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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
T2 150-298 Sentence denotes p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis.
T3 299-379 Sentence denotes A p8-deficient mouse strain was generated as a tool to investigate its function.
T4 380-683 Sentence denotes Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic sensitivity to pancreatitis induction.
T5 684-938 Sentence denotes The protective mechanism might involve the pancreatitis-associated protein (PAP I), whose strong induction during pancreatitis is p8-dependent, because administration of anti-PAP I antibodies to rats increased pancreatic inflammation during pancreatitis.
T6 939-1127 Sentence denotes In addition, 100 ng/ml PAP I in the culture medium of macrophages prevented their activation by tumor necrosis factor alpha, strongly suggesting that PAP I was an anti-inflammatory factor.
T7 1128-1275 Sentence denotes Finally, PAP I was able to inhibit NFkappaB activation by tumor necrosis factor alpha, in macrophages and in the AR42J pancreatic acinar cell line.
T8 1276-1440 Sentence denotes In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I.
T1 0-149 Sentence denotes p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
T2 150-298 Sentence denotes p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis.
T3 299-379 Sentence denotes A p8-deficient mouse strain was generated as a tool to investigate its function.
T4 380-683 Sentence denotes Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic sensitivity to pancreatitis induction.
T5 684-938 Sentence denotes The protective mechanism might involve the pancreatitis-associated protein (PAP I), whose strong induction during pancreatitis is p8-dependent, because administration of anti-PAP I antibodies to rats increased pancreatic inflammation during pancreatitis.
T6 939-1127 Sentence denotes In addition, 100 ng/ml PAP I in the culture medium of macrophages prevented their activation by tumor necrosis factor alpha, strongly suggesting that PAP I was an anti-inflammatory factor.
T7 1128-1275 Sentence denotes Finally, PAP I was able to inhibit NFkappaB activation by tumor necrosis factor alpha, in macrophages and in the AR42J pancreatic acinar cell line.
T8 1276-1440 Sentence denotes In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I.

sentences

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
T2 150-298 Sentence denotes p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis.
T3 299-379 Sentence denotes A p8-deficient mouse strain was generated as a tool to investigate its function.
T4 380-683 Sentence denotes Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic sensitivity to pancreatitis induction.
T5 684-938 Sentence denotes The protective mechanism might involve the pancreatitis-associated protein (PAP I), whose strong induction during pancreatitis is p8-dependent, because administration of anti-PAP I antibodies to rats increased pancreatic inflammation during pancreatitis.
T6 939-1127 Sentence denotes In addition, 100 ng/ml PAP I in the culture medium of macrophages prevented their activation by tumor necrosis factor alpha, strongly suggesting that PAP I was an anti-inflammatory factor.
T7 1128-1275 Sentence denotes Finally, PAP I was able to inhibit NFkappaB activation by tumor necrosis factor alpha, in macrophages and in the AR42J pancreatic acinar cell line.
T8 1276-1440 Sentence denotes In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 446-454 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1035-1040 HP_0002664 denotes tumor
T2 1186-1191 HP_0002664 denotes tumor

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 35-53 Phenotype denotes acute pancreatitis HP:0001735
T2 115-127 Phenotype denotes pancreatitis HP:0001733
T3 285-297 Phenotype denotes pancreatitis HP:0001733
T4 398-416 Phenotype denotes acute pancreatitis HP:0001735
T5 660-672 Phenotype denotes pancreatitis HP:0001733
T6 727-739 Phenotype denotes pancreatitis HP:0001733
T7 798-810 Phenotype denotes pancreatitis HP:0001733
T8 894-917 Phenotype denotes pancreatic inflammation HP:0001733
T9 925-937 Phenotype denotes pancreatitis HP:0001733
T10 1035-1040 Phenotype denotes tumor HP:0002664
T11 1186-1191 Phenotype denotes tumor HP:0002664
T12 1340-1358 Phenotype denotes acute pancreatitis HP:0001735

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 35-53 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T2 115-127 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T3 285-297 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T4 398-416 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T5 446-454 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T6 660-672 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T7 727-739 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T8 760-763 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579
T10 798-810 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T11 859-862 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579
T13 905-917 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T14 925-937 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T15 962-965 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579
T17 1035-1040 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T18 1089-1092 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579
T20 1137-1140 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579
T22 1186-1191 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T23 1340-1358 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T24 1434-1437 Disease denotes PAP http://purl.obolibrary.org/obo/MONDO_0001437|http://purl.obolibrary.org/obo/MONDO_0012579

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
T2 150-298 Sentence denotes p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis.
T3 299-379 Sentence denotes A p8-deficient mouse strain was generated as a tool to investigate its function.
T4 380-683 Sentence denotes Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic sensitivity to pancreatitis induction.
T5 684-938 Sentence denotes The protective mechanism might involve the pancreatitis-associated protein (PAP I), whose strong induction during pancreatitis is p8-dependent, because administration of anti-PAP I antibodies to rats increased pancreatic inflammation during pancreatitis.
T6 939-1127 Sentence denotes In addition, 100 ng/ml PAP I in the culture medium of macrophages prevented their activation by tumor necrosis factor alpha, strongly suggesting that PAP I was an anti-inflammatory factor.
T7 1128-1275 Sentence denotes Finally, PAP I was able to inhibit NFkappaB activation by tumor necrosis factor alpha, in macrophages and in the AR42J pancreatic acinar cell line.
T8 1276-1440 Sentence denotes In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 314-319 OrganismTaxon denotes mouse 10088|10090
T3 570-574 OrganismTaxon denotes mice 10088
T4 879-883 OrganismTaxon denotes rats 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 235-258 Body_part denotes pancreatic acinar cells http://purl.obolibrary.org/obo/CL_0002064
T2 446-454 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T4 993-1004 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T5 1218-1229 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T6 1247-1269 Body_part denotes pancreatic acinar cell http://purl.obolibrary.org/obo/CL_0002064

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 446-454 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 235-258 Cell denotes pancreatic acinar cells http://purl.obolibrary.org/obo/CL:0002064
T2 993-1004 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 1218-1229 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T6 1247-1269 Cell denotes pancreatic acinar cell http://purl.obolibrary.org/obo/CL:0002064
T7 1258-1269 Cell denotes acinar cell http://purl.obolibrary.org/obo/CL:0000622