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PubMed:14678959 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 164-311 OBJECTIVE denotes The purpose is to evaluate the association of glutathione S-transferase pi (GST-pi) amplification and cisplatin resistance in head and neck cancer.
T2 333-642 METHODS denotes An analysis of chromosomal abnormalities in 10 head and neck cancer cell lines by comparative genomic hybridization was performed. GST-pi amplification and expression were evaluated in head and neck cell lines and paraffin-embedded tissue by fluorescence in situ hybridization (FISH) and immunohistochemistry.
T3 652-1599 RESULTS denotes Changes in the DNA copy number were seen in all 10 cell lines by comparative genomic hybridization. The most frequent chromosomal alterations were: gain at 3q; loss at 3p; gain at 8q; loss of 18q; gain at 20q; loss at 8p; and gain of 11q11-q13. Using FISH, 9 of 10 cell lines showed increased GST-pi copy number. GST-pi amplification was detected in 7 of 10 cell lines. Five were relatively cisplatin resistant, and 2 were relatively cisplatin sensitive (mean IC(50), 11.2 and 2.75 microM). Two relatively cisplatin-sensitive cell lines showed GST-pi gain and another relatively cisplatin-sensitive cell line had predominantly two copies of the gene. In 10 tumor specimens, 4 had two copies of GST-pi. All 4 had a complete response to neoadjuvant chemotherapy, 3 of whom are alive >50 months from treatment compared with 2 patients showing GST-pi amplification. Neither responded to chemotherapy, and both died of disease <9 months from diagnosis.
T4 1613-1850 CONCLUSIONS denotes Using FISH, GST-pi amplification is a common event in head and neck squamous cell carcinoma and may be associated with cisplatin resistance and poor clinical outcomes in head and neck cancer patients treated with cisplatin-based therapy.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 304-310 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14678959-0#0#25#gene27306 0-25 gene27306 denotes Glutathione S-transferase
14678959-0#86#123#diseaseC1168401 86-123 diseaseC1168401 denotes head and neck squamous cell carcinoma
14678959-1#46#71#gene27306 210-235 gene27306 denotes glutathione S-transferase
14678959-1#126#146#diseaseC0278996 290-310 diseaseC0278996 denotes head and neck cancer
14678959-13#12#15#gene373156 1625-1628 gene373156 denotes GST
14678959-13#12#15#gene133482 1625-1628 gene133482 denotes GST
14678959-13#12#15#gene373156 1625-1628 gene373156 denotes GST
14678959-13#12#15#gene133482 1625-1628 gene133482 denotes GST
14678959-13#54#91#diseaseC1168401 1667-1704 diseaseC1168401 denotes head and neck squamous cell carcinoma
14678959-13#170#190#diseaseC0278996 1783-1803 diseaseC0278996 denotes head and neck cancer
0#25#gene2730686#123#diseaseC1168401 14678959-0#0#25#gene27306 14678959-0#86#123#diseaseC1168401 associated_with Glutathione S-transferase,head and neck squamous cell carcinoma
46#71#gene27306126#146#diseaseC0278996 14678959-1#46#71#gene27306 14678959-1#126#146#diseaseC0278996 associated_with glutathione S-transferase,head and neck cancer
12#15#gene37315654#91#diseaseC1168401 14678959-13#12#15#gene373156 14678959-13#54#91#diseaseC1168401 associated_with GST,head and neck squamous cell carcinoma
12#15#gene373156170#190#diseaseC0278996 14678959-13#12#15#gene373156 14678959-13#170#190#diseaseC0278996 associated_with GST,head and neck cancer
12#15#gene13348254#91#diseaseC1168401 14678959-13#12#15#gene133482 14678959-13#54#91#diseaseC1168401 associated_with GST,head and neck squamous cell carcinoma
12#15#gene133482170#190#diseaseC0278996 14678959-13#12#15#gene133482 14678959-13#170#190#diseaseC0278996 associated_with GST,head and neck cancer
12#15#gene37315654#91#diseaseC1168401 14678959-13#12#15#gene373156 14678959-13#54#91#diseaseC1168401 associated_with GST,head and neck squamous cell carcinoma
12#15#gene373156170#190#diseaseC0278996 14678959-13#12#15#gene373156 14678959-13#170#190#diseaseC0278996 associated_with GST,head and neck cancer
12#15#gene13348254#91#diseaseC1168401 14678959-13#12#15#gene133482 14678959-13#54#91#diseaseC1168401 associated_with GST,head and neck squamous cell carcinoma
12#15#gene133482170#190#diseaseC0278996 14678959-13#12#15#gene133482 14678959-13#170#190#diseaseC0278996 associated_with GST,head and neck cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-25 gene:27306 denotes Glutathione S-transferase
T1 86-123 disease:C1168401 denotes head and neck squamous cell carcinoma
T2 240-243 gene:373156 denotes GST
T3 290-310 disease:C0278996 denotes head and neck cancer
T4 210-235 gene:27306 denotes glutathione S-transferase
T5 290-310 disease:C0278996 denotes head and neck cancer
T6 240-243 gene:133482 denotes GST
T7 290-310 disease:C0278996 denotes head and neck cancer
R1 T0 T1 associated_with Glutathione S-transferase,head and neck squamous cell carcinoma
R2 T2 T3 associated_with GST,head and neck cancer
R3 T4 T5 associated_with glutathione S-transferase,head and neck cancer
R4 T6 T7 associated_with GST,head and neck cancer