PubMed:147119 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/147119","sourcedb":"PubMed","sourceid":"147119","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/147119","text":"Human leucocyte antigens and mixed lymphocyte reaction in severe pre-eclampsia.\nHuman leucocyte antigens (HLA) and mixed lymphocyte reactions (MLR) were studied in 38 women with severe pre-eclampsia and their husbands. Thirty-nine women with normal pregnancies and their husbands served as controls. Thirty-three of the control women were matched for age and parity with members of the study group. Infants were studied when possible. HLA compatibility was increased in the pre-eclamptic group compared with matched controls and with theoretical estimates for possible matings. The one-way MLR at delivery showed diminished response of maternal to paternal and cord cells in pre-eclamptic women. This reduced maternal reactivity in women with pre-eclampsia may have a role in the illness, and paternal/maternal histocompatibility may be a feature of the severe form.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":185,"end":198},"obj":"HP_0100602"},{"id":"T2","span":{"begin":189,"end":198},"obj":"HP_0100601"},{"id":"T3","span":{"begin":743,"end":756},"obj":"HP_0100602"},{"id":"T4","span":{"begin":747,"end":756},"obj":"HP_0100601"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":80,"end":218},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":219,"end":299},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":300,"end":398},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":399,"end":434},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":435,"end":577},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":578,"end":695},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":696,"end":866},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":218},"obj":"Sentence"},{"id":"T3","span":{"begin":219,"end":299},"obj":"Sentence"},{"id":"T4","span":{"begin":300,"end":398},"obj":"Sentence"},{"id":"T5","span":{"begin":399,"end":434},"obj":"Sentence"},{"id":"T6","span":{"begin":435,"end":577},"obj":"Sentence"},{"id":"T7","span":{"begin":578,"end":695},"obj":"Sentence"},{"id":"T8","span":{"begin":696,"end":866},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"}]},{"project":"Preeclampsia","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":65,"end":78},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":185,"end":198},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":743,"end":756},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"attributes":[{"subj":"PD-Preeclampsia-B_T1","pred":"source","obj":"Preeclampsia"},{"subj":"PD-Preeclampsia-B_T2","pred":"source","obj":"Preeclampsia"},{"subj":"PD-Preeclampsia-B_T3","pred":"source","obj":"Preeclampsia"}]},{"project":"Preeclampsia-compare","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":65,"end":78},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":185,"end":198},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":474,"end":487},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T4","span":{"begin":675,"end":688},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T5","span":{"begin":743,"end":756},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"attributes":[{"subj":"PD-Preeclampsia-B_T1","pred":"source","obj":"Preeclampsia-compare"},{"subj":"PD-Preeclampsia-B_T2","pred":"source","obj":"Preeclampsia-compare"},{"subj":"PD-Preeclampsia-B_T3","pred":"source","obj":"Preeclampsia-compare"},{"subj":"PD-Preeclampsia-B_T4","pred":"source","obj":"Preeclampsia-compare"},{"subj":"PD-Preeclampsia-B_T5","pred":"source","obj":"Preeclampsia-compare"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93ece8","default":true},{"id":"sentences","color":"#ecce93"},{"id":"Preeclampsia","color":"#b493ec"},{"id":"Preeclampsia-compare","color":"#93ec9a"}]}]}}