PubMed:14975762
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/14975762","sourcedb":"PubMed","sourceid":"14975762","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/14975762","text":"Expression of p300 protects cardiac myocytes from apoptosis in vivo.\nDoxorubicin is an anti-tumor agent that represses cardiac-specific gene expression and induces myocardial cell apoptosis. Doxorubicin depletes cardiac p300, a transcriptional coactivator that is required for the maintenance of the differentiated phenotype of cardiac myocytes. However, the role of p300 in protection against doxorubicin-induced apoptosis is unknown. Transgenic mice overexpressing p300 in the heart and wild-type mice were subjected to doxorubicin treatment. Compared with wild-type mice, transgenic mice exhibited higher survival rate as well as more preserved left ventricular function and cardiac expression of alpha-sarcomeric actin. Doxorubicin induced myocardial cell apoptosis in wild-type mice but not in transgenic mice. Expression of p300 increased the cardiac level of bcl-2 and mdm-2, but not that of p53 or other members of the bcl-2 family. These findings demonstrate that overexpression of p300 protects cardiac myocytes from doxorubicin-induced apoptosis and reduces the extent of acute heart failure in adult mice in vivo.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":92,"end":97},"obj":"HP_0002664"},{"id":"T2","span":{"begin":1089,"end":1102},"obj":"HP_0001635"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":69,"end":80},"obj":"Chemical"},{"id":"T2","span":{"begin":92,"end":97},"obj":"Disease"},{"id":"T3","span":{"begin":191,"end":202},"obj":"Chemical"},{"id":"T4","span":{"begin":394,"end":405},"obj":"Chemical"},{"id":"T5","span":{"begin":522,"end":533},"obj":"Chemical"},{"id":"T6","span":{"begin":724,"end":735},"obj":"Chemical"},{"id":"T7","span":{"begin":1027,"end":1038},"obj":"Chemical"},{"id":"T8","span":{"begin":1089,"end":1102},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#a193ec","default":true},{"id":"bc5cdr-valid-experiment","color":"#9eec93"}]}]}}