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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.
T2 90-110 Sentence denotes BACKGROUND AND AIMS:
T3 111-272 Sentence denotes The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation.
T4 273-345 Sentence denotes We investigated the expression of CCL21 and CCR7 in chronic hepatitis C.
T5 346-418 Sentence denotes The effects of CCL21 on hepatic stellate cells (HSCs) were also studied.
T6 419-427 Sentence denotes METHODS:
T7 428-511 Sentence denotes Expression of CCL21 was assessed by in situ hybridization and immunohistochemistry.
T8 512-559 Sentence denotes CCR7 on T cells was analyzed by flow cytometry.
T9 560-622 Sentence denotes Cultured human HSCs were studied in their activated phenotype.
T10 623-631 Sentence denotes RESULTS:
T11 632-716 Sentence denotes In patients with chronic hepatitis C, expression of CCL21 and CCR7 was up-regulated.
T12 717-902 Sentence denotes CCL21 was detected in the portal tracts and around inflammatory lymphoid follicles, in proximity to T lymphocytes and dendritic cells, which contributed to expression of this chemokine.
T13 903-984 Sentence denotes Expression of CCR7 was also increased in patients with primary biliary cirrhosis.
T14 985-1223 Sentence denotes Intrahepatic CD8(+) T lymphocytes isolated from patients with chronic hepatitis C had a significantly higher percentage of positivity for CCR7 than those from healthy controls, and the expression of CCR7 was associated with that of CXCR3.
T15 1224-1366 Sentence denotes Cultured HSCs expressed functional CCR7, the activation of which stimulated cell migration and accelerated wound healing in an in vitro model.
T16 1367-1560 Sentence denotes Exposure of HSCs to CCL21 triggered several signaling pathways, including extracellular signal-regulated kinase, Akt, and nuclear factor kappaB, resulting in induction of proinflammatory genes.
T17 1561-1573 Sentence denotes CONCLUSIONS:
T18 1574-1806 Sentence denotes Expression of CCL21 during chronic hepatitis C is implicated in the recruitment of T lymphocytes and the organization of inflammatory lymphoid tissue and may promote fibrogenesis in the inflamed areas via activation of CCR7 on HSCs.
T1 0-89 Sentence denotes The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.
T2 90-110 Sentence denotes BACKGROUND AND AIMS:
T3 111-272 Sentence denotes The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation.
T4 273-345 Sentence denotes We investigated the expression of CCL21 and CCR7 in chronic hepatitis C.
T5 346-418 Sentence denotes The effects of CCL21 on hepatic stellate cells (HSCs) were also studied.
T6 419-427 Sentence denotes METHODS:
T7 428-511 Sentence denotes Expression of CCL21 was assessed by in situ hybridization and immunohistochemistry.
T8 512-559 Sentence denotes CCR7 on T cells was analyzed by flow cytometry.
T9 560-622 Sentence denotes Cultured human HSCs were studied in their activated phenotype.
T10 623-631 Sentence denotes RESULTS:
T11 632-716 Sentence denotes In patients with chronic hepatitis C, expression of CCL21 and CCR7 was up-regulated.
T12 717-902 Sentence denotes CCL21 was detected in the portal tracts and around inflammatory lymphoid follicles, in proximity to T lymphocytes and dendritic cells, which contributed to expression of this chemokine.
T13 903-984 Sentence denotes Expression of CCR7 was also increased in patients with primary biliary cirrhosis.
T14 985-1223 Sentence denotes Intrahepatic CD8(+) T lymphocytes isolated from patients with chronic hepatitis C had a significantly higher percentage of positivity for CCR7 than those from healthy controls, and the expression of CCR7 was associated with that of CXCR3.
T15 1224-1366 Sentence denotes Cultured HSCs expressed functional CCR7, the activation of which stimulated cell migration and accelerated wound healing in an in vitro model.
T16 1367-1560 Sentence denotes Exposure of HSCs to CCL21 triggered several signaling pathways, including extracellular signal-regulated kinase, Akt, and nuclear factor kappaB, resulting in induction of proinflammatory genes.
T17 1561-1573 Sentence denotes CONCLUSIONS:
T18 1574-1806 Sentence denotes Expression of CCL21 during chronic hepatitis C is implicated in the recruitment of T lymphocytes and the organization of inflammatory lymphoid tissue and may promote fibrogenesis in the inflamed areas via activation of CCR7 on HSCs.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 111-418 OBJECTIVE denotes The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied.
T2 428-622 METHODS denotes Expression of CCL21 was assessed by in situ hybridization and immunohistochemistry. CCR7 on T cells was analyzed by flow cytometry. Cultured human HSCs were studied in their activated phenotype.
T3 632-1560 RESULTS denotes In patients with chronic hepatitis C, expression of CCL21 and CCR7 was up-regulated. CCL21 was detected in the portal tracts and around inflammatory lymphoid follicles, in proximity to T lymphocytes and dendritic cells, which contributed to expression of this chemokine. Expression of CCR7 was also increased in patients with primary biliary cirrhosis. Intrahepatic CD8(+) T lymphocytes isolated from patients with chronic hepatitis C had a significantly higher percentage of positivity for CCR7 than those from healthy controls, and the expression of CCR7 was associated with that of CXCR3. Cultured HSCs expressed functional CCR7, the activation of which stimulated cell migration and accelerated wound healing in an in vitro model. Exposure of HSCs to CCL21 triggered several signaling pathways, including extracellular signal-regulated kinase, Akt, and nuclear factor kappaB, resulting in induction of proinflammatory genes.
T4 1574-1806 CONCLUSIONS denotes Expression of CCL21 during chronic hepatitis C is implicated in the recruitment of T lymphocytes and the organization of inflammatory lymphoid tissue and may promote fibrogenesis in the inflamed areas via activation of CCR7 on HSCs.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14517790-0#14#19#gene6366 14-19 gene6366 denotes CCL21
14517790-0#69#88#diseaseC0524910 69-88 diseaseC0524910 denotes chronic hepatitis C
14517790-12#219#223#gene1236 1793-1797 gene1236 denotes CCR7
14517790-12#27#46#diseaseC0524910 1601-1620 diseaseC0524910 denotes chronic hepatitis C
14517790-8#14#18#gene1236 917-921 gene1236 denotes CCR7
14517790-8#55#80#diseaseC0008312 958-983 diseaseC0008312 denotes primary biliary cirrhosis
14517790-9#232#237#gene2833 1217-1222 gene2833 denotes CXCR3
14517790-9#62#81#diseaseC0524910 1047-1066 diseaseC0524910 denotes chronic hepatitis C
14#19#gene636669#88#diseaseC0524910 14517790-0#14#19#gene6366 14517790-0#69#88#diseaseC0524910 associated_with CCL21,chronic hepatitis C
219#223#gene123627#46#diseaseC0524910 14517790-12#219#223#gene1236 14517790-12#27#46#diseaseC0524910 associated_with CCR7,chronic hepatitis C
14#18#gene123655#80#diseaseC0008312 14517790-8#14#18#gene1236 14517790-8#55#80#diseaseC0008312 associated_with CCR7,primary biliary cirrhosis
232#237#gene283362#81#diseaseC0524910 14517790-9#232#237#gene2833 14517790-9#62#81#diseaseC0524910 associated_with CXCR3,chronic hepatitis C

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1123-1127 gene:1236 denotes CCR7
T1 1047-1066 disease:C0524910 denotes chronic hepatitis C
T2 1184-1188 gene:1236 denotes CCR7
T3 1047-1066 disease:C0524910 denotes chronic hepatitis C
T4 1217-1222 gene:2833 denotes CXCR3
T5 1047-1066 disease:C0524910 denotes chronic hepatitis C
R1 T0 T1 associated_with CCR7,chronic hepatitis C
R2 T2 T3 associated_with CCR7,chronic hepatitis C
R3 T4 T5 associated_with CXCR3,chronic hepatitis C