PubMed:14712309 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/14712309","sourcedb":"PubMed","sourceid":"14712309","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/14712309","text":"Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis.\nWe analyzed the frequency of single-nucleotide polymorphisms (SNPs) at positions -1053 (rs 2981572), 1380 (rs 2981573), 1462 (rs 2232360), and 3978 (rs 1518108) of the human interleukin-20 (IL-20) gene by tetraprimer ARMS-PCR method. A significant association between patients with psoriasis and the G allele at position -1053 (P\u003c0.05) was established. The pairwise linkage disequilibrium (LD) matrix showed that the nearly complete LD was present within the polymorphisms at positions -1053, 1380, and 1462 of the IL-20 gene. We found that patients with plaque psoriasis had a higher frequency of the HT3 GAA haplotype (P\u003c0.01, OR 2.341, 95% CI: 1.346-4.074) compared to the control group. Likewise, the HT3 GAA haplotype was associated with an increased risk of early-onset psoriasis (P\u003c0.01, OR 2.305, 95% CI: 1.285-4.132), late onset of disease (P\u003c0.01, OR 2.542, 95% CI: 1.266-5.102), familial psoriasis (P\u003c0.02, OR 2.220, 95% CI: 1.249-3.945), and sporadic disease (P\u003c0.01, OR 2.523, 95% CI: 1.390-4.580). Our data indicate that IL-20 gene polymorphisms should have a role in determining susceptibility to plaque-type psoriasis. The possible role of the studied SNPs in the regulation of the expression of IL-20 is unknown yet and needs further studies.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":364,"end":373},"obj":"HP_0003765"},{"id":"T2","span":{"begin":644,"end":653},"obj":"HP_0003765"},{"id":"T3","span":{"begin":858,"end":867},"obj":"HP_0003765"},{"id":"T4","span":{"begin":981,"end":990},"obj":"HP_0003765"},{"id":"T5","span":{"begin":1206,"end":1215},"obj":"HP_0003765"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":684,"end":687},"obj":"gene:144125"},{"id":"T1","span":{"begin":637,"end":653},"obj":"disease:C0406317"},{"id":"T2","span":{"begin":1117,"end":1122},"obj":"gene:50604"},{"id":"T3","span":{"begin":1206,"end":1215},"obj":"disease:C0033860"},{"id":"T4","span":{"begin":1117,"end":1122},"obj":"gene:27190"},{"id":"T5","span":{"begin":1206,"end":1215},"obj":"disease:C0033860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"22","span":{"begin":170,"end":180},"obj":"SNP"},{"id":"23","span":{"begin":189,"end":199},"obj":"SNP"},{"id":"24","span":{"begin":208,"end":218},"obj":"SNP"},{"id":"25","span":{"begin":231,"end":241},"obj":"SNP"}],"attributes":[{"id":"A22","pred":"resolved_to","subj":"22","obj":"tmVar:rs2981572;VariantGroup:3;CorrespondingGene:50604;RS#:2981572;CorrespondingSpecies:9606"},{"id":"A23","pred":"resolved_to","subj":"23","obj":"tmVar:rs2981573;VariantGroup:2;CorrespondingGene:50604;RS#:2981573;CorrespondingSpecies:9606"},{"id":"A24","pred":"resolved_to","subj":"24","obj":"tmVar:rs2232360;VariantGroup:0;CorrespondingGene:50604;RS#:2232360;CorrespondingSpecies:9606"},{"id":"A25","pred":"resolved_to","subj":"25","obj":"tmVar:rs1518108;VariantGroup:1;RS#:1518108"},{"subj":"22","pred":"source","obj":"PubTator4TogoVar"},{"subj":"23","pred":"source","obj":"PubTator4TogoVar"},{"subj":"24","pred":"source","obj":"PubTator4TogoVar"},{"subj":"25","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"PubTatorOnTogoVar","denotations":[{"id":"22","span":{"begin":170,"end":180},"obj":"SNP"},{"id":"23","span":{"begin":189,"end":199},"obj":"SNP"},{"id":"24","span":{"begin":208,"end":218},"obj":"SNP"},{"id":"25","span":{"begin":231,"end":241},"obj":"SNP"},{"id":"T1","span":{"begin":170,"end":180},"obj":"SNP"},{"id":"T2","span":{"begin":189,"end":199},"obj":"SNP"},{"id":"T3","span":{"begin":208,"end":218},"obj":"SNP"},{"id":"T4","span":{"begin":231,"end":241},"obj":"SNP"}],"attributes":[{"id":"A22","pred":"resolved_to","subj":"22","obj":"tmVar:rs2981572;VariantGroup:3;CorrespondingGene:50604;RS#:2981572;CorrespondingSpecies:9606"},{"id":"A23","pred":"resolved_to","subj":"23","obj":"tmVar:rs2981573;VariantGroup:2;CorrespondingGene:50604;RS#:2981573;CorrespondingSpecies:9606"},{"id":"A24","pred":"resolved_to","subj":"24","obj":"tmVar:rs2232360;VariantGroup:0;CorrespondingGene:50604;RS#:2232360;CorrespondingSpecies:9606"},{"id":"A25","pred":"resolved_to","subj":"25","obj":"tmVar:rs1518108;VariantGroup:1;RS#:1518108"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs2981572;VariantGroup:3;CorrespondingGene:50604;RS#:2981572;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs2981573;VariantGroup:2;CorrespondingGene:50604;RS#:2981573;CorrespondingSpecies:9606"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs2232360;VariantGroup:0;CorrespondingGene:50604;RS#:2232360;CorrespondingSpecies:9606"},{"id":"A4","pred":"resolved_to","subj":"T4","obj":"tmVar:rs1518108;VariantGroup:1;RS#:1518108"},{"subj":"22","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"23","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"24","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"25","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T1","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T2","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T3","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T4","pred":"source","obj":"PubTatorOnTogoVar"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#9993ec","default":true},{"id":"DisGeNET","color":"#a6ec93"},{"id":"PubTator4TogoVar","color":"#ec93c0"},{"id":"PubTatorOnTogoVar","color":"#93daec"}]}]}}