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PubMed:14645238 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 912-917 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324

sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas.
T2 94-224 Sentence denotes Amplification of the MYCN gene, resulting in overexpression of MYCN, distinguishes a subset of neuroblastomas with poor prognosis.
T3 225-303 Sentence denotes We recently identified MYCN as a target gene of the E2F transcription factors.
T4 304-385 Sentence denotes Here we show that Sp1 and Sp3 cooperate with E2F-1 to activate the MYCN promoter.
T5 386-583 Sentence denotes However, in a neuroblastoma cell line that does not express MYCN, overexpression of E2F-1 was not sufficient to activate the MYCN promoter even in the presence of trichostatin A and 5-aza-cytidine.
T6 584-755 Sentence denotes This was because of a failure of E2F-1 to bind to the MYCN promoter in these cells, although access of E2F-1 to the inactive MYCN promoter was not blocked by a nucleosome.
T7 756-945 Sentence denotes Differences in nucleosomal organization of the MYCN promoter in different cell lines did not correlate with gene activation per se but with the switch from basal to activated transcription.
T8 946-1164 Sentence denotes Binding of E2F and Sp1/Sp3 to the MYCN promoter in vivo correlated with acetylation of histones H3 and H4 and recruitment of RNA polymerase II and the protein acetyltransferase Tip60 but not with nucleosome remodeling.
T9 1165-1431 Sentence denotes Our results define distinct chromatin states of the MYCN promoter, indicate that factors in addition to E2F and Sp1/Sp3 are required to activate MYCN in neuroblastomas, and provide evidence for a novel mechanism of controlling access of E2F to selected target genes.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 189-203 HP_0003006 denotes neuroblastomas
T2 400-413 HP_0003006 denotes neuroblastoma
T3 1318-1332 HP_0003006 denotes neuroblastomas

PennBioIE

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes E2F
T2 8-11 protein denotes Sp1
T3 12-15 protein denotes Sp3
T4 65-69 protein denotes MYCN
T5 78-92 protein denotes neuroblastomas
T6 96-107 protein denotes plification
T7 115-119 protein denotes MYCN
T8 157-161 protein denotes MYCN
T9 189-203 protein denotes neuroblastomas
T10 248-252 protein denotes MYCN
T11 277-280 protein denotes E2F
T12 322-325 protein denotes Sp1
T13 330-333 protein denotes Sp3
T14 349-354 protein denotes E2F-1
T15 371-375 protein denotes MYCN
T16 400-413 protein denotes neuroblastoma
T17 446-450 protein denotes MYCN
T18 470-475 protein denotes E2F-1
T19 511-515 protein denotes MYCN
T20 617-622 protein denotes E2F-1
T21 638-642 protein denotes MYCN
T22 687-692 protein denotes E2F-1
T23 709-713 protein denotes MYCN
T24 803-807 protein denotes MYCN
T25 957-960 protein denotes E2F
T26 965-968 protein denotes Sp1
T27 969-972 protein denotes Sp3
T28 980-984 protein denotes MYCN
T29 1033-1044 protein denotes histones H3
T30 1049-1051 protein denotes H4
T31 1071-1088 protein denotes RNA polymerase II
T32 1105-1128 protein denotes acetyltransferase Tip60
T33 1217-1221 protein denotes MYCN
T34 1269-1272 protein denotes E2F
T35 1277-1280 protein denotes Sp1
T36 1281-1284 protein denotes Sp3
T37 1310-1314 protein denotes MYCN
T38 1318-1332 protein denotes neuroblastomas
T39 1402-1405 protein denotes E2F

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14645238-0#65#69#gene4613 65-69 gene4613 denotes MYCN
14645238-0#78#92#diseaseC0027819 78-92 diseaseC0027819 denotes neuroblastomas
65#69#gene461378#92#diseaseC0027819 14645238-0#65#69#gene4613 14645238-0#78#92#diseaseC0027819 associated_with MYCN,neuroblastomas

DisGeNET

Id Subject Object Predicate Lexical cue
T0 65-69 gene:4613 denotes MYCN
T1 78-92 disease:C0027819 denotes neuroblastomas
T2 157-161 gene:4613 denotes MYCN
T3 189-203 disease:C0027819 denotes neuroblastomas
T4 1310-1314 gene:4613 denotes MYCN
T5 1318-1332 disease:C0027819 denotes neuroblastomas
T6 1217-1221 gene:4613 denotes MYCN
T7 1318-1332 disease:C0027819 denotes neuroblastomas
R1 T0 T1 associated_with MYCN,neuroblastomas
R2 T2 T3 associated_with MYCN,neuroblastomas
R3 T4 T5 associated_with MYCN,neuroblastomas
R4 T6 T7 associated_with MYCN,neuroblastomas

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 78-92 Phenotype denotes neuroblastomas HP:0003006
T2 189-203 Phenotype denotes neuroblastomas HP:0003006
T3 400-413 Phenotype denotes neuroblastoma HP:0003006
T4 1318-1332 Phenotype denotes neuroblastomas HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 78-92 Disease denotes neuroblastomas http://purl.obolibrary.org/obo/MONDO_0005072
T2 189-203 Disease denotes neuroblastomas http://purl.obolibrary.org/obo/MONDO_0005072
T3 400-413 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T4 1318-1332 Disease denotes neuroblastomas http://purl.obolibrary.org/obo/MONDO_0005072