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PubMed:1409710 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
1409710-0#92#113#gene7450 92-113 gene7450 denotes von Willebrand factor
1409710-0#0#22#diseaseC0042974 0-22 diseaseC0042974 denotes von Willebrand disease
92#113#gene74500#22#diseaseC0042974 1409710-0#92#113#gene7450 1409710-0#0#22#diseaseC0042974 associated_with von Willebrand factor,von Willebrand disease

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-150 Sentence denotes von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.
TextSentencer_T2 151-309 Sentence denotes von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib.
TextSentencer_T3 310-433 Sentence denotes For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin.
TextSentencer_T4 434-709 Sentence denotes A missense mutation, Gly-561-->Ser, was identified within the proposed glycoprotein Ib binding domain of vWF in the proband with von Willebrand disease type B, a unique variant characterized by no ristocetin-induced, but normal botrocetin-induced, binding to glycoprotein Ib.
TextSentencer_T5 710-930 Sentence denotes The corresponding mutant recombinant protein, rvWF(G561S), formed normal multimers and exhibited the same functional defect as the patient's plasma vWF, confirming that this mutation causes von Willebrand disease type B.
TextSentencer_T6 931-1134 Sentence denotes These data show that botrocetin and ristocetin cofactor activities of vWF can be dissociated by a point mutation and confirm that these mediators promote vWF binding to platelets by different mechanisms.
TextSentencer_T7 1135-1394 Sentence denotes The normal botrocetin-induced binding and the defective ristocetin-induced binding of rvWF(G561S) suggest that the primary defect in von Willebrand disease type B may be a failure of normal allosteric regulation of the glycoprotein Ib binding function of vWF.
T1 0-150 Sentence denotes von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.
T2 151-309 Sentence denotes von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib.
T3 310-433 Sentence denotes For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin.
T4 434-709 Sentence denotes A missense mutation, Gly-561-->Ser, was identified within the proposed glycoprotein Ib binding domain of vWF in the proband with von Willebrand disease type B, a unique variant characterized by no ristocetin-induced, but normal botrocetin-induced, binding to glycoprotein Ib.
T5 710-930 Sentence denotes The corresponding mutant recombinant protein, rvWF(G561S), formed normal multimers and exhibited the same functional defect as the patient's plasma vWF, confirming that this mutation causes von Willebrand disease type B.
T6 931-1134 Sentence denotes These data show that botrocetin and ristocetin cofactor activities of vWF can be dissociated by a point mutation and confirm that these mediators promote vWF binding to platelets by different mechanisms.
T7 1135-1394 Sentence denotes The normal botrocetin-induced binding and the defective ristocetin-induced binding of rvWF(G561S) suggest that the primary defect in von Willebrand disease type B may be a failure of normal allosteric regulation of the glycoprotein Ib binding function of vWF.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 402-413 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
PD-UBERON-AE-B_T2 408-413 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 0-22 ORDO:903 denotes von Willebrand disease
AB1 563-585 ORDO:903 denotes von Willebrand disease
AB2 900-922 ORDO:903 denotes von Willebrand disease
AB3 1268-1290 ORDO:903 denotes von Willebrand disease

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 402-413 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
PD-UBERON-AE-B_T2 408-413 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 0-29 SpecificDisease:D014842 denotes von Willebrand disease type B
T2 92-106 Modifier:D014842 denotes von Willebrand
T3 151-165 Modifier:D014842 denotes von Willebrand
T4 563-592 SpecificDisease:D014842 denotes von Willebrand disease type B
T5 900-929 SpecificDisease:D014842 denotes von Willebrand disease type B
T6 1268-1297 SpecificDisease:D014842 denotes von Willebrand disease type B

DisGeNET

Id Subject Object Predicate Lexical cue
T0 858-861 gene:7450 denotes vWF
T1 900-922 disease:C0042974 denotes von Willebrand disease
R1 T0 T1 associated_with vWF,von Willebrand disease

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T293 0-29 SpecificDisease denotes von Willebrand disease type B D014842
T294 92-106 Modifier denotes von Willebrand D014842
T295 151-165 Modifier denotes von Willebrand D014842
T296 563-592 SpecificDisease denotes von Willebrand disease type B D014842
T297 900-929 SpecificDisease denotes von Willebrand disease type B D014842
T298 1268-1297 SpecificDisease denotes von Willebrand disease type B D014842

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T293 0-29 SpecificDisease denotes von Willebrand disease type B D014842
T294 92-106 Modifier denotes von Willebrand D014842
T295 151-165 Modifier denotes von Willebrand D014842
T296 563-592 SpecificDisease denotes von Willebrand disease type B D014842
T297 900-929 SpecificDisease denotes von Willebrand disease type B D014842
T298 1268-1297 SpecificDisease denotes von Willebrand disease type B D014842

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 23-29 SpecificDisease denotes type B
T2 586-592 SpecificDisease denotes type B
T3 923-929 SpecificDisease denotes type B
T4 1291-1297 SpecificDisease denotes type B

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 92-929 SpecificDisease denotes von Willebrand factor binding to platelet glycoprotein Ib. von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib. For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin. A missense mutation, Gly-561-->Ser, was identified within the proposed glycoprotein Ib binding domain of vWF in the proband with von Willebrand disease type B, a unique variant characterized by no ristocetin-induced, but normal botrocetin-induced, binding to glycoprotein Ib. The corresponding mutant recombinant protein, rvWF(G561S), formed normal multimers and exhibited the same functional defect as the patient's plasma vWF, confirming that this mutation causes von Willebrand disease type B
T2 562-591 SpecificDisease denotes von Willebrand disease type
T3 899-928 SpecificDisease denotes von Willebrand disease type
T4 1268-1297 SpecificDisease denotes von Willebrand disease type B

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 15-29 SpecificDisease denotes disease type B
T2 563-592 SpecificDisease denotes von Willebrand disease type B
T3 900-929 SpecificDisease denotes von Willebrand disease type B
T4 1268-1297 SpecificDisease denotes von Willebrand disease type B

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 0-29 SpecificDisease denotes von Willebrand disease type B
T2 92-149 CompositeMention denotes von Willebrand factor binding to platelet glycoprotein Ib
T3 151-178 Modifier denotes von Willebrand factor (vWF)
T4 563-592 SpecificDisease denotes von Willebrand disease type B
T5 900-929 SpecificDisease denotes von Willebrand disease type B
T6 1268-1297 SpecificDisease denotes von Willebrand disease type B