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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 288-295 HP_0002664 denotes cancers
T2 400-417 HP_0002894 denotes pancreatic cancer
T3 411-417 HP_0002664 denotes cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 546-579 gene:627 denotes brain-derived neurotrophic factor
T1 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T2 591-597 gene:4909 denotes NT-4/5
T3 681-698 disease:C0235974 denotes pancreatic cancer
T4 591-597 gene:4909 denotes NT-4/5
T5 681-698 disease:C0346647 denotes pancreatic cancer
T6 591-597 gene:4909 denotes NT-4/5
T7 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T8 662-665 gene:3560 denotes P75
T9 681-698 disease:C0235974 denotes pancreatic cancer
T10 662-665 gene:3560 denotes P75
T11 681-698 disease:C0346647 denotes pancreatic cancer
T12 662-665 gene:11168 denotes P75
T13 681-698 disease:C0235974 denotes pancreatic cancer
T14 662-665 gene:11168 denotes P75
T15 681-698 disease:C0346647 denotes pancreatic cancer
T16 662-665 gene:1523 denotes P75
T17 681-698 disease:C0235974 denotes pancreatic cancer
T18 662-665 gene:1523 denotes P75
T19 681-698 disease:C0346647 denotes pancreatic cancer
T20 662-665 gene:27036 denotes P75
T21 681-698 disease:C0235974 denotes pancreatic cancer
T22 662-665 gene:27036 denotes P75
T23 681-698 disease:C0346647 denotes pancreatic cancer
T24 662-665 gene:8570 denotes P75
T25 681-698 disease:C0235974 denotes pancreatic cancer
T26 662-665 gene:8570 denotes P75
T27 681-698 disease:C0346647 denotes pancreatic cancer
T28 662-665 gene:3059 denotes P75
T29 681-698 disease:C0235974 denotes pancreatic cancer
T30 662-665 gene:3059 denotes P75
T31 681-698 disease:C0346647 denotes pancreatic cancer
T32 662-665 gene:7133 denotes P75
T33 681-698 disease:C0235974 denotes pancreatic cancer
T34 662-665 gene:7133 denotes P75
T35 681-698 disease:C0346647 denotes pancreatic cancer
T36 662-665 gene:3560 denotes P75
T37 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T38 662-665 gene:11168 denotes P75
T39 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T40 662-665 gene:1523 denotes P75
T41 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T42 662-665 gene:27036 denotes P75
T43 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T44 662-665 gene:8570 denotes P75
T45 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T46 662-665 gene:3059 denotes P75
T47 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
T48 662-665 gene:7133 denotes P75
T49 726-758 disease:C1335302 denotes pancreatic ductal adenocarcinoma
R1 T0 T1 associated_with brain-derived neurotrophic factor,pancreatic ductal adenocarcinoma
R2 T2 T3 associated_with NT-4/5,pancreatic cancer
R3 T4 T5 associated_with NT-4/5,pancreatic cancer
R4 T6 T7 associated_with NT-4/5,pancreatic ductal adenocarcinoma
R5 T8 T9 associated_with P75,pancreatic cancer
R6 T10 T11 associated_with P75,pancreatic cancer
R7 T12 T13 associated_with P75,pancreatic cancer
R8 T14 T15 associated_with P75,pancreatic cancer
R9 T16 T17 associated_with P75,pancreatic cancer
R10 T18 T19 associated_with P75,pancreatic cancer
R11 T20 T21 associated_with P75,pancreatic cancer
R12 T22 T23 associated_with P75,pancreatic cancer
R13 T24 T25 associated_with P75,pancreatic cancer
R14 T26 T27 associated_with P75,pancreatic cancer
R15 T28 T29 associated_with P75,pancreatic cancer
R16 T30 T31 associated_with P75,pancreatic cancer
R17 T32 T33 associated_with P75,pancreatic cancer
R18 T34 T35 associated_with P75,pancreatic cancer
R19 T36 T37 associated_with P75,pancreatic ductal adenocarcinoma
R20 T38 T39 associated_with P75,pancreatic ductal adenocarcinoma
R21 T40 T41 associated_with P75,pancreatic ductal adenocarcinoma
R22 T42 T43 associated_with P75,pancreatic ductal adenocarcinoma
R23 T44 T45 associated_with P75,pancreatic ductal adenocarcinoma
R24 T46 T47 associated_with P75,pancreatic ductal adenocarcinoma
R25 T48 T49 associated_with P75,pancreatic ductal adenocarcinoma

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 159-485 OBJECTIVE denotes Neurotrophins (NTs) can stimulate cell proliferation and differentiation in various cell types, and play a role in certain human cancers. In this study we analyzed the expression and localization of NTs and their receptors in microdissected pancreatic cancer tissue samples, and studied their ability to stimulate cell growth.
T2 507-1081 METHODS denotes The expression of nerve growth factor, brain-derived neurotrophic factor, NT-3, and NT-4/5, and the receptors tropomyosin receptor kinase A, B, and C, and P75 was studied in pancreatic cancer cell lines, and normal and pancreatic ductal adenocarcinoma (PDAC) tissue samples by quantitative reverse transcription-PCR. Laser capture microdissection was performed in 21 PDAC samples, and mRNA levels were determined in cancer cells, acinar cells, desmoplastic stroma areas, and nerve fibers. Cell growth assays with NTs and in coculture with dorsal root ganglia were performed.
T3 1091-1691 RESULTS denotes NT receptors were differentially expressed in the cancer cell lines, whereas tropomyosin receptor kinase C was not detectable. NTs modulated pancreatic cancer cell growth. Analysis of nonmicrodissected samples revealed that all of the receptors and tested ligands were overexpressed in PDAC when compared with normal pancreas. Analysis of laser captured samples revealed that NTs and their receptors were expressed in the cancer cells but were especially abundant in the intratumoral nerves. Coculture of dorsal root ganglia with T3M4 cells significantly enhanced the proliferation of this cell line.
T4 1704-2076 CONCLUSIONS denotes The abundance of NTs in the intratumoral nerves in PDAC and the presence of NT receptors in the cancer cells, in conjunction with the ability of NTs to modulate pancreatic cancer cell growth, point to potential paracrine and autocrine effects of NTs in PDAC. Thus, our findings provide additional evidence that blocking NT actions may have a therapeutic potential in PDAC.