PubMed:14687488 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/14687488","sourcedb":"PubMed","sourceid":"14687488","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/14687488","text":"Expression of hypoxia-inducible factor 1alpha in human normal, benign, and malignant prostate tissue.\nOBJECTIVE: To investigate hypoxia-inducible factor 1alpha (HIF-1alpha) protein expression in normal prostates (NP), benign prostatic glandular hyperplasia (BPH), and prostate adenocarcinoma (Pca).\nMETHODS: HIF-1alpha protein expression was determined by immunohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 13 cases of NP, 28 cases of BPH, and 34 cases of Pca. In cases of Pca, the relationship between HIF-1alpha protein expression and certain clinicopathological factors, such as clinicopathologic stage and Gleason score, was evaluated.\nRESULTS: NP manifested no immunoreactivity, whereas Pca and BPH showed significantly increased HIF-1alpha protein expression. A significantly higher expression was observed in Pca specimens compared with BPH samples. In Pca, no significant relationship between HIF-1alpha protein expression and clinicopathological factors was found.\nCONCLUSION: Our findings of increased HIF-1alpha protein expression in BPH and Pca specimens suggests the potential role of this protein in BPH and Pca.","tracks":[{"project":"CoMAGC","denotations":[{"id":"T1","span":{"begin":1046,"end":1064},"obj":"Gene"},{"id":"E1","span":{"begin":1065,"end":1075},"obj":"Gene_expression"},{"id":"E2","span":{"begin":1036,"end":1045},"obj":"Positive_regulation"},{"id":"T2","span":{"begin":1079,"end":1082},"obj":"prostate cancer"},{"id":"T3","span":{"begin":1148,"end":1151},"obj":"prostate cancer"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T1","obj":"E1"},{"id":"R2","pred":"themeOf","subj":"E1","obj":"E2"},{"id":"R3","pred":"CGE-increased","subj":"T1","obj":"T2"},{"id":"R4","pred":"CCS-normalTOcancer","subj":"T1","obj":"T2"},{"id":"R5","pred":"PT-observation","subj":"T1","obj":"T2"},{"id":"R3","pred":"IGE-unidentifiable","subj":"T1","obj":"T2"}],"attributes":[{"subj":"T1","pred":"source","obj":"CoMAGC"},{"subj":"E1","pred":"source","obj":"CoMAGC"},{"subj":"E2","pred":"source","obj":"CoMAGC"},{"subj":"T2","pred":"source","obj":"CoMAGC"},{"subj":"T3","pred":"source","obj":"CoMAGC"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"CoMAGC","color":"#93ecac","default":true}]}]}}