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PubMed:14722123 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1.
T2 165-381 Sentence denotes Down-regulation of several key actin-binding proteins, such as alpha-actinin, vinculin, gelsolin, and tropomyosins (TMs), is considered to contribute to the disorganized cytoskeleton present in many neoplastic cells.
T3 382-473 Sentence denotes TMs stabilize actin filaments against the gel severing actions of proteins such as cofilin.
T4 474-632 Sentence denotes Among multiple TMs expressed in non-muscle cells, tropomyosin-1 (TM1) isoform induces stress fibers and functions as a suppressor of malignant transformation.
T5 633-751 Sentence denotes However, the molecular mechanisms of TM1-mediated cytoskeletal effects and tumor suppression remain poorly understood.
T6 752-858 Sentence denotes We have hypothesized that the ability of TM1 to stabilize microfilaments is crucial for tumor suppression.
T7 859-1040 Sentence denotes In this study, by employing a variant TM1, which contains an N-terminal hemagglutinin epitope tag, we demonstrate that the N terminus is a key determinant of tropomyosin-1 function.
T8 1041-1181 Sentence denotes Unlike the wild type TM1, the modified protein fails to restore stress fibers and inhibit anchorage-independent growth in transformed cells.
T9 1182-1376 Sentence denotes Furthermore, the N-terminal modification of TM1 disorganizes the cytoskeleton and delays cytokinesis in normal cells, abolishes binding to F-actin, and disrupts the dimeric associations in vivo.
T10 1377-1578 Sentence denotes The functionally defective TM1 allows the association of cofilin to stress fibers and disorganizes the microfilaments, whereas wild type TM1 appears to restrict the binding of cofilin to stress fibers.
T11 1579-1701 Sentence denotes TM1-induced cytoskeletal reorganization appears to be mediated through preventing cofilin interaction with microfilaments.
T12 1702-1873 Sentence denotes Our studies provide in vivo functional evidence that the N terminus is a critical determinant of TM1 functions, which in turn determines the organization of stress fibers.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 510-516 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 708-713 HP_0002664 denotes tumor
T2 840-845 HP_0002664 denotes tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 708-713 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 840-845 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 708-713 Phenotype denotes tumor HP:0002664
T2 840-845 Phenotype denotes tumor HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 335-347 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856
T2 396-411 Body_part denotes actin filaments http://purl.obolibrary.org/obo/GO_0005884
T3 510-522 Body_part denotes muscle cells http://purl.obolibrary.org/obo/CL_0000187
T4 810-824 Body_part denotes microfilaments http://purl.obolibrary.org/obo/GO_0005884
T5 1247-1259 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856
T6 1480-1494 Body_part denotes microfilaments http://purl.obolibrary.org/obo/GO_0005884
T7 1686-1700 Body_part denotes microfilaments http://purl.obolibrary.org/obo/GO_0005884

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 510-516 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 364-380 Cell denotes neoplastic cells http://purl.obolibrary.org/obo/CL:0001063
T2 510-522 Cell denotes muscle cells http://purl.obolibrary.org/obo/CL:0000187