balance was examined.
T4 418-564 DRI_Background denotes Hepatic stellate cells (HSCs) were isolated from male Wistar rats and cultured with TJ-9 (0-1000 microg/ml) on uncoated plastic dishes for 4 days.
T5 565-746 DRI_Approach denotes To elucidate the effects on the MMPs/TIMPs balance by TJ-9, quantitative analysis of type IV collagen-degrading activity, gelatin zymography and reverse zymography were carried out.
T6 747-842 DRI_Approach denotes Northern blot analysis was performed to determine the expression of MMP-2, 13 and TIMP-1 mRNAs.
T7 843-970 DRI_Background denotes TJ-9 treatment resulted in dose-dependent upregulation of MMP-2, 13 mRNA and downregulation of TIMP-1 mRNA up to 500 microg/ml.
T8 971-1182 DRI_Background denotes Gelatin zymography, reverse zymography and quantitative analysis of type IV collagen-degrading activity confirmed that TJ-9 increased MMP-2 activity and prevented TIMP-1, 2 activities in a dose-dependent manner.
T9 1183-1322 DRI_Outcome denotes SB203580 diminished the reduction of mRNA as well as the activity of TIMP-1 by TJ-9 and induction of mRNA as well as the activity of MMP-2.
T10 1323-1448 DRI_Background denotes These results show that TJ-9 increased MMP-2, 13 activity with reduced TIMP-1, 2 activities on HSCs possibly via P38 pathway.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 186-260 DRI_Approach denotes We have reported that Sho-saiko-to (TJ-9) prevents liver fibrosis in vivo.
T2 261-417 DRI_Approach denotes To gain further insights into the effect of TJ-9, the matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) balance was examined.
T3 418-564 DRI_Background denotes Hepatic stellate cells (HSCs) were isolated from male Wistar rats and cultured with TJ-9 (0-1000 microg/ml) on uncoated plastic dishes for 4 days.
T4 565-746 DRI_Approach denotes To elucidate the effects on the MMPs/TIMPs balance by TJ-9, quantitative analysis of type IV collagen-degrading activity, gelatin zymography and reverse zymography were carried out.
T5 747-842 DRI_Approach denotes Northern blot analysis was performed to determine the expression of MMP-2, 13 and TIMP-1 mRNAs.
T6 843-970 DRI_Background denotes TJ-9 treatment resulted in dose-dependent upregulation of MMP-2, 13 mRNA and downregulation of TIMP-1 mRNA up to 500 microg/ml.
T7 971-1182 DRI_Background denotes Gelatin zymography, reverse zymography and quantitative analysis of type IV collagen-degrading activity confirmed that TJ-9 increased MMP-2 activity and prevented TIMP-1, 2 activities in a dose-dependent manner.
T8 1183-1322 DRI_Outcome denotes SB203580 diminished the reduction of mRNA as well as the activity of TIMP-1 by TJ-9 and induction of mRNA as well as the activity of MMP-2.
T9 1323-1448 DRI_Background denotes These results show that TJ-9 increased MMP-2, 13 activity with reduced TIMP-1, 2 activities on HSCs possibly via P38 pathway.