| Id |
Subject |
Object |
Predicate |
Lexical cue |
| BEL:20000520 |
625-761 |
cat(p(MGI:Icmt)) increases bp(GOBP:"cell growth") |
denotes |
Inactivation of Icmt inhibited cell growth and K-Ras-induced oncogenic transformation, both in soft agar assays and in a nude mice model |
| BEL:20000522 |
625-761 |
cat(p(MGI:Icmt)) increases (gtp(p(MGI:Kras)) increases path(MESHD:Neoplasms)) |
denotes |
Inactivation of Icmt inhibited cell growth and K-Ras-induced oncogenic transformation, both in soft agar assays and in a nude mice model |
| BEL:20000524 |
1201-1373 |
cat(p(MGI:Icmt)) increases (kin(p(MGI:Braf)) increases path(MESHD:Neoplasms)) |
denotes |
The effect of inactivating Icmt was not limited to the inhibition of K-Ras-induced transformation: inactivation of Icmt blocked transformation by an oncogenic form of B-Raf |
| BEL:20000526 |
625-761 |
gtp(p(MGI:Kras)) increases path(MESHD:Neoplasms) |
denotes |
Inactivation of Icmt inhibited cell growth and K-Ras-induced oncogenic transformation, both in soft agar assays and in a nude mice model |
| BEL:20000528 |
1201-1373 |
kin(p(MGI:Braf)) increases path(MESHD:Neoplasms) |
denotes |
The effect of inactivating Icmt was not limited to the inhibition of K-Ras-induced transformation: inactivation of Icmt blocked transformation by an oncogenic form of B-Raf |
| BEL:20000520 |
625-761 |
cat(p(MGI:Icmt)) increases bp(GOBP:"cell growth") |
denotes |
Inactivation of Icmt inhibited cell growth and K-Ras-induced oncogenic transformation, both in soft agar assays and in a nude mice model |
| BEL:20035954 |
625-761 |
gtp(p(MGI:Kras)) increases path(MESHD:Neoplasms) |
denotes |
Inactivation of Icmt inhibited cell growth and K-Ras-induced oncogenic transformation, both in soft agar assays and in a nude mice model |
| BEL:20037742 |
1201-1372 |
kin(p(MGI:Braf)) increases path(MESHD:Neoplasms) |
denotes |
The effect of inactivating Icmt was not limited to the inhibition of K-Ras-induced transformation: inactivation of Icmt blocked transformation by an oncogenic form of B-Ra |
| BEL:20031728 |
225-344 |
cat(p(MGI:Icmt)) directlyIncreases gtp(p(MGI:Hras)) |
denotes |
In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane |
| BEL:20031732 |
225-344 |
cat(p(MGI:Icmt)) directlyIncreases gtp(p(MGI:Kras)) |
denotes |
In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane |
| BEL:20031744 |
872-1199 |
cat(p(MGI:Icmt)) decreases p(MGI:Cdkn1a) |
denotes |
levels of RhoA were greatly reduced as a consequence of accelerated protein turnover. In addition, there was a large Ras/Erk1/2-dependent increase in p21(Cip1), which was probably a consequence of the reduced levels of RhoA. Deletion of p21(Cip1) restored the ability of K-Ras-Icmt(Delta/Delta) fibroblasts to grow in soft agar |
| BEL:20031746 |
872-1199 |
cat(p(MGI:Icmt)) increases p(MGI:Rhoa) |
denotes |
levels of RhoA were greatly reduced as a consequence of accelerated protein turnover. In addition, there was a large Ras/Erk1/2-dependent increase in p21(Cip1), which was probably a consequence of the reduced levels of RhoA. Deletion of p21(Cip1) restored the ability of K-Ras-Icmt(Delta/Delta) fibroblasts to grow in soft agar |
