PubMed:1492121
Annnotations
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1741-1749 | HP_0001909 | denotes | leukemia |
| T2 | 1782-1791 | HP_0012740 | denotes | papilloma |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-30 | DNA | denotes | lymphokine genes |
| T2 | 34-41 | cell_type | denotes | T cells |
| T3 | 51-74 | DNA | denotes | cis-acting DNA elements |
| T4 | 132-139 | cell_type | denotes | T cells |
| T5 | 186-210 | cell_type | denotes | antigen presenting cells |
| T6 | 294-319 | cell_line | denotes | helper T cell (Th) clones |
| T7 | 321-324 | cell_line | denotes | Th1 |
| T8 | 329-332 | cell_line | denotes | Th2 |
| T9 | 384-392 | protein | denotes | cytokine |
| T10 | 394-404 | protein | denotes | lymphokine |
| T11 | 520-536 | DNA | denotes | lymphokine genes |
| T12 | 698-714 | DNA | denotes | lymphokine genes |
| T13 | 927-938 | protein | denotes | lymphokines |
| T14 | 962-1010 | protein | denotes | granulocyte-macrophage colony stimulating factor |
| T15 | 1012-1018 | protein | denotes | GM-CSF |
| T16 | 1091-1108 | DNA | denotes | cis-acting region |
| T17 | 1122-1144 | DNA | denotes | GM-CSF promoter region |
| T18 | 1197-1211 | DNA | denotes | reporter genes |
| T19 | 1338-1341 | DNA | denotes | GM2 |
| T20 | 1343-1349 | DNA | denotes | GC-box |
| T21 | 1354-1382 | DNA | denotes | conserved lymphokine element |
| T22 | 1384-1388 | DNA | denotes | CLE0 |
| T23 | 1391-1394 | DNA | denotes | GM2 |
| T24 | 1405-1417 | DNA | denotes | binding site |
| T25 | 1481-1487 | protein | denotes | NF-GM2 |
| T26 | 1506-1526 | protein | denotes | transcription factor |
| T27 | 1527-1532 | protein | denotes | NF-kB |
| T28 | 1534-1540 | DNA | denotes | GC-box |
| T29 | 1546-1558 | DNA | denotes | binding site |
| T30 | 1563-1592 | protein | denotes | constitutively bound proteins |
| T31 | 1609-1621 | DNA | denotes | binding site |
| T32 | 1692-1714 | protein | denotes | Viral trans-activators |
| T33 | 1723-1726 | protein | denotes | Tax |
| T34 | 1771-1773 | protein | denotes | E2 |
| T35 | 1845-1860 | DNA | denotes | lymphokine gene |
| T36 | 1885-1900 | protein | denotes | T cell receptor |
| T37 | 1902-1905 | protein | denotes | TCR |
| T38 | 1958-1960 | protein | denotes | E2 |
| T39 | 1965-1968 | protein | denotes | Tax |
| T40 | 2054-2076 | protein | denotes | viral trans-activators |
| T41 | 2103-2122 | protein | denotes | DNA binding protein |
| T42 | 2131-2136 | protein | denotes | NF-kB |
| T43 | 2141-2144 | protein | denotes | Sp1 |
| T44 | 2148-2167 | DNA | denotes | cis-acting DNA site |
| T45 | 2180-2195 | DNA | denotes | lymphokine gene |
| T46 | 2215-2218 | protein | denotes | TCR |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 14-30 | NP | denotes | lymphokine genes |
| C2 | 34-41 | NP | denotes | T cells |
| C3 | 51-74 | NP | denotes | cis-acting DNA elements |
| C4 | 75-79 | NP | denotes | that |
| C5 | 91-97 | NP | denotes | T cell |
| C6 | 132-139 | NP | denotes | T cells |
| C7 | 281-333 | NP | denotes | Two types of helper T cell (Th) clones (Th1 and Th2) |
| C8 | 417-421 | NP | denotes | They |
| C9 | 520-536 | NP | denotes | lymphokine genes |
| C10 | 590-594 | NP | denotes | they |
| C11 | 612-626 | NP | denotes | the mechanisms |
| C12 | 652-657 | NP | denotes | those |
| C13 | 658-663 | NP | denotes | which |
| C14 | 693-714 | NP | denotes | most lymphokine genes |
| C16 | 733-786 | NP | denotes | phorbol esters (phorbol 12-myristate 13 acetate, PMA) |
| C17 | 791-818 | NP | denotes | calcium ionophores (A23187) |
| C15 | 733-818 | NP | denotes | phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) |
| C18 | 835-840 | NP | denotes | their |
| C19 | 864-877 | NP | denotes | phorbol ester |
| C20 | 887-904 | NP | denotes | calcium ionophore |
| C21 | 958-1019 | NP | denotes | the granulocyte-macrophage colony stimulating factor (GM-CSF) |
| C22 | 1047-1062 | NP | denotes | the two signals |
| C24 | 1122-1128 | NP | denotes | GM-CSF |
| C23 | 1089-1167 | NP | denotes | a cis-acting region spanning the GM-CSF promoter region (positions -95 to +27) |
| C25 | 1168-1172 | NP | denotes | that |
| C26 | 1338-1341 | NP | denotes | GM2 |
| C27 | 1343-1349 | NP | denotes | GC-box |
| C28 | 1354-1389 | NP | denotes | conserved lymphokine element (CLE0) |
| C29 | 1391-1394 | NP | denotes | GM2 |
| C30 | 1422-1432 | NP | denotes | protein(s) |
| C31 | 1433-1438 | NP | denotes | whose |
| C32 | 1463-1466 | NP | denotes | PMA |
| C33 | 1468-1479 | NP | denotes | One protein |
| C34 | 1481-1487 | NP | denotes | NF-GM2 |
| C35 | 1502-1532 | NP | denotes | the transcription factor NF-kB |
| C36 | 1534-1540 | NP | denotes | GC-box |
| C37 | 1594-1598 | NP | denotes | CLEO |
| C38 | 1626-1636 | NP | denotes | protein(s) |
| C39 | 1637-1642 | NP | denotes | whose |
| C40 | 1676-1679 | NP | denotes | PMA |
| C41 | 1684-1690 | NP | denotes | A23187 |
| C43 | 1723-1803 | NP | denotes | Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) |
| C42 | 1692-1812 | NP | denotes | Viral trans-activators such as Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) proteins |
| C44 | 1817-1829 | NP | denotes | other agents |
| C45 | 1830-1835 | NP | denotes | which |
| C47 | 1845-1860 | NP | denotes | lymphokine gene |
| C46 | 1845-1871 | NP | denotes | lymphokine gene expression |
| C48 | 1885-1925 | NP | denotes | T cell receptor (TCR) mediated signaling |
| C49 | 1958-1968 | NP | denotes | E2 and Tax |
| C50 | 1997-2001 | NP | denotes | they |
| C51 | 2044-2048 | NP | denotes | them |
| C52 | 2050-2076 | NP | denotes | The viral trans-activators |
| C53 | 2131-2136 | NP | denotes | NF-kB |
| C54 | 2148-2167 | NP | denotes | cis-acting DNA site |
| C56 | 2180-2195 | NP | denotes | lymphokine gene |
| C55 | 2180-2206 | NP | denotes | lymphokine gene expression |
| C57 | 2215-2239 | NP | denotes | TCR-mediated stimulation |
| R1 | C4 | C3 | coref-relat | that,cis-acting DNA elements |
| R2 | C5 | C2 | coref-ident | T cell,T cells |
| R3 | C6 | C5 | coref-ident | T cells,T cell |
| R4 | C8 | C7 | coref-pron | They,Two types of helper T cell (Th) clones (Th1 and Th2) |
| R5 | C9 | C1 | coref-ident | lymphokine genes,lymphokine genes |
| R6 | C10 | C9 | coref-pron | they,lymphokine genes |
| R7 | C12 | C11 | coref-pron | those,the mechanisms |
| R8 | C13 | C12 | coref-relat | which,those |
| R9 | C14 | C9 | coref-other | most lymphokine genes,lymphokine genes |
| R10 | C18 | C14 | coref-pron | their,most lymphokine genes |
| R11 | C19 | C16 | coref-ident | phorbol ester,"phorbol esters (phorbol 12-myristate 13 acetate, PMA)" |
| R12 | C20 | C17 | coref-ident | calcium ionophore,calcium ionophores (A23187) |
| R13 | C22 | C15 | coref-other | the two signals,"phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187)" |
| R14 | C24 | C21 | coref-ident | GM-CSF,the granulocyte-macrophage colony stimulating factor (GM-CSF) |
| R15 | C25 | C23 | coref-relat | that,a cis-acting region spanning the GM-CSF promoter region (positions -95 to +27) |
| R16 | C29 | C26 | coref-ident | GM2,GM2 |
| R17 | C31 | C30 | coref-relat | whose,protein(s) |
| R18 | C32 | C16 | coref-other | PMA,"phorbol esters (phorbol 12-myristate 13 acetate, PMA)" |
| R19 | C34 | C33 | coref-appos | NF-GM2,One protein |
| R20 | C36 | C27 | coref-ident | GC-box,GC-box |
| R21 | C37 | C28 | coref-ident | CLEO,conserved lymphokine element (CLE0) |
| R22 | C39 | C38 | coref-relat | whose,protein(s) |
| R23 | C40 | C32 | coref-ident | PMA,PMA |
| R24 | C41 | C17 | coref-ident | A23187,calcium ionophores (A23187) |
| R25 | C45 | C44 | coref-relat | which,other agents |
| R26 | C47 | C9 | coref-ident | lymphokine gene,lymphokine genes |
| R27 | C49 | C43 | coref-ident | E2 and Tax,"Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV)" |
| R28 | C50 | C49 | coref-pron | they,E2 and Tax |
| R29 | C51 | C49 | coref-pron | them,E2 and Tax |
| R30 | C52 | C42 | coref-ident | The viral trans-activators,"Viral trans-activators such as Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) proteins" |
| R31 | C53 | C35 | coref-ident | NF-kB,the transcription factor NF-kB |
| R32 | C54 | C3 | coref-other | cis-acting DNA site,cis-acting DNA elements |
| R33 | C56 | C47 | coref-ident | lymphokine gene,lymphokine gene |
| R34 | C55 | C46 | coref-ident | lymphokine gene expression,lymphokine gene expression |
| R35 | C57 | C48 | coref-other | TCR-mediated stimulation,T cell receptor (TCR) mediated signaling |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 14-24 | cui:C0024297 | denotes | lymphokine |
| E2-ti-1 | 25-30 | cui:C0017337 | denotes | genes |
| E3-ti-1 | 34-41 | cui:C0039194 | denotes | T cells |
| E4-ti-1 | 43-47 | cui:C0035820 | denotes | role |
| E5-ti-1 | 62-65 | cui:C0012854 | denotes | DNA |
| E6-ti-1 | 51-74 | cui:C0599780 | denotes | cis-acting DNA elements |
| E7-ti-1 | 91-108 | cui:C1155065 | denotes | T cell activation |
| T1 | 0-10 | STIMULATES | denotes | Activation |
| T2 | 31-33 | LOCATION_OF | denotes | in |
| E1-ab-1 | 132-139 | cui:C0039194 | denotes | T cells |
| E2-ab-1 | 175-182 | cui:C0003320 | denotes | antigen |
| E3-ab-1 | 186-210 | cui:C0003315 | denotes | antigen presenting cells |
| E4-ab-1 | 246-252 | cui:C0439662 | denotes | immune |
| E5-ab-1 | 257-279 | cui:C1155266 | denotes | inflammatory responses |
| E1-ab-2 | 281-284 | cui:C0205448 | denotes | Two |
| E2-ab-2 | 285-290 | cui:C0332307 | denotes | types |
| E3-ab-2 | 294-307 | cui:C0018894 | denotes | helper T cell |
| E4-ab-2 | 313-319 | cui:C0009013 | denotes | clones |
| E5-ab-2 | 321-324 | entrez:51497 | denotes | Th1 |
| E6-ab-2 | 353-358 | cui:C1527178 | denotes | basis |
| E7-ab-2 | 362-371 | cui:C1547020 | denotes | different |
| E8-ab-2 | 372-380 | cui:C0449774 | denotes | patterns |
| E9-ab-2 | 384-392 | cui:C0079189 | denotes | cytokine |
| E10-ab-2 | 394-404 | cui:C0024297 | denotes | lymphokine |
| E11-ab-2 | 406-415 | cui:C0015283 | denotes | secretion |
| T3 | 384-404 | ISA | denotes | cytokine (lymphokine |
| E1-ab-3 | 436-443 | cui:C1274040 | denotes | outcome |
| E2-ab-3 | 450-459 | cui:C0003320 | denotes | antigenic |
| E3-ab-3 | 460-468 | cui:C0871261 | denotes | response |
| E4-ab-3 | 476-483 | cui:C0020168 | denotes | humoral |
| E5-ab-3 | 487-509 | cui:C0020966 | denotes | cell-mediated immunity |
| E1-ab-4 | 520-530 | cui:C0024297 | denotes | lymphokine |
| E2-ab-4 | 531-536 | cui:C0017337 | denotes | genes |
| E3-ab-4 | 569-576 | cui:C0003320 | denotes | antigen |
| E4-ab-4 | 577-588 | cui:C1292856 | denotes | stimulation |
| E5-ab-4 | 616-626 | cui:C0441712 | denotes | mechanisms |
| E6-ab-4 | 627-633 | cui:C0205214 | denotes | common |
| E7-ab-4 | 683-687 | cui:C0017337 | denotes | gene |
| T4 | 577-588 | STIMULATES | denotes | stimulation |
| E1-ab-5 | 698-708 | cui:C0024297 | denotes | lymphokine |
| E2-ab-5 | 709-714 | cui:C0017337 | denotes | genes |
| E3-ab-5 | 718-729 | cui:C0205195 | denotes | combination |
| E4-ab-5 | 733-747 | cui:C0031586 | denotes | phorbol esters |
| E5-ab-5 | 749-780 | cui:C0039654 | denotes | phorbol 12-myristate 13 acetate |
| E6-ab-5 | 782-785 | cui:C0048451 | denotes | PMA |
| E7-ab-5 | 791-809 | cui:C0444420 | denotes | calcium ionophores |
| E8-ab-5 | 811-817 | cui:C0878412 | denotes | A23187 |
| E9-ab-5 | 841-848 | cui:C0205289 | denotes | maximal |
| E10-ab-5 | 849-858 | cui:C0857127 | denotes | induction |
| T5 | 733-780 | ISA | denotes | phorbol esters (phorbol 12-myristate 13 acetate |
| T6 | 718-729 | COEXISTS_WITH | denotes | combination |
| T7 | 733-780 | COEXISTS_WITH | denotes | phorbol esters (phorbol 12-myristate 13 acetate |
| E1-ab-6 | 864-877 | cui:C0031586 | denotes | phorbol ester |
| E2-ab-6 | 887-904 | cui:C0444420 | denotes | calcium ionophore |
| E3-ab-6 | 919-926 | cui:C0443302 | denotes | several |
| E4-ab-6 | 927-938 | cui:C0024297 | denotes | lymphokines |
| E1-ab-7 | 944-954 | cui:C0033268 | denotes | production |
| E2-ab-7 | 962-1010 | cui:C0079460 | denotes | granulocyte-macrophage colony stimulating factor |
| E3-ab-7 | 1051-1054 | cui:C0205448 | denotes | two |
| E1-ab-8 | 1095-1101 | cui:C0427611 | denotes | acting |
| E2-ab-8 | 1102-1108 | cui:C0205147 | denotes | region |
| E3-ab-8 | 1122-1128 | cui:C0079460 | denotes | GM-CSF |
| E4-ab-8 | 1129-1144 | cui:C0033413 | denotes | promoter region |
| E5-ab-8 | 1146-1155 | cui:C0733755 | denotes | positions |
| E6-ab-8 | 1197-1211 | cui:C0206414 | denotes | reporter genes |
| E7-ab-8 | 1215-1224 | cui:C0205374 | denotes | transient |
| E8-ab-8 | 1225-1237 | cui:C0040669 | denotes | transfection |
| E9-ab-8 | 1238-1244 | cui:C1510438 | denotes | assays |
| E1-ab-9 | 1246-1253 | cui:C1517331 | denotes | Further |
| E2-ab-9 | 1254-1262 | cui:C0936012 | denotes | analysis |
| E3-ab-9 | 1274-1279 | cui:C0205449 | denotes | three |
| E4-ab-9 | 1280-1288 | cui:C0013879 | denotes | elements |
| E5-ab-9 | 1302-1311 | cui:C0442799 | denotes | efficient |
| E6-ab-9 | 1312-1321 | cui:C0857127 | denotes | induction |
| E7-ab-9 | 1346-1349 | cui:C0179400 | denotes | box |
| E8-ab-9 | 1364-1374 | cui:C0024297 | denotes | lymphokine |
| E9-ab-9 | 1375-1382 | cui:C0013879 | denotes | element |
| E1-ab-10 | 1405-1417 | cui:C0005456 | denotes | binding site |
| E2-ab-10 | 1422-1431 | cui:C0072393 | denotes | protein(s |
| E3-ab-10 | 1463-1466 | cui:C0048451 | denotes | PMA |
| E1-ab-11 | 1468-1471 | cui:C0205447 | denotes | One |
| E2-ab-11 | 1472-1479 | cui:C0033684 | denotes | protein |
| E3-ab-11 | 1481-1487 | cui:C0392760 | denotes | NF-GM2 |
| E4-ab-11 | 1491-1498 | cui:C0871364 | denotes | similar |
| E5-ab-11 | 1506-1532 | cui:C0079904 | denotes | transcription factor NF-kB |
| E1-ab-12 | 1537-1540 | cui:C0179400 | denotes | box |
| E2-ab-12 | 1546-1558 | cui:C0005456 | denotes | binding site |
| E3-ab-12 | 1584-1592 | cui:C0033684 | denotes | proteins |
| E1-ab-13 | 1609-1621 | cui:C0005456 | denotes | binding site |
| E2-ab-13 | 1626-1635 | cui:C0072393 | denotes | protein(s |
| E3-ab-13 | 1676-1679 | cui:C0048451 | denotes | PMA |
| E4-ab-13 | 1684-1690 | cui:C0878412 | denotes | A23187 |
| E1-ab-14 | 1692-1697 | cui:C0521026 | denotes | Viral |
| E2-ab-14 | 1698-1714 | cui:C0040627 | denotes | trans-activators |
| E3-ab-14 | 1723-1726 | cui:C0039371 | denotes | Tax |
| E4-ab-14 | 1728-1755 | cui:C0086427 | denotes | human T cell leukemia virus |
| E5-ab-14 | 1759-1765 | cui:C0020094 | denotes | HTLV-1 |
| E6-ab-14 | 1775-1797 | cui:C0006072 | denotes | bovine papilloma virus |
| E7-ab-14 | 1799-1802 | cui:C0006072 | denotes | BPV |
| E8-ab-14 | 1804-1812 | cui:C0033684 | denotes | proteins |
| E9-ab-14 | 1823-1829 | cui:C0450442 | denotes | agents |
| E10-ab-14 | 1845-1855 | cui:C0024297 | denotes | lymphokine |
| E11-ab-14 | 1856-1871 | cui:C0017262 | denotes | gene expression |
| E12-ab-14 | 1875-1884 | cui:C0741847 | denotes | bypassing |
| E13-ab-14 | 1885-1900 | cui:C0034790 | denotes | T cell receptor |
| E14-ab-14 | 1916-1925 | cui:C0037083 | denotes | signaling |
| T8 | 1804-1855 | ISA | denotes | proteins are other agents which activate lymphokine |
| T9 | 1836-1844 | STIMULATES | denotes | activate |
| T10 | 1907-1915 | AFFECTS | denotes | mediated |
| T11 | 1804-1855 | STIMULATES | denotes | proteins are other agents which activate lymphokine |
| E1-ab-15 | 1965-1968 | cui:C0039371 | denotes | Tax |
| E2-ab-15 | 2018-2035 | cui:C0162775 | denotes | sequence homology |
| E1-ab-16 | 2054-2059 | cui:C0521026 | denotes | viral |
| E2-ab-16 | 2060-2076 | cui:C0040627 | denotes | trans-activators |
| E3-ab-16 | 2103-2122 | cui:C0012940 | denotes | DNA binding protein |
| E4-ab-16 | 2131-2136 | cui:C0079904 | denotes | NF-kB |
| E5-ab-16 | 2141-2144 | cui:C1335858 | denotes | Sp1 |
| E6-ab-16 | 2152-2158 | cui:C0427611 | denotes | acting |
| E7-ab-16 | 2159-2162 | cui:C0012854 | denotes | DNA |
| E8-ab-16 | 2163-2167 | cui:C0205145 | denotes | site |
| E9-ab-16 | 2180-2190 | cui:C0024297 | denotes | lymphokine |
| E10-ab-16 | 2191-2206 | cui:C0017262 | denotes | gene expression |
| E11-ab-16 | 2215-2218 | cui:C0034790 | denotes | TCR |
| E12-ab-16 | 2219-2227 | cui:C0086597 | denotes | mediated |
| E13-ab-16 | 2228-2239 | cui:C1292856 | denotes | stimulation |
| T12 | 2103-2136 | ISA | denotes | DNA binding protein such as NF-kB |
| T13 | 2087-2093 | INTERACTS_WITH | denotes | target |
| T14 | 2172-2179 | STIMULATES | denotes | promote |
| T15 | 2103-2136 | INTERACTS_WITH | denotes | DNA binding protein such as NF-kB |
| R1 | E6-ti-1 | T1 | subjectOf | cis-acting DNA elements,Activation |
| R2 | E1-ti-1 | T1 | objectOf | lymphokine,Activation |
| R3 | E3-ti-1 | T2 | subjectOf | T cells,in |
| R4 | E1-ti-1 | T2 | objectOf | lymphokine,in |
| R5 | E10-ab-2 | T3 | subjectOf | lymphokine,cytokine (lymphokine |
| R6 | E9-ab-2 | T3 | objectOf | cytokine,cytokine (lymphokine |
| R7 | E1-ab-4 | T4 | subjectOf | lymphokine,stimulation |
| R8 | E3-ab-4 | T4 | objectOf | antigen,stimulation |
| R9 | E5-ab-5 | T5 | subjectOf | phorbol 12-myristate 13 acetate,phorbol esters (phorbol 12-myristate 13 acetate |
| R10 | E4-ab-5 | T5 | objectOf | phorbol esters,phorbol esters (phorbol 12-myristate 13 acetate |
| R11 | E1-ab-5 | T6 | subjectOf | lymphokine,combination |
| R12 | E4-ab-5 | T6 | objectOf | phorbol esters,combination |
| R13 | E1-ab-5 | T7 | subjectOf | lymphokine,phorbol esters (phorbol 12-myristate 13 acetate |
| R14 | E5-ab-5 | T7 | objectOf | phorbol 12-myristate 13 acetate,phorbol esters (phorbol 12-myristate 13 acetate |
| R15 | E10-ab-14 | T8 | subjectOf | lymphokine,proteins are other agents which activate lymphokine |
| R16 | E8-ab-14 | T8 | objectOf | proteins,proteins are other agents which activate lymphokine |
| R17 | E8-ab-14 | T9 | subjectOf | proteins,activate |
| R18 | E10-ab-14 | T9 | objectOf | lymphokine,activate |
| R19 | E13-ab-14 | T10 | subjectOf | T cell receptor,mediated |
| R20 | E14-ab-14 | T10 | objectOf | signaling,mediated |
| R21 | E10-ab-14 | T11 | subjectOf | lymphokine,proteins are other agents which activate lymphokine |
| R22 | E10-ab-14 | T11 | objectOf | lymphokine,proteins are other agents which activate lymphokine |
| R23 | E4-ab-16 | T12 | subjectOf | NF-kB,DNA binding protein such as NF-kB |
| R24 | E3-ab-16 | T12 | objectOf | DNA binding protein,DNA binding protein such as NF-kB |
| R25 | E2-ab-16 | T13 | subjectOf | trans-activators,target |
| R26 | E3-ab-16 | T13 | objectOf | DNA binding protein,target |
| R27 | E5-ab-16 | T14 | subjectOf | Sp1,promote |
| R28 | E9-ab-16 | T14 | objectOf | lymphokine,promote |
| R29 | E2-ab-16 | T15 | subjectOf | trans-activators,DNA binding protein such as NF-kB |
| R30 | E4-ab-16 | T15 | objectOf | NF-kB,DNA binding protein such as NF-kB |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-117 | Sentence | denotes | Activation of lymphokine genes in T cells: role of cis-acting DNA elements that respond to T cell activation signals. |
| S2 | 118-280 | Sentence | denotes | Activation of T cells is initiated by the recognition of antigen on antigen presenting cells to exert the effector functions in immune and inflammatory responses. |
| S3 | 281-416 | Sentence | denotes | Two types of helper T cell (Th) clones (Th1 and Th2) are defined on the basis of different patterns of cytokine (lymphokine) secretion. |
| S4 | 417-510 | Sentence | denotes | They determine the outcome of an antigenic response toward humoral or cell-mediated immunity. |
| S5 | 511-688 | Sentence | denotes | Although lymphokine genes are coordinately regulated upon antigen stimulation, they are regulated by the mechanisms common to all as well as those which are unique to each gene. |
| S6 | 689-859 | Sentence | denotes | For most lymphokine genes, a combination of phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) is required for their maximal induction. |
| S7 | 860-939 | Sentence | denotes | Yet phorbol ester alone or calcium ionophore alone produce several lymphokines. |
| S8 | 940-1063 | Sentence | denotes | The production of the granulocyte-macrophage colony stimulating factor (GM-CSF) is completely dependent on the two signals. |
| S9 | 1064-1245 | Sentence | denotes | We have previously found a cis-acting region spanning the GM-CSF promoter region (positions -95 to +27) that confers inducibility to reporter genes in transient transfection assays. |
| S10 | 1246-1390 | Sentence | denotes | Further analysis identified three elements required for efficient induction, referred to as GM2, GC-box and conserved lymphokine element (CLE0). |
| S11 | 1391-1467 | Sentence | denotes | GM2 defines a binding site for protein(s) whose binding is inducible by PMA. |
| S12 | 1468-1533 | Sentence | denotes | One protein, NF-GM2 is similar to the transcription factor NF-kB. |
| S13 | 1534-1593 | Sentence | denotes | GC-box is a binding site for constitutively bound proteins. |
| S14 | 1594-1691 | Sentence | denotes | CLEO defines a binding site for protein(s) whose optimum binding is stimulated by PMA and A23187. |
| S15 | 1692-1926 | Sentence | denotes | Viral trans-activators such as Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) proteins are other agents which activate lymphokine gene expression by bypassing T cell receptor (TCR) mediated signaling. |
| S16 | 1927-2049 | Sentence | denotes | The trans-activation domain of E2 and Tax is interchangeable although they have no obvious sequence homology between them. |
| S17 | 2050-2240 | Sentence | denotes | The viral trans-activators appear to target specific DNA binding protein such as NF-kB and Sp1 to cis-acting DNA site and promote lymphokine gene expression without TCR-mediated stimulation. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-30 | DNA_family_or_group | denotes | lymphokine genes |
| T2 | 34-41 | cell_type | denotes | T cells |
| T3 | 51-74 | DNA_domain_or_region | denotes | cis-acting DNA elements |
| T4 | 91-116 | other_name | denotes | T cell activation signals |
| T5 | 132-139 | cell_type | denotes | T cells |
| T6 | 186-210 | cell_type | denotes | antigen presenting cells |
| T7 | 224-242 | other_name | denotes | effector functions |
| T8 | 246-252 | other_name | denotes | immune |
| T9 | 257-279 | other_name | denotes | inflammatory responses |
| T10 | 294-319 | cell_line | denotes | helper T cell (Th) clones |
| T11 | 321-324 | cell_line | denotes | Th1 |
| T12 | 329-332 | cell_line | denotes | Th2 |
| T13 | 384-392 | protein_family_or_group | denotes | cytokine |
| T14 | 394-404 | protein_family_or_group | denotes | lymphokine |
| T15 | 520-530 | protein_family_or_group | denotes | lymphokine |
| T16 | 569-588 | other_name | denotes | antigen stimulation |
| T17 | 698-714 | DNA_family_or_group | denotes | lymphokine genes |
| T18 | 733-747 | other_organic_compound | denotes | phorbol esters |
| T19 | 749-780 | other_organic_compound | denotes | phorbol 12-myristate 13 acetate |
| T20 | 782-785 | other_organic_compound | denotes | PMA |
| T21 | 791-809 | other_organic_compound | denotes | calcium ionophores |
| T22 | 811-817 | other_organic_compound | denotes | A23187 |
| T23 | 864-877 | other_organic_compound | denotes | phorbol ester |
| T24 | 887-904 | other_organic_compound | denotes | calcium ionophore |
| T25 | 927-938 | protein_family_or_group | denotes | lymphokines |
| T26 | 962-1010 | protein_molecule | denotes | granulocyte-macrophage colony stimulating factor |
| T27 | 1012-1018 | protein_molecule | denotes | GM-CSF |
| T28 | 1091-1108 | DNA_domain_or_region | denotes | cis-acting region |
| T29 | 1122-1128 | protein_molecule | denotes | GM-CSF |
| T30 | 1197-1211 | DNA_family_or_group | denotes | reporter genes |
| T31 | 1215-1244 | other_name | denotes | transient transfection assays |
| T32 | 1338-1341 | DNA_domain_or_region | denotes | GM2 |
| T33 | 1343-1349 | DNA_domain_or_region | denotes | GC-box |
| T34 | 1354-1363 | DNA_domain_or_region | denotes | conserved |
| T35 | 1364-1374 | protein_family_or_group | denotes | lymphokine |
| T36 | 1384-1388 | DNA_domain_or_region | denotes | CLE0 |
| T37 | 1391-1394 | DNA_domain_or_region | denotes | GM2 |
| T38 | 1405-1417 | DNA_domain_or_region | denotes | binding site |
| T39 | 1463-1466 | other_organic_compound | denotes | PMA |
| T40 | 1481-1487 | protein_molecule | denotes | NF-GM2 |
| T41 | 1506-1526 | protein_family_or_group | denotes | transcription factor |
| T42 | 1527-1532 | protein_molecule | denotes | NF-kB |
| T43 | 1534-1540 | DNA_domain_or_region | denotes | GC-box |
| T44 | 1546-1558 | DNA_domain_or_region | denotes | binding site |
| T45 | 1563-1592 | protein_family_or_group | denotes | constitutively bound proteins |
| T46 | 1609-1621 | DNA_domain_or_region | denotes | binding site |
| T47 | 1676-1679 | other_organic_compound | denotes | PMA |
| T48 | 1684-1690 | other_organic_compound | denotes | A23187 |
| T49 | 1692-1714 | protein_family_or_group | denotes | Viral trans-activators |
| T50 | 1723-1726 | protein_family_or_group | denotes | Tax |
| T51 | 1728-1757 | virus | denotes | human T cell leukemia virus-1 |
| T52 | 1759-1765 | virus | denotes | HTLV-1 |
| T53 | 1771-1773 | protein_molecule | denotes | E2 |
| T54 | 1775-1797 | virus | denotes | bovine papilloma virus |
| T55 | 1799-1802 | virus | denotes | BPV |
| T56 | 1845-1860 | DNA_domain_or_region | denotes | lymphokine gene |
| T57 | 1885-1900 | protein_family_or_group | denotes | T cell receptor |
| T58 | 1902-1905 | protein_family_or_group | denotes | TCR |
| T59 | 1958-1960 | protein_molecule | denotes | E2 |
| T60 | 1965-1968 | protein_family_or_group | denotes | Tax |
| T61 | 2054-2076 | protein_family_or_group | denotes | viral trans-activators |
| T62 | 2103-2122 | protein_family_or_group | denotes | DNA binding protein |
| T63 | 2131-2136 | protein_family_or_group | denotes | NF-kB |
| T64 | 2141-2144 | protein_molecule | denotes | Sp1 |
| T65 | 2148-2167 | DNA_domain_or_region | denotes | cis-acting DNA site |
| T66 | 2180-2195 | DNA_domain_or_region | denotes | lymphokine gene |
| T67 | 2215-2218 | protein_family_or_group | denotes | TCR |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 35-42 | C0039194 | denotes | cells: |
| T2 | 2181-2191 | C0024297 | denotes | ymphokine |
| T3 | 1846-1856 | C0024297 | denotes | ymphokine |
| T4 | 1365-1375 | C0024297 | denotes | ymphokine |
| T5 | 928-939 | C0024297 | denotes | ymphokines. |
| T6 | 699-709 | C0024297 | denotes | ymphokine |
| T7 | 521-531 | C0024297 | denotes | ymphokine |
| T8 | 395-405 | C0024297 | denotes | ymphokine) |
| T9 | 15-25 | C0024297 | denotes | ymphokine |
| T10 | 2160-2163 | C0012854 | denotes | NA |
| T11 | 63-66 | C0012854 | denotes | NA |
| T12 | 92-109 | C1155065 | denotes | cell activation |
| T13 | 44-48 | C1705810 | denotes | ole |
| T14 | 1056-1063 | C1710082 | denotes | ignals. |
| T15 | 110-117 | C1710082 | denotes | ignals. |
| T16 | 1677-1680 | C0039654 | denotes | MA |
| T17 | 1464-1467 | C0039654 | denotes | MA. |
| T18 | 783-786 | C0039654 | denotes | MA) |
| T19 | 2153-2159 | C0079613 | denotes | cting |
| T20 | 1096-1102 | C0079613 | denotes | cting |
| T21 | 710-715 | C0017337 | denotes | enes, |
| T22 | 684-688 | C0017337 | denotes | ene. |
| T23 | 532-537 | C0017337 | denotes | enes |
| T24 | 888-905 | C0444420 | denotes | alcium ionophore |
| T25 | 792-809 | C0444420 | denotes | alcium ionophores |
| T26 | 1610-1622 | C0005456 | denotes | inding site |
| T27 | 1547-1559 | C0005456 | denotes | inding site |
| T28 | 1406-1418 | C0005456 | denotes | inding site |
| T29 | 865-878 | C0031586 | denotes | horbol ester |
| T30 | 734-748 | C0031586 | denotes | horbol esters |
| T31 | 2061-2077 | C0040627 | denotes | rans-activators |
| T32 | 1699-1715 | C0040627 | denotes | rans-activators |
| T33 | 1685-1691 | C0878412 | denotes | 23187. |
| T34 | 812-818 | C0878412 | denotes | 23187) |
| T35 | 295-308 | C0018894 | denotes | elper T cell |
| T36 | 2132-2137 | C0079904 | denotes | F-kB |
| T37 | 1507-1533 | C0079904 | denotes | ranscription factor NF-kB. |
| T38 | 1130-1145 | C0033413 | denotes | romoter region |
| T39 | 1760-1766 | C0020094 | denotes | TLV-1) |
| T40 | 1123-1129 | C0079460 | denotes | M-CSF |
| T41 | 407-416 | C0036536 | denotes | ecretion. |
| T42 | 1966-1969 | C0039371 | denotes | ax |
| T43 | 1724-1727 | C0039371 | denotes | ax |
| T44 | 1198-1212 | C0206414 | denotes | eporter genes |
| T45 | 1451-1460 | C0205263 | denotes | nducible |
| T46 | 1313-1322 | C0205263 | denotes | nduction, |
| T47 | 1182-1194 | C0205263 | denotes | nducibility |
| T48 | 850-859 | C0205263 | denotes | nduction. |
| T49 | 1917-1926 | C0037083 | denotes | ignaling. |
| T50 | 1805-1813 | C0033684 | denotes | roteins |
| T51 | 1473-1480 | C0033684 | denotes | rotein, |
| T52 | 1376-1383 | C0013879 | denotes | lement |
| T53 | 1281-1289 | C0013879 | denotes | lements |
| T54 | 1255-1263 | C1524024 | denotes | nalysis |
| T55 | 1226-1238 | C0040669 | denotes | ransfection |
| T56 | 385-393 | C0079189 | denotes | ytokine |
| T57 | 1652-1659 | C1167622 | denotes | inding |
| T58 | 1579-1583 | C1167622 | denotes | ound |
| T59 | 1440-1447 | C1167622 | denotes | inding |
| T60 | 2085-2087 | C1883351 | denotes | o |
| T61 | 1333-1335 | C1883351 | denotes | o |
| T62 | 314-320 | C0009013 | denotes | lones |
| T63 | 2104-2123 | C0012940 | denotes | NA binding protein |
| T64 | 2019-2036 | C0162775 | denotes | equence homology |
| T65 | 1538-1541 | C0179400 | denotes | ox |
| T66 | 1347-1350 | C0179400 | denotes | ox |
| T67 | 1800-1803 | C0006072 | denotes | PV) |
| T68 | 1776-1798 | C0006072 | denotes | ovine papilloma virus, |
| T69 | 1959-1961 | C3539520 | denotes | 2 |
| T70 | 1772-1774 | C3539520 | denotes | 2 |
| T71 | 2220-2228 | C0127400 | denotes | ediated |
| T72 | 1908-1916 | C0127400 | denotes | ediated |
| T73 | 1290-1298 | C1514873 | denotes | equired |
| T74 | 823-831 | C1514873 | denotes | equired |
| T75 | 2197-2206 | C0185117 | denotes | xpression |
| T76 | 1862-1872 | C0185117 | denotes | xpression |
| T77 | 1535-1537 | C3537453 | denotes | C- |
| T78 | 1344-1346 | C3537453 | denotes | C- |
| T79 | 2229-2240 | C1292856 | denotes | timulation. |
| T80 | 578-589 | C1292856 | denotes | timulation, |
| T81 | 2149-2152 | C1504308 | denotes | is- |
| T82 | 1092-1095 | C1504308 | denotes | is- |
| T83 | 2055-2060 | C0521026 | denotes | iral |
| T84 | 1693-1698 | C0521026 | denotes | iral |
| T85 | 1052-1055 | C0205448 | denotes | wo |
| T86 | 282-285 | C0205448 | denotes | wo |
| T87 | 570-576 | C0003320 | denotes | ntigen |
| T88 | 1264-1273 | C1551388 | denotes | dentified |
| T89 | 2078-2084 | C0700364 | denotes | ppear |
| T90 | 215-220 | C0015264 | denotes | xert |
| T91 | 322-325 | C1423842 | denotes | h1 |
| T92 | 1084-1089 | C0150312 | denotes | ound |
| T93 | 2173-2180 | C0033414 | denotes | romote |
| T94 | 1324-1332 | C0205543 | denotes | eferred |
| T95 | 2088-2094 | C1521840 | denotes | arget |
| T96 | 1837-1845 | C1515877 | denotes | ctivate |
| T97 | 1824-1830 | C1254351 | denotes | gents |
| T98 | 1110-1118 | C1711300 | denotes | panning |
| T99 | 477-484 | C0597811 | denotes | umoral |
| T100 | 1216-1225 | C0205374 | denotes | ransient |
| T101 | 1103-1109 | C0205147 | denotes | egion |
| T102 | 1147-1156 | C0733755 | denotes | ositions |
| T103 | 1239-1245 | C1510438 | denotes | ssays. |
| T104 | 1663-1673 | C1948023 | denotes | timulated |
| T105 | 628-634 | C1522138 | denotes | ommon |
| T106 | 1303-1312 | C0442799 | denotes | fficient |
| T107 | 617-627 | C0441712 | denotes | echanisms |
| T108 | 669-675 | C1710548 | denotes | nique |
| T109 | 842-849 | C0806909 | denotes | aximal |
| T110 | 719-730 | C1947911 | denotes | ombination |
| T111 | 1938-1948 | C1879547 | denotes | ctivation |
| T112 | 1035-1043 | C1701901 | denotes | ependent |
| T113 | 437-444 | C1274040 | denotes | utcome |
| T114 | 1949-1955 | C1883221 | denotes | omain |
| T115 | 1932-1937 | C2826298 | denotes | rans- |
| T116 | 286-291 | C0332307 | denotes | ypes |
| T117 | 1492-1499 | C2348205 | denotes | imilar |
| T118 | 354-359 | C1874451 | denotes | asis |
| T119 | 339-346 | C1704788 | denotes | efined |
| T120 | 363-372 | C1705242 | denotes | ifferent |
| T121 | 373-381 | C0449774 | denotes | atterns |
| T122 | 144-153 | C1704686 | denotes | nitiated |
| T123 | 1247-1254 | C1517331 | denotes | urther |
| T124 | 920-927 | C0439064 | denotes | everal |
| T125 | 1469-1472 | C0205447 | denotes | ne |
| T126 | 1644-1651 | C2698651 | denotes | ptimum |
| T127 | 310-312 | C1420718 | denotes | h) |
| T128 | 1275-1280 | C0205449 | denotes | hree |
| T129 | 451-469 | C1314973 | denotes | ntigenic response |
| T130 | 1024-1034 | C0205197 | denotes | ompletely |
| T131 | 2164-2168 | C0205145 | denotes | ite |
| T132 | 2008-2010 | C1298908 | denotes | o |
| T133 | 2095-2103 | C0205369 | denotes | pecific |
| T134 | 1876-1885 | C0741847 | denotes | ypassing |