| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-95 |
Sentence |
denotes |
MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis. |
| T2 |
96-239 |
Sentence |
denotes |
Rescue of embryonic lethality in MDM4(-/-) mice through concomitant loss of p53 has revealed a functional partnership between the two proteins. |
| T3 |
240-344 |
Sentence |
denotes |
Biochemical studies have suggested that MDM4 may act as a negative regulator of p53 levels and activity. |
| T4 |
345-470 |
Sentence |
denotes |
On the other hand, MDM4 overexpression has been reported to stabilize p53 levels and to counteract MDM2-degradative activity. |
| T5 |
471-552 |
Sentence |
denotes |
We have investigated the functional role of MDM4 overexpression on cell behavior. |
| T6 |
553-774 |
Sentence |
denotes |
In both established and primary cells cultured under stress conditions, overexpression of MDM4 significantly increased p53-dependent cell death, in correlation with enhanced induction of the endogenous p53 protein levels. |
| T7 |
775-902 |
Sentence |
denotes |
This phenomenon was associated with induced p53 transcriptional activity and increased levels of the proapoptotic protein, Bax. |
| T8 |
903-1018 |
Sentence |
denotes |
Further, p53 stabilization was accompanied by decreased association of the protein to its negative regulator, MDM2. |
| T9 |
1019-1213 |
Sentence |
denotes |
These findings reveal a novel role for MDM4 by demonstrating that in non-tumor cells under stress conditions it may act as a positive regulator of p53 activity, mainly by controlling p53 levels. |
| T10 |
1214-1321 |
Sentence |
denotes |
They also indicate a major distinction between the biological consequences of MDM4 and MDM2 overexpression. |
