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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 97-306 DRI_Challenge denotes The introduction of potent antiretroviral drugs for the treatment of patients with human immunodeficiency virus (HIV) infection has dramatically reduced the prevalence of HIV-associated neurological disorders.
T2 307-365 DRI_Challenge denotes Such diseases can be mediated by proteolytic enzymes, i.e.
T3 458-656 DRI_Background denotes The aim of this study was to investigate whether the antiretroviral drugs commonly used for the treatment of HIV-infected patients modulate the activity of MMPs in astrocyte and microglial cultures.
T4 657-856 DRI_Background denotes Primary cultures of rat astrocyte and microglia were treated with different doses of zidovudine (AZT) or indinavir (IDV) for 20 h and simultaneously activated by exposure to lipopolysaccharide (LPS).
T5 857-1086 DRI_Background denotes Culture supernatants collected from astrocytes and microglia after 24 h incubation were subjected to gelatin zymography and western blot analysis for the assessment of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) protein levels.
T6 1087-1227 DRI_Background denotes Total RNA was extracted from glial cells and used for reverse transcriptase-polymerase chain reaction for the assessment of mRNA expression.
T7 1228-1336 DRI_Outcome denotes Our results indicate that both astrocyte and microglial cells constitutively express MMP-2 mRNA and protein.
T8 1337-1438 DRI_Background denotes LPS treatment increased MMP-2 mRNA and protein expression in astrocytes, but not in microglial cells.
T9 1439-1586 DRI_Outcome denotes The treatment with both AZT and IDV dose-dependently inhibited the expression of MMP-2 in astrocytes, whereas it had no effect on microglial cells.
T10 1587-1776 DRI_Background denotes The expression of MMP-9 in both astrocytes and microglia was induced by LPS treatment and was dose-dependently inhibited by AZT and IDV treatment in LPS-stimulated astrocytes and microglia.
T11 1777-2038 DRI_Background denotes These results raise the possibility that AZT and IDV interfere directly with MMP production in glial cells and independently from their antiviral activity, thus suggesting the possible therapeutical use in neurological diseases associated with MMPs involvement.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-14 D019380 denotes Anti-HIV drugs
T2 0-14 D019380 denotes Anti-HIV drugs
T3 5-8 57667 denotes HIV
T4 5-8 D006678 denotes HIV
T5 5-8 11709 denotes HIV
T6 5-8 11676 denotes HIV
T7 5-8 12721 denotes HIV
T9 42-48 UBERON:0027368 denotes matrix
T10 42-67 D020782 denotes matrix metalloproteinases
T12 86-95 CL:0000129 denotes microglia
T13 139-144 CHEBI:23888 denotes drugs
T15 180-208 12721 denotes human immunodeficiency virus
T16 180-208 D006678 denotes human immunodeficiency virus
T17 210-213 57667 denotes HIV
T18 210-213 D006678 denotes HIV
T19 210-213 11709 denotes HIV
T20 210-213 11676 denotes HIV
T21 210-213 12721 denotes HIV
T22 210-224 D015658 denotes HIV) infection
T23 210-224 D015658 denotes HIV) infection
T26 268-271 57667 denotes HIV
T27 268-271 D006678 denotes HIV
T28 268-271 11709 denotes HIV
T29 268-271 11676 denotes HIV
T30 268-271 12721 denotes HIV
T31 283-305 D009422 denotes neurological disorders
T32 283-305 D009422 denotes neurological disorders
T33 340-359 D010447 denotes proteolytic enzymes
T34 366-372 UBERON:0027368 denotes matrix
T35 366-391 D020782 denotes matrix metalloproteinases
T37 393-397 D020782 denotes MMPs
T38 418-429 D018093 denotes gelatinases
T39 526-531 CHEBI:23888 denotes drugs
T40 567-570 57667 denotes HIV
T41 567-570 D006678 denotes HIV
T42 567-570 11709 denotes HIV
T43 567-570 11676 denotes HIV
T44 567-570 12721 denotes HIV
T45 614-618 D020782 denotes MMPs
T46 622-631 CL:0000127 denotes astrocyte
T48 677-680 PR:P63003-1 denotes rat
T49 677-680 PR:Q2G0B1 denotes rat
T50 677-680 PR:Q8VHJ4 denotes rat
T47 677-680 10116 denotes rat
T51 677-680 D051381 denotes rat
T52 681-690 CL:0000127 denotes astrocyte
T53 695-704 CL:0000129 denotes microglia
T56 742-752 11413 denotes zidovudine
T54 742-752 D015215 denotes zidovudine
T55 742-752 D015215 denotes zidovudine
T57 742-752 CHEBI:10110 denotes zidovudine
T58 754-757 CHEBI:161680 denotes AZT
T59 754-757 CHEBI:10110 denotes AZT
T63 762-771 114289 denotes indinavir
T60 762-771 D019469 denotes indinavir
T61 762-771 CHEBI:44032 denotes indinavir
T62 762-771 D019469 denotes indinavir
T67 831-849 CHEBI:89981 denotes lipopolysaccharide
T68 831-849 CHEBI:16412 denotes lipopolysaccharide
T70 851-854 PR:Q9QUK6 denotes LPS
T72 851-854 PR:000001155 denotes LPS
T69 851-854 CHEBI:89981 denotes LPS
T73 851-854 CHEBI:52603 denotes LPS
T74 851-854 CHEBI:16412 denotes LPS
T71 851-854 C536528 denotes LPS
T75 908-917 CL:0000129 denotes microglia
T76 924-928 CVCL_8262 denotes 24 h
T77 958-965 4716 denotes gelatin
T78 958-965 D005780 denotes gelatin
T79 958-965 CHEBI:5291 denotes gelatin
T80 1025-1028 CHEBI:340824 denotes MMP
T83 1025-1028 CHEBI:59761 denotes MMP
T84 1025-1030 PR:P08253 denotes MMP-2
T85 1025-1030 Q9GLE5 denotes MMP-2
T86 1025-1030 P08253 denotes MMP-2
T87 1025-1030 Q90611 denotes MMP-2
T89 1025-1030 PR:Q8MPP3 denotes MMP-2
T90 1025-1030 P33436 denotes MMP-2
T91 1025-1030 PR:Q90611 denotes MMP-2
T92 1025-1030 PR:P33436 denotes MMP-2
T93 1025-1030 PR:000010479 denotes MMP-2
T94 1025-1030 PR:P33434 denotes MMP-2
T95 1025-1030 P33434 denotes MMP-2
T96 1025-1030 P50757 denotes MMP-2
T88 1025-1030 GO:0004228 denotes MMP-2
T99 1032-1044 P08253 denotes gelatinase A
T100 1032-1044 Q90611 denotes gelatinase A
T102 1032-1044 PR:000010479 denotes gelatinase A
T103 1032-1044 P33436 denotes gelatinase A
T104 1032-1044 P33434 denotes gelatinase A
T105 1032-1044 P50757 denotes gelatinase A
T101 1032-1044 D020778 denotes gelatinase A
T106 1050-1053 CHEBI:340824 denotes MMP
T109 1050-1053 CHEBI:59761 denotes MMP
T110 1050-1055 PR:P50282 denotes MMP-9
T111 1050-1055 PR:P14780 denotes MMP-9
T112 1050-1055 P14780 denotes MMP-9
T113 1050-1055 PR:P41245 denotes MMP-9
T114 1050-1055 P41246 denotes MMP-9
T115 1050-1055 P41245 denotes MMP-9
T116 1050-1055 PR:P52176 denotes MMP-9
T117 1050-1055 P50282 denotes MMP-9
T119 1050-1055 PR:000010491 denotes MMP-9
T120 1050-1055 P52176 denotes MMP-9
T121 1050-1055 O18733 denotes MMP-9
T118 1050-1055 GO:0004229 denotes MMP-9
T125 1057-1069 P14780 denotes gelatinase B
T126 1057-1069 P41246 denotes gelatinase B
T127 1057-1069 P41245 denotes gelatinase B
T128 1057-1069 P50282 denotes gelatinase B
T129 1057-1069 PR:000010491 denotes gelatinase B
T130 1057-1069 P52176 denotes gelatinase B
T131 1057-1069 O18733 denotes gelatinase B
T124 1057-1069 D020780 denotes gelatinase B
T136 1071-1078 SO:0000104 denotes protein
T135 1071-1078 PR:000000001 denotes protein
T132 1071-1078 GO:0003675 denotes protein
T133 1071-1078 CHEBI:36080 denotes protein
T134 1071-1078 CHEBI:11122 denotes protein
T140 1093-1096 SO:0000356 denotes RNA
T137 1093-1096 CHEBI:33697 denotes RNA
T138 1093-1096 D012313 denotes RNA
T139 1093-1096 GO:0005562 denotes RNA
T141 1141-1148 SO:0001031 denotes reverse
T142 1141-1162 P23072 denotes reverse transcriptase
T143 1141-1162 P21329 denotes reverse transcriptase
T144 1141-1162 P23071 denotes reverse transcriptase
T145 1141-1162 P21328 denotes reverse transcriptase
T147 1141-1162 P23070 denotes reverse transcriptase
T148 1141-1162 Q9NBX4 denotes reverse transcriptase
T149 1141-1162 Q95SX7 denotes reverse transcriptase
T146 1141-1162 D012194 denotes reverse transcriptase
T155 1149-1162 GO:0003968 denotes transcriptase
T233 1149-1162 GO:0003899 denotes transcriptase
T257 1149-1162 GO:0034062 denotes transcriptase
T274 1174-1179 SO:0000419 denotes chain
T275 1174-1188 MOP:0000635 denotes chain reaction
T278 1211-1215 SO:0000234 denotes mRNA
T276 1211-1215 D012333 denotes mRNA
T277 1211-1215 CHEBI:33699 denotes mRNA
T279 1259-1268 CL:0000127 denotes astrocyte
T280 1313-1316 CHEBI:340824 denotes MMP
T283 1313-1316 CHEBI:59761 denotes MMP
T284 1313-1318 PR:P08253 denotes MMP-2
T285 1313-1318 Q9GLE5 denotes MMP-2
T286 1313-1318 P08253 denotes MMP-2
T287 1313-1318 Q90611 denotes MMP-2
T289 1313-1318 PR:Q8MPP3 denotes MMP-2
T290 1313-1318 P33436 denotes MMP-2
T291 1313-1318 PR:Q90611 denotes MMP-2
T292 1313-1318 PR:P33436 denotes MMP-2
T293 1313-1318 PR:000010479 denotes MMP-2
T294 1313-1318 PR:P33434 denotes MMP-2
T295 1313-1318 P33434 denotes MMP-2
T296 1313-1318 P50757 denotes MMP-2
T288 1313-1318 GO:0004228 denotes MMP-2
T299 1319-1323 SO:0000234 denotes mRNA
T297 1319-1323 D012333 denotes mRNA
T298 1319-1323 CHEBI:33699 denotes mRNA
T304 1328-1335 SO:0000104 denotes protein
T303 1328-1335 PR:000000001 denotes protein
T300 1328-1335 GO:0003675 denotes protein
T301 1328-1335 CHEBI:36080 denotes protein
T302 1328-1335 CHEBI:11122 denotes protein
T306 1337-1340 PR:Q9QUK6 denotes LPS
T308 1337-1340 PR:000001155 denotes LPS
T305 1337-1340 CHEBI:89981 denotes LPS
T309 1337-1340 CHEBI:52603 denotes LPS
T310 1337-1340 CHEBI:16412 denotes LPS
T307 1337-1340 C536528 denotes LPS
T311 1361-1364 CHEBI:340824 denotes MMP
T314 1361-1364 CHEBI:59761 denotes MMP
T315 1361-1366 PR:P08253 denotes MMP-2
T316 1361-1366 Q9GLE5 denotes MMP-2
T317 1361-1366 P08253 denotes MMP-2
T318 1361-1366 Q90611 denotes MMP-2
T320 1361-1366 PR:Q8MPP3 denotes MMP-2
T321 1361-1366 P33436 denotes MMP-2
T322 1361-1366 PR:Q90611 denotes MMP-2
T323 1361-1366 PR:P33436 denotes MMP-2
T324 1361-1366 PR:000010479 denotes MMP-2
T325 1361-1366 PR:P33434 denotes MMP-2
T326 1361-1366 P33434 denotes MMP-2
T327 1361-1366 P50757 denotes MMP-2
T319 1361-1366 GO:0004228 denotes MMP-2
T330 1367-1371 SO:0000234 denotes mRNA
T328 1367-1371 D012333 denotes mRNA
T329 1367-1371 CHEBI:33699 denotes mRNA
T335 1376-1383 SO:0000104 denotes protein
T334 1376-1383 PR:000000001 denotes protein
T331 1376-1383 GO:0003675 denotes protein
T332 1376-1383 CHEBI:36080 denotes protein
T333 1376-1383 CHEBI:11122 denotes protein
T336 1463-1466 CHEBI:161680 denotes AZT
T337 1463-1466 CHEBI:10110 denotes AZT
T338 1520-1523 CHEBI:340824 denotes MMP
T341 1520-1523 CHEBI:59761 denotes MMP
T342 1520-1525 PR:P08253 denotes MMP-2
T343 1520-1525 Q9GLE5 denotes MMP-2
T344 1520-1525 P08253 denotes MMP-2
T345 1520-1525 Q90611 denotes MMP-2
T347 1520-1525 PR:Q8MPP3 denotes MMP-2
T348 1520-1525 P33436 denotes MMP-2
T349 1520-1525 PR:Q90611 denotes MMP-2
T350 1520-1525 PR:P33436 denotes MMP-2
T351 1520-1525 PR:000010479 denotes MMP-2
T352 1520-1525 PR:P33434 denotes MMP-2
T353 1520-1525 P33434 denotes MMP-2
T354 1520-1525 P50757 denotes MMP-2
T346 1520-1525 GO:0004228 denotes MMP-2
T355 1605-1608 CHEBI:340824 denotes MMP
T358 1605-1608 CHEBI:59761 denotes MMP
T359 1605-1610 PR:P50282 denotes MMP-9
T360 1605-1610 PR:P14780 denotes MMP-9
T361 1605-1610 P14780 denotes MMP-9
T362 1605-1610 PR:P41245 denotes MMP-9
T363 1605-1610 P41246 denotes MMP-9
T364 1605-1610 P41245 denotes MMP-9
T365 1605-1610 PR:P52176 denotes MMP-9
T366 1605-1610 P50282 denotes MMP-9
T368 1605-1610 PR:000010491 denotes MMP-9
T369 1605-1610 P52176 denotes MMP-9
T370 1605-1610 O18733 denotes MMP-9
T367 1605-1610 GO:0004229 denotes MMP-9
T371 1634-1643 CL:0000129 denotes microglia
T373 1659-1662 PR:Q9QUK6 denotes LPS
T375 1659-1662 PR:000001155 denotes LPS
T374 1659-1662 C536528 denotes LPS
T372 1659-1662 CHEBI:89981 denotes LPS
T376 1659-1662 CHEBI:52603 denotes LPS
T377 1659-1662 CHEBI:16412 denotes LPS
T378 1711-1714 CHEBI:161680 denotes AZT
T379 1711-1714 CHEBI:10110 denotes AZT
T381 1736-1739 PR:Q9QUK6 denotes LPS
T383 1736-1739 PR:000001155 denotes LPS
T382 1736-1739 C536528 denotes LPS
T380 1736-1739 CHEBI:89981 denotes LPS
T384 1736-1739 CHEBI:52603 denotes LPS
T385 1736-1739 CHEBI:16412 denotes LPS
T386 1766-1775 CL:0000129 denotes microglia
T387 1818-1821 CHEBI:161680 denotes AZT
T388 1818-1821 CHEBI:10110 denotes AZT
T391 1854-1857 PR:O04529 denotes MMP
T389 1854-1857 CHEBI:340824 denotes MMP
T392 1854-1857 CHEBI:59761 denotes MMP
T390 1854-1857 GO:0004235 denotes MMP
T393 1913-1922 CHEBI:22587 denotes antiviral
T394 2021-2025 D020782 denotes MMPs

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 186-202 HP_0002721 denotes immunodeficiency
T2 283-305 HP_0000707 denotes neurological disorders

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-96 DRI_Background denotes Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia.
T2 97-306 DRI_Challenge denotes The introduction of potent antiretroviral drugs for the treatment of patients with human immunodeficiency virus (HIV) infection has dramatically reduced the prevalence of HIV-associated neurological disorders.
T3 307-365 DRI_Challenge denotes Such diseases can be mediated by proteolytic enzymes, i.e.
T4 366-457 DRI_Unspecified denotes matrix metalloproteinases (MMPs) and, in particular gelatinases, released from glial cells.
T5 458-656 DRI_Background denotes The aim of this study was to investigate whether the antiretroviral drugs commonly used for the treatment of HIV-infected patients modulate the activity of MMPs in astrocyte and microglial cultures.
T6 657-856 DRI_Background denotes Primary cultures of rat astrocyte and microglia were treated with different doses of zidovudine (AZT) or indinavir (IDV) for 20 h and simultaneously activated by exposure to lipopolysaccharide (LPS).
T7 857-1086 DRI_Background denotes Culture supernatants collected from astrocytes and microglia after 24 h incubation were subjected to gelatin zymography and western blot analysis for the assessment of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) protein levels.
T8 1087-1227 DRI_Background denotes Total RNA was extracted from glial cells and used for reverse transcriptase-polymerase chain reaction for the assessment of mRNA expression.
T9 1228-1336 DRI_Outcome denotes Our results indicate that both astrocyte and microglial cells constitutively express MMP-2 mRNA and protein.
T10 1337-1438 DRI_Background denotes LPS treatment increased MMP-2 mRNA and protein expression in astrocytes, but not in microglial cells.
T11 1439-1586 DRI_Outcome denotes The treatment with both AZT and IDV dose-dependently inhibited the expression of MMP-2 in astrocytes, whereas it had no effect on microglial cells.
T12 1587-1776 DRI_Background denotes The expression of MMP-9 in both astrocytes and microglia was induced by LPS treatment and was dose-dependently inhibited by AZT and IDV treatment in LPS-stimulated astrocytes and microglia.
T13 1777-2038 DRI_Background denotes These results raise the possibility that AZT and IDV interfere directly with MMP production in glial cells and independently from their antiviral activity, thus suggesting the possible therapeutical use in neurological diseases associated with MMPs involvement.