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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-38 Sentence denotes [Frontal dementia or dementia praecox?
TextSentencer_T2 39-100 Sentence denotes A case report of a psychotic disorder with a severe decline].
TextSentencer_T3 101-139 Sentence denotes Démence frontale ou "démence précoce"?
TextSentencer_T4 140-226 Sentence denotes A propos de l'observation d'un trouble psychotique associé a une détérioration sévère.
TextSentencer_T5 227-240 Sentence denotes INTRODUCTION:
TextSentencer_T6 241-389 Sentence denotes Many authors have described these last years the difficulty to establish a differential diagnosis between schizophrenia and frontotemporal dementia.
TextSentencer_T7 390-470 Sentence denotes However treatment and prognosis of these two separate diseases are not the same.
TextSentencer_T8 471-659 Sentence denotes Schizophrenia is a chronic syndrome with an early onset during teenage or young adulthood period and the major features consist of delirious ideas, hallucinations and psychic dissociation.
TextSentencer_T9 660-763 Sentence denotes However a large variety of different symptoms describes the disease and creates a heterogeneous entity.
TextSentencer_T10 764-885 Sentence denotes The diagnosis, exclusively defined by clinical signs, is then difficult and has led to the research of specific symptoms.
TextSentencer_T11 886-1186 Sentence denotes These involve multiple psychological processes, such as perception (hallucinations), reality testing (delusions), thought processes (loose associations), feeling (flatness, inappropriate affect), behaviour (catatonia, disorganization), attention, concentration, motivation (avolition), and judgement.
TextSentencer_T12 1187-1477 Sentence denotes The characteristic symptoms of schizophrenia have often been conceptualised as falling into three broad categories including positive (hallucination, delision), negative (affective flattening, alogia, avolition) and disorganised (poor attention, disorganised speech and behaviour) symptoms.
TextSentencer_T13 1478-1531 Sentence denotes No single symptom is pathogonomonic of schizophrenia.
TextSentencer_T14 1532-1667 Sentence denotes These psychological and behavioural characteristics are associated with a variety of impairments in occupational or social functioning.
TextSentencer_T15 1668-1729 Sentence denotes Cognition impairments are also associated with schizophrenia.
TextSentencer_T16 1730-1928 Sentence denotes Since the original clinical description by Kraepelin and Bleuler, abnormalities in attentional, associative and volitional cognitive processes have been considered central features of schizophrenia.
TextSentencer_T17 1929-2098 Sentence denotes Long term memory deficits, attentional and executive dysfunctions are described in the neurocognitive profile of schizophrenic patients, with a large degree of severity.
TextSentencer_T18 2099-2257 Sentence denotes The pathophysiology of schizophrenia is not well known but may be better understood by neuronal dysfunctions rather than by a specific anatomical abnormality.
TextSentencer_T19 2258-2353 Sentence denotes Frontotemporal lobar degeneration (FTLD) is one of the most common causes of cortical dementia.
TextSentencer_T20 2354-2475 Sentence denotes FTLD is associated with an anatomical atrophy that can be generalised, with a frontotemporal or focal lobar predominance.
TextSentencer_T21 2476-2556 Sentence denotes Histologically there is severe neuronal loss, gliosis and a state of spongiosis.
TextSentencer_T22 2557-2621 Sentence denotes In a minority of case Pick cells and Pick bodies are also found.
TextSentencer_T23 2622-2795 Sentence denotes The usual clinical features of FTLD are divided in three prototypic syndromes: frontotemporal dementia (FTD), progressive non-fluent aphasia (PA) and semantic dementia (SD).
TextSentencer_T24 2796-2850 Sentence denotes FTD is the most common clinical manifestation of FTLD.
TextSentencer_T25 2851-3026 Sentence denotes FTD is first characterised by profound alteration in personality and social conduct, characterised by inertia and loss of volition or social disinhibition and distractibility.
TextSentencer_T26 3027-3075 Sentence denotes There is emotional blunting and loss of insight.
TextSentencer_T27 3076-3229 Sentence denotes Speech output is typically economical, leading ultimately to mutism, although a press of speech may be present in some overactive, disinhibited patients.
TextSentencer_T28 3230-3295 Sentence denotes Memory is relatively preserved in the early stage of the disease.
TextSentencer_T29 3296-3468 Sentence denotes Cognitive deficits occur in the domains of attention, planning and problems solving, whereas primary tools of language, perception and spatial functions are well preserved.
TextSentencer_T30 3469-3599 Sentence denotes PA is an initial disorder of expressive language, characterised by effortful speech production, phonologic and grammatical errors.
TextSentencer_T31 3600-3710 Sentence denotes Difficulties in reading and writing also occur but understanding of word meaning is relatively well preserved.
TextSentencer_T32 3711-3858 Sentence denotes In SD a severe naming and word comprehension impairment occur on the beginning in the context of fluent, effortless, and grammatical speech output.
TextSentencer_T33 3859-3930 Sentence denotes There is also an inability to recognise the meaning of visual percepts.
TextSentencer_T34 3931-4023 Sentence denotes The clinical syndromes of FTLD are associated with the brain topography of the degeneration.
TextSentencer_T35 4024-4233 Sentence denotes So considerable clinical overlap can exist between schizophrenia and FTLD and the object of the following case report is to remind the difficulty to make a differential diagnosis between these two pathologies.
TextSentencer_T36 4234-4246 Sentence denotes CASE REPORT:
TextSentencer_T37 4247-4419 Sentence denotes A 34 year old non-married man is admitted in mental health district of a general hospital for behavioural disturbances that include repeated aggressions towards his family.
TextSentencer_T38 4420-4491 Sentence denotes At initial interview visual and auditives hallucinations are described.
TextSentencer_T39 4492-4579 Sentence denotes The patient doesn't care about these abnormalities and a poverty of speech is observed.
TextSentencer_T40 4580-4647 Sentence denotes The affects, globally blunted, show some degree of sadness however.
TextSentencer_T41 4648-4708 Sentence denotes The patient's birth and early development were unremarkable.
TextSentencer_T42 4709-4806 Sentence denotes At the age of 26, the patient dismissed from his job because of poor performance and absenteeism.
TextSentencer_T43 4807-4930 Sentence denotes He spent a lot of time watching TV, showed poverty of speech and become sometimes angry and violent without an explanation.
TextSentencer_T44 4931-5073 Sentence denotes He was hospitalised for several months and a schizophrenia including predominant negative features, hallucinations and delusion was diagnosed.
TextSentencer_T45 5074-5184 Sentence denotes He was treated with bromperidol, could go back to home and was followed by a general practitioner for 8 years.
TextSentencer_T46 5185-5292 Sentence denotes The patient had a stereotyped way of life during these years with a poor communication and little activity.
TextSentencer_T47 5293-5428 Sentence denotes During the months preceding the current hospitalisation, these characteristics and avolition emphasised, urinary incontinence appeared.
TextSentencer_T48 5429-5549 Sentence denotes The patient receives risperidone 8 mg/day associated with citalopram 40 mg/day during several months of hospitalisation.
TextSentencer_T49 5550-5633 Sentence denotes No significant evolution is observed regarding apathic and stereotyped way of live.
TextSentencer_T50 5634-5682 Sentence denotes The capacity of communication remains very poor.
TextSentencer_T51 5683-5750 Sentence denotes Neurocognitive assessments reveal multiple and severe dysfunctions.
TextSentencer_T52 5751-5815 Sentence denotes Memory, executive and attentional tasks are extremely disturbed.
TextSentencer_T53 5816-5898 Sentence denotes Physical and neurological examinations reveal an isolated bilateral Babinski sign.
TextSentencer_T54 5899-5985 Sentence denotes Cerebral scanner and magnetic resonance show bifrontal atrophy and PET scan is normal.
TextSentencer_T55 5986-6081 Sentence denotes There are no significant abnormalities found on blood and urine samples and on lumbar puncture.
TextSentencer_T56 6082-6170 Sentence denotes The patient is sent to a chronic neuropsychiatric hospital and the treatment is stopped.
TextSentencer_T57 6171-6224 Sentence denotes One year later, a comparative evaluation is realised.
TextSentencer_T58 6225-6271 Sentence denotes The general clinical state shows no evolution.
TextSentencer_T59 6272-6374 Sentence denotes Neurocognitive assessments are repeated and severe dysfunctions are observed with more perseverations.
TextSentencer_T60 6375-6386 Sentence denotes DISCUSSION:
TextSentencer_T61 6387-6525 Sentence denotes A diagnosis of FTLD for this patient can be discussed regarding clinical features, neurocognitive testings and neuroradiological findings.
TextSentencer_T62 6526-6574 Sentence denotes Schizophrenia is a major differential diagnosis.
TextSentencer_T63 6575-6718 Sentence denotes Psychotic symptoms like hallucinations and age of onset are essential observations for the diagnosis of schizophrenia but can not exclude FTLD.
TextSentencer_T64 6719-6834 Sentence denotes Memory, intellectual functions, executive and attentional abilities may all be disturbed in schizophrenia and FTLD.
TextSentencer_T65 6835-6928 Sentence denotes Cerebral abnormalities well established in schizophrenia are lateral ventricles enlargements.
TextSentencer_T66 6929-7040 Sentence denotes Frontal lobar atrophy is a major argument for FTLD and is only a sporadic finding in schizophrenic populations.
TextSentencer_T67 7041-7107 Sentence denotes Schizophrenia and FTLD could be comorbid diseases by several ways.
TextSentencer_T68 7108-7119 Sentence denotes CONCLUSION:
TextSentencer_T69 7120-7202 Sentence denotes A differential diagnosis between schizophrenia and FTLD is difficult to establish.
TextSentencer_T70 7203-7291 Sentence denotes Schizophrenia is a heterogeneous disease with a large variety of cognitive dysfunctions.
TextSentencer_T71 7292-7356 Sentence denotes Neurocognitive tools may improve our knowledge of schizophrenia.
T1 0-38 Sentence denotes [Frontal dementia or dementia praecox?
T2 39-100 Sentence denotes A case report of a psychotic disorder with a severe decline].
T3 101-139 Sentence denotes Démence frontale ou "démence précoce"?
T4 140-226 Sentence denotes A propos de l'observation d'un trouble psychotique associé a une détérioration sévère.
T5 227-240 Sentence denotes INTRODUCTION:
T6 241-389 Sentence denotes Many authors have described these last years the difficulty to establish a differential diagnosis between schizophrenia and frontotemporal dementia.
T7 390-470 Sentence denotes However treatment and prognosis of these two separate diseases are not the same.
T8 471-659 Sentence denotes Schizophrenia is a chronic syndrome with an early onset during teenage or young adulthood period and the major features consist of delirious ideas, hallucinations and psychic dissociation.
T9 660-763 Sentence denotes However a large variety of different symptoms describes the disease and creates a heterogeneous entity.
T10 764-885 Sentence denotes The diagnosis, exclusively defined by clinical signs, is then difficult and has led to the research of specific symptoms.
T11 886-1186 Sentence denotes These involve multiple psychological processes, such as perception (hallucinations), reality testing (delusions), thought processes (loose associations), feeling (flatness, inappropriate affect), behaviour (catatonia, disorganization), attention, concentration, motivation (avolition), and judgement.
T12 1187-1477 Sentence denotes The characteristic symptoms of schizophrenia have often been conceptualised as falling into three broad categories including positive (hallucination, delision), negative (affective flattening, alogia, avolition) and disorganised (poor attention, disorganised speech and behaviour) symptoms.
T13 1478-1531 Sentence denotes No single symptom is pathogonomonic of schizophrenia.
T14 1532-1667 Sentence denotes These psychological and behavioural characteristics are associated with a variety of impairments in occupational or social functioning.
T15 1668-1729 Sentence denotes Cognition impairments are also associated with schizophrenia.
T16 1730-1928 Sentence denotes Since the original clinical description by Kraepelin and Bleuler, abnormalities in attentional, associative and volitional cognitive processes have been considered central features of schizophrenia.
T17 1929-2098 Sentence denotes Long term memory deficits, attentional and executive dysfunctions are described in the neurocognitive profile of schizophrenic patients, with a large degree of severity.
T18 2099-2257 Sentence denotes The pathophysiology of schizophrenia is not well known but may be better understood by neuronal dysfunctions rather than by a specific anatomical abnormality.
T19 2258-2353 Sentence denotes Frontotemporal lobar degeneration (FTLD) is one of the most common causes of cortical dementia.
T20 2354-2475 Sentence denotes FTLD is associated with an anatomical atrophy that can be generalised, with a frontotemporal or focal lobar predominance.
T21 2476-2556 Sentence denotes Histologically there is severe neuronal loss, gliosis and a state of spongiosis.
T22 2557-2621 Sentence denotes In a minority of case Pick cells and Pick bodies are also found.
T23 2622-2795 Sentence denotes The usual clinical features of FTLD are divided in three prototypic syndromes: frontotemporal dementia (FTD), progressive non-fluent aphasia (PA) and semantic dementia (SD).
T24 2796-2850 Sentence denotes FTD is the most common clinical manifestation of FTLD.
T25 2851-3026 Sentence denotes FTD is first characterised by profound alteration in personality and social conduct, characterised by inertia and loss of volition or social disinhibition and distractibility.
T26 3027-3075 Sentence denotes There is emotional blunting and loss of insight.
T27 3076-3229 Sentence denotes Speech output is typically economical, leading ultimately to mutism, although a press of speech may be present in some overactive, disinhibited patients.
T28 3230-3295 Sentence denotes Memory is relatively preserved in the early stage of the disease.
T29 3296-3468 Sentence denotes Cognitive deficits occur in the domains of attention, planning and problems solving, whereas primary tools of language, perception and spatial functions are well preserved.
T30 3469-3599 Sentence denotes PA is an initial disorder of expressive language, characterised by effortful speech production, phonologic and grammatical errors.
T31 3600-3710 Sentence denotes Difficulties in reading and writing also occur but understanding of word meaning is relatively well preserved.
T32 3711-3858 Sentence denotes In SD a severe naming and word comprehension impairment occur on the beginning in the context of fluent, effortless, and grammatical speech output.
T33 3859-3930 Sentence denotes There is also an inability to recognise the meaning of visual percepts.
T34 3931-4023 Sentence denotes The clinical syndromes of FTLD are associated with the brain topography of the degeneration.
T35 4024-4233 Sentence denotes So considerable clinical overlap can exist between schizophrenia and FTLD and the object of the following case report is to remind the difficulty to make a differential diagnosis between these two pathologies.
T36 4234-4246 Sentence denotes CASE REPORT:
T37 4247-4419 Sentence denotes A 34 year old non-married man is admitted in mental health district of a general hospital for behavioural disturbances that include repeated aggressions towards his family.
T38 4420-4491 Sentence denotes At initial interview visual and auditives hallucinations are described.
T39 4492-4579 Sentence denotes The patient doesn't care about these abnormalities and a poverty of speech is observed.
T40 4580-4647 Sentence denotes The affects, globally blunted, show some degree of sadness however.
T41 4648-4708 Sentence denotes The patient's birth and early development were unremarkable.
T42 4709-4806 Sentence denotes At the age of 26, the patient dismissed from his job because of poor performance and absenteeism.
T43 4807-4930 Sentence denotes He spent a lot of time watching TV, showed poverty of speech and become sometimes angry and violent without an explanation.
T44 4931-5073 Sentence denotes He was hospitalised for several months and a schizophrenia including predominant negative features, hallucinations and delusion was diagnosed.
T45 5074-5184 Sentence denotes He was treated with bromperidol, could go back to home and was followed by a general practitioner for 8 years.
T46 5185-5292 Sentence denotes The patient had a stereotyped way of life during these years with a poor communication and little activity.
T47 5293-5428 Sentence denotes During the months preceding the current hospitalisation, these characteristics and avolition emphasised, urinary incontinence appeared.
T48 5429-5549 Sentence denotes The patient receives risperidone 8 mg/day associated with citalopram 40 mg/day during several months of hospitalisation.
T49 5550-5633 Sentence denotes No significant evolution is observed regarding apathic and stereotyped way of live.
T50 5634-5682 Sentence denotes The capacity of communication remains very poor.
T51 5683-5750 Sentence denotes Neurocognitive assessments reveal multiple and severe dysfunctions.
T52 5751-5815 Sentence denotes Memory, executive and attentional tasks are extremely disturbed.
T53 5816-5898 Sentence denotes Physical and neurological examinations reveal an isolated bilateral Babinski sign.
T54 5899-5985 Sentence denotes Cerebral scanner and magnetic resonance show bifrontal atrophy and PET scan is normal.
T55 5986-6081 Sentence denotes There are no significant abnormalities found on blood and urine samples and on lumbar puncture.
T56 6082-6170 Sentence denotes The patient is sent to a chronic neuropsychiatric hospital and the treatment is stopped.
T57 6171-6224 Sentence denotes One year later, a comparative evaluation is realised.
T58 6225-6271 Sentence denotes The general clinical state shows no evolution.
T59 6272-6374 Sentence denotes Neurocognitive assessments are repeated and severe dysfunctions are observed with more perseverations.
T60 6375-6386 Sentence denotes DISCUSSION:
T61 6387-6525 Sentence denotes A diagnosis of FTLD for this patient can be discussed regarding clinical features, neurocognitive testings and neuroradiological findings.
T62 6526-6574 Sentence denotes Schizophrenia is a major differential diagnosis.
T63 6575-6718 Sentence denotes Psychotic symptoms like hallucinations and age of onset are essential observations for the diagnosis of schizophrenia but can not exclude FTLD.
T64 6719-6834 Sentence denotes Memory, intellectual functions, executive and attentional abilities may all be disturbed in schizophrenia and FTLD.
T65 6835-6928 Sentence denotes Cerebral abnormalities well established in schizophrenia are lateral ventricles enlargements.
T66 6929-7040 Sentence denotes Frontal lobar atrophy is a major argument for FTLD and is only a sporadic finding in schizophrenic populations.
T67 7041-7107 Sentence denotes Schizophrenia and FTLD could be comorbid diseases by several ways.
T68 7108-7119 Sentence denotes CONCLUSION:
T69 7120-7202 Sentence denotes A differential diagnosis between schizophrenia and FTLD is difficult to establish.
T70 7203-7291 Sentence denotes Schizophrenia is a heterogeneous disease with a large variety of cognitive dysfunctions.
T71 7292-7356 Sentence denotes Neurocognitive tools may improve our knowledge of schizophrenia.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 347-360 HP_0100753 denotes schizophrenia
T2 365-388 HP_0002145 denotes frontotemporal dementia
T3 380-388 HP_0000726 denotes dementia
T4 471-484 HP_0100753 denotes Schizophrenia
T5 619-633 HP_0000738 denotes hallucinations
T6 954-968 HP_0000738 denotes hallucinations
T7 988-997 HP_0000746 denotes delusions
T8 1218-1231 HP_0100753 denotes schizophrenia
T9 1322-1335 HP_0000738 denotes hallucination
T10 1517-1530 HP_0100753 denotes schizophrenia
T11 1668-1689 HP_0100543 denotes Cognition impairments
T12 1715-1728 HP_0100753 denotes schizophrenia
T13 1914-1927 HP_0100753 denotes schizophrenia
T14 2122-2135 HP_0100753 denotes schizophrenia
T15 2344-2352 HP_0000726 denotes dementia
T16 2507-2520 HP_0002529 denotes neuronal loss
T17 2522-2529 HP_0002171 denotes gliosis
T18 2701-2724 HP_0002145 denotes frontotemporal dementia
T19 2716-2724 HP_0000726 denotes dementia
T20 2755-2762 HP_0002381 denotes aphasia
T21 2772-2789 HP_0030219 denotes semantic dementia
T22 2781-2789 HP_0000726 denotes dementia
T23 2953-2960 HP_0030216 denotes inertia
T24 2992-3005 HP_0000734 denotes disinhibition
T25 3036-3054 HP_0030213 denotes emotional blunting
T26 3137-3143 HP_0002300 denotes mutism
T27 3207-3219 HP_0000734 denotes disinhibited
T28 3296-3314 HP_0100543 denotes Cognitive deficits
T29 4075-4088 HP_0100753 denotes schizophrenia

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 9-17 HP:0000726 denotes dementia
TI2 21-29 HP:0000726 denotes dementia
AB1 347-360 HP:0100753 denotes schizophrenia
AB2 365-388 HP:0002145 denotes frontotemporal dementia
AB3 471-484 HP:0100753 denotes Schizophrenia
AB4 619-633 HP:0000738 denotes hallucinations
AB5 954-968 HP:0000738 denotes hallucinations
AB6 988-997 HP:0000746 denotes delusions
AB7 1218-1231 HP:0100753 denotes schizophrenia
AB8 1266-1273 HP:0002527 denotes falling
AB9 1322-1335 HP:0000738 denotes hallucination
AB10 1517-1530 HP:0100753 denotes schizophrenia
AB11 1715-1728 HP:0100753 denotes schizophrenia
AB12 1914-1927 HP:0100753 denotes schizophrenia
AB13 2122-2135 HP:0100753 denotes schizophrenia
AB14 2344-2352 HP:0000726 denotes dementia
AB15 2522-2529 HP:0002171 denotes gliosis
AB16 2701-2724 HP:0002145 denotes frontotemporal dementia
AB17 2755-2762 HP:0002381 denotes aphasia
AB18 2772-2789 HP:0030219 denotes semantic dementia
AB19 2953-2960 HP:0030216 denotes inertia
AB20 2992-3005 HP:0000734 denotes disinhibition
AB21 3036-3054 HP:0030213 denotes emotional blunting
AB22 3137-3143 HP:0002300 denotes mutism
AB23 4075-4088 HP:0100753 denotes schizophrenia
AB24 4462-4476 HP:0000738 denotes hallucinations
AB25 4976-4989 HP:0100753 denotes schizophrenia
AB26 5031-5045 HP:0000738 denotes hallucinations
AB27 5050-5058 HP:0000746 denotes delusion
AB28 5398-5418 HP:0000020 denotes urinary incontinence
AB29 5884-5897 HP:0003487 denotes Babinski sign
AB30 6359-6373 HP:0030223 denotes perseverations
AB31 6526-6539 HP:0100753 denotes Schizophrenia
AB32 6599-6613 HP:0000738 denotes hallucinations
AB33 6679-6692 HP:0100753 denotes schizophrenia
AB34 6811-6824 HP:0100753 denotes schizophrenia
AB35 6878-6891 HP:0100753 denotes schizophrenia
AB36 7041-7054 HP:0100753 denotes Schizophrenia
AB37 7153-7166 HP:0100753 denotes schizophrenia
AB38 7203-7216 HP:0100753 denotes Schizophrenia
AB39 7342-7355 HP:0100753 denotes schizophrenia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1894-1901 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 3986-3991 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T3 6034-6039 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T4 6044-6049 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 2732-2762 ORDO:100070 denotes progressive non-fluent aphasia
AB2 2772-2789 ORDO:100069 denotes semantic dementia

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1894-1901 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 6034-6039 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T3 3986-3991 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T4 2186-2194 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T5 2507-2515 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T6 6044-6049 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine