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PubMed:14707488 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 21-40 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T2 209-228 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T3 323-342 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T4 386-393 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 21-40 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T2 209-228 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T3 323-342 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T4 386-393 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-187 Sentence denotes Determination of UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III in patients sera with chronic hepatitis and liver cirrhosis using a monoclonal antibody.
TextSentencer_T2 188-438 Sentence denotes The glycoprotein UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III (GnT-III) catalyzes the addition of N-acetylglucosamine via a beta-1, 4-linkage to the beta-linked mannose of the trimannosyl core of N-linked glycans.
TextSentencer_T3 439-724 Sentence denotes It has been reported that the expression of GnT-III increases in many oncogenically transformed cells and human hepatocellular carcinoma (HCC) tissues, and GnT-III enzyme activity in serum can be used for the detection and monitoring of primary hepatomas and hepatocellular carcinomas.
TextSentencer_T4 725-977 Sentence denotes A solid-phase enzyme-linked immunosorbent sandwich assay in which a polyclonal antibody (PAb) to aglycosylrecombinant GnT-III (AGR-GnT-III) and a monoclonal antibody (mAb) are employed as a capture protein and probe protein, respectively, is described.
TextSentencer_T5 978-1097 Sentence denotes The sensitivity of the PAb-mAb sandwich assay, as determined by the dose-response effect for AGR-GnT-III, was 10 ng/ml.
TextSentencer_T6 1098-1204 Sentence denotes This assay was specific for GnT-III and did not detect beta-1, 6-N-acetylglucosaminyltrasferase-V (GnT-V).
TextSentencer_T7 1205-1416 Sentence denotes AGR-GnT-III concentrations in 377 serum specimens were determined by the PAb-mAb sandwich assay and the results were analyzed based on the disease category, using 1.99 microg/mL (AGR-GnT-III) as a cut-off value.
TextSentencer_T8 1417-1508 Sentence denotes The AGR-GnT-III level of 61 normal serum samples was 0.57 +/- 0.71 microg/ml (mean +/- SD).
TextSentencer_T9 1509-1720 Sentence denotes The results revealed an elevation in serum AGR-GnT-III levels in 60 of 86 patients (3.03 +/- 2.04 microg/ml) with liver cirrhosis (LC) and 86 of 91 patients (2.73 +/- 0.59 microg/ml) with chronic hepatitis (CH).
TextSentencer_T10 1721-1961 Sentence denotes By contrast, 3 of 61 normal subjects, 9 of 34 patients (1.02 +/- 1.03 microg/ml) with acute hepatitis and 8 of 38 patients (1.79 +/- 0.56 microg/ml) with a variety of non-hepatic diseases exhibited a slight increase above the cut-off value.
TextSentencer_T11 1962-2060 Sentence denotes These results indicate that serum AGR-GnT-III levels are elevated predominantly in LC or CH cases.
TextSentencer_T12 2061-2283 Sentence denotes Serum AGR-GnT-III concentration, as measured by the developed PAb-mAb sandwich assay, may be a useful differential marker as a diagnostic aid for CH and/or LC and warrants further investigations with expanded serum panels.
T1 0-187 Sentence denotes Determination of UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III in patients sera with chronic hepatitis and liver cirrhosis using a monoclonal antibody.
T2 188-438 Sentence denotes The glycoprotein UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III (GnT-III) catalyzes the addition of N-acetylglucosamine via a beta-1, 4-linkage to the beta-linked mannose of the trimannosyl core of N-linked glycans.
T3 439-724 Sentence denotes It has been reported that the expression of GnT-III increases in many oncogenically transformed cells and human hepatocellular carcinoma (HCC) tissues, and GnT-III enzyme activity in serum can be used for the detection and monitoring of primary hepatomas and hepatocellular carcinomas.
T4 725-977 Sentence denotes A solid-phase enzyme-linked immunosorbent sandwich assay in which a polyclonal antibody (PAb) to aglycosylrecombinant GnT-III (AGR-GnT-III) and a monoclonal antibody (mAb) are employed as a capture protein and probe protein, respectively, is described.
T5 978-1097 Sentence denotes The sensitivity of the PAb-mAb sandwich assay, as determined by the dose-response effect for AGR-GnT-III, was 10 ng/ml.
T6 1098-1204 Sentence denotes This assay was specific for GnT-III and did not detect beta-1, 6-N-acetylglucosaminyltrasferase-V (GnT-V).
T7 1205-1416 Sentence denotes AGR-GnT-III concentrations in 377 serum specimens were determined by the PAb-mAb sandwich assay and the results were analyzed based on the disease category, using 1.99 microg/mL (AGR-GnT-III) as a cut-off value.
T8 1417-1508 Sentence denotes The AGR-GnT-III level of 61 normal serum samples was 0.57 +/- 0.71 microg/ml (mean +/- SD).
T9 1509-1720 Sentence denotes The results revealed an elevation in serum AGR-GnT-III levels in 60 of 86 patients (3.03 +/- 2.04 microg/ml) with liver cirrhosis (LC) and 86 of 91 patients (2.73 +/- 0.59 microg/ml) with chronic hepatitis (CH).
T10 1721-1961 Sentence denotes By contrast, 3 of 61 normal subjects, 9 of 34 patients (1.02 +/- 1.03 microg/ml) with acute hepatitis and 8 of 38 patients (1.79 +/- 0.56 microg/ml) with a variety of non-hepatic diseases exhibited a slight increase above the cut-off value.
T11 1962-2060 Sentence denotes These results indicate that serum AGR-GnT-III levels are elevated predominantly in LC or CH cases.
T12 2061-2283 Sentence denotes Serum AGR-GnT-III concentration, as measured by the developed PAb-mAb sandwich assay, may be a useful differential marker as a diagnostic aid for CH and/or LC and warrants further investigations with expanded serum panels.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 143-148 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1623-1628 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 551-575 HP_0001402 denotes hepatocellular carcinoma
T2 698-723 HP_0001402 denotes hepatocellular carcinomas
T3 1629-1638 HP_0001394 denotes cirrhosis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 121-138 Disease denotes chronic hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T2 143-158 Disease denotes liver cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T3 551-575 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T4 577-580 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T5 684-693 Disease denotes hepatomas http://purl.obolibrary.org/obo/MONDO_0007256
T6 698-723 Disease denotes hepatocellular carcinomas http://purl.obolibrary.org/obo/MONDO_0007256
T7 1623-1638 Disease denotes liver cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T8 1640-1642 Disease denotes LC http://purl.obolibrary.org/obo/MONDO_0005155
T9 1697-1714 Disease denotes chronic hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T10 1716-1718 Disease denotes CH http://purl.obolibrary.org/obo/MONDO_0002251
T11 1807-1822 Disease denotes acute hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T12 1892-1908 Disease denotes hepatic diseases http://purl.obolibrary.org/obo/MONDO_0005154
T13 2045-2047 Disease denotes LC http://purl.obolibrary.org/obo/MONDO_0005155
T14 2051-2053 Disease denotes CH http://purl.obolibrary.org/obo/MONDO_0002251
T15 2207-2209 Disease denotes CH http://purl.obolibrary.org/obo/MONDO_0002251
T16 2217-2219 Disease denotes LC http://purl.obolibrary.org/obo/MONDO_0005155

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 143-148 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1623-1628 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 545-550 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 143-148 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 1623-1628 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 121-138 Phenotype denotes chronic hepatitis HP:0200123
T2 143-158 Phenotype denotes liver cirrhosis HP:0001394
T3 551-575 Phenotype denotes hepatocellular carcinoma HP:0001402
T4 577-580 Phenotype denotes HCC HP:0001402
T5 698-723 Phenotype denotes hepatocellular carcinomas HP:0001402
T6 1623-1638 Phenotype denotes liver cirrhosis HP:0001394
T7 1640-1642 Phenotype denotes LC HP:0001394
T8 1697-1714 Phenotype denotes chronic hepatitis HP:0200123
T9 1716-1718 Phenotype denotes CH HP:0200123
T10 1807-1822 Phenotype denotes acute hepatitis HP:0200119
T11 2045-2047 Phenotype denotes LC HP:0001394
T12 2051-2053 Phenotype denotes CH HP:0200123
T13 2207-2209 Phenotype denotes CH HP:0200123
T14 2217-2219 Phenotype denotes LC HP:0001394