PubMed:14663338
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 150-318 | DRI_Outcome | denotes | Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during the first day after focal ischemia and might be involved in the pathogenesis of tissue damage. |
| T2 | 319-442 | DRI_Outcome | denotes | We previously showed MMP-9 in the extracellular space of brain parenchyma along with neutrophil recruitment after ischemia. |
| T3 | 443-556 | DRI_Approach | denotes | In the present study, we tested whether neutrophils were a direct source of enhanced MMP-9 in the ischemic brain. |
| T4 | 557-738 | DRI_Background | denotes | Neutrophil infiltration was prevented either by injecting an antibody against ICAM-1, which abrogates neutrophil adhesion to the endothelial vessel wall, or by inducing neutropenia. |
| T5 | 739-863 | DRI_Background | denotes | One-hour intraluminal middle cerebral artery occlusion with reperfusion was induced, and studies were performed at 24 hours. |
| T6 | 979-1010 | DRI_Background | denotes | The expression of MMP-9 (mainly |
| T7 | 1026-1121 | DRI_Background | denotes | and dimers and, to a lesser extent, 88-kDa form) increased in brain after ischemia/reperfusion. |
| T8 | 1122-1219 | DRI_Background | denotes | Treatments preventing neutrophil infiltration failed to preclude the ischemia-induced increase in |
| T9 | 1233-1291 | DRI_Background | denotes | form and gelatinase activity in neurons and blood vessels. |
| T10 | 1292-1349 | DRI_Background | denotes | However, these treatments prevented the major increase in |
| T11 | 1363-1379 | DRI_Background | denotes | form and dimers. |
| T12 | 1380-1492 | DRI_Challenge | denotes | We conclude that neutrophil infiltration highly contributes to enhanced MMP-9 in the ischemic brain by releasing |
| T13 | 1506-1570 | DRI_Challenge | denotes | , which might participate in the tissular inflammatory reaction. |
c_corpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-10 | CL:0000775 | denotes | Neutrophil |
| T2 | 34-40 | UBERON:0027368 | denotes | matrix |
| T4 | 34-60 | P14780 | denotes | matrix metalloproteinase-9 |
| T5 | 34-60 | P41246 | denotes | matrix metalloproteinase-9 |
| T6 | 34-60 | P41245 | denotes | matrix metalloproteinase-9 |
| T7 | 34-60 | P50282 | denotes | matrix metalloproteinase-9 |
| T8 | 34-60 | PR:000010491 | denotes | matrix metalloproteinase-9 |
| T9 | 34-60 | P52176 | denotes | matrix metalloproteinase-9 |
| T10 | 34-60 | O18733 | denotes | matrix metalloproteinase-9 |
| T3 | 34-60 | D020780 | denotes | matrix metalloproteinase-9 |
| T11 | 77-82 | UBERON:6110636 | denotes | brain |
| T12 | 77-82 | UBERON:0000955 | denotes | brain |
| T13 | 118-140 | UBERON:0001627 | denotes | middle cerebral artery |
| T14 | 125-140 | D002539 | denotes | cerebral artery |
| T16 | 125-140 | D002539 | denotes | cerebral artery |
| T18 | 144-148 | 10118 | denotes | rats |
| T19 | 144-148 | 10116 | denotes | rats |
| T20 | 144-148 | D051381 | denotes | rats |
| T21 | 178-181 | CHEBI:340824 | denotes | MMP |
| T24 | 178-181 | CHEBI:59761 | denotes | MMP |
| T25 | 178-183 | PR:P50282 | denotes | MMP-9 |
| T26 | 178-183 | PR:P14780 | denotes | MMP-9 |
| T27 | 178-183 | P14780 | denotes | MMP-9 |
| T28 | 178-183 | PR:P41245 | denotes | MMP-9 |
| T29 | 178-183 | P41246 | denotes | MMP-9 |
| T30 | 178-183 | P41245 | denotes | MMP-9 |
| T31 | 178-183 | PR:P52176 | denotes | MMP-9 |
| T32 | 178-183 | P50282 | denotes | MMP-9 |
| T34 | 178-183 | PR:000010491 | denotes | MMP-9 |
| T35 | 178-183 | P52176 | denotes | MMP-9 |
| T36 | 178-183 | O18733 | denotes | MMP-9 |
| T33 | 178-183 | GO:0004229 | denotes | MMP-9 |
| T37 | 207-216 | UBERON:0000955 | denotes | the brain |
| T40 | 250-258 | D007511 | denotes | ischemia |
| T41 | 250-258 | D007511 | denotes | ischemia |
| T42 | 288-300 | GO:0009405 | denotes | pathogenesis |
| T43 | 304-310 | UBERON:0000479 | denotes | tissue |
| T44 | 340-343 | CHEBI:340824 | denotes | MMP |
| T47 | 340-343 | CHEBI:59761 | denotes | MMP |
| T48 | 340-345 | PR:P50282 | denotes | MMP-9 |
| T49 | 340-345 | PR:P14780 | denotes | MMP-9 |
| T50 | 340-345 | P14780 | denotes | MMP-9 |
| T51 | 340-345 | PR:P41245 | denotes | MMP-9 |
| T52 | 340-345 | P41246 | denotes | MMP-9 |
| T53 | 340-345 | P41245 | denotes | MMP-9 |
| T54 | 340-345 | PR:P52176 | denotes | MMP-9 |
| T55 | 340-345 | P50282 | denotes | MMP-9 |
| T57 | 340-345 | PR:000010491 | denotes | MMP-9 |
| T58 | 340-345 | P52176 | denotes | MMP-9 |
| T59 | 340-345 | O18733 | denotes | MMP-9 |
| T56 | 340-345 | GO:0004229 | denotes | MMP-9 |
| T61 | 353-372 | GO:0005615 | denotes | extracellular space |
| T62 | 376-381 | UBERON:6110636 | denotes | brain |
| T63 | 376-381 | UBERON:0000955 | denotes | brain |
| T64 | 382-392 | UBERON:0000353 | denotes | parenchyma |
| T65 | 404-414 | CL:0000775 | denotes | neutrophil |
| T66 | 433-441 | D007511 | denotes | ischemia |
| T67 | 433-441 | D007511 | denotes | ischemia |
| T68 | 528-531 | CHEBI:340824 | denotes | MMP |
| T71 | 528-531 | CHEBI:59761 | denotes | MMP |
| T72 | 528-533 | PR:P50282 | denotes | MMP-9 |
| T73 | 528-533 | PR:P14780 | denotes | MMP-9 |
| T74 | 528-533 | P14780 | denotes | MMP-9 |
| T75 | 528-533 | PR:P41245 | denotes | MMP-9 |
| T76 | 528-533 | P41246 | denotes | MMP-9 |
| T77 | 528-533 | P41245 | denotes | MMP-9 |
| T78 | 528-533 | PR:P52176 | denotes | MMP-9 |
| T79 | 528-533 | P50282 | denotes | MMP-9 |
| T81 | 528-533 | PR:000010491 | denotes | MMP-9 |
| T82 | 528-533 | P52176 | denotes | MMP-9 |
| T83 | 528-533 | O18733 | denotes | MMP-9 |
| T80 | 528-533 | GO:0004229 | denotes | MMP-9 |
| T84 | 550-555 | UBERON:6110636 | denotes | brain |
| T85 | 550-555 | UBERON:0000955 | denotes | brain |
| T86 | 557-567 | CL:0000775 | denotes | Neutrophil |
| T87 | 618-626 | GO:0019815 | denotes | antibody |
| T88 | 618-626 | GO:0042571 | denotes | antibody |
| T89 | 618-626 | GO:0019814 | denotes | antibody |
| T90 | 618-626 | GO:0003823 | denotes | antibody |
| T92 | 635-641 | PR:Q00238 | denotes | ICAM-1 |
| T93 | 635-641 | P13597 | denotes | ICAM-1 |
| T95 | 635-641 | Q5NKV9 | denotes | ICAM-1 |
| T96 | 635-641 | Q00238 | denotes | ICAM-1 |
| T97 | 635-641 | P33729 | denotes | ICAM-1 |
| T98 | 635-641 | PR:P05362 | denotes | ICAM-1 |
| T100 | 635-641 | P05362 | denotes | ICAM-1 |
| T101 | 635-641 | Q5NKV4 | denotes | ICAM-1 |
| T102 | 635-641 | Q28806 | denotes | ICAM-1 |
| T103 | 635-641 | Q5NKV6 | denotes | ICAM-1 |
| T104 | 635-641 | Q95132 | denotes | ICAM-1 |
| T105 | 635-641 | PR:000001467 | denotes | ICAM-1 |
| T106 | 635-641 | PR:P13597 | denotes | ICAM-1 |
| T94 | 635-641 | D018799 | denotes | ICAM-1 |
| T99 | 635-641 | D018799 | denotes | ICAM-1 |
| T107 | 659-669 | CL:0000775 | denotes | neutrophil |
| T108 | 698-704 | UBERON:0000055 | denotes | vessel |
| T109 | 705-709 | UBERON:0000060 | denotes | wall |
| T110 | 726-737 | D009503 | denotes | neutropenia |
| T111 | 726-737 | D009503 | denotes | neutropenia |
| T112 | 761-783 | UBERON:0001627 | denotes | middle cerebral artery |
| T113 | 761-793 | D020244 | denotes | middle cerebral artery occlusion |
| T114 | 761-793 | D020244 | denotes | middle cerebral artery occlusion |
| T120 | 905-908 | CHEBI:340824 | denotes | MMP |
| T123 | 905-908 | CHEBI:59761 | denotes | MMP |
| T124 | 905-910 | PR:P50282 | denotes | MMP-9 |
| T125 | 905-910 | PR:P14780 | denotes | MMP-9 |
| T126 | 905-910 | P14780 | denotes | MMP-9 |
| T127 | 905-910 | PR:P41245 | denotes | MMP-9 |
| T128 | 905-910 | P41246 | denotes | MMP-9 |
| T129 | 905-910 | P41245 | denotes | MMP-9 |
| T130 | 905-910 | PR:P52176 | denotes | MMP-9 |
| T131 | 905-910 | P50282 | denotes | MMP-9 |
| T133 | 905-910 | PR:000010491 | denotes | MMP-9 |
| T134 | 905-910 | P52176 | denotes | MMP-9 |
| T135 | 905-910 | O18733 | denotes | MMP-9 |
| T132 | 905-910 | GO:0004229 | denotes | MMP-9 |
| T136 | 972-975 | CHEBI:340824 | denotes | MMP |
| T139 | 972-975 | CHEBI:59761 | denotes | MMP |
| T140 | 972-977 | PR:P50282 | denotes | MMP-9 |
| T141 | 972-977 | PR:P14780 | denotes | MMP-9 |
| T142 | 972-977 | P14780 | denotes | MMP-9 |
| T143 | 972-977 | PR:P41245 | denotes | MMP-9 |
| T144 | 972-977 | P41246 | denotes | MMP-9 |
| T145 | 972-977 | P41245 | denotes | MMP-9 |
| T146 | 972-977 | PR:P52176 | denotes | MMP-9 |
| T147 | 972-977 | P50282 | denotes | MMP-9 |
| T149 | 972-977 | PR:000010491 | denotes | MMP-9 |
| T150 | 972-977 | P52176 | denotes | MMP-9 |
| T151 | 972-977 | O18733 | denotes | MMP-9 |
| T148 | 972-977 | GO:0004229 | denotes | MMP-9 |
| T152 | 997-1000 | CHEBI:340824 | denotes | MMP |
| T155 | 997-1000 | CHEBI:59761 | denotes | MMP |
| T156 | 997-1002 | PR:P50282 | denotes | MMP-9 |
| T157 | 997-1002 | PR:P14780 | denotes | MMP-9 |
| T158 | 997-1002 | P14780 | denotes | MMP-9 |
| T159 | 997-1002 | PR:P41245 | denotes | MMP-9 |
| T160 | 997-1002 | P41246 | denotes | MMP-9 |
| T161 | 997-1002 | P41245 | denotes | MMP-9 |
| T162 | 997-1002 | PR:P52176 | denotes | MMP-9 |
| T163 | 997-1002 | P50282 | denotes | MMP-9 |
| T165 | 997-1002 | PR:000010491 | denotes | MMP-9 |
| T166 | 997-1002 | P52176 | denotes | MMP-9 |
| T167 | 997-1002 | O18733 | denotes | MMP-9 |
| T164 | 997-1002 | GO:0004229 | denotes | MMP-9 |
| T169 | 1088-1093 | UBERON:6110636 | denotes | brain |
| T170 | 1088-1093 | UBERON:0000955 | denotes | brain |
| T171 | 1100-1108 | D007511 | denotes | ischemia |
| T172 | 1100-1108 | D007511 | denotes | ischemia |
| T173 | 1144-1154 | CL:0000775 | denotes | neutrophil |
| T174 | 1191-1199 | D007511 | denotes | ischemia |
| T175 | 1191-1199 | D007511 | denotes | ischemia |
| T176 | 1227-1230 | CHEBI:340824 | denotes | MMP |
| T179 | 1227-1230 | CHEBI:59761 | denotes | MMP |
| T180 | 1227-1232 | PR:P50282 | denotes | MMP-9 |
| T181 | 1227-1232 | PR:P14780 | denotes | MMP-9 |
| T182 | 1227-1232 | P14780 | denotes | MMP-9 |
| T183 | 1227-1232 | PR:P41245 | denotes | MMP-9 |
| T184 | 1227-1232 | P41246 | denotes | MMP-9 |
| T185 | 1227-1232 | P41245 | denotes | MMP-9 |
| T186 | 1227-1232 | PR:P52176 | denotes | MMP-9 |
| T187 | 1227-1232 | P50282 | denotes | MMP-9 |
| T189 | 1227-1232 | PR:000010491 | denotes | MMP-9 |
| T190 | 1227-1232 | P52176 | denotes | MMP-9 |
| T191 | 1227-1232 | O18733 | denotes | MMP-9 |
| T188 | 1227-1232 | GO:0004229 | denotes | MMP-9 |
| T193 | 1242-1252 | Q833V7 | denotes | gelatinase |
| T192 | 1242-1252 | D018093 | denotes | gelatinase |
| T194 | 1277-1290 | UBERON:0004537 | denotes | blood vessels |
| T195 | 1357-1360 | CHEBI:340824 | denotes | MMP |
| T198 | 1357-1360 | CHEBI:59761 | denotes | MMP |
| T199 | 1357-1362 | PR:P50282 | denotes | MMP-9 |
| T200 | 1357-1362 | PR:P14780 | denotes | MMP-9 |
| T201 | 1357-1362 | P14780 | denotes | MMP-9 |
| T202 | 1357-1362 | PR:P41245 | denotes | MMP-9 |
| T203 | 1357-1362 | P41246 | denotes | MMP-9 |
| T204 | 1357-1362 | P41245 | denotes | MMP-9 |
| T205 | 1357-1362 | PR:P52176 | denotes | MMP-9 |
| T206 | 1357-1362 | P50282 | denotes | MMP-9 |
| T208 | 1357-1362 | PR:000010491 | denotes | MMP-9 |
| T209 | 1357-1362 | P52176 | denotes | MMP-9 |
| T210 | 1357-1362 | O18733 | denotes | MMP-9 |
| T207 | 1357-1362 | GO:0004229 | denotes | MMP-9 |
| T211 | 1397-1407 | CL:0000775 | denotes | neutrophil |
| T212 | 1452-1455 | CHEBI:340824 | denotes | MMP |
| T215 | 1452-1455 | CHEBI:59761 | denotes | MMP |
| T216 | 1452-1457 | PR:P50282 | denotes | MMP-9 |
| T217 | 1452-1457 | PR:P14780 | denotes | MMP-9 |
| T218 | 1452-1457 | P14780 | denotes | MMP-9 |
| T219 | 1452-1457 | PR:P41245 | denotes | MMP-9 |
| T220 | 1452-1457 | P41246 | denotes | MMP-9 |
| T221 | 1452-1457 | P41245 | denotes | MMP-9 |
| T222 | 1452-1457 | PR:P52176 | denotes | MMP-9 |
| T223 | 1452-1457 | P50282 | denotes | MMP-9 |
| T225 | 1452-1457 | PR:000010491 | denotes | MMP-9 |
| T226 | 1452-1457 | P52176 | denotes | MMP-9 |
| T227 | 1452-1457 | O18733 | denotes | MMP-9 |
| T224 | 1452-1457 | GO:0004229 | denotes | MMP-9 |
| T228 | 1474-1479 | UBERON:6110636 | denotes | brain |
| T229 | 1474-1479 | UBERON:0000955 | denotes | brain |
| T230 | 1493-1496 | CHEBI:340824 | denotes | MMP |
| T233 | 1493-1496 | CHEBI:59761 | denotes | MMP |
| T234 | 1493-1498 | PR:P50282 | denotes | MMP-9 |
| T235 | 1493-1498 | PR:P14780 | denotes | MMP-9 |
| T236 | 1493-1498 | P14780 | denotes | MMP-9 |
| T237 | 1493-1498 | PR:P41245 | denotes | MMP-9 |
| T238 | 1493-1498 | P41246 | denotes | MMP-9 |
| T239 | 1493-1498 | P41245 | denotes | MMP-9 |
| T240 | 1493-1498 | PR:P52176 | denotes | MMP-9 |
| T241 | 1493-1498 | P50282 | denotes | MMP-9 |
| T243 | 1493-1498 | PR:000010491 | denotes | MMP-9 |
| T244 | 1493-1498 | P52176 | denotes | MMP-9 |
| T245 | 1493-1498 | O18733 | denotes | MMP-9 |
| T242 | 1493-1498 | GO:0004229 | denotes | MMP-9 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 726-737 | HP_0001875 | denotes | neutropenia |
UseCases_ArguminSci_Discourse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-149 | DRI_Approach | denotes | Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats. |
| T2 | 150-318 | DRI_Outcome | denotes | Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during the first day after focal ischemia and might be involved in the pathogenesis of tissue damage. |
| T3 | 319-442 | DRI_Outcome | denotes | We previously showed MMP-9 in the extracellular space of brain parenchyma along with neutrophil recruitment after ischemia. |
| T4 | 443-556 | DRI_Approach | denotes | In the present study, we tested whether neutrophils were a direct source of enhanced MMP-9 in the ischemic brain. |
| T5 | 557-738 | DRI_Background | denotes | Neutrophil infiltration was prevented either by injecting an antibody against ICAM-1, which abrogates neutrophil adhesion to the endothelial vessel wall, or by inducing neutropenia. |
| T6 | 739-863 | DRI_Background | denotes | One-hour intraluminal middle cerebral artery occlusion with reperfusion was induced, and studies were performed at 24 hours. |
| T7 | 864-897 | DRI_Unspecified | denotes | Circulating neutrophils expressed |
| T8 | 898-910 | Token_Label.OUTSIDE | denotes | 95-kDa MMP-9 |
| T9 | 911-978 | DRI_Unspecified | denotes | and dimers, and infiltrated neutrophils stained positive for MMP-9. |
| T10 | 979-1010 | DRI_Background | denotes | The expression of MMP-9 (mainly |
| T11 | 1011-1025 | Token_Label.OUTSIDE | denotes | 95-kDa proform |
| T12 | 1026-1121 | DRI_Background | denotes | and dimers and, to a lesser extent, 88-kDa form) increased in brain after ischemia/reperfusion. |
| T13 | 1122-1219 | DRI_Background | denotes | Treatments preventing neutrophil infiltration failed to preclude the ischemia-induced increase in |
| T14 | 1220-1232 | Token_Label.OUTSIDE | denotes | 88-kDa MMP-9 |
| T15 | 1233-1291 | DRI_Background | denotes | form and gelatinase activity in neurons and blood vessels. |
| T16 | 1292-1349 | DRI_Background | denotes | However, these treatments prevented the major increase in |
| T17 | 1350-1362 | Token_Label.OUTSIDE | denotes | 95-kDa MMP-9 |
| T18 | 1363-1379 | DRI_Background | denotes | form and dimers. |
| T19 | 1380-1492 | DRI_Challenge | denotes | We conclude that neutrophil infiltration highly contributes to enhanced MMP-9 in the ischemic brain by releasing |
| T20 | 1493-1506 | Token_Label.OUTSIDE | denotes | MMP-9 proform |
| T21 | 1506-1570 | DRI_Challenge | denotes | , which might participate in the tissular inflammatory reaction. |