PubMed:14766760
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-116 | Sentence | denotes | JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. |
| T2 | 117-342 | Sentence | denotes | Elevated endogenous JNK activity and resistance to Fas receptor-mediated apoptosis have recently been implicated in progression of prostate cancer and can promote resistance to apoptosis in response to chemotherapeutic drugs. |
| T3 | 343-474 | Sentence | denotes | In addition, JNK has been demonstrated to promote transformation of epithelial cells by increasing both proliferation and survival. |
| T4 | 475-695 | Sentence | denotes | Although numerous studies have reported a role for JNK in promoting Fas receptor-mediated apoptosis, there is a paucity in the literature studying the antiapoptotic function of JNK during Fas receptor-mediated apoptosis. |
| T5 | 696-877 | Sentence | denotes | Consequently, we have used the recently described specific JNK inhibitor SP600125 and RNA interference to inhibit endogenous JNK activity in the prostate carcinoma cell line DU 145. |
| T6 | 878-1050 | Sentence | denotes | We demonstrated that endogenous JNK activity increased the expression of a kinase, HIPK3, that has previously been implicated in multidrug resistance in a number of tumors. |
| T7 | 1051-1102 | Sentence | denotes | HIPK3 has also been reported to phosphorylate FADD. |
| T8 | 1103-1331 | Sentence | denotes | The interaction between FADD and caspase-8 was inhibited, but abrogation of JNK activity or HIPK3 expression was found to restore this interaction and increased the sensitivity of DU 145 cells to Fas receptor-mediated apoptosis. |
| T9 | 1332-1577 | Sentence | denotes | In conclusion, we present novel evidence that JNK regulates the expression of HIPK3 in prostate cancer cells, and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 91-99 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T2 | 248-256 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T3 | 841-849 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T4 | 1419-1427 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 248-263 | HP_0012125 | denotes | prostate cancer |
| T2 | 257-263 | HP_0002664 | denotes | cancer |
| T3 | 1043-1049 | HP_0002664 | denotes | tumors |
| T4 | 1419-1434 | HP_0012125 | denotes | prostate cancer |
| T5 | 1428-1434 | HP_0002664 | denotes | cancer |
CoMAGC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1195-1200 | Gene | denotes | HIPK3 |
| E1 | 1201-1211 | Gene_expression | denotes | expression |
| E2 | 1165-1175 | Negative_regulation | denotes | abrogation |
| T2 | 1283-1289 | prostate cancer | denotes | DU 145 |
| R1 | T1 | E1 | themeOf | HIPK3,expression |
| R2 | E1 | E2 | themeOf | expression,abrogation |
| R3 | T1 | T2 | CGE-decreased | HIPK3,DU 145 |
| R4 | T1 | T2 | CCS-cancerTOnormal | HIPK3,DU 145 |
| R5 | T1 | T2 | PT-causality | HIPK3,DU 145 |
| R3 | T1 | T2 | IGE-unidentifiable | HIPK3,DU 145 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 91-99 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T2 | 248-256 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T3 | 841-849 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T4 | 1419-1427 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 91-109 | Disease | denotes | prostate carcinoma | http://purl.obolibrary.org/obo/MONDO_0005159 |
| T2 | 248-263 | Disease | denotes | prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
| T3 | 841-859 | Disease | denotes | prostate carcinoma | http://purl.obolibrary.org/obo/MONDO_0005159 |
| T4 | 1043-1049 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 1419-1434 | Disease | denotes | prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 91-99 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T2 | 248-256 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T3 | 411-427 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T4 | 841-849 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T5 | 1419-1427 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |