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PubMed:14663336 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 116-289 DRI_Challenge denotes During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina.
T2 290-413 DRI_Background denotes MMP-2 is secreted in latent form (pro-MMP-2), but the activation of pro-MMP-2 in the ischemic territory has not been shown.
T3 414-795 DRI_Background denotes Immunohistochemical and in situ hybridization studies of the expression of the direct activators of MMP-2, MT1-MMP and MT3-MMP, and the indirect activation system tissue plasminogen activator, urokinase (u-PA), its receptor (u-PAR), and its inhibitor PAI-1 after middle cerebral artery occlusion/reperfusion were undertaken in basal ganglia samples from 26 adolescent male baboons.
T4 796-980 DRI_Outcome denotes The expressions of all three MMPs, u-PA, u-PAR, and PA1-1, but not tissue plasminogen activator, were increased from 1 hour after middle cerebral artery occlusion in the ischemic core.
T5 981-1120 DRI_Outcome denotes mRNA transcripts confirmed the increases in latent MMP-2, u-PA, u-PAR, and PAI-1 antigen very early after middle cerebral artery occlusion.
T6 1121-1269 DRI_Outcome denotes The expression patterns are consistent with secretion of pro-MMP-2 and its activators in the ischemic core, perhaps from separate cell compartments.
T7 1270-1463 DRI_Outcome denotes The rapid and coordinate appearance of pro-MMP-2 and its activation apparatus suggest that in the primate striatum this protease may participate in matrix injury during focal cerebral ischemia.

c_corpus

Id Subject Object Predicate Lexical cue
T1 30-36 UBERON:0027368 denotes matrix
T2 30-56 Q9GLE5 denotes matrix metalloproteinase-2
T3 30-56 P08253 denotes matrix metalloproteinase-2
T4 30-56 Q8MPP3 denotes matrix metalloproteinase-2
T5 30-56 Q90611 denotes matrix metalloproteinase-2
T7 30-56 PR:000010479 denotes matrix metalloproteinase-2
T8 30-56 P33436 denotes matrix metalloproteinase-2
T9 30-56 P33434 denotes matrix metalloproteinase-2
T10 30-56 P50757 denotes matrix metalloproteinase-2
T6 30-56 D020778 denotes matrix metalloproteinase-2
T12 97-114 D002545 denotes cerebral ischemia
T13 97-114 D002545 denotes cerebral ischemia
T16 129-146 D002545 denotes cerebral ischemia
T17 129-146 D002545 denotes cerebral ischemia
T20 148-154 UBERON:0027368 denotes matrix
T21 148-174 Q9GLE5 denotes matrix metalloproteinase-2
T22 148-174 P08253 denotes matrix metalloproteinase-2
T23 148-174 Q8MPP3 denotes matrix metalloproteinase-2
T24 148-174 Q90611 denotes matrix metalloproteinase-2
T26 148-174 PR:000010479 denotes matrix metalloproteinase-2
T27 148-174 P33436 denotes matrix metalloproteinase-2
T28 148-174 P33434 denotes matrix metalloproteinase-2
T29 148-174 P50757 denotes matrix metalloproteinase-2
T25 148-174 D020778 denotes matrix metalloproteinase-2
T31 173-179 PR:O04529 denotes 2 (MMP
T32 176-179 CHEBI:340824 denotes MMP
T35 176-179 CHEBI:59761 denotes MMP
T36 176-181 PR:P08253 denotes MMP-2
T37 176-181 Q9GLE5 denotes MMP-2
T38 176-181 P08253 denotes MMP-2
T39 176-181 Q90611 denotes MMP-2
T41 176-181 PR:Q8MPP3 denotes MMP-2
T42 176-181 P33436 denotes MMP-2
T43 176-181 PR:Q90611 denotes MMP-2
T44 176-181 PR:P33436 denotes MMP-2
T45 176-181 PR:000010479 denotes MMP-2
T46 176-181 PR:P33434 denotes MMP-2
T47 176-181 P33434 denotes MMP-2
T48 176-181 P50757 denotes MMP-2
T40 176-181 GO:0004228 denotes MMP-2
T49 276-288 GO:0005604 denotes basal lamina
T50 276-288 UBERON:0000482 denotes basal lamina
T54 290-293 CHEBI:340824 denotes MMP
T57 290-293 CHEBI:59761 denotes MMP
T58 290-295 PR:P08253 denotes MMP-2
T59 290-295 Q9GLE5 denotes MMP-2
T60 290-295 P08253 denotes MMP-2
T61 290-295 Q90611 denotes MMP-2
T63 290-295 PR:Q8MPP3 denotes MMP-2
T64 290-295 P33436 denotes MMP-2
T65 290-295 PR:Q90611 denotes MMP-2
T66 290-295 PR:P33436 denotes MMP-2
T67 290-295 PR:000010479 denotes MMP-2
T68 290-295 PR:P33434 denotes MMP-2
T69 290-295 P33434 denotes MMP-2
T70 290-295 P50757 denotes MMP-2
T62 290-295 GO:0004228 denotes MMP-2
T71 324-327 CVCL_N817 denotes pro
T75 324-327 SO:0001439 denotes pro
T77 324-333 C069860 denotes pro-MMP-2
T82 328-333 PR:P08253 denotes MMP-2
T83 328-333 Q9GLE5 denotes MMP-2
T84 328-333 P08253 denotes MMP-2
T85 328-333 Q90611 denotes MMP-2
T87 328-333 PR:Q8MPP3 denotes MMP-2
T88 328-333 P33436 denotes MMP-2
T89 328-333 PR:Q90611 denotes MMP-2
T90 328-333 PR:P33436 denotes MMP-2
T91 328-333 PR:000010479 denotes MMP-2
T92 328-333 PR:P33434 denotes MMP-2
T93 328-333 P33434 denotes MMP-2
T94 328-333 P50757 denotes MMP-2
T86 328-333 GO:0004228 denotes MMP-2
T95 358-361 CVCL_N817 denotes pro
T99 358-361 SO:0001439 denotes pro
T101 358-367 C069860 denotes pro-MMP-2
T106 362-367 PR:P08253 denotes MMP-2
T107 362-367 Q9GLE5 denotes MMP-2
T108 362-367 P08253 denotes MMP-2
T109 362-367 Q90611 denotes MMP-2
T111 362-367 PR:Q8MPP3 denotes MMP-2
T112 362-367 P33436 denotes MMP-2
T113 362-367 PR:Q90611 denotes MMP-2
T114 362-367 PR:P33436 denotes MMP-2
T115 362-367 PR:000010479 denotes MMP-2
T116 362-367 PR:P33434 denotes MMP-2
T117 362-367 P33434 denotes MMP-2
T118 362-367 P50757 denotes MMP-2
T110 362-367 GO:0004228 denotes MMP-2
T119 514-517 CHEBI:340824 denotes MMP
T122 514-517 CHEBI:59761 denotes MMP
T123 514-519 PR:P08253 denotes MMP-2
T124 514-519 Q9GLE5 denotes MMP-2
T125 514-519 P08253 denotes MMP-2
T126 514-519 Q90611 denotes MMP-2
T128 514-519 PR:Q8MPP3 denotes MMP-2
T129 514-519 P33436 denotes MMP-2
T130 514-519 PR:Q90611 denotes MMP-2
T131 514-519 PR:P33436 denotes MMP-2
T132 514-519 PR:000010479 denotes MMP-2
T133 514-519 PR:P33434 denotes MMP-2
T134 514-519 P33434 denotes MMP-2
T135 514-519 P50757 denotes MMP-2
T127 514-519 GO:0004228 denotes MMP-2
T158 521-524 CVCL_2501 denotes MT1
T143 521-524 GO:0047152 denotes MT1
T152 521-524 GO:0043791 denotes MT1
T161 521-524 GO:0043834 denotes MT1
T177 521-528 Q9XT90 denotes MT1-MMP
T178 521-528 P50281 denotes MT1-MMP
T179 521-528 Q9GLE4 denotes MT1-MMP
T180 521-528 PR:000010474 denotes MT1-MMP
T181 521-528 Q10739 denotes MT1-MMP
T182 521-528 Q95220 denotes MT1-MMP
T184 521-528 P53690 denotes MT1-MMP
T183 521-528 D053511 denotes MT1-MMP
T187 525-528 GO:0004235 denotes MMP
T191 533-536 CVCL_M516 denotes MT3
T196 533-536 CVCL_M520 denotes MT3
T198 533-536 CVCL_2129 denotes MT3
T215 533-540 P51512 denotes MT3-MMP
T216 533-540 O35548 denotes MT3-MMP
T218 533-540 PR:000010476 denotes MT3-MMP
T219 533-540 Q9WTR0 denotes MT3-MMP
T217 533-540 D053513 denotes MT3-MMP
T222 537-540 GO:0004235 denotes MMP
T225 577-583 UBERON:0000479 denotes tissue
T226 577-605 D010959 denotes tissue plasminogen activator
T227 577-605 D010959 denotes tissue plasminogen activator
T246 584-605 P17811 denotes plasminogen activator
T248 607-616 D014568 denotes urokinase
T250 618-622 D014568 denotes u-PA
T249 618-622 GO:0008243 denotes u-PA
T251 639-644 P49616 denotes u-PAR
T252 639-644 PR:000001969 denotes u-PAR
T253 639-644 Q9GK79 denotes u-PAR
T254 639-644 Q9GK80 denotes u-PAR
T255 639-644 Q05588 denotes u-PAR
T256 639-644 Q9GK78 denotes u-PAR
T257 639-644 Q03405 denotes u-PAR
T258 639-644 Q9GK77 denotes u-PAR
T259 639-644 P35456 denotes u-PAR
T261 641-644 44741 denotes PAR
T260 641-644 CVCL_E801 denotes PAR
T262 655-664 CHEBI:35222 denotes inhibitor
T268 665-668 CVCL_0479 denotes PAI
T271 665-668 CVCL_J288 denotes PAI
T272 665-670 P22777 denotes PAI-1
T273 665-670 P13909 denotes PAI-1
T274 665-670 PR:P05121 denotes PAI-1
T276 665-670 P05121 denotes PAI-1
T277 665-670 P50449 denotes PAI-1
T278 665-670 PR:P20961 denotes PAI-1
T279 665-670 P79335 denotes PAI-1
T280 665-670 PR:Q42440 denotes PAI-1
T281 665-670 PR:P22777 denotes PAI-1
T283 665-670 P20961 denotes PAI-1
T284 665-670 PR:000014702 denotes PAI-1
T275 665-670 D017395 denotes PAI-1
T282 665-670 D017395 denotes PAI-1
T285 677-699 UBERON:0001627 denotes middle cerebral artery
T286 677-709 D020244 denotes middle cerebral artery occlusion
T287 677-709 D020244 denotes middle cerebral artery occlusion
T292 741-754 UBERON:0002420 denotes basal ganglia
T295 741-754 UBERON:0006098 denotes basal ganglia
T296 741-754 UBERON:0010011 denotes basal ganglia
T293 741-754 D001480 denotes basal ganglia
T294 741-754 D001480 denotes basal ganglia
T298 782-786 UBERON:0003101 denotes male
T299 782-786 CHEBI:30780 denotes male
T300 787-794 D010215 denotes baboons
T301 825-829 D020782 denotes MMPs
T303 831-835 D014568 denotes u-PA
T302 831-835 GO:0008243 denotes u-PA
T304 837-842 P49616 denotes u-PAR
T305 837-842 PR:000001969 denotes u-PAR
T306 837-842 Q9GK79 denotes u-PAR
T307 837-842 Q9GK80 denotes u-PAR
T308 837-842 Q05588 denotes u-PAR
T309 837-842 Q9GK78 denotes u-PAR
T310 837-842 Q03405 denotes u-PAR
T311 837-842 Q9GK77 denotes u-PAR
T312 837-842 P35456 denotes u-PAR
T314 839-842 44741 denotes PAR
T313 839-842 CVCL_E801 denotes PAR
T315 848-851 PR:Q99L02 denotes PA1
T317 848-851 PR:Q9BTK6 denotes PA1
T319 848-851 PR:000012201 denotes PA1
T320 848-851 Q41480 denotes PA1
T316 848-851 CVCL_T887 denotes PA1
T318 848-851 CVCL_0479 denotes PA1
T321 848-851 CVCL_J288 denotes PA1
T322 863-869 UBERON:0000479 denotes tissue
T323 863-891 D010959 denotes tissue plasminogen activator
T324 863-891 D010959 denotes tissue plasminogen activator
T343 870-891 P17811 denotes plasminogen activator
T345 926-948 UBERON:0001627 denotes middle cerebral artery
T346 926-958 D020244 denotes middle cerebral artery occlusion
T347 926-958 D020244 denotes middle cerebral artery occlusion
T352 975-979 GO:0019013 denotes core
T355 981-985 SO:0000234 denotes mRNA
T353 981-985 D012333 denotes mRNA
T354 981-985 CHEBI:33699 denotes mRNA
T356 1032-1035 CHEBI:340824 denotes MMP
T359 1032-1035 CHEBI:59761 denotes MMP
T360 1032-1037 PR:P08253 denotes MMP-2
T361 1032-1037 Q9GLE5 denotes MMP-2
T362 1032-1037 P08253 denotes MMP-2
T363 1032-1037 Q90611 denotes MMP-2
T365 1032-1037 PR:Q8MPP3 denotes MMP-2
T366 1032-1037 P33436 denotes MMP-2
T367 1032-1037 PR:Q90611 denotes MMP-2
T368 1032-1037 PR:P33436 denotes MMP-2
T369 1032-1037 PR:000010479 denotes MMP-2
T370 1032-1037 PR:P33434 denotes MMP-2
T371 1032-1037 P33434 denotes MMP-2
T372 1032-1037 P50757 denotes MMP-2
T364 1032-1037 GO:0004228 denotes MMP-2
T374 1039-1043 D014568 denotes u-PA
T373 1039-1043 GO:0008243 denotes u-PA
T375 1045-1050 P49616 denotes u-PAR
T376 1045-1050 PR:000001969 denotes u-PAR
T377 1045-1050 Q9GK79 denotes u-PAR
T378 1045-1050 Q9GK80 denotes u-PAR
T379 1045-1050 Q05588 denotes u-PAR
T380 1045-1050 Q9GK78 denotes u-PAR
T381 1045-1050 Q03405 denotes u-PAR
T382 1045-1050 Q9GK77 denotes u-PAR
T383 1045-1050 P35456 denotes u-PAR
T385 1047-1050 44741 denotes PAR
T384 1047-1050 CVCL_E801 denotes PAR
T391 1056-1059 CVCL_0479 denotes PAI
T394 1056-1059 CVCL_J288 denotes PAI
T395 1056-1061 P22777 denotes PAI-1
T396 1056-1061 P13909 denotes PAI-1
T397 1056-1061 PR:P05121 denotes PAI-1
T399 1056-1061 P05121 denotes PAI-1
T400 1056-1061 P50449 denotes PAI-1
T401 1056-1061 PR:P20961 denotes PAI-1
T402 1056-1061 P79335 denotes PAI-1
T403 1056-1061 PR:Q42440 denotes PAI-1
T404 1056-1061 PR:P22777 denotes PAI-1
T406 1056-1061 P20961 denotes PAI-1
T407 1056-1061 PR:000014702 denotes PAI-1
T398 1056-1061 D017395 denotes PAI-1
T405 1056-1061 D017395 denotes PAI-1
T408 1062-1069 D000941 denotes antigen
T409 1062-1069 CHEBI:59132 denotes antigen
T410 1062-1069 D000941 denotes antigen
T411 1087-1109 UBERON:0001627 denotes middle cerebral artery
T412 1087-1119 D020244 denotes middle cerebral artery occlusion
T413 1087-1119 D020244 denotes middle cerebral artery occlusion
T418 1165-1174 GO:0046903 denotes secretion
T419 1165-1174 UBERON:0000456 denotes secretion
T424 1178-1181 SO:0001439 denotes pro
T420 1178-1181 CVCL_N817 denotes pro
T426 1178-1187 C069860 denotes pro-MMP-2
T431 1182-1187 PR:P08253 denotes MMP-2
T432 1182-1187 Q9GLE5 denotes MMP-2
T433 1182-1187 P08253 denotes MMP-2
T434 1182-1187 Q90611 denotes MMP-2
T436 1182-1187 PR:Q8MPP3 denotes MMP-2
T437 1182-1187 P33436 denotes MMP-2
T438 1182-1187 PR:Q90611 denotes MMP-2
T439 1182-1187 PR:P33436 denotes MMP-2
T440 1182-1187 PR:000010479 denotes MMP-2
T441 1182-1187 PR:P33434 denotes MMP-2
T442 1182-1187 P33434 denotes MMP-2
T443 1182-1187 P50757 denotes MMP-2
T435 1182-1187 GO:0004228 denotes MMP-2
T444 1223-1227 GO:0019013 denotes core
T449 1309-1312 SO:0001439 denotes pro
T445 1309-1312 CVCL_N817 denotes pro
T451 1309-1318 C069860 denotes pro-MMP-2
T456 1313-1318 PR:P08253 denotes MMP-2
T457 1313-1318 Q9GLE5 denotes MMP-2
T458 1313-1318 P08253 denotes MMP-2
T459 1313-1318 Q90611 denotes MMP-2
T461 1313-1318 PR:Q8MPP3 denotes MMP-2
T462 1313-1318 P33436 denotes MMP-2
T463 1313-1318 PR:Q90611 denotes MMP-2
T464 1313-1318 PR:P33436 denotes MMP-2
T465 1313-1318 PR:000010479 denotes MMP-2
T466 1313-1318 PR:P33434 denotes MMP-2
T467 1313-1318 P33434 denotes MMP-2
T468 1313-1318 P50757 denotes MMP-2
T460 1313-1318 GO:0004228 denotes MMP-2
T469 1368-1375 D011323 denotes primate
T470 1376-1384 UBERON:0002435 denotes striatum
T471 1376-1384 UBERON:0005383 denotes striatum
T472 1390-1398 P68985 denotes protease
T473 1390-1398 P30202 denotes protease
T474 1390-1398 P42672 denotes protease
T475 1390-1398 P11826 denotes protease
T476 1390-1398 Q5TJ03 denotes protease
T477 1390-1398 O71070 denotes protease
T478 1390-1398 P63122 denotes protease
T479 1390-1398 P63131 denotes protease
T480 1390-1398 Q9IIH4 denotes protease
T481 1390-1398 P10270 denotes protease
T482 1390-1398 Q8JN66 denotes protease
T483 1390-1398 O40958 denotes protease
T484 1390-1398 P10265 denotes protease
T485 1390-1398 Q9QM72 denotes protease
T486 1390-1398 P63119 denotes protease
T487 1390-1398 Q9WF19 denotes protease
T488 1390-1398 P63120 denotes protease
T489 1390-1398 P63125 denotes protease
T490 1390-1398 P63124 denotes protease
T491 1390-1398 P68986 denotes protease
T492 1390-1398 Q96629 denotes protease
T493 1390-1398 P63121 denotes protease
T494 1390-1398 P09569 denotes protease
T495 1390-1398 P03253 denotes protease
T496 1390-1398 P63129 denotes protease
T497 1390-1398 P10381 denotes protease
T498 1390-1398 P07885 denotes protease
T499 1390-1398 Q83906 denotes protease
T500 1390-1398 P19119 denotes protease
T501 1390-1398 P63127 denotes protease
T502 1390-1398 Q84177 denotes protease
T503 1390-1398 P19151 denotes protease
T504 1390-1398 Q9Y6I0 denotes protease
T505 1390-1398 P63123 denotes protease
T506 1390-1398 P68984 denotes protease
T507 1390-1398 P87563 denotes protease
T508 1390-1398 P03252 denotes protease
T509 1390-1398 O71150 denotes protease
T510 1390-1398 P11825 denotes protease
T511 1418-1424 UBERON:0027368 denotes matrix
T512 1445-1462 D002545 denotes cerebral ischemia
T513 1445-1462 D002545 denotes cerebral ischemia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 129-146 HP_0002637 denotes cerebral ischemia
T2 1445-1462 HP_0002637 denotes cerebral ischemia

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-115 DRI_Approach denotes Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia.
T2 116-289 DRI_Challenge denotes During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina.
T3 290-413 DRI_Background denotes MMP-2 is secreted in latent form (pro-MMP-2), but the activation of pro-MMP-2 in the ischemic territory has not been shown.
T4 414-795 DRI_Background denotes Immunohistochemical and in situ hybridization studies of the expression of the direct activators of MMP-2, MT1-MMP and MT3-MMP, and the indirect activation system tissue plasminogen activator, urokinase (u-PA), its receptor (u-PAR), and its inhibitor PAI-1 after middle cerebral artery occlusion/reperfusion were undertaken in basal ganglia samples from 26 adolescent male baboons.
T5 796-980 DRI_Outcome denotes The expressions of all three MMPs, u-PA, u-PAR, and PA1-1, but not tissue plasminogen activator, were increased from 1 hour after middle cerebral artery occlusion in the ischemic core.
T6 981-1120 DRI_Outcome denotes mRNA transcripts confirmed the increases in latent MMP-2, u-PA, u-PAR, and PAI-1 antigen very early after middle cerebral artery occlusion.
T7 1121-1269 DRI_Outcome denotes The expression patterns are consistent with secretion of pro-MMP-2 and its activators in the ischemic core, perhaps from separate cell compartments.
T8 1270-1463 DRI_Outcome denotes The rapid and coordinate appearance of pro-MMP-2 and its activation apparatus suggest that in the primate striatum this protease may participate in matrix injury during focal cerebral ischemia.