PubMed:1482802
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1482802","sourcedb":"PubMed","sourceid":"1482802","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1482802","text":"Outcomes of cefazolin versus ceftriaxone therapy in treating lower respiratory tract infections in adults.\nOBJECTIVE: To determine whether choice of a first- versus third-generation cephalosporin as initial therapy for lower respiratory tract infections in hospitalized adults affects the course and duration of care, both of which may influence antimicrobial treatment cost.\nDESIGN: Retrospective analysis of discharge abstracts and hospital pharmacy records.\nSETTING: Forty-eight US acute-care hospitals.\nPATIENTS: One thousand ninety-two hospitalized adults (aged \u003e 17 y) with principal diagnoses of lower respiratory tract infections (DRGs 79-80, 89-90).\nINTERVENTIONS: Cefazolin or ceftriaxone, given as sole antimicrobial therapy for at least one day.\nMAIN OUTCOME MEASURES: (1) The number of patients who received another parenteral antibiotic anytime prior to hospital discharge; (2) the number of days during which patients received any parenteral antibiotic while in the hospital; and (3) the number of days patients remained hospitalized following the start of antibiotic therapy.\nRESULTS: Patients treated with cefazolin (n = 763) were more likely to receive another parenteral antibiotic while in the hospital (30.3 vs. 20.7 percent; p \u003c 0.001) and received more total days of therapy (7.2 vs. 6.7 d; p \u003c 0.05) than those treated with ceftriaxone (n = 329). Although the time to hospital discharge did not differ in the full sample (9.2 d for both groups), it was greater among those receiving cefazolin (8.6 vs. 8.0 d; p \u003c 0.05) when patients with lengths of stay exceeding 24 days were excluded from both groups.\nCONCLUSIONS: In addition to acquisition cost, differences in course and duration of care should be considered when determining the most cost-effective choice for antimicrobial therapy.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":219,"end":253},"obj":"HP_0002783"},{"id":"T2","span":{"begin":225,"end":253},"obj":"HP_0011947"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"AnEM_abstracts","denotations":[{"id":"T1","span":{"begin":219,"end":242},"obj":"Multi-tissue_structure"},{"id":"T2","span":{"begin":603,"end":626},"obj":"Multi-tissue_structure"},{"id":"T3","span":{"begin":61,"end":84},"obj":"Multi-tissue_structure"}],"attributes":[{"subj":"T1","pred":"source","obj":"AnEM_abstracts"},{"subj":"T2","pred":"source","obj":"AnEM_abstracts"},{"subj":"T3","pred":"source","obj":"AnEM_abstracts"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ec9893","default":true},{"id":"AnEM_abstracts","color":"#93a7ec"}]}]}}