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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-153 Sentence denotes Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.
TextSentencer_T2 154-205 Sentence denotes Adiponectin (APM1) is an adipocyte-derived peptide.
TextSentencer_T3 206-280 Sentence denotes The APM1 gene is located on chromosome 3q27 and linked to type 2 diabetes.
TextSentencer_T4 281-394 Sentence denotes In patients with type 2 diabetes, the adiponectin level in plasma is decreased in comparison to healthy subjects.
TextSentencer_T5 395-753 Sentence denotes To identify genetic defects of the APM1 gene that contribute to the development of type 2 diabetes, we genotyped 13 single nucleotide polymorphisms (SNPs) in 106 patients with type 2 diabetes, 325 patients with impaired glucose tolerance (IGT), and 497 nondiabetic control subjects in Swedish Caucasians by using dynamic allele-specific hybridization (DASH).
TextSentencer_T6 754-987 Sentence denotes We found that SNPs -11426(A/G) and -11377(G/C) in the proximal promoter region had significant differences of allele frequencies between type 2 diabetic patients and nondiabetic control subjects (P = 0.02 and P = 0.04, respectively).
TextSentencer_T7 988-1265 Sentence denotes SNP-11426(A/G) was significantly associated with fasting plasma glucose in type 2 diabetic patients (P = 0.02) and in IGT subjects (P = 0.04), while the patients carrying CC and CG genotypes for SNP-11377(G/C) had a higher BMI than the patients with the GG genotype (P = 0.03).
TextSentencer_T8 1266-1434 Sentence denotes Haplotype analysis of 13 SNPs in the APM1 gene showed that estimates of haplotype frequencies in Swedish Caucasians are similar to those estimated in French Caucasians.
TextSentencer_T9 1435-1540 Sentence denotes However, no significant association of haplotypes with type 2 diabetes and IGT was detected in our study.
TextSentencer_T10 1541-1696 Sentence denotes The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes.
T1 0-153 Sentence denotes Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.
T2 154-205 Sentence denotes Adiponectin (APM1) is an adipocyte-derived peptide.
T3 206-280 Sentence denotes The APM1 gene is located on chromosome 3q27 and linked to type 2 diabetes.
T4 281-394 Sentence denotes In patients with type 2 diabetes, the adiponectin level in plasma is decreased in comparison to healthy subjects.
T5 395-753 Sentence denotes To identify genetic defects of the APM1 gene that contribute to the development of type 2 diabetes, we genotyped 13 single nucleotide polymorphisms (SNPs) in 106 patients with type 2 diabetes, 325 patients with impaired glucose tolerance (IGT), and 497 nondiabetic control subjects in Swedish Caucasians by using dynamic allele-specific hybridization (DASH).
T6 754-987 Sentence denotes We found that SNPs -11426(A/G) and -11377(G/C) in the proximal promoter region had significant differences of allele frequencies between type 2 diabetic patients and nondiabetic control subjects (P = 0.02 and P = 0.04, respectively).
T7 988-1265 Sentence denotes SNP-11426(A/G) was significantly associated with fasting plasma glucose in type 2 diabetic patients (P = 0.02) and in IGT subjects (P = 0.04), while the patients carrying CC and CG genotypes for SNP-11377(G/C) had a higher BMI than the patients with the GG genotype (P = 0.03).
T8 1266-1434 Sentence denotes Haplotype analysis of 13 SNPs in the APM1 gene showed that estimates of haplotype frequencies in Swedish Caucasians are similar to those estimated in French Caucasians.
T9 1435-1540 Sentence denotes However, no significant association of haplotypes with type 2 diabetes and IGT was detected in our study.
T10 1541-1696 Sentence denotes The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 606-632 HP_0000833 denotes impaired glucose tolerance

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14749263-0#84#88#gene9370 84-88 gene9370 denotes APM1
14749263-0#84#88#gene201501 84-88 gene201501 denotes APM1
14749263-0#115#130#diseaseC0011860 115-130 diseaseC0011860 denotes type 2 diabetes
14749263-4#35#39#gene9370 430-434 gene9370 denotes APM1
14749263-4#35#39#gene201501 430-434 gene201501 denotes APM1
14749263-4#35#39#gene9370 430-434 gene9370 denotes APM1
14749263-4#35#39#gene201501 430-434 gene201501 denotes APM1
14749263-4#211#237#diseaseC0271650 606-632 diseaseC0271650 denotes impaired glucose tolerance
14749263-4#239#242#diseaseC0271650 634-637 diseaseC0271650 denotes IGT
84#88#gene9370115#130#diseaseC0011860 14749263-0#84#88#gene9370 14749263-0#115#130#diseaseC0011860 associated_with APM1,type 2 diabetes
84#88#gene201501115#130#diseaseC0011860 14749263-0#84#88#gene201501 14749263-0#115#130#diseaseC0011860 associated_with APM1,type 2 diabetes
35#39#gene9370211#237#diseaseC0271650 14749263-4#35#39#gene9370 14749263-4#211#237#diseaseC0271650 associated_with APM1,impaired glucose tolerance
35#39#gene9370239#242#diseaseC0271650 14749263-4#35#39#gene9370 14749263-4#239#242#diseaseC0271650 associated_with APM1,IGT
35#39#gene201501211#237#diseaseC0271650 14749263-4#35#39#gene201501 14749263-4#211#237#diseaseC0271650 associated_with APM1,impaired glucose tolerance
35#39#gene201501239#242#diseaseC0271650 14749263-4#35#39#gene201501 14749263-4#239#242#diseaseC0271650 associated_with APM1,IGT
35#39#gene9370211#237#diseaseC0271650 14749263-4#35#39#gene9370 14749263-4#211#237#diseaseC0271650 associated_with APM1,impaired glucose tolerance
35#39#gene9370239#242#diseaseC0271650 14749263-4#35#39#gene9370 14749263-4#239#242#diseaseC0271650 associated_with APM1,IGT
35#39#gene201501211#237#diseaseC0271650 14749263-4#35#39#gene201501 14749263-4#211#237#diseaseC0271650 associated_with APM1,impaired glucose tolerance
35#39#gene201501239#242#diseaseC0271650 14749263-4#35#39#gene201501 14749263-4#239#242#diseaseC0271650 associated_with APM1,IGT

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2084 84-88 gene:9370 denotes APM1
T2085 115-130 disease:C0011860 denotes type 2 diabetes
R1 T2084 T2085 associated_with APM1,type 2 diabetes
R2 T2084 T2085 associated_with APM1,type 2 diabetes

DisGeNET

Id Subject Object Predicate Lexical cue
T0 430-434 gene:9370 denotes APM1
T1 478-493 disease:C0011860 denotes type 2 diabetes
T2 430-434 gene:201501 denotes APM1
T3 478-493 disease:C0011860 denotes type 2 diabetes
T4 430-434 gene:9370 denotes APM1
T5 571-586 disease:C0011860 denotes type 2 diabetes
T6 430-434 gene:201501 denotes APM1
T7 571-586 disease:C0011860 denotes type 2 diabetes
T8 430-434 gene:9370 denotes APM1
T9 606-632 disease:C0271650 denotes impaired glucose tolerance
T10 430-434 gene:201501 denotes APM1
T11 606-632 disease:C0271650 denotes impaired glucose tolerance
T12 430-434 gene:9370 denotes APM1
T13 634-637 disease:C0271650 denotes IGT
T14 430-434 gene:201501 denotes APM1
T15 634-637 disease:C0271650 denotes IGT
R1 T0 T1 associated_with APM1,type 2 diabetes
R2 T2 T3 associated_with APM1,type 2 diabetes
R3 T4 T5 associated_with APM1,type 2 diabetes
R4 T6 T7 associated_with APM1,type 2 diabetes
R5 T8 T9 associated_with APM1,impaired glucose tolerance
R6 T10 T11 associated_with APM1,impaired glucose tolerance
R7 T12 T13 associated_with APM1,IGT
R8 T14 T15 associated_with APM1,IGT