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PubMed:138589 JSONTXT

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Oryza_sentences

Id Subject Object Predicate Lexical cue
T1 0-28 Sentence denotes Mucidin resistance in yeast.
T2 29-161 Sentence denotes Isolation, characterization and genetic analysis of nuclear and mitochondrial mucidin-resistant mutants of Saccharomyces cerevisiae.
T3 162-373 Sentence denotes Mutants of Saccharomyces cerevisiae resistant to the antibiotic mucidin, a specific inhibitor of electron transport between cytochrome b and c, were isolated and divided into three phenotypic groups, as follows.
T4 374-507 Sentence denotes Class 1 mutants were cross-resistant to a variety of mitochondrial inhibitors and exhibited no resistance at the mitochondrial level.
T5 508-628 Sentence denotes Class 2 mutants were specifically resistant to mucidin exhibiting resistance also at the level of isolated mitochondria.
T6 629-965 Sentence denotes Biochemical studies indicated that the mucidin resistance in class 2 mutants involved a modification of mucidin binding of inhibitory sites on the mitochondrial inner membrane without a significance change in the sensitivity of mitochondrial oxygen uptake to antimycin A, 2-heptyl-4-hydroxyquinoline-N-oxide, and 2,3-dimercaptopropanol.
T7 966-1211 Sentence denotes Class 3 was represented by a mutant which showed a high degree of resistance to mucidin and was cross-resistant to a variety of mitochondrial inhibitors at the cellular level but exhibited only a resistance to mucidin at the mitochondrial level.
T8 1212-1372 Sentence denotes Genetic analysis of mucidin-resistant mutants revealed the presence of both nuclear and mitochondrial genes determining mucidin resistance/sensitivity in yeast.
T9 1373-1553 Sentence denotes Resistance to mucidin in class 1 mutants was due to a single-gene nuclear recessive mutation (mucPR) whereas that in class 2 mutants was caused by mutations of mitochondrial genes.
T10 1554-1654 Sentence denotes Resistance in class 3 mutant was determined both by single-gene nuclear and mitochondrial mutations.
T11 1655-1824 Sentence denotes In the mitochondrial mutants the mucidin resistance segregated mitotically and the resistance determinant was lost upon induction of petite mutation by ethidium bromide.
T12 1825-2000 Sentence denotes Allelism tests indicated that the mucidin resistance mutations fell into two genetic loci (MUC1 and MUC2) which were apparently not closely linked in the mitochondrial genome.
T13 2001-2137 Sentence denotes Recombination studies showed that the two mitochondrial mucidin loci were not allelic with other mitochondrial loci RIB1, RIB2 and OLI1.
T14 2138-2332 Sentence denotes An extremely high mucidin resistance at the cellular level was shown to arise from synergistic interaction of the nuclear gene mucPR and the mitochondrial mucidin-resistance gene (MR) in a cell.
T15 2333-2552 Sentence denotes The results suggest that at least two mitochondrial gene products, responsible for mucidin resistance/sensitivity in yeast, take part in the formation of the cytochrome bc1 region of the mitochondrial respiratory chain.