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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-59 Sentence denotes Galectin 3 and its binding protein in rheumatoid arthritis.
T2 60-70 Sentence denotes OBJECTIVE:
T3 71-380 Sentence denotes To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.
T4 381-389 Sentence denotes METHODS:
T5 390-582 Sentence denotes Synovial tissues from patients with RA or osteoarthritis (OA), as well as from healthy controls, were analyzed for galectins 1 and 3 and G3BP by in situ hybridization and immunohistochemistry.
T6 583-786 Sentence denotes Levels of galectin 3 and G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA).
T7 787-1033 Sentence denotes In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry.
T8 1034-1042 Sentence denotes RESULTS:
T9 1043-1198 Sentence denotes In RA, galectin 3 messenger RNA and protein stained throughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction.
T10 1199-1325 Sentence denotes In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion.
T11 1326-1430 Sentence denotes In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP.
T12 1431-1541 Sentence denotes Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only.
T13 1542-1757 Sentence denotes In RA, serum galectin 3 correlated with C-reactive protein levels, whereas G3BP was associated with joint destruction and/or synovial cell activation as measured by the levels of cartilage oligomeric matrix protein.
T14 1758-1909 Sentence denotes In vitro, RA synovial fibroblasts showed an increased release of galectin 3 into culture medium, as measured by ELISA, but decreased secretion of G3BP.
T15 1910-2048 Sentence denotes In RA synovial fibroblasts with low basal expression of galectin 3, TNFalpha increased its intracellular level in a dose-dependent manner.
T16 2049-2123 Sentence denotes In contrast, IL-1beta or anti-CD40 monoclonal antibodies showed no effect.
T17 2124-2135 Sentence denotes CONCLUSION:
T18 2136-2280 Sentence denotes Our data indicate that galectin 3 and G3BP are not only involved in inflammation, but also contribute to the activation of synovial fibroblasts.
T19 2281-2354 Sentence denotes The intracellular accumulation of galectin 3 can be enhanced by TNFalpha.
T20 2355-2431 Sentence denotes Thus, galectin 3 and G3BP represent novel markers of disease activity in RA.
T1 0-59 Sentence denotes Galectin 3 and its binding protein in rheumatoid arthritis.
T2 60-70 Sentence denotes OBJECTIVE:
T3 71-380 Sentence denotes To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.
T4 381-389 Sentence denotes METHODS:
T5 390-582 Sentence denotes Synovial tissues from patients with RA or osteoarthritis (OA), as well as from healthy controls, were analyzed for galectins 1 and 3 and G3BP by in situ hybridization and immunohistochemistry.
T6 583-786 Sentence denotes Levels of galectin 3 and G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA).
T7 787-1033 Sentence denotes In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry.
T8 1034-1042 Sentence denotes RESULTS:
T9 1043-1198 Sentence denotes In RA, galectin 3 messenger RNA and protein stained throughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction.
T10 1199-1325 Sentence denotes In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion.
T11 1326-1430 Sentence denotes In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP.
T12 1431-1541 Sentence denotes Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only.
T13 1542-1757 Sentence denotes In RA, serum galectin 3 correlated with C-reactive protein levels, whereas G3BP was associated with joint destruction and/or synovial cell activation as measured by the levels of cartilage oligomeric matrix protein.
T14 1758-1909 Sentence denotes In vitro, RA synovial fibroblasts showed an increased release of galectin 3 into culture medium, as measured by ELISA, but decreased secretion of G3BP.
T15 1910-2048 Sentence denotes In RA synovial fibroblasts with low basal expression of galectin 3, TNFalpha increased its intracellular level in a dose-dependent manner.
T16 2049-2123 Sentence denotes In contrast, IL-1beta or anti-CD40 monoclonal antibodies showed no effect.
T17 2124-2135 Sentence denotes CONCLUSION:
T18 2136-2280 Sentence denotes Our data indicate that galectin 3 and G3BP are not only involved in inflammation, but also contribute to the activation of synovial fibroblasts.
T19 2281-2354 Sentence denotes The intracellular accumulation of galectin 3 can be enhanced by TNFalpha.
T20 2355-2431 Sentence denotes Thus, galectin 3 and G3BP represent novel markers of disease activity in RA.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 71-380 OBJECTIVE denotes To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.
T2 390-1033 METHODS denotes Synovial tissues from patients with RA or osteoarthritis (OA), as well as from healthy controls, were analyzed for galectins 1 and 3 and G3BP by in situ hybridization and immunohistochemistry. Levels of galectin 3 and G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA). In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry.
T3 1043-2123 RESULTS denotes In RA, galectin 3 messenger RNA and protein stained throughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction. In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion. In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP. Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only. In RA, serum galectin 3 correlated with C-reactive protein levels, whereas G3BP was associated with joint destruction and/or synovial cell activation as measured by the levels of cartilage oligomeric matrix protein. In vitro, RA synovial fibroblasts showed an increased release of galectin 3 into culture medium, as measured by ELISA, but decreased secretion of G3BP. In RA synovial fibroblasts with low basal expression of galectin 3, TNFalpha increased its intracellular level in a dose-dependent manner. In contrast, IL-1beta or anti-CD40 monoclonal antibodies showed no effect.
T4 2136-2431 CONCLUSIONS denotes Our data indicate that galectin 3 and G3BP are not only involved in inflammation, but also contribute to the activation of synovial fibroblasts. The intracellular accumulation of galectin 3 can be enhanced by TNFalpha. Thus, galectin 3 and G3BP represent novel markers of disease activity in RA.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 174-194 HP_0001370 denotes rheumatoid arthritis
T2 185-194 HP_0001369 denotes arthritis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14558084-0#0#10#gene3958 608-839 gene3958 denotes G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA). In vitro, the intracellular expression of galectin 3
14558084-0#38#58#diseaseC0003873 1097-1607 diseaseC0003873 denotes roughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction. In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion. In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP. Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only. In RA, serum galectin 3 correlated with C-reactive protein levels
14558084-1#66#92#gene3959 137-163 gene3959 denotes galectin 3 binding protein
14558084-1#103#123#diseaseC0003873 174-194 diseaseC0003873 denotes rheumatoid arthritis
14558084-1#125#127#diseaseC0003873 196-198 diseaseC0003873 denotes RA
14558084-15#21#25#gene10146 2376-2380 gene10146 denotes G3BP
14558084-15#73#75#diseaseC0003873 2428-2430 diseaseC0003873 denotes RA
14558084-3#25#29#gene10146 608-612 gene10146 denotes G3BP
14558084-3#84#86#diseaseC0029408 667-669 diseaseC0029408 denotes OA
14558084-4#42#52#gene3958 829-839 gene3958 denotes galectin 3
14558084-4#109#136#gene7124 896-923 gene7124 denotes tumor necrosis factor alpha
14558084-4#138#146#gene7124 925-933 gene7124 denotes TNFalpha
14558084-4#188#192#gene958 975-979 gene958 denotes CD40
14558084-4#63#65#diseaseC0029408 850-852 diseaseC0029408 denotes OA
14558084-4#56#58#diseaseC0003873 843-845 diseaseC0003873 denotes RA
14558084-4#63#65#diseaseC0029408 850-852 diseaseC0029408 denotes OA
14558084-4#56#58#diseaseC0003873 843-845 diseaseC0003873 denotes RA
14558084-4#63#65#diseaseC0029408 850-852 diseaseC0029408 denotes OA
14558084-4#56#58#diseaseC0003873 843-845 diseaseC0003873 denotes RA
14558084-4#63#65#diseaseC0029408 850-852 diseaseC0029408 denotes OA
14558084-5#94#98#gene10146 1137-1141 gene10146 denotes G3BP
14558084-5#138#154#diseaseC0238790 1181-1197 diseaseC0238790 denotes bone destruction
14558084-6#31#41#gene3956 1230-1240 gene3956 denotes galectin 1
14558084-6#71#73#diseaseC0003873 1270-1272 diseaseC0003873 denotes RA
0#10#gene395838#58#diseaseC0003873 14558084-0#0#10#gene3958 14558084-0#38#58#diseaseC0003873 associated_with "G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA). In vitro, the intracellular expression of galectin 3","roughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction. In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion. In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP. Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only. In RA, serum galectin 3 correlated with C-reactive protein levels"
66#92#gene3959103#123#diseaseC0003873 14558084-1#66#92#gene3959 14558084-1#103#123#diseaseC0003873 associated_with galectin 3 binding protein,rheumatoid arthritis
66#92#gene3959125#127#diseaseC0003873 14558084-1#66#92#gene3959 14558084-1#125#127#diseaseC0003873 associated_with galectin 3 binding protein,RA
21#25#gene1014673#75#diseaseC0003873 14558084-15#21#25#gene10146 14558084-15#73#75#diseaseC0003873 associated_with G3BP,RA
25#29#gene1014684#86#diseaseC0029408 14558084-3#25#29#gene10146 14558084-3#84#86#diseaseC0029408 associated_with G3BP,OA
42#52#gene395863#65#diseaseC0029408 14558084-4#42#52#gene3958 14558084-4#63#65#diseaseC0029408 associated_with galectin 3,OA
42#52#gene395856#58#diseaseC0003873 14558084-4#42#52#gene3958 14558084-4#56#58#diseaseC0003873 associated_with galectin 3,RA
42#52#gene395863#65#diseaseC0029408 14558084-4#42#52#gene3958 14558084-4#63#65#diseaseC0029408 associated_with galectin 3,OA
42#52#gene395856#58#diseaseC0003873 14558084-4#42#52#gene3958 14558084-4#56#58#diseaseC0003873 associated_with galectin 3,RA
42#52#gene395863#65#diseaseC0029408 14558084-4#42#52#gene3958 14558084-4#63#65#diseaseC0029408 associated_with galectin 3,OA
42#52#gene395856#58#diseaseC0003873 14558084-4#42#52#gene3958 14558084-4#56#58#diseaseC0003873 associated_with galectin 3,RA
42#52#gene395863#65#diseaseC0029408 14558084-4#42#52#gene3958 14558084-4#63#65#diseaseC0029408 associated_with galectin 3,OA
109#136#gene712463#65#diseaseC0029408 14558084-4#109#136#gene7124 14558084-4#63#65#diseaseC0029408 associated_with tumor necrosis factor alpha,OA
109#136#gene712456#58#diseaseC0003873 14558084-4#109#136#gene7124 14558084-4#56#58#diseaseC0003873 associated_with tumor necrosis factor alpha,RA
109#136#gene712463#65#diseaseC0029408 14558084-4#109#136#gene7124 14558084-4#63#65#diseaseC0029408 associated_with tumor necrosis factor alpha,OA
109#136#gene712456#58#diseaseC0003873 14558084-4#109#136#gene7124 14558084-4#56#58#diseaseC0003873 associated_with tumor necrosis factor alpha,RA
109#136#gene712463#65#diseaseC0029408 14558084-4#109#136#gene7124 14558084-4#63#65#diseaseC0029408 associated_with tumor necrosis factor alpha,OA
109#136#gene712456#58#diseaseC0003873 14558084-4#109#136#gene7124 14558084-4#56#58#diseaseC0003873 associated_with tumor necrosis factor alpha,RA
109#136#gene712463#65#diseaseC0029408 14558084-4#109#136#gene7124 14558084-4#63#65#diseaseC0029408 associated_with tumor necrosis factor alpha,OA
138#146#gene712463#65#diseaseC0029408 14558084-4#138#146#gene7124 14558084-4#63#65#diseaseC0029408 associated_with TNFalpha,OA
138#146#gene712456#58#diseaseC0003873 14558084-4#138#146#gene7124 14558084-4#56#58#diseaseC0003873 associated_with TNFalpha,RA
138#146#gene712463#65#diseaseC0029408 14558084-4#138#146#gene7124 14558084-4#63#65#diseaseC0029408 associated_with TNFalpha,OA
138#146#gene712456#58#diseaseC0003873 14558084-4#138#146#gene7124 14558084-4#56#58#diseaseC0003873 associated_with TNFalpha,RA
138#146#gene712463#65#diseaseC0029408 14558084-4#138#146#gene7124 14558084-4#63#65#diseaseC0029408 associated_with TNFalpha,OA
138#146#gene712456#58#diseaseC0003873 14558084-4#138#146#gene7124 14558084-4#56#58#diseaseC0003873 associated_with TNFalpha,RA
138#146#gene712463#65#diseaseC0029408 14558084-4#138#146#gene7124 14558084-4#63#65#diseaseC0029408 associated_with TNFalpha,OA
188#192#gene95863#65#diseaseC0029408 14558084-4#188#192#gene958 14558084-4#63#65#diseaseC0029408 associated_with CD40,OA
188#192#gene95856#58#diseaseC0003873 14558084-4#188#192#gene958 14558084-4#56#58#diseaseC0003873 associated_with CD40,RA
188#192#gene95863#65#diseaseC0029408 14558084-4#188#192#gene958 14558084-4#63#65#diseaseC0029408 associated_with CD40,OA
188#192#gene95856#58#diseaseC0003873 14558084-4#188#192#gene958 14558084-4#56#58#diseaseC0003873 associated_with CD40,RA
188#192#gene95863#65#diseaseC0029408 14558084-4#188#192#gene958 14558084-4#63#65#diseaseC0029408 associated_with CD40,OA
188#192#gene95856#58#diseaseC0003873 14558084-4#188#192#gene958 14558084-4#56#58#diseaseC0003873 associated_with CD40,RA
188#192#gene95863#65#diseaseC0029408 14558084-4#188#192#gene958 14558084-4#63#65#diseaseC0029408 associated_with CD40,OA
94#98#gene10146138#154#diseaseC0238790 14558084-5#94#98#gene10146 14558084-5#138#154#diseaseC0238790 associated_with G3BP,bone destruction
31#41#gene395671#73#diseaseC0003873 14558084-6#31#41#gene3956 14558084-6#71#73#diseaseC0003873 associated_with galectin 1,RA

DisGeNET

Id Subject Object Predicate Lexical cue
T0 220-273 gene:3958 denotes galectin 1, and to explore whether soluble galectin 3
T1 1270-1272 disease:C0003873 denotes RA
T2 278-282 gene:10146 denotes G3BP
T3 1270-1272 disease:C0003873 denotes RA
R1 T0 T1 associated_with "galectin 1, and to explore whether soluble galectin 3",RA
R2 T2 T3 associated_with G3BP,RA