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PubMed:13966587 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-61 Sentence denotes Effects of oxyphenbutazone (Tandearil) on plasma seromucoids.
T2 62-64 Sentence denotes I.
T3 65-94 Sentence denotes In experimental inflammation.
T4 95-311 Sentence denotes Some metabolic aspects of seromucoids in inflammation were elucidated by the use of oxyphenbutazone (OPB), a potent anti-inflammatory drug whose mode of action is fundamentally different from that of corticosteroids.
T5 312-402 Sentence denotes Inflammation was induced in rats by intraperitoneal injection of 3 ml. of 1% formaldehyde.
T6 403-517 Sentence denotes This resulted in an immediate and remarkable increase in the plasma seromucoid level, which persisted for 23 days.
T7 518-649 Sentence denotes The subcutaneous injection of OPB (100 mg./kg.), six hours after formal-dehyde treatment, significantly lowered plasma seromucoids.
T8 650-768 Sentence denotes The decrease was more pronounced when the same dosage of OPB was administered 24 hours before formal-dehyde injection.
T9 769-870 Sentence denotes However, no effects were detected with single or repeated injections of OPB in a dosage of 50 mg./kg.
T10 871-953 Sentence denotes Furthermore, the plasma seromucoid levels of normal rats were uninfluenced by OPB.
T11 954-1163 Sentence denotes From these results, it was postulated that some mediating or stimulating factor was released at the site of injury that was responsible for the increased synthesis of seromucoids and that was inhibited by OPB.
T12 1164-1312 Sentence denotes The lowering effect of OPB was in contrast to the action of ACTH and cortisone, which latter do not alter the increased plasma level of seromucoids.
T13 1313-1427 Sentence denotes These results further confirm that plasma seromucoid regulation is independent of the pituitary-adrenal mechanism.
T1 0-61 Sentence denotes Effects of oxyphenbutazone (Tandearil) on plasma seromucoids.
T2 62-64 Sentence denotes I.
T3 65-94 Sentence denotes In experimental inflammation.
T4 95-311 Sentence denotes Some metabolic aspects of seromucoids in inflammation were elucidated by the use of oxyphenbutazone (OPB), a potent anti-inflammatory drug whose mode of action is fundamentally different from that of corticosteroids.
T5 312-402 Sentence denotes Inflammation was induced in rats by intraperitoneal injection of 3 ml. of 1% formaldehyde.
T6 403-517 Sentence denotes This resulted in an immediate and remarkable increase in the plasma seromucoid level, which persisted for 23 days.
T7 518-649 Sentence denotes The subcutaneous injection of OPB (100 mg./kg.), six hours after formal-dehyde treatment, significantly lowered plasma seromucoids.
T8 650-768 Sentence denotes The decrease was more pronounced when the same dosage of OPB was administered 24 hours before formal-dehyde injection.
T9 769-870 Sentence denotes However, no effects were detected with single or repeated injections of OPB in a dosage of 50 mg./kg.
T10 871-953 Sentence denotes Furthermore, the plasma seromucoid levels of normal rats were uninfluenced by OPB.
T11 954-1163 Sentence denotes From these results, it was postulated that some mediating or stimulating factor was released at the site of injury that was responsible for the increased synthesis of seromucoids and that was inhibited by OPB.
T12 1164-1312 Sentence denotes The lowering effect of OPB was in contrast to the action of ACTH and cortisone, which latter do not alter the increased plasma level of seromucoids.
T13 1313-1427 Sentence denotes These results further confirm that plasma seromucoid regulation is independent of the pituitary-adrenal mechanism.