PubMed:1482376
Annnotations
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 92-108 | HP_0002721 | denotes | immunodeficiency |
| T2 | 161-177 | HP_0002721 | denotes | immunodeficiency |
| T3 | 934-939 | HP_0002664 | denotes | tumor |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 43-53 | protein | denotes | NF-kappa B |
| T2 | 68-81 | cell_type | denotes | human T cells |
| T3 | 195-228 | DNA | denotes | long terminal repeat (LTR) region |
| T4 | 232-248 | DNA | denotes | HIV proviral DNA |
| T5 | 276-298 | protein | denotes | nuclear factor kappa B |
| T6 | 300-310 | protein | denotes | NF-kappa B |
| T7 | 322-347 | protein | denotes | transcriptional activator |
| T8 | 499-509 | protein | denotes | NF-kappa B |
| T9 | 630-640 | protein | denotes | NF-kappa B |
| T10 | 757-771 | cell_line | denotes | Jurkat T cells |
| T11 | 901-911 | protein | denotes | NF-kappa B |
| T12 | 934-961 | protein | denotes | tumor necrosis factor-alpha |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-17 | NP | denotes | Alpha-lipoic acid |
| C3 | 43-53 | NP | denotes | NF-kappa B |
| C2 | 43-64 | NP | denotes | NF-kappa B activation |
| C4 | 68-81 | NP | denotes | human T cells |
| C5 | 83-124 | NP | denotes | Acquired immunodeficiency syndrome (AIDS) |
| C6 | 153-189 | NP | denotes | a human immunodeficiency virus (HIV) |
| C7 | 232-235 | NP | denotes | HIV |
| C8 | 276-311 | NP | denotes | nuclear factor kappa B (NF-kappa B) |
| C9 | 317-347 | NP | denotes | this transcriptional activator |
| C10 | 368-371 | NP | denotes | HIV |
| C11 | 426-455 | NP | denotes | reactive oxygen species (ROS) |
| C13 | 499-509 | NP | denotes | NF-kappa B |
| C12 | 499-520 | NP | denotes | NF-kappa B activation |
| C14 | 553-560 | NP | denotes | reports |
| C15 | 561-565 | NP | denotes | that |
| C16 | 566-578 | NP | denotes | antioxidants |
| C17 | 579-584 | NP | denotes | which |
| C18 | 595-598 | NP | denotes | ROS |
| C20 | 630-640 | NP | denotes | NF-kappa B |
| C19 | 612-640 | NP | denotes | the activation of NF-kappa B |
| C21 | 658-661 | NP | denotes | HIV |
| C22 | 686-698 | NP | denotes | antioxidants |
| C23 | 737-741 | NP | denotes | AIDS |
| C24 | 757-771 | NP | denotes | Jurkat T cells |
| C25 | 798-825 | NP | denotes | a natural thiol antioxidant |
| C26 | 827-844 | NP | denotes | alpha-lipoic acid |
| C28 | 901-911 | NP | denotes | NF-kappa B |
| C27 | 901-1021 | NP | denotes | NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml) |
| C29 | 1048-1065 | NP | denotes | alpha-lipoic acid |
| C30 | 1222-1239 | NP | denotes | alpha-lipoic acid |
| C31 | 1260-1264 | NP | denotes | AIDS |
| R1 | C7 | C6 | coref-ident | HIV,a human immunodeficiency virus (HIV) |
| R2 | C8 | C3 | coref-ident | nuclear factor kappa B (NF-kappa B),NF-kappa B |
| R3 | C9 | C8 | coref-ident | this transcriptional activator,nuclear factor kappa B (NF-kappa B) |
| R4 | C10 | C9 | coref-ident | HIV,this transcriptional activator |
| R5 | C13 | C8 | coref-ident | NF-kappa B,nuclear factor kappa B (NF-kappa B) |
| R6 | C12 | C2 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R7 | C15 | C14 | coref-relat | that,reports |
| R8 | C17 | C16 | coref-relat | which,antioxidants |
| R9 | C18 | C11 | coref-ident | ROS,reactive oxygen species (ROS) |
| R10 | C20 | C13 | coref-ident | NF-kappa B,NF-kappa B |
| R11 | C19 | C12 | coref-ident | the activation of NF-kappa B,NF-kappa B activation |
| R12 | C21 | C10 | coref-ident | HIV,HIV |
| R13 | C22 | C16 | coref-ident | antioxidants,antioxidants |
| R14 | C23 | C5 | coref-ident | AIDS,Acquired immunodeficiency syndrome (AIDS) |
| R15 | C24 | C4 | coref-other | Jurkat T cells,human T cells |
| R16 | C25 | C1 | coref-other | a natural thiol antioxidant,Alpha-lipoic acid |
| R17 | C26 | C25 | coref-appos | alpha-lipoic acid,a natural thiol antioxidant |
| R18 | C28 | C20 | coref-ident | NF-kappa B,NF-kappa B |
| R19 | C27 | C19 | coref-ident | NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml),the activation of NF-kappa B |
| R20 | C29 | C26 | coref-ident | alpha-lipoic acid,alpha-lipoic acid |
| R21 | C30 | C29 | coref-ident | alpha-lipoic acid,alpha-lipoic acid |
| R22 | C31 | C23 | coref-ident | AIDS,AIDS |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-17 | cui:C0023791 | denotes | Alpha-lipoic acid |
| E2-ti-1 | 23-29 | cui:C0237399 | denotes | potent |
| E3-ti-1 | 30-39 | cui:C0243077 | denotes | inhibitor |
| E4-ti-1 | 43-53 | cui:C0079904 | denotes | NF-kappa B |
| E5-ti-1 | 68-81 | cui:C0427861 | denotes | human T cells |
| T1 | 54-64 | STIMULATES | denotes | activation |
| E1-ab-1 | 83-117 | cui:C0001175 | denotes | Acquired immunodeficiency syndrome |
| E2-ab-1 | 138-147 | cui:C0021311 | denotes | infection |
| E3-ab-1 | 155-183 | cui:C0019682 | denotes | human immunodeficiency virus |
| T2 | 125-132 | CAUSES | denotes | results |
| E1-ab-2 | 195-215 | cui:C0023978 | denotes | long terminal repeat |
| E2-ab-2 | 222-228 | cui:C0205147 | denotes | region |
| E3-ab-2 | 232-248 | cui:C0486959 | denotes | HIV proviral DNA |
| E4-ab-2 | 258-271 | cui:C0005456 | denotes | binding sites |
| E5-ab-2 | 276-298 | cui:C0079904 | denotes | nuclear factor kappa B |
| E6-ab-2 | 322-347 | cui:C1336776 | denotes | transcriptional activator |
| E7-ab-2 | 368-371 | cui:C0020114 | denotes | HIV |
| E8-ab-2 | 368-371 | cui:C0021051 | denotes | HIV |
| E9-ab-2 | 368-382 | cui:C0042767 | denotes | HIV activation |
| T3 | 359-367 | AFFECTS | denotes | regulate |
| E1-ab-3 | 384-390 | cui:C0332185 | denotes | Recent |
| E2-ab-3 | 391-399 | cui:C0243095 | denotes | findings |
| E3-ab-3 | 426-449 | cui:C0162772 | denotes | reactive oxygen species |
| E4-ab-3 | 459-487 | cui:C0086982 | denotes | signal transduction pathways |
| E5-ab-3 | 499-509 | cui:C0079904 | denotes | NF-kappa B |
| T4 | 510-520 | STIMULATES | denotes | activation |
| E1-ab-4 | 526-533 | cui:C0150312 | denotes | present |
| E2-ab-4 | 534-539 | cui:C0008972 | denotes | study |
| E3-ab-4 | 566-578 | cui:C0003402 | denotes | antioxidants |
| E4-ab-4 | 595-598 | cui:C0162772 | denotes | ROS |
| E5-ab-4 | 630-640 | cui:C0079904 | denotes | NF-kappa B |
| E6-ab-4 | 658-661 | cui:C0019682 | denotes | HIV |
| E7-ab-4 | 662-675 | cui:C0040649 | denotes | transcription |
| E8-ab-4 | 686-698 | cui:C0003402 | denotes | antioxidants |
| E9-ab-4 | 714-732 | cui:C1611640 | denotes | therapeutic agents |
| E10-ab-4 | 737-741 | cui:C0001175 | denotes | AIDS |
| T5 | 686-732 | ISA | denotes | antioxidants can be used as therapeutic agents |
| T6 | 686-732 | ISA | denotes | antioxidants can be used as therapeutic agents |
| T7 | 616-626 | STIMULATES | denotes | activation |
| T8 | 616-626 | STIMULATES | denotes | activation |
| T9 | 733-736 | TREATS | denotes | for |
| T10 | 686-732 | TREATS | denotes | antioxidants can be used as therapeutic agents |
| T11 | 686-732 | TREATS | denotes | antioxidants can be used as therapeutic agents |
| E1-ab-5 | 757-771 | cui:C0376448 | denotes | Jurkat T cells |
| E2-ab-5 | 783-788 | cui:C0007634 | denotes | cells |
| E3-ab-5 | 800-807 | cui:C0205296 | denotes | natural |
| E4-ab-5 | 808-813 | cui:C0038734 | denotes | thiol |
| E5-ab-5 | 814-825 | cui:C0003402 | denotes | antioxidant |
| E6-ab-5 | 827-844 | cui:C0023791 | denotes | alpha-lipoic acid |
| E7-ab-5 | 859-870 | cui:C1292856 | denotes | stimulation |
| E8-ab-5 | 874-879 | cui:C0007634 | denotes | cells |
| E9-ab-5 | 901-911 | cui:C0079904 | denotes | NF-kappa B |
| E10-ab-5 | 934-961 | cui:C1448177 | denotes | tumor necrosis factor-alpha |
| E11-ab-5 | 979-1010 | cui:C0039654 | denotes | phorbol 12-myristate 13-acetate |
| T12 | 814-844 | ISA | denotes | antioxidant, alpha-lipoic acid |
| T13 | 859-870 | AUGMENTS | denotes | stimulation |
| T14 | 912-922 | STIMULATES | denotes | activation |
| T15 | 923-930 | AUGMENTS | denotes | induced |
| T16 | 923-930 | AUGMENTS | denotes | induced |
| T17 | 814-844 | STIMULATES | denotes | antioxidant, alpha-lipoic acid |
| E1-ab-6 | 1027-1037 | cui:C0243077 | denotes | inhibitory |
| E2-ab-6 | 1048-1065 | cui:C0023791 | denotes | alpha-lipoic acid |
| E3-ab-6 | 1082-1086 | cui:C0442824 | denotes | very |
| E4-ab-6 | 1087-1093 | cui:C0237399 | denotes | potent |
| E5-ab-6 | 1124-1132 | cui:C0205197 | denotes | complete |
| E6-ab-6 | 1176-1192 | cui:C0001047 | denotes | N-acetylcysteine |
| E1-ab-7 | 1200-1207 | cui:C1274040 | denotes | results |
| E2-ab-7 | 1222-1239 | cui:C0023791 | denotes | alpha-lipoic acid |
| E3-ab-7 | 1247-1256 | cui:C1280500 | denotes | effective |
| E4-ab-7 | 1260-1264 | cui:C0001175 | denotes | AIDS |
| E5-ab-7 | 1265-1277 | cui:C0039796 | denotes | therapeutics |
| T18 | 1257-1259 | ASSOCIATED_WITH | denotes | in |
| R1 | E1-ti-1 | T1 | subjectOf | Alpha-lipoic acid,activation |
| R2 | E4-ti-1 | T1 | objectOf | NF-kappa B,activation |
| R3 | E2-ab-1 | T2 | subjectOf | infection,results |
| R4 | E1-ab-1 | T2 | objectOf | Acquired immunodeficiency syndrome,results |
| R5 | E6-ab-2 | T3 | subjectOf | transcriptional activator,regulate |
| R6 | E9-ab-2 | T3 | objectOf | HIV activation,regulate |
| R7 | E3-ab-3 | T4 | subjectOf | reactive oxygen species,activation |
| R8 | E5-ab-3 | T4 | objectOf | NF-kappa B,activation |
| R9 | E8-ab-4 | T5 | subjectOf | antioxidants,antioxidants can be used as therapeutic agents |
| R10 | E9-ab-4 | T5 | objectOf | therapeutic agents,antioxidants can be used as therapeutic agents |
| R11 | E3-ab-4 | T6 | subjectOf | antioxidants,antioxidants can be used as therapeutic agents |
| R12 | E9-ab-4 | T6 | objectOf | therapeutic agents,antioxidants can be used as therapeutic agents |
| R13 | E8-ab-4 | T7 | subjectOf | antioxidants,activation |
| R14 | E5-ab-4 | T7 | objectOf | NF-kappa B,activation |
| R15 | E3-ab-4 | T8 | subjectOf | antioxidants,activation |
| R16 | E5-ab-4 | T8 | objectOf | NF-kappa B,activation |
| R17 | E9-ab-4 | T9 | subjectOf | therapeutic agents,for |
| R18 | E10-ab-4 | T9 | objectOf | AIDS,for |
| R19 | E8-ab-4 | T10 | subjectOf | antioxidants,antioxidants can be used as therapeutic agents |
| R20 | E10-ab-4 | T10 | objectOf | AIDS,antioxidants can be used as therapeutic agents |
| R21 | E3-ab-4 | T11 | subjectOf | antioxidants,antioxidants can be used as therapeutic agents |
| R22 | E10-ab-4 | T11 | objectOf | AIDS,antioxidants can be used as therapeutic agents |
| R23 | E6-ab-5 | T12 | subjectOf | alpha-lipoic acid,"antioxidant, alpha-lipoic acid" |
| R24 | E5-ab-5 | T12 | objectOf | antioxidant,"antioxidant, alpha-lipoic acid" |
| R25 | E6-ab-5 | T13 | subjectOf | alpha-lipoic acid,stimulation |
| R26 | E8-ab-5 | T13 | objectOf | cells,stimulation |
| R27 | E5-ab-5 | T14 | subjectOf | antioxidant,activation |
| R28 | E9-ab-5 | T14 | objectOf | NF-kappa B,activation |
| R29 | E10-ab-5 | T15 | subjectOf | tumor necrosis factor-alpha,induced |
| R30 | E1-ab-5 | T15 | objectOf | Jurkat T cells,induced |
| R31 | E11-ab-5 | T16 | subjectOf | phorbol 12-myristate 13-acetate,induced |
| R32 | E1-ab-5 | T16 | objectOf | Jurkat T cells,induced |
| R33 | E6-ab-5 | T17 | subjectOf | alpha-lipoic acid,"antioxidant, alpha-lipoic acid" |
| R34 | E9-ab-5 | T17 | objectOf | NF-kappa B,"antioxidant, alpha-lipoic acid" |
| R35 | E2-ab-7 | T18 | subjectOf | alpha-lipoic acid,in |
| R36 | E4-ab-7 | T18 | objectOf | AIDS,in |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-82 | Sentence | denotes | Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. |
| S2 | 83-190 | Sentence | denotes | Acquired immunodeficiency syndrome (AIDS) results from infection with a human immunodeficiency virus (HIV). |
| S3 | 191-383 | Sentence | denotes | The long terminal repeat (LTR) region of HIV proviral DNA contains binding sites for nuclear factor kappa B (NF-kappa B), and this transcriptional activator appears to regulate HIV activation. |
| S4 | 384-521 | Sentence | denotes | Recent findings suggest an involvement of reactive oxygen species (ROS) in signal transduction pathways leading to NF-kappa B activation. |
| S5 | 522-742 | Sentence | denotes | The present study was based on reports that antioxidants which eliminate ROS should block the activation of NF-kappa B and subsequently HIV transcription, and thus antioxidants can be used as therapeutic agents for AIDS. |
| S6 | 743-1022 | Sentence | denotes | Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml). |
| S7 | 1023-1193 | Sentence | denotes | The inhibitory action of alpha-lipoic acid was found to be very potent as only 4 mM was needed for a complete inhibition, whereas 20 mM was required for N-acetylcysteine. |
| S8 | 1194-1278 | Sentence | denotes | These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-17 | other_organic_compound | denotes | Alpha-lipoic acid |
| T2 | 43-53 | protein_molecule | denotes | NF-kappa B |
| T3 | 68-81 | cell_type | denotes | human T cells |
| T4 | 83-117 | other_name | denotes | Acquired immunodeficiency syndrome |
| T5 | 119-123 | other_name | denotes | AIDS |
| T6 | 155-183 | virus | denotes | human immunodeficiency virus |
| T7 | 185-188 | virus | denotes | HIV |
| T8 | 195-228 | DNA_domain_or_region | denotes | long terminal repeat (LTR) region |
| T9 | 232-235 | virus | denotes | HIV |
| T10 | 276-298 | protein_molecule | denotes | nuclear factor kappa B |
| T11 | 300-310 | protein_molecule | denotes | NF-kappa B |
| T12 | 322-347 | protein_family_or_group | denotes | transcriptional activator |
| T13 | 368-371 | virus | denotes | HIV |
| T14 | 426-449 | other_organic_compound | denotes | reactive oxygen species |
| T15 | 451-454 | other_organic_compound | denotes | ROS |
| T16 | 459-487 | other_name | denotes | signal transduction pathways |
| T17 | 499-509 | protein_molecule | denotes | NF-kappa B |
| T18 | 566-578 | other_organic_compound | denotes | antioxidants |
| T19 | 595-598 | other_organic_compound | denotes | ROS |
| T20 | 630-640 | protein_molecule | denotes | NF-kappa B |
| T21 | 658-661 | virus | denotes | HIV |
| T22 | 686-698 | other_organic_compound | denotes | antioxidants |
| T23 | 737-741 | other_name | denotes | AIDS |
| T24 | 757-771 | cell_line | denotes | Jurkat T cells |
| T25 | 800-825 | other_organic_compound | denotes | natural thiol antioxidant |
| T26 | 827-844 | other_organic_compound | denotes | alpha-lipoic acid |
| T27 | 901-911 | protein_molecule | denotes | NF-kappa B |
| T28 | 934-961 | protein_molecule | denotes | tumor necrosis factor-alpha |
| T29 | 979-1010 | other_organic_compound | denotes | phorbol 12-myristate 13-acetate |
| T30 | 1048-1065 | other_organic_compound | denotes | alpha-lipoic acid |
| T31 | 1176-1192 | amino_acid_monomer | denotes | N-acetylcysteine |
| T32 | 1222-1239 | other_organic_compound | denotes | alpha-lipoic acid |
| T33 | 1260-1264 | other_name | denotes | AIDS |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1223-1240 | C0023791 | denotes | lpha-lipoic acid |
| T2 | 1049-1066 | C0023791 | denotes | lpha-lipoic acid |
| T3 | 828-845 | C0023791 | denotes | lpha-lipoic acid, |
| T4 | 1-18 | C0023791 | denotes | lpha-lipoic acid |
| T5 | 913-922 | C1879547 | denotes | ctivation |
| T6 | 617-627 | C1879547 | denotes | ctivation |
| T7 | 511-521 | C1879547 | denotes | ctivation. |
| T8 | 373-383 | C1879547 | denotes | ctivation. |
| T9 | 55-65 | C1879547 | denotes | ctivation |
| T10 | 1088-1094 | C3245505 | denotes | otent |
| T11 | 24-30 | C3245505 | denotes | otent |
| T12 | 659-662 | C0019682 | denotes | IV |
| T13 | 369-372 | C0019682 | denotes | IV |
| T14 | 1261-1265 | C0001175 | denotes | IDS |
| T15 | 738-742 | C0001175 | denotes | IDS. |
| T16 | 84-118 | C0001175 | denotes | cquired immunodeficiency syndrome |
| T17 | 902-912 | C0079904 | denotes | F-kappa B |
| T18 | 631-641 | C0079904 | denotes | F-kappa B |
| T19 | 500-510 | C0079904 | denotes | F-kappa B |
| T20 | 277-299 | C0079904 | denotes | uclear factor kappa B |
| T21 | 815-826 | C0003402 | denotes | ntioxidant, |
| T22 | 596-599 | C0162772 | denotes | OS |
| T23 | 427-450 | C0162772 | denotes | eactive oxygen species |
| T24 | 935-962 | C1456820 | denotes | umor necrosis factor-alpha |
| T25 | 1177-1193 | C0001047 | denotes | -acetylcysteine. |
| T26 | 1077-1079 | C1883351 | denotes | o |
| T27 | 891-893 | C1883351 | denotes | o |
| T28 | 357-359 | C1883351 | denotes | o |
| T29 | 663-676 | C0040649 | denotes | ranscription, |
| T30 | 259-272 | C0005456 | denotes | inding sites |
| T31 | 1112-1118 | C0027552 | denotes | eeded |
| T32 | 1028-1038 | C3463820 | denotes | nhibitory |
| T33 | 1071-1076 | C0150312 | denotes | ound |
| T34 | 885-890 | C0150312 | denotes | ound |
| T35 | 527-534 | C0150312 | denotes | resent |
| T36 | 894-901 | C0018790 | denotes | nhibit |
| T37 | 139-148 | C0009450 | denotes | nfection |
| T38 | 809-814 | C0038734 | denotes | hiol |
| T39 | 246-249 | C0012854 | denotes | NA |
| T40 | 1201-1208 | C2825142 | denotes | esults |
| T41 | 126-133 | C2825142 | denotes | esults |
| T42 | 349-356 | C0700364 | denotes | ppears |
| T43 | 607-612 | C0332206 | denotes | lock |
| T44 | 875-880 | C0007634 | denotes | ells |
| T45 | 250-258 | C2700400 | denotes | ontains |
| T46 | 554-561 | C0700287 | denotes | eports |
| T47 | 860-871 | C1292856 | denotes | timulation |
| T48 | 323-348 | C1336776 | denotes | ranscriptional activator |
| T49 | 401-408 | C1705535 | denotes | uggest |
| T50 | 392-400 | C2926606 | denotes | indings |
| T51 | 535-540 | C2603343 | denotes | tudy |
| T52 | 545-550 | C1705938 | denotes | ased |
| T53 | 715-733 | C0304231 | denotes | herapeutic agents |
| T54 | 774-775 | C2827734 | denotes | |
| T55 | 784-792 | C2699156 | denotes | ells/ml) |
| T56 | 1164-1172 | C1514873 | denotes | equired |
| T57 | 707-711 | C1273517 | denotes | sed |
| T58 | 1125-1133 | C0205197 | denotes | omplete |
| T59 | 1134-1144 | C0021469 | denotes | nhibition, |
| T60 | 1248-1257 | C1280519 | denotes | ffective |
| T61 | 924-931 | C0205263 | denotes | nduced |
| T62 | 412-423 | C1314939 | denotes | nvolvement |
| T63 | 1039-1045 | C0441472 | denotes | ction |
| T64 | 489-496 | C1522538 | denotes | eading |
| T65 | 223-229 | C0205147 | denotes | egion |
| T66 | 385-390 | C0332185 | denotes | ecent |
| T67 | 1083-1087 | C0442824 | denotes | ery |
| T68 | 1098-1102 | C0205171 | denotes | nly |
| T69 | 1266-1278 | C0039796 | denotes | herapeutics. |
| T70 | 801-808 | C0205296 | denotes | atural |