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PubMed:14607217 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 91-281 DRI_Background denotes Changes in genomic and phenotypic expression of progressing prostate tumors and their stroma occur in a dynamic fashion based on bidirectional signaling from stromal-epithelial interactions.
T2 282-403 DRI_Challenge denotes These interactions may underlie the ability of prostate cancer cells to survive and proliferate in the prostate and bone.
T3 404-677 DRI_Background denotes By investigating the phenotypic and genotypic changes of stromal cells adjacent to cancer cells and the reciprocal changes of cancer cells, novel molecular markers may be developed to diagnose cancer earlier before pathologic appearance of cancer cells at the primary site.
T4 678-807 DRI_Background denotes Attacking epithelial and stromal elements together is a unique approach to both localized and metastatic prostate cancer therapy.
T5 808-958 DRI_Background denotes Co-targeting both tumor cells and stroma requires identifying a reliable tumor and tissue-specific cis-DNA element, such as osteocalcin (OC) promoter.
T6 959-1119 DRI_Background denotes OC expression is elevated in prostate tumor cells and in prostate and bone stromal cells interdigitating with both localized and metastatic prostate epithelium.
T7 1120-1216 DRI_Approach denotes We have previously designed an adenovirus-based therapeutic gene vehicle and demonstrated that a
T8 1250-1448 DRI_Approach denotes vector (Ad vector) is highly efficient in blocking the growth of cancer cells in culture, including cells without androgen receptor as well as cells that do or do not make prostate-specific antigen.
T9 1449-1593 DRI_Background denotes In vivo, intravenous administration of an Ad-OC vector was effective against preexisting human prostate cancer subcutaneous and bone xenografts.
T10 1594-1674 DRI_Approach denotes The addition of vitamin D(3) enhanced further viral replication at target sites.
T11 1675-1832 DRI_Background denotes Co-targeting tumor cells and stroma using systemic Ad vector is a viable and promising option for treatment of both localized and metastatic prostate cancer.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 151-166 HP_0012125 denotes prostate tumors
T2 160-166 HP_0002664 denotes tumors
T3 318-344 HP_0012125 denotes ability of prostate cancer
T4 329-344 HP_0012125 denotes prostate cancer
T5 338-344 HP_0002664 denotes cancer
T6 487-493 HP_0002664 denotes cancer
T7 530-536 HP_0002664 denotes cancer
T8 597-603 HP_0002664 denotes cancer
T9 644-650 HP_0002664 denotes cancer
T10 783-798 HP_0012125 denotes prostate cancer
T11 792-798 HP_0002664 denotes cancer
T12 826-831 HP_0002664 denotes tumor
T13 881-886 HP_0002664 denotes tumor
T14 988-1002 HP_0012125 denotes prostate tumor
T15 997-1002 HP_0002664 denotes tumor
T16 1315-1321 HP_0002664 denotes cancer
T17 1544-1559 HP_0012125 denotes prostate cancer
T18 1553-1559 HP_0002664 denotes cancer
T19 1688-1693 HP_0002664 denotes tumor
T20 1816-1831 HP_0012125 denotes prostate cancer
T21 1825-1831 HP_0002664 denotes cancer

CoMAGC

Id Subject Object Predicate Lexical cue
T1 959-961 Gene denotes OC
E1 962-972 Gene_expression denotes expression
E2 976-984 Positive_regulation denotes elevated
T2 988-1002 prostate cancer denotes prostate tumor
R1 T1 E1 themeOf OC,expression
R2 E1 E2 themeOf expression,elevated
R3 T1 T2 CGE-increased OC,prostate tumor
R4 T1 T2 CCS-normalTOcancer OC,prostate tumor
R5 T1 T2 PT-observation OC,prostate tumor
R3 T1 T2 IGE-unchanged OC,prostate tumor

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1494-1496 gene:632 denotes OC
T1 1544-1559 disease:C0376358 denotes prostate cancer
T2 1494-1496 gene:632 denotes OC
T3 1544-1559 disease:C0600139 denotes prostate cancer
R1 T0 T1 associated_with OC,prostate cancer
R2 T2 T3 associated_with OC,prostate cancer