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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 159-562 BACKGROUND denotes A recent study revealed that single nucleotide polymorphism (SNP) at codon 388 (Gly or Arg) of fibroblast growth factor receptor 4 (FGFR4) was associated with prognosis in patients with carcinoma of the breast and colorectal carcinoma. The purpose of the current study was to investigate the correlation between codon 388 SNP and clinical prognosis in patients with sarcoma of the bone and soft tissues.
T2 572-1002 METHODS denotes Tumor samples were obtained from 143 patients with high-grade bone and soft tissue sarcomas at Okayama University Hospital between 1986-2002, and from 102 healthy volunteers. SNP of codon 388 was detected by sequencing and fragment length of polymerase chain reaction products digested by restriction enzyme. The chi-square test was used to compare genotype distribution and the Kaplan-Meier method was used for survival analysis.
T3 1012-1665 RESULTS denotes With regard to FGFR4 genotypes in the 143 patients studied, 54 (37.8%) were Gly/Gly, 72 (50.3%) were Gly/Arg, and 17 (11.9%) were Arg/Arg, findings that were not significantly different from those of controls (P = 0.97). With regard to cumulative overall and metastasis-free survival, patients with the Gly/Gly genotype were found to have a better prognosis (P = 0.085 and P = 0.27, respectively). FGFR4 SNP was found to be correlated significantly with overall and metastasis-free survival in patients with soft tissue sarcomas (P = 0.029 and P = 0.045, respectively), but not in those patients with bone sarcomas (P = 0.88 and P = 0.75, respectively).
T4 1679-2026 CONCLUSIONS denotes In the current study, the authors found a significant correlation between FGFR4 SNP and prognosis in patients with soft tissue sarcoma, although the samples were comprised of various histologic types. This SNP might be used to improve the prediction of clinical prognosis and lead to new treatment strategies in patients with soft tissue sarcomas.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 345-368 HP_0003002 denotes carcinoma of the breast
T2 362-393 HP_0003002 denotes breast and colorectal carcinoma
T3 525-532 HP_0100242 denotes sarcoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14601095-0#34#69#gene2264 34-69 gene2264 denotes fibroblast growth factor receptor 4
14601095-0#126#145#diseaseC1261473 126-145 diseaseC1261473 denotes soft tissue sarcoma
14601095-1#95#130#gene2264 254-289 gene2264 denotes fibroblast growth factor receptor 4
14601095-1#132#137#gene2264 291-296 gene2264 denotes FGFR4
14601095-1#186#209#diseaseC0678222 345-368 diseaseC0678222 denotes carcinoma of the breast
14601095-1#214#234#diseaseC0009402 373-393 diseaseC0009402 denotes colorectal carcinoma
14601095-1#186#209#diseaseC0678222 345-368 diseaseC0678222 denotes carcinoma of the breast
14601095-1#214#234#diseaseC0009402 373-393 diseaseC0009402 denotes colorectal carcinoma
14601095-8#0#5#gene2264 1410-1415 gene2264 denotes FGFR4
14601095-8#68#78#diseaseC0027627 1478-1488 diseaseC0027627 denotes metastasis
14601095-8#203#216#diseaseC0029463 1613-1626 diseaseC0029463 denotes bone sarcomas
34#69#gene2264126#145#diseaseC1261473 14601095-0#34#69#gene2264 14601095-0#126#145#diseaseC1261473 associated_with fibroblast growth factor receptor 4,soft tissue sarcoma
95#130#gene2264186#209#diseaseC0678222 14601095-1#95#130#gene2264 14601095-1#186#209#diseaseC0678222 associated_with fibroblast growth factor receptor 4,carcinoma of the breast
95#130#gene2264214#234#diseaseC0009402 14601095-1#95#130#gene2264 14601095-1#214#234#diseaseC0009402 associated_with fibroblast growth factor receptor 4,colorectal carcinoma
95#130#gene2264186#209#diseaseC0678222 14601095-1#95#130#gene2264 14601095-1#186#209#diseaseC0678222 associated_with fibroblast growth factor receptor 4,carcinoma of the breast
95#130#gene2264214#234#diseaseC0009402 14601095-1#95#130#gene2264 14601095-1#214#234#diseaseC0009402 associated_with fibroblast growth factor receptor 4,colorectal carcinoma
132#137#gene2264186#209#diseaseC0678222 14601095-1#132#137#gene2264 14601095-1#186#209#diseaseC0678222 associated_with FGFR4,carcinoma of the breast
132#137#gene2264214#234#diseaseC0009402 14601095-1#132#137#gene2264 14601095-1#214#234#diseaseC0009402 associated_with FGFR4,colorectal carcinoma
132#137#gene2264186#209#diseaseC0678222 14601095-1#132#137#gene2264 14601095-1#186#209#diseaseC0678222 associated_with FGFR4,carcinoma of the breast
132#137#gene2264214#234#diseaseC0009402 14601095-1#132#137#gene2264 14601095-1#214#234#diseaseC0009402 associated_with FGFR4,colorectal carcinoma
0#5#gene226468#78#diseaseC0027627 14601095-8#0#5#gene2264 14601095-8#68#78#diseaseC0027627 associated_with FGFR4,metastasis
0#5#gene2264203#216#diseaseC0029463 14601095-8#0#5#gene2264 14601095-8#203#216#diseaseC0029463 associated_with FGFR4,bone sarcomas

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1410-1415 gene:2264 denotes FGFR4
T1 1613-1626 disease:C0029463 denotes bone sarcomas
T2 1410-1415 gene:2264 denotes FGFR4
T3 1478-1488 disease:C0027627 denotes metastasis
T4 1410-1415 gene:2264 denotes FGFR4
T5 1520-1540 disease:C1261473 denotes soft tissue sarcomas
T6 1410-1415 gene:2264 denotes FGFR4
T7 1478-1488 disease:C2939420 denotes metastasis
T8 1753-1758 gene:2264 denotes FGFR4
T9 1794-1813 disease:C1261473 denotes soft tissue sarcoma
R1 T0 T1 associated_with FGFR4,bone sarcomas
R2 T2 T3 associated_with FGFR4,metastasis
R3 T4 T5 associated_with FGFR4,soft tissue sarcomas
R4 T6 T7 associated_with FGFR4,metastasis
R5 T8 T9 associated_with FGFR4,soft tissue sarcoma