PubMed:14508679 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/14508679","sourcedb":"PubMed","sourceid":"14508679","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/14508679","text":"Tandem duplication of alkaline phosphatase genes and polymorphism in the intergenic sequence in Bombyx mori.\nAlkaline phosphatases are ubiquitous in organisms from bacteria to human. Two alkaline phosphatase genes, Alp-m and Alp-s, were independently cloned from the silkworm Bombyx mori. They were mapped to a small DNA region and shown to be organized in tandem. Exon-intron structures of the two genes were highly conserved, with the exception of the second intron in Alp-m, which has no counterpart in Alp-s. The similarity between the nucleotide sequences of the exons of the two genes was strikingly high (60-79%), suggesting that Alp-m and Alp-s originated from a duplication of their common ancestor gene. The intergenic sequence between the two Alp genes shows length polymorphism in different B. mori strains, which can be explained by presence/absence of two putative insertion sequences. This structural variation suggests a possible scenario for the divergence of the two Alp genes after the duplication event.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":671,"end":682},"obj":"HP_0009609"},{"id":"T2","span":{"begin":1005,"end":1016},"obj":"HP_0009609"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"silkworm","denotations":[{"id":"T1","span":{"begin":96,"end":107},"obj":"Species:7091"},{"id":"T2","span":{"begin":176,"end":181},"obj":"Species:9606"},{"id":"T3","span":{"begin":215,"end":220},"obj":"Gene:693074"},{"id":"T4","span":{"begin":225,"end":230},"obj":"Gene:692396"},{"id":"T5","span":{"begin":267,"end":275},"obj":"Species:7091"},{"id":"T6","span":{"begin":276,"end":287},"obj":"Species:7091"},{"id":"T7","span":{"begin":471,"end":476},"obj":"Gene:693074"},{"id":"T8","span":{"begin":506,"end":511},"obj":"Gene:692396"},{"id":"T9","span":{"begin":637,"end":642},"obj":"Gene:693074"},{"id":"T10","span":{"begin":647,"end":652},"obj":"Gene:692396"},{"id":"T11","span":{"begin":803,"end":810},"obj":"Species:7091"}],"attributes":[{"subj":"T1","pred":"source","obj":"silkworm"},{"subj":"T2","pred":"source","obj":"silkworm"},{"subj":"T3","pred":"source","obj":"silkworm"},{"subj":"T4","pred":"source","obj":"silkworm"},{"subj":"T5","pred":"source","obj":"silkworm"},{"subj":"T6","pred":"source","obj":"silkworm"},{"subj":"T7","pred":"source","obj":"silkworm"},{"subj":"T8","pred":"source","obj":"silkworm"},{"subj":"T9","pred":"source","obj":"silkworm"},{"subj":"T10","pred":"source","obj":"silkworm"},{"subj":"T11","pred":"source","obj":"silkworm"}]},{"project":"silkwormbase","denotations":[{"id":"T1","span":{"begin":96,"end":107},"obj":"Species:7091"},{"id":"T10","span":{"begin":647,"end":652},"obj":"Gene:692396"},{"id":"T11","span":{"begin":803,"end":810},"obj":"Species:7091"},{"id":"T2","span":{"begin":176,"end":181},"obj":"Species:9606"},{"id":"T3","span":{"begin":215,"end":220},"obj":"Gene:693074"},{"id":"T4","span":{"begin":225,"end":230},"obj":"Gene:692396"},{"id":"T5","span":{"begin":267,"end":275},"obj":"Species:7091"},{"id":"T6","span":{"begin":276,"end":287},"obj":"Species:7091"},{"id":"T7","span":{"begin":471,"end":476},"obj":"Gene:693074"},{"id":"T8","span":{"begin":506,"end":511},"obj":"Gene:692396"},{"id":"T9","span":{"begin":637,"end":642},"obj":"Gene:693074"}],"attributes":[{"subj":"T1","pred":"source","obj":"silkwormbase"},{"subj":"T10","pred":"source","obj":"silkwormbase"},{"subj":"T11","pred":"source","obj":"silkwormbase"},{"subj":"T2","pred":"source","obj":"silkwormbase"},{"subj":"T3","pred":"source","obj":"silkwormbase"},{"subj":"T4","pred":"source","obj":"silkwormbase"},{"subj":"T5","pred":"source","obj":"silkwormbase"},{"subj":"T6","pred":"source","obj":"silkwormbase"},{"subj":"T7","pred":"source","obj":"silkwormbase"},{"subj":"T8","pred":"source","obj":"silkwormbase"},{"subj":"T9","pred":"source","obj":"silkwormbase"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93ecc1","default":true},{"id":"silkworm","color":"#eca793"},{"id":"silkwormbase","color":"#9399ec"}]}]}}