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PubMed:14247717 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 367-376 HP_0000967 denotes petechial

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES.
T2 106-227 Sentence denotes Lysosomal granules of rabbit exudate polymorphonuclear (PMN) leucocytes were isolated and then lysed by freezing-thawing.
T3 228-388 Sentence denotes Topical application of this material to rat and rabbit mesentery produced sticking and emigration of leucocytes, stasis of blood flow, and petechial hemorrhage.
T4 389-499 Sentence denotes The granule-free, supernatant fraction of the homogenized leucocytes failed to produce any of these reactions.
T5 500-710 Sentence denotes Cationic proteins extracted from these granules by weak acid and precipitated by ethanol at concentrations of 20 and 45 per cent, were also tested on heterologous, homologous, and autologous mesenteric vessels.
T6 711-856 Sentence denotes The 20 per cent ethanol-precipitated fraction produced all of the aforementioned injury reactions, whereas the 45 per cent fraction was inactive.
T7 857-999 Sentence denotes The intensity of inflammatory changes produced by the active cationic protein fraction was greater than that produced by lysed whole granules.
T8 1000-1122 Sentence denotes Both the 20 per cent and 45 per cent ethanol fractions of cationic protein induced clumping of rabbit platelets, in vitro.
T9 1123-1248 Sentence denotes The 20 per cent ethanol fraction also caused a slight acceleration in rate of swelling of isolated rabbit liver mitochondria.
T10 1249-1307 Sentence denotes The active material proved to be non-pyrogenic in rabbits.
T11 1308-1441 Sentence denotes This material exhibited no kinin-like effects when tested on isolated smooth muscle preparations (rabbit aorta and guinea pig ileum).
T12 1442-1574 Sentence denotes In the rat, the protein produced a transient vasodepression which was inhibited by pretreatment of the animal with an antihistamine.
T13 1575-1720 Sentence denotes Ultraviolet absorption data and ribose assays showed that the 20 per cent ethanol fraction contained only 4 per cent or less of ribonucleic acid.
T14 1721-1872 Sentence denotes Upon electrophoresis in starch gel, using acid buffer, this fraction separated into at least three major components which migrated towards the cathode.
T15 1873-2029 Sentence denotes Precipitation of one of the slowly migrating components by titration of the fraction to pH 10.5 greatly increased the inflammatory activity of the material.
T16 2030-2185 Sentence denotes The inflammatory basic protein fraction was essentially devoid of acid phosphatase, beta glucuronidase, acid ribonuclease, lysozyme, and catalase activity.
T17 2186-2297 Sentence denotes The non-inflammatory basic protein fraction contained appreciable quantities of acid ribonuclease and lysozyme.
T18 2298-2564 Sentence denotes The foregoing data demonstrate that certain of the cationic proteins present in lysosomes of rabbit exudate PMN leucocytes can reproduce one of the cardinal features of the inflammatory response; namely, adhesion and emigration of leucocytes in the microcirculation.
T19 2565-2778 Sentence denotes These findings offer fresh support for the role of lysosomes in the pathogenesis of tissue injury, and may help to account for the propagation of leucocyte emigration to peak numbers during inflammatory reactions.
T1 0-105 Sentence denotes PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES.
T2 106-227 Sentence denotes Lysosomal granules of rabbit exudate polymorphonuclear (PMN) leucocytes were isolated and then lysed by freezing-thawing.
T3 228-388 Sentence denotes Topical application of this material to rat and rabbit mesentery produced sticking and emigration of leucocytes, stasis of blood flow, and petechial hemorrhage.
T4 389-499 Sentence denotes The granule-free, supernatant fraction of the homogenized leucocytes failed to produce any of these reactions.
T5 500-710 Sentence denotes Cationic proteins extracted from these granules by weak acid and precipitated by ethanol at concentrations of 20 and 45 per cent, were also tested on heterologous, homologous, and autologous mesenteric vessels.
T6 711-856 Sentence denotes The 20 per cent ethanol-precipitated fraction produced all of the aforementioned injury reactions, whereas the 45 per cent fraction was inactive.
T7 857-999 Sentence denotes The intensity of inflammatory changes produced by the active cationic protein fraction was greater than that produced by lysed whole granules.
T8 1000-1122 Sentence denotes Both the 20 per cent and 45 per cent ethanol fractions of cationic protein induced clumping of rabbit platelets, in vitro.
T9 1123-1248 Sentence denotes The 20 per cent ethanol fraction also caused a slight acceleration in rate of swelling of isolated rabbit liver mitochondria.
T10 1249-1307 Sentence denotes The active material proved to be non-pyrogenic in rabbits.
T11 1308-1441 Sentence denotes This material exhibited no kinin-like effects when tested on isolated smooth muscle preparations (rabbit aorta and guinea pig ileum).
T12 1442-1574 Sentence denotes In the rat, the protein produced a transient vasodepression which was inhibited by pretreatment of the animal with an antihistamine.
T13 1575-1720 Sentence denotes Ultraviolet absorption data and ribose assays showed that the 20 per cent ethanol fraction contained only 4 per cent or less of ribonucleic acid.
T14 1721-1872 Sentence denotes Upon electrophoresis in starch gel, using acid buffer, this fraction separated into at least three major components which migrated towards the cathode.
T15 1873-2029 Sentence denotes Precipitation of one of the slowly migrating components by titration of the fraction to pH 10.5 greatly increased the inflammatory activity of the material.
T16 2030-2185 Sentence denotes The inflammatory basic protein fraction was essentially devoid of acid phosphatase, beta glucuronidase, acid ribonuclease, lysozyme, and catalase activity.
T17 2186-2297 Sentence denotes The non-inflammatory basic protein fraction contained appreciable quantities of acid ribonuclease and lysozyme.
T18 2298-2564 Sentence denotes The foregoing data demonstrate that certain of the cationic proteins present in lysosomes of rabbit exudate PMN leucocytes can reproduce one of the cardinal features of the inflammatory response; namely, adhesion and emigration of leucocytes in the microcirculation.
T19 2565-2778 Sentence denotes These findings offer fresh support for the role of lysosomes in the pathogenesis of tissue injury, and may help to account for the propagation of leucocyte emigration to peak numbers during inflammatory reactions.