> top > docs > PubMed:14701804 > annotations

PubMed:14701804 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome.
T2 83-482 Sentence denotes Murine PIRH2 (mPIRH2) was recently identified as a RING finger-containing ubiquitin-protein isopeptide ligase that interacts with both p53 and the human androgen receptor. mpirh2 is a p53-responsive gene that is up-regulated by UV, and mPIRH2 protein has the capacity to polyubiquitylate p53, perhaps leading to p53 destruction. mpirh2 therefore has properties similar to those of the oncogene mdm2.
T3 483-560 Sentence denotes Here, we have identified human PIRH2 (hPIRH2) as a TIP60-interacting protein.
T4 561-704 Sentence denotes To investigate its regulation, we characterized hPIRH2 in parallel with hPIRH2 variants possessing mutations of conserved RING finger residues.
T5 705-851 Sentence denotes We observed that wild-type hPIRH2 is an unstable protein with a short half-life and is a target for RING domain-dependent proteasomal degradation.
T6 852-913 Sentence denotes Accordingly, we found that hPIRH2 was ubiquitylated in cells.
T7 914-1082 Sentence denotes The TIP60-hPIRH2 association appeared to regulate hPIRH2 stability; coexpression of TIP60 enhanced hPIRH2 protein stability and altered hPIRH2 subcellular localization.
T8 1083-1197 Sentence denotes These results suggest that hPIRH2 activities can be controlled, at the post-translational level, in multiple ways.

LocText

Id Subject Object Predicate Lexical cue
T1 11-16 taxonomy:9606 denotes human
T2 17-22 uniprot:Q96PM5 denotes PIRH2
T3 57-62 uniprot:Q92993 denotes TIP60
T4 83-89 taxonomy:10090 denotes Murine
T5 90-95 uniprot:Q9CR50 denotes PIRH2
T6 97-103 uniprot:Q9CR50 denotes mPIRH2
T7 218-221 uniprot:P02340 denotes p53
T8 230-235 taxonomy:9606 denotes human
T9 255-261 uniprot:Q9CR50 denotes mpirh2
T10 267-270 uniprot:P02340 denotes p53
T11 319-325 uniprot:Q9CR50 denotes mPIRH2
T12 371-374 uniprot:P02340 denotes p53
T13 395-398 uniprot:P02340 denotes p53
T14 412-418 uniprot:Q9CR50 denotes mpirh2
T15 477-481 uniprot:P23804 denotes mdm2
T16 508-513 taxonomy:9606 denotes human
T17 514-519 uniprot:Q96PM5 denotes PIRH2
T18 521-527 uniprot:Q96PM5 denotes hPIRH2
T19 534-539 uniprot:Q92993 denotes TIP60
T20 609-615 uniprot:Q96PM5 denotes hPIRH2
T21 633-639 uniprot:Q96PM5 denotes hPIRH2
T22 732-738 uniprot:Q96PM5 denotes hPIRH2
T23 879-885 uniprot:Q96PM5 denotes hPIRH2
T24 918-923 uniprot:Q92993 denotes TIP60
T25 924-930 uniprot:Q96PM5 denotes hPIRH2
T26 964-970 uniprot:Q96PM5 denotes hPIRH2
T27 998-1003 uniprot:Q92993 denotes TIP60
T28 1013-1019 uniprot:Q96PM5 denotes hPIRH2
T29 1050-1056 uniprot:Q96PM5 denotes hPIRH2
T30 1110-1116 uniprot:Q96PM5 denotes hPIRH2

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 11-16 OrganismTaxon denotes human 9606
T2 230-235 OrganismTaxon denotes human 9606
T3 508-513 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 134-145 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T2 683-694 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624